Synthetic studies on neoclerodane diterpenes from Salvia splendens: oxidative modifications of ring A

Tetrahedron

Volumn 65, Issue 8, 2009, Pages 1708-1715

  Fontana, Gianfranco ^a   Savona, Giuseppe ^a   Rodríguez, Benjamín ^b   Dersch, Christina M ^c   Rothman, Richard B ^c   Prisinzano, Thomas E ^d  

^a UNIVERSITY OF PALERMO   (Italy)

^b INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^d UNIVERSITY OF KANSAS   (United States)

Author keywords

Neoclerodane diterpenes; Opioid receptors; Salvia splendens; Semisynthetic derivatives

Indexed keywords

8 EPI SALVIARIN; KAPPA OPIATE RECEPTOR; NEOCLERODANE; OPIATE AGONIST; SALVIARIN; SALVINORIN A; SPLENDIDIN; SPLENOLIDE B; TERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; DRUG BINDING; OXIDATION; PRIORITY JOURNAL; SALVIA; SALVIA SPLENDENS; STRUCTURE ACTIVITY RELATION;

MENTHA; SALVIA DIVINORUM; SALVIA SPLENDENS;

EID: 58349091236     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2008.12.009     Document Type: Article

References (9)

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9. Compound 6 is sparingly soluble in many solvents. However, it can be extracted from the reaction mixture with EtOAc, in which this compound forms a stable opaque dispersion.