Automated analysis of postoperative behaviour: Assessment of homecagescan as a novel method to rapidly identify pain and analgesic effects in mice

Laboratory Animals

Volumn 43, Issue 1, 2009, Pages 17-26

  Roughan, J V ^a   Wright Williams, S L ^a   Flecknell, P A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Analgesia; Behaviour; Cleversys; Mouse; Pain

Indexed keywords

ISOFLURANE; MELOXICAM;

ANALGESIA; ANESTHESIA; ANIMAL BEHAVIOR; ARTICLE; AUTOMATION; COMPUTER PROGRAM; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; PAIN ASSESSMENT; POSTOPERATIVE PAIN; VASECTOMY; WEIGHT CHANGE;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED STRAINS; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; POSTOPERATIVE PERIOD; SENSITIVITY AND SPECIFICITY; SOFTWARE; THIAZINES; THIAZOLES; VASECTOMY;

MUS; RATTUS; RODENTIA;

EID: 58349094964     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2008.007156     Document Type: Article

References (19)

1. Kupers RC, Nuytten D, De Castro-Costa M, Gybels JM. A time course analysis of the changes in spontaneous and evoked behaviour in a rat model of neuropathic pain. Pain 1992;50:101-11
2. McGeown D, Danbury TC, Waterman-Pearson AE, Kestin SC. Effect of carprofen on lameness in broiler chickens. Vet Rec 1999;24:668-71
3. Roughan JV, Flecknell PA. Evaluation of a short duration behaviour-based post-operative pain scoring system in rats. Eur J Pain 2003;7:397-406
4. Roughan JV, Flecknell PA. Training in behaviour-based post-operative pain scoring in rats - an evaluation based on improved recognition of analgesic requirements. Appl Anim Behav Sci 2006;96:327-42
5. Wright-Williams SL, Courade J-P, Richardson CA, Roughan JV, Flecknell PA. Effects of vasectomy surgery and meloxicam treatment on faecal corticosterone levels and behaviour in two strains of laboratory mouse. Pain 2007;130:108-18
6. de Visser L, van den Bos R, Spruijt BM. Automated home cage observation as a tool to measure the effects of wheel running on cage floor locomotion. Behav Brain Res 2005;160:382-8
7. Clark MD, Krugner-Higby LA, Smith LJ, Heath TD, Clark KL, Olson D. Evaluation of liposome-encapsulated oxymorphone hydrochloride in mice after splenectomy. Comp Med 2004;54:558-63
8. Hayes KE, Raucci JA, Gades NM, Toth LA. An evaluation of analgesic regimens for abdominal surgery in mice. Contemp Top Lab Anim Sci 2000;39:18-23
9. Goecke JC, Awad H, Lawson JC, Boivin GJ. Evaluating postoperative analgesics in mice using telemetry. Comp Med 2005;55:37-44
10. van de Weerd HA, Bulthuis RJA, Bergman AF, et al. Validation of a new system for the automatic registration of behaviour in mice and rats. Behav Processes 2001;53:11-20
11. Steele AD, Jackson WS, King OD, Lindqvist S. The power of automated high-resolution behaviour analysis revealed by its application to mouse models of Huntington's and prion diseases. PNAS 2007;104:1983 -8
12. Roughan JV, Flecknell PA. Behavioural effects of laparotomy and analgesic effects of ketoprofen and carprofen in rats. Pain 2001;90:65 - 74
13. Molony V, Kent JE, McKendrick IJ. Validation of a method for assessment of an acute pain in lambs. Appl Anim Behav Sci 2002;76:215-38
14. Roughan JV, Flecknell PA. Behaviour-based assessment of the duration of laparotomy-induced abdominal pain and the analgesic effects of carprofen and buprenorphine in rats. Behav Pharmacol 2004;15:461 -72
15. Martin TJ, Buechler NL, Kahn W, Crews JC, Eiseach JC. Effects of laparotomy on spontaneous exploratory activity and conditional operant responding in the rat. Anesthesiology 2004;101:191 -203
16. Ogino K, Saito K, Osugi T, Satoh H. Meloxicam (Mobic): a review of its pharmacological and clinical profile. Folia Pharmacol Jpn 2002;120:391-7
17. Santos ARS, Vedana EMA, De Freitas GAG. Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice. Inflamm Res 1998;47:302-7
18. Gades NM, Danneman PJ, Wixson SK, Tolley EA. The magnitude and duration of the analgesic effect of morphine, butorphanol and buprenorphine in rats and mice. Contemp Top Lab Anim Sci 2000;39:8-13
19. Chesler EJ, Wilson SG, Lariviere WR, Rodriguez-Zas SL, Mogil JS. Identification and ranking of genetic and laboratory environment factors influencing a behavioural trait, thermal nociception, via computational analysis of a large data archive. Neurosci Biobehav Rev 2002;26:907-23