Prolonged intrahepatic cholestasis after exposure to loxoprofen

Clinical Therapeutics

Volumn 30, Issue 12, 2008, Pages 2402-2406

  Ichikawa, Takeshi ^a   Sato, Hiroko ^a   Kaira, Kyoichi ^a   Oh I, Shinsuke ^a   Kakizaki, Satoru ^a   Sato, Ken ^a   Takagi, Hitoshi ^a   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

case report; cholestasis; loxoprofen; NSAID

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE; HLA A24 ANTIGEN; HLA B44 ANTIGEN; HLA DR4 ANTIGEN; INCHINKO TO; LIVER ENZYME; LOXOPROFEN; MEFENAMIC ACID; METHYLPREDNISOLONE; PREDNISOLONE; URSODEOXYCHOLIC ACID;

ABDOMINAL PAIN; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANAMNESIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DISEASE COURSE; DRUG WITHDRAWAL; DYSMENORRHEA; ECHOGRAPHY; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTRAHEPATIC CHOLESTASIS; JAUNDICE; LABORATORY TEST; LIVER BIOPSY; LIVER FUNCTION TEST; NAUSEA; PHYSICAL EXAMINATION; PLASMAPHERESIS; PRURITUS; RECOMMENDED DRUG DOSE; SCORING SYSTEM;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BILIRUBIN; CHOLESTASIS, INTRAHEPATIC; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; JAUNDICE; METHYLPREDNISOLONE; PHENYLPROPIONATES; PLASMA EXCHANGE; PRURITUS; TIME FACTORS;

EID: 58249130819     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2008.12.012     Document Type: Article

References (21)

1. Chang C.Y., and Schiano T.D. Review article: Drug hepatotoxicity. Aliment Pharmacol Ther 25 (2007) 1135-1151
2. Erlinger S. Drug-induced cholestasis. J Hepatol 26 Suppl 1 (1997) 1-4
3. Desmet V.J. Vanishing bile duct syndrome in drug-induced liver disease. J Hepatol 26 Suppl 1 (1997) 31-35
4. Friis H., and Andreasen P.B. Druginduced hepatic injury: An analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987. J Intern Med 232 (1992) 133-138
5. Taghian M., Tran T.A., Bresson-Hadni S., et al. Acute vanishing bile duct syndrome after ibuprofen therapy in a child. J Pediatr 145 (2004) 273-276
6. Van Steenbergen W., Peeters P., De Bondt J., et al. Nimesulide-induced acute hepatitis: Evidence from six cases. J Hepatol 29 (1998) 135-141
7. Loxonin (loxoprofen sodium hydrate) tablets/powder [product information] (2006), Daiichi Sankyo Co, Ltd, Tokyo, Japan
8. Riendeau D., Salem M., Styhler A., et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett 14 (2004) 1201-1203
9. Noguchi M., Kimoto A., Gierse J.K., et al. Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites. Biol Pharm Bull 28 (2005) 2075-2079
10. Confatanin (loxoprofen sodium hydrate) tablets [product information] (2006), Towa Pharmaceutical Co, Ltd, Osaka, Japan
11. Desmet V.J. Destructive intrahepatic bile duct diseases. Recent Prog Med 81 (1990) 392-398
12. Inao M., Mochida S., Matsui A., et al. Japanese herbal medicine Inchin-koto as a therapeutic drug for liver fibrosis. J Hepatol 41 (2004) 584-591
13. Ho D.W., Fan S.T., To J., et al. Selective plasma filtration for treatment of fulminant hepatic failure induced by D-galactosamine in a pig model. Gut 50 (2002) 869-876
14. Berson A., Fréneaux E., Larrey D., et al. Possible role of HLA in hepatotoxicity. An exploratory study in 71 patients with drug-induced idiosyncratic hepatitis. J Hepatol 20 (1994) 336-342
15. Naranjo C.A., Busto U., Sellers E.M., et al. A method for eliminating the probability of adverse drug reactions. Clin Pharmacol Ther 30 (1981) 239-245
16. Ministry of Health, Labour and Welfare of Japan (MHLW). Pharmaceuticals and medical devices safety information [MHLW Web site] [in Japanese]. http://www1.mhlw.go.jp/houdou/1205/h05261-a_15.html#12. Accessed June 10, 2008.
17. Chitturi S., and Farrell G.C. Drug-induced cholestasis. Semin Gastrointest Dis 12 (2001) 113-124
18. Boelsterli U.A., Zimmerman H.J., and Kretz-Rommel A. Idiosyncratic liver toxicity of nonsteroidal antiinflammatory drugs: Molecular mechanisms and pathology. Crit Rev Toxicol 25 (1995) 207-235
19. Castell J.V., and Castell M. Allergic hepatitis induced by drugs. Curr Opin Allergy Clin Immunol 6 (2006) 258-265
20. Kurosaki M., Takagi H., and Mori M. HLA-A33/B44/DR6 is highly related to intrahepatic cholestasis induced by tiopronin. Dig Dis Sci 45 (2000) 1103-1108
21. Batts K.P., Moore S.B., Perkins J.D., et al. Influence of positive lymphocyte crossmatch and HLA mismatching on vanishing bile duct syndrome in human liver allografts. Transplantation 45 (1988) 376-379