Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: An open label pilot study

International Clinical Psychopharmacology

Volumn 24, Issue 1, 2009, Pages 29-33

  Pae, Chi Un ^a,c,e,f   Marks, David M ^c   Han, Changsu ^b,c   Masand, Prakash S ^c,d   Patkar, Ashwin A ^c  

^a The Catholic University of Korea   (South Korea)

^b Korea University   (South Korea)

^c DUKE UNIVERSITY   (United States)

^d STATE UNIVERSITY OF NEW YORK   (United States)

^e The Catholic University of Korea   (South Korea)

^f DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antidepressant; Augmentation; Posttraumatic stress disorder; Pregabalin

Indexed keywords

ANTIDEPRESSANT AGENT; ESCITALOPRAM; LORAZEPAM; MIRTAZAPINE; PAROXETINE; PREGABALIN; PROPRANOLOL;

ACCIDENT; ADULT; ARTICLE; BLURRED VISION; CLINICAL ARTICLE; CONTROLLED RELEASE FORMULATION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIAGNOSTIC VALUE; DIZZINESS; DOSE RESPONSE; DRUG EFFICACY; FEMALE; HUMAN; KOREA; MALE; MONTGOMERY ASBERG DEPRESSION RATING SCALE; OPEN STUDY; PILOT STUDY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; RATING SCALE; SOMNOLENCE; VISUAL ANALOG SCALE; XEROSTOMIA;

ACCIDENTS; ADULT; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; DRUG THERAPY, COMBINATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PSYCHIATRIC STATUS RATING SCALES; STRESS DISORDERS, POST-TRAUMATIC; TREATMENT OUTCOME;

EID: 58349094358     PISSN: 02681315     EISSN: None     Source Type: Journal    
DOI: 10.1097/YIC.0b013e32831feea9     Document Type: Article

References (41)

1. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, IV edition (DSM-IV). Washington, DC: American Psychiatric Press.
2. Arnold LM, Crofford LJ, Martin SA, Young JP, Sharma U (2007). The effect of anxiety and depression on improvements in pain in a randomized, controlled trial of pregabalin for treatment of fibromyalgia Pain Med 8:633-638.
3. Amold LM, Russell LJ, Diri EW, Duan WR, Young JP Jr, Sharma U, et al. (2008). A 14-week, randomized, double-blinded, placebo-controlled monotherapy trial of pregabalin in patients with fibromyalgia. J Pain 9:792-805.
4. Bech P (2007). Dose-response relationship of pregabalin in patients with generalized anxiety disorder. A pooled analysis of four placebo-controlled trials. Pharmacopsychiatry 40:163-168.
5. Brady K, Pearlstein T, Asnis GM, Baker D, Rothbaum B, Sikes CR, et al. (2000a). Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial. JAMA 283:1837- 1844.
6. Brady KT, Killeen TK, Brewerton T, Lucerini S (2000b). Comorbidity of psychiatric disorders and posttraumatic stress disorder. J Clin Psychiatry 61 (Suppl 7):22-32.
7. Connor KM, Davidson JR (2001). SPRINT: a brief global assessment of post-traumatic stress disorder. Int Clin Psychopharmacol 16:279-284.
8. Crofford LJ, Rowbotham MC, Mease PJ, Russell LJ, Dworkin RH, Corbin AE, et al. (2005). Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 52:1264-1273.
9. Crofford LJ, Mease PJ, Simpson SL, Young JP Jr, Martin SA, Haig GM, et al. (2008). Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalin. Pain 136:419-431.
10. Cyr M, Farrar MK (2000). Treatment for posttraumatic stress disorder. Ann Pharmacother 34:366-376.
11. Davis LL, Davidson JR, Ward LC, Bartolucci A, Bowden CL, Petty F (2008). Divalproex in the treatment of posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial in a veteran population. J Clin Psychopharmacol 28:84-88.
12. Feldmann TB (1987). Alprazolam in the treatment of posttraumatic stress disorder. J Clin Psychiatry 48:216-217.
13. Feltner DE, Crockatt JG, Dubovsky SJ, Conn CK, Shrivastava RK, Targum SD, et al. (2003). A randomized, double-blind, placebo-controlled, fixed-dose, multicenter study of pregabalin in patients with generalized anxiety disorder. J Clin Psychopharmacol 23:240-249.
14. Freeman R, Durso-Decruz E, Emir B (2008). Efficacy, safety, and tolerability of pregabalin treatment for painful diabetic peripheral neuropathy: findings from seven randomized, controlled trials across a range of doses. Diabetes Care 31:1448-1454.
15. Gajraj NM (2007). Pregabalin: its pharmacology and use in pain management. Anesth Analg 105:1805-1815.
16. Guy W (1976.) Clinical global impressions. In: ECDEU Assessment Manual for Psychopharmacology, revised (DHEW publ no ADM 76-338). Rockville, MD: National Institute of Mental Health, pp. 218-222.
17. Katz J, Melzack R (1999). Measurement of pain. Surg Clin North Am 79:231-252.
18. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB (1995). Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 52:1048-1060.
19. Kinrys G, Wygant LE, Pardo TB, Melo M (2006). Levetiracetam for treatmentrefractory posttraumatic stress disorder. J Clin Psychiatry 67:211-214.
20. Levine J, Schooler NR (1986). SAFTEE: a technique for the systematic assessment of side effects in clinical trials. Psychopharmacol Bull 22: 343-381.
21. Lindley SE, Carlson EB, Hill K (2007). A randomized, double-blind, placebocontrolled trial of augmentation topiramate for chronic combat-related posttraumatic stress disorder. J Clin Psychopharmacol 27:677-681.
22. Londborg PD, Hegel MT, Goldstein S, Goldstein D, Himmelhoch JM, Maddock R, et al. (2001). Sertraline treatment of posttraumatic stress disorder: results of
23. 24 weeks of open-label continuation treatment. J Clin Psychiatry 62: 325-331.
24. Marshall RD, Beebe KL, Oldham M, Zaninelli R (2001a). Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled study. Am J Psychiatry 158:1982-1988.
25. Marshall RD, Olfson M, Hellman F, Blanco C, Guardino M, Struening EL (2001 b). Comorbidity, impairment, and suicidality in subthreshold PTSD. Am J Psychiatry 158:1467-1473.
26. Mease PJ, Russell IJ, Arnold LM, Florian H, Young JP Jr, Martin SA, et al. (2008). A randomized, double-blind, placebo-controlled, phase III trial of pregabalin in the treatment of patients with fibromyalgia. J Rheumatol 35:502-514.
27. Montgomery SA, Asberg M (1979). A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382-389.
28. Montgomery SA, Tobias K, Zornberg GL, Kasper S, Pande AC (2006). Efficacy and safety of pregabalin in the treatment of generalized anxiety disorder: a 6-week, multicenter, randomized, double-blind, placebo-controlled comparison of pregabalin and venlafaxine. J Clin Psychiatry 67:771-782.
29. Owen RT (2007). Pregabalin: its efficacy, safety and tolerability profile in fibromyalgia syndrome. Drugs Today (Barc) 43:857-863.
30. Pae CU, Lim HK, Peindl K, Ajwani N, Serretti A, Patkar AA, et al. (2008). The atypical antipsychotics olanzapine and risperidone in the treatment of posttraumatic stress disorder: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials. Int Clin Psychopharmacol 23:1-8.
31. Pande AC, Crockatt JG, Feltner DE, Janney CA, Smith WT, Weisler R, et al. (2003). Pregabalin in generalized anxiety disorder: a placebo-controlled trial. Am J Psychiatry 160:533-540.
32. Pande AC, Feltner DE, Jefferson JW, Davidson JR, Pollack M, Stein MB, et al. (2004). Efficacy of the novel anxiolytic pregabalin in social anxiety disorder: a placebo-controlled, multicenter study. J Clin Psychopharmacol 24:141-149.
33. Rickels K, Pollack MH, Feltner DE, Lydiard RB, Zimbroff DL, Bielski RJ, et al. (2005). Pregabalin for treatment of generalized anxiety disorder: a 4-week, multicenter, double-blind, placebo-controlled trial of pregabalin and alprazolam. Arch Gen Psychiatry 62:1022-1030.
34. Rothbaum BO, Cahill SP, Foa EB, Davidson JR, Compton J, Connor KM, et al. (2006). Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorder. J Trauma Stress 19:625-638.
35. Rothbaum BO, Killeen TK, Davidson JR, Brady KT, Connor KM, Heekin MH (2008). Placebo-controlled trial of risperidone augmentation for selective serotonin reuptake inhibitor-resistant civilian posttraumatic stress disorder. J Clin Psychiatry 69:520-525.
36. Sheehan DV (1983). The anxiety disease. New York: Scribner's.
37. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59 (Suppl 20):22-33; quiz 34-57.
38. Stein MB, Kline NA, Matloff JL (2002). Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study. Am J Psychiatry 159:1777-1779.
39. Stein MB, Kerridge C, Dimsdale JE, Hoyt DB (2007). Pharmacotherapy to prevent PTSD: results from a randomized controlled proof-of-concept trial in physically injured patients. J Trauma Stress 20:923-932.
40. Stein DJ, Baldwin DS, Baldinetti F, Mandel F (2008). Efficacy of pregabalin in depressive symptoms associated with generalized anxiety disorder a pooled analysis of 6 studies. Eur Neuropsychopharmacol 18:422-430.
41. Zohar J, Matar MA, Ifergane G, Kaplan Z, Cohen H (2008). Brief post-stressor treatment with pregabalin in an animal model for PTSD: short-term anxiolytic effects without long-term anxiogenic effect. Eur Neuropsychopharmacol 18:653-666.