Coexistence of different tissue tumourigenesis in an N-methyl-N- nitrosourea-induced mammary carcinoma model: A histopathological report in Sprague-Dawley rats

Laboratory Animals

Volumn 43, Issue 1, 2009, Pages 60-64

  Esendagli, G ^a   Yilmaz, G ^c   Canpinar, H ^a   Gunel Ozcan, A ^d   Guc, M O ^b   Guc, D ^a  

^a Department of Urology   (United Kingdom)

^b HACETTEPE UNIVERSITY   (Turkey)

^c ANKARA UNIVERSITY   (Turkey)

^d KIRIKKALE UNIVERSITY   (Turkey)

Author keywords

Animal model; Chemical carcinogenesis; Mammary carcinoma; N methyl n nitrosourea

Indexed keywords

METHYLNITROSOUREA;

ADENOMATOUS POLYP; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CARCINOGENESIS; FEMALE; FIBROADENOMA; HISTOPATHOLOGY; MUSCLE DEVELOPMENT; NERVE SHEATH TUMOR; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; TUMOR CLASSIFICATION;

ANIMALS; CARCINOMA, DUCTAL, BREAST; DIAGNOSIS, DIFFERENTIAL; DISEASE MODELS, ANIMAL; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; NEOPLASMS, MULTIPLE PRIMARY; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; MURINAE; RATTUS;

EID: 58349090250     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2008.007076     Document Type: Article

References (24)

1. Monceviciute-Eringiene E. Neoplastic growth: the consequence of evolutionary malignant resistance to chronic damage for survival of cells (review of a new theory of the origin of cancer). Med Hypotheses 2005;65:595 - 604
2. Tomatis L. Role of experimental and epidemiological evidence of carcinogenicity in the primary prevention of cancer. Ann 1st Super Sanita 2006;42:113-17
3. Macejova D, Brtko J. Chemically induced carcinogenesis: a comparison of 1-methyl-1-nitrosourea, 7,12-dimethylbenzanthracene, diethylnitroso-amine and azoxymethan models (minireview). Endocr Regul 2001;35:53 -9
4. Ting A, Kimler B, Fabian C, Petroff B. Characterization of a preclinical model of simultaneous breast and ovarian cancer progression. Carcinogenesis 2007;28:130-5
5. Robbiano L, Parodi A, Venturelli S, Brambilla G. Comparison of DNA alkylation, fragmentation, and repair in maternal and foetal tissues of pregnant rats treated with a single dose of ethyl methanesulfonate, ethyl-N-nitrosourea, N-nitrosodiethylamine, and methyl-N-nitrosourea. Teratog Carcinog Mutagen 1989;9:157-66
6. Russo J, Gusterson BA, Rogers AE, Russo IH, Wellings SR, Zwieten MJ. Comparative study of human and rat mammary tumourigenesis. Lab 1nvest 1990;62:244-78
7. Sukumar S, Barbacid M. Specific patterns of oncogene activation in transplacentally induced tumours. Proc Natl Acad Sci USA 1990;87:718-22
8. Thompson TA, Haag JD, Gould MN. ras gene mutations are absent in MNU-induced mammary carcinomas from aging rats. Carcinogenesis 2000;21:1917-22
9. Thompson H, McGinley J, Wolfe P, Singh M, Steele V, Kelloff G. Temporal sequence of mammary intraductal proliferations, ductal carcinomas in situ and adenocarcinomas induced by 1-methyl-1-nitrosourea in rats. Carcinogenesis 1998;19:2181-5
10. Brown K, Buchmann A, Balmain A. Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumour progression. Proc Nat Acad Sci USA 1990;87:538-42
11. Williams JR. Medical Ethics Manual. 1st edn. Axbridge: World Health Communication Associates, 2005
12. Allen TC. Haematoxylin and eosin. In: Prophet EB, Mills B, Arrington JB, Sobin LH, eds. Laboratory Methods in Histotechnology. Washington, DC: American Registry of Pathology, 1992:53-8
13. Dabbs DJ. Diagnostic 1mmunohistochemistry. 1st edn. Philadelphia: Churchill Livingstone, 2002
14. Niwa K, Tanaka T, Mori H, et al. Rapid induction of endometrial carcinoma in ICR mice treated with N-methyl-N-nitrosourea and 17 beta-estradiol. Jpn J Cancer Res 1991;82:1391-6
15. de Silva Franchi C, Bacchi M, Padovani C, de Camargo J. Thymic lymphomas in Wistar rats exposed to N-methyl-N-nitrosourea (MNU). Cancer Sci 2003;94:240-3
16. Zhou S, Wang G, Chen B, Wang P. Effect of dietary fatty acids on tumourigenesis of colon cancer induced by methyl nitrosourea in rats. J Environ Pathol Toxicol Oncol 2000;19:81-6
17. Thompson HJ, Singh M. Rat models of premalignant breast disease. J Mammary Gland Biol Neoplasia 2000;5:409-20
18. Thompson HJ, McGinley JN, Rothhammer K, Singh M. Rapid induction of mammary intraductal proliferations, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methyl-1-nitrosourea. Carcinogenesis 1995;16:2407-11
19. Ariazi JL, Haag JD, Lindstrom MJ, Gould MN. Mammary glands of sexually immature rats are more susceptible than those of mature rats to the carcinogenic, lethal, and mutagenic effects of N-nitroso-N-methylurea. Mol Carcinog 2005;43:155-64
20. Thompson HJ, Adlakha H, Singh M. Effect of carcinogen dose and age at administration on induction of mammary carcinogenesis by 1-methyl-1-nitrosourea. Carcinogenesis 1992;13:1535-9
21. Yamate J, Sakamori M, Kuwamura M, Kotani T. Neoplastic and non-neoplastic cell lines from a malignant peripheral nerve sheath tumour of the cervix of a rat. J Comp Pathol 2007;137:9-21
22. Bosland MC, Prinsen MK, Rivenson A, Weisburger JH. Induction of skin and thyroid tumours in male rats by N-methyl-N-nitrosourea after sequential treatment with cyproterone acetate and testosterone propionate: effects of castration, rat strain and time of carcinogen injection. Carcinogenesis 1992;13:669-74
23. Anderson CE, Salter DM. Schwannoma with focal smooth muscle differentiation: a potential pitfall in the interpretation of core biopsies. Histopathology 2005;46:592-4
24. Rodriguez FJ, Scheithauer BW, Abell-Aleff PC, Elamin E, Erlandson RA. Low grade malignant peripheral nerve sheath tumour with smooth muscle differentiation. Acta Neuropathol 2007;113:705-9