Serum leptin level in geriatric patients with hip fractures: Possible correlation to biochemical parameters of bone remodeling

Archives of Gerontology and Geriatrics

Volumn 48, Issue 2, 2009, Pages 250-253

  Shabat, S ^a   Nyska, M ^a   Eintacht, S ^a   Lis, M ^a   Bogomolni, A ^a   Berner, Y ^a   Kestanbaum Shainkin, R ^a  

^a MEIR MEDICAL CENTER   (Israel)

Author keywords

25(OH)D3; Bone metabolism in eldelry; Hip fractures; Leptin; Teleopeptide type I collagen (ICTP)

Indexed keywords

25 HYDROXYVITAMIN D; ALBUMIN; CALCIUM; CHOLESTEROL; COLLAGEN TYPE 1; GLUCOSE; LEPTIN; SODIUM;

AGED; ARTICLE; BONE REMODELING; CALCIUM METABOLISM; FEMALE; HIP FRACTURE; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; OSTEOLYSIS; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BONE REMODELING; CALCIFEDIOL; CASE-CONTROL STUDIES; COHORT STUDIES; DIHYDROXYCHOLECALCIFEROLS; FEMALE; HIP FRACTURES; HUMANS; LEPTIN; MALE; PEPTIDE FRAGMENTS; PROCOLLAGEN; SEX DISTRIBUTION;

EID: 58349089727     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.archger.2008.02.003     Document Type: Article

References (20)

1. Behre H.M., Simoni M., and Nieschlag E. Strong association between serum levels of leptin and testosterone in men. Clin. Endocrinol. (Oxford) 47 (1997) 237-240
2. Berlyne G.M., Ben-Ari J., Kushelevsky A., Idelman A., Galinsky D., Hirsch M., Shainkin R., Yagil R., and Zlotnik M. The aetiology of senile osteoporosis: secondary hyperparathyroidism due to renal failure. Q. J. Med. 175 (1975) 505-521
3. Blain H., Vuillemin A., Guillemin F., Durant R., Hanesse B., de Talance N., Doucet B., and Jeandel C. Serum leptin level is a predictor of bone mineral density in postmenopausal women. J. Clin. Endocrinol. Metab. 87 (2002) 1030-1035
4. Cummings S.R., Kelsey J.L., Nevitt M.C., and O'Dowd K.J. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol. Rev. 7 (1985) 178-208
5. Ducy P., Schinke T., and Karsenty G. The osteoblast: a sophisticated fibroblast under central surveillance. Science 289 (2000) 1501-1504
6. Gennari C. Calcium and vitamin D nutrition and bone disease of the elderly. Public Health Nutr. 4 (2001) 547-559
7. Halleux C.M., Servais I., Reul B.A., Detry R., and Brichard S.M. Multihormonal control of ob gene expression and leptin secretion from cultural human visceral adipose tissue; increased responsiveness to glucocorticoids in obesity. J. Clin. Endocrinol. Metab. 83 (1998) 902-910
8. Hedlund R., and Lindgren U. Trauma type, age and gender as determinants of hip fractures. J. Orthop. Res. 5 (1987) 242-246
9. Isidori A.M., Strollo F., More M., Caprio M., Aversa A., Moretti C., Frajese G., Riondino G., and Fabbri A. Leptin and aging: correlation with endocrine changes in male and female healthy adult populations of different body weights. J. Clin. Endocrinol. Metab. 85 (2000) 1954-1962
10. Koistinen H.A., Koivisto V.A., Karonen S.L., Ronnemaa T., and Tilvis R.S. Serum leptin and longevity. Aging (Milano) 10 (1998) 449-454
11. Lamberts S.W., Van den Beld A.W., and Van der Lely A.J. The endocrinology of aging. Science 278 (1997) 419-424
12. Maugeri D., Bonanno M.R., Speciale S., Santangelo A., Lentini A., Russo M.S., Calanna A., Malaguarnera M., Motta M., Testai M., and Panebianco P. The leptin, a new hormone of adipose tissue: clinical findings and perspectives in geriatrics. Arch. Gerontol. Geriatr. 34 (2002) 47-54
13. Meller Y., Kestenbaum R.S., Shany S., Galinsky D., Zuili I., Yankovitch N., Giat J., Conforti A., and Torok G. Parathormone, calcitonin, and vitamin D metabolites during normal fracture healing in geriatric patients. Clin. Orthop. 199 (1985) 272-279
14. Ostlund R.E., Yang J.W., Klein S., and Gingerich R. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J. Clin. Endocrinol. Metab. 81 (1996) 3909-3913
15. Potts J.T., and Juppner H. Metabolic Bone Disease and Clinically Related Disorders. 2nd ed. (1998), Academic Press, San Diego pp. 52-94
16. Reid I.R. Relationship among body mass, its component, and bone. Bone 31 (2002) 547-555
17. Reseland J.E., Syversen U., Bakke I., Qvigstad G., Eide L.G., Hjertner O., Gordeladze J.O., and Drevon C.A. Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J. Bone Miner. Res. 16 (2001) 1426-1433
18. Rosenbaum M., Nicolson M., Hirsch J., Heymsfield S.B., Gallagher D., Chu F., and Leibel R.L. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J. Clin. Endocrinol. Metab. 81 (1996) 3424-3427
19. Steppan C.M., Crawford D.T., Chidsey-Frink K.L., Ke H., and Swick A.G. Leptin is a potent stimulator of bone growth in ob/ob mice. Regul. Pept. 92 (2000) 73-78
20. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human analogue. Nature 372 (1994) 425-432