Moxonidine prevents ischemia/reperfusion-induced renal injury in rats

European Journal of Pharmacology

Volumn 603, Issue 1-3, 2009, Pages 73-78

  Tsutsui, Hidenobu ^a,b   Sugiura, Takahiro ^a   Hayashi, Kentaro ^a   Ohkita, Mamoru ^a   Takaoka, Masanori ^a   Yukimura, Tokihito ^b   Matsumura, Yasuo ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b OSAKA OHTANI UNIVERSITY   (Japan)

Author keywords

Acute kidney injury; Ischemia reperfusion; Moxonidine; Norepinephrine; Renal sympathetic nerve activity

Indexed keywords

MOXONIDINE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CLAMP; ARTICLE; CONTROLLED STUDY; KIDNEY DYSFUNCTION; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY VEIN; MALE; NEPHRECTOMY; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL ARTERY; RENAL PROTECTION; REPERFUSION INJURY; SYMPATHETIC NERVE;

ADRENERGIC AGONISTS; ANIMALS; IMIDAZOLES; IMIDAZOLINES; INJECTIONS, INTRAVENOUS; ISCHEMIA; KIDNEY; KIDNEY DISEASES; MALE; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SYMPATHETIC NERVOUS SYSTEM; TIME FACTORS; VEINS;

EID: 58249141197     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.12.012     Document Type: Article

References (26)

1. Baines A.D. Nervous disorders of renal function. Clin. Biochem. 16 (1983) 134-140
2. Bohmann C., Schollmeyer P., and Rump L.C. Effects of imidazolines on noradrenaline release in rat isolated kidney. Naunyn-Schmiedeberg's Arch. Pharmacol. 349 (1994) 118-124
3. Caramelo C., Espinosa G., Manzarbeitia F., Cernadas M.R., Pérez Tejerizo G., Tan D., Mosquera J.R., Digiuni E., Montón M., Millás I., Hernando L., Casado S., and López-Farré A. Role of endothelium-related mechanisms in the pathophysiology of renal ischemia/reperfusion in normal rabbits. Circ. Res. 79 (1996) 1031-1038
4. Chevalier R.L., and Finn F. Effects of propranolol on post-ischemic acute renal failure. Nephron 25 (1980) 77-81
5. Conger J.D., Robinette J.B., and Hammond W.S. Differences in vascular reactivity in models of ischemic acute renal failure. Kidney Int. 39 (1991) 1087-1097
6. Edelstein C.L., Ling H., and Schrier R.W. The nature of renal cell injury. Kidney Int. 51 (1997) 1341-1351
7. Ernsberger P., Damon T.H., Graff L.M., Schafer S.G., and Christen M.O. Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for I1-imidazoline sites. J. Pharmacol. Exp. Ther. 264 (1993) 172-182
8. Fujii T., Kurata H., Takaoka M., Muraoka T., Fujisawa Y., Shokoji T., Nishiyama A., Abe Y., and Matsumura Y. The role of renal sympathetic nervous system in the pathogenesis of ischemic acute renal failure. Eur. J. Pharmacol. 481 (2003) 241-248
9. Hayashi K., Matsumura Y., Yoshida Y., Suzuki Y., and Morimoto S. The role of endogenous angiotensin II in antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs. J. Cardiovasc. Pharmacol. 17 (1991) 807-813
10. Iaina A., and Eliahou H.E. The sympathetic nervous system in the pathogenesis of acute renal failure. Clin. Exp. Dial. Apher. 7 (1983) 115-125
11. Lieberthal W., and Levine J.S. Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury. Am. J. Physiol. 271 (1996) F477-F488
12. Morris S.T.W., and Reid J.L. Moxonidine: a review. J. Hum. Hypertens. 11 (1997) 629-635
13. Moss N.G. Renal function and renal afferent and efferent nerve activity. Am. J. Physiol. 243 (1982) F425-F433
14. Ogawa T., Mimura Y., and Kaminishi M. Renal denervation abolishes the protective effects of ischaemic preconditioning on function and haemodynamics in ischemia-reperfused rat kidneys. Acta Physiol. Scand. 174 (2002) 291-297
15. Paxions G., and Watson C. The Rat Brain (1998), Academic Press, San Diego, CA
16. Raasch W., jungbluth B., Schäfer U., Häuser W., and Dominiak P. Modification of noradrenaline release in pithed spontaneously hypertensive rats by I1-binding sites in addition to α2-adrenoceptors. J. Pharmacol. Exp. Ther. 304 (2003) 1063-1071
17. Recordani G.M., Moss N.G., and Waselkov L. Renal chemoreceptors in the rat. Circ. Res. 43 (1978) 534-543
18. Shokoji T., Nishiyama A., Fujisawa Y., Hitomi H., Kiyomoto H., Takahashi N., Kimura S., Kohno M., and Abe Y. Renal sympathetic nerve responses to Tempol in spontaneously hypertensive rats. Hypertension 41 (2003) 266-273
19. Solez K., D, Agostini R.J., Stawowy L., Freedman M.T., Scott Jr. W.W., Siegelman S.S., and Heptinstall R.H. Beneficial effect of propranolol in a histologically appropriate model of postischemic acute renal failure. Am. J. Pathol. 88 (1977) 163-192
20. Solez K., Freshwater M.F., and Su C.-T. The effect of propranolol on postischemic acute renal failure in the rat. Transplantation 24 (1997) 148-151
21. Solez K., Ideura T., Silvia C.B., Hamilton B., and Saito H. Clonidine after renal ischemia to lessen acute renal failure and microvascular damage. Kidney Int. 18 (1980) 309-322
22. Sugiura T., Tsutsui H., Takaoka M., Kobuchi S., Hayashi K., Fujii T., and Matsumura Y. Protective effect of agmatine on ischemia/reperfusion-induced renal injury in rats. J. Cardiovasc. Pharmacol. 51 (2008) 223-230
23. Sun M.K., Regunathan S., and Reis D.J. Cardiovascular responses to agmatine, a clonidine-displacing substance, in anesthetized rat. Clin. Exp. Hypertens. 17 (1995) 115-128
24. Thadani R., Pasccual M., and Bonventre J.V. Acute renal failure. N. Engl. J. Med. 334 (1996) 1146-1448
25. Van Zwieten P.A. Central imidazoline (I1) receptors as targets of centrally acting antihypertensives: moxonidine and rilmenidine. J. Hypertens. 15 (1997) 117-125
26. Ye S., Zhong H., Duong V.N., and Campese V.M. Losartan reduces central and peripheral sympathetic nerve activity in a rat model of neurogenic hypertension. Hypertension 39 (2002) 1101-1106