Acoustic and Kinetic Behaviour of Definity in Mice Exposed to High Frequency Ultrasound

Ultrasound in Medicine and Biology

Volumn 35, Issue 2, 2009, Pages 296-307

  Stapleton, Shawn ^a,b   Goodman, Heather ^b   Zhou, Yu Qing ^c   Cherin, Emmanuel ^b   Henkelman, R Mark ^a,c   Burns, Peter N ^a,b   Foster, F Stuart ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

contrast agent; Dose response; High frequency; Microbubbles; Mouse; Quantification; Small animal imaging; Tail vein catheter; Ultrasound; Ultrasound biomicroscopy

Indexed keywords

CONTRAST AGENT; DOSE RESPONSE; HIGH FREQUENCY; MICROBUBBLES; MOUSE; QUANTIFICATION; SMALL ANIMAL IMAGING; TAIL VEIN CATHETER; ULTRASOUND; ULTRASOUND BIOMICROSCOPY;

ACOUSTIC WAVES; AGENTS; BACKSCATTERING; BLOOD; CATHETERS; DEIONIZED WATER; FREQUENCY RESPONSE; MEDICAL IMAGING; ULTRASONIC TRANSMISSION; ULTRASONICS;

ULTRASONIC IMAGING;

ECHO CONTRAST MEDIUM; PERFLUTREN; WATER;

ACOUSTICS; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD FLOW; CONCENTRATION RESPONSE; CONTRAST ENHANCEMENT; DOSE RESPONSE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; ECHOGRAPHY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; JUGULAR VEIN; MICROBUBBLE; MOUSE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; ULTRASOUND;

ANIMALS; CONTRAST MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; FLUOROCARBONS; HEART RATE; JUGULAR VEINS; MICE; MICROSPHERES; MOVEMENT; RANDOM ALLOCATION; SCATTERING, RADIATION; TIME FACTORS; ULTRASONICS;

EID: 58249130389     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2008.08.010     Document Type: Article

References (28)

1. Albrecht T., Blomley M.J., Cosgrove D.O., Taylor-Robinson S.D., Jayaram V., Eckersley R., Urbank A., Butler-Barnes J., and Patel N. Noninvasive diagnosis of hepatic cirrhosis by transit-time analysis of an ultrasound contrast agent. Lancet 353 (1999) 1579-1583
2. Becher H., and Burns P.N. Handbook of contrast echocardiography: Left ventricular function and myocardial perfusion (2000), Springer-Verlag
3. Bouakaz A., de Jong N., Cachard C., and Jouini K. On the effects of lung filtering and cardiac pressure on the standard properties of ultrasound contrast agent. Ultrasonics 36 (1998) 703-708
4. Cobbold R.S.C. Foundations of biomedical ultrasound (2007), Oxford University Press, New York
5. Correas J.-M., Burns P.N., Lai X., and Qi X. Infusion versus bolus of an ultrasound contrast agent: In vivo dose-response measurement of BR1. Invest Radiol 35 (2000) 72-79
6. de Jong N., Hoff L., Skotland T., and Bom N. Absorption and scatter of encapsulated gas filled microspheres: Theoretical considerations and some measurements. Ultrasonics 30 (1992) 95-103
7. Deng C.X., Lizzi F.L., Silverman R.H., Ursea R., and Coleman D.J. Imaging and spectrum analysis of contrast agents in the in vivo rabbit eye using very high frequency ultrasound. Ultrasound Med Biol 24 (1998) 381 294
8. Ekersley R.J., Sedellar J.P.M., Blomley M.J.K., Wijkstra H., deSouza N.M., Cosgrove D.O., and de la Rosette J. Quantitative microbubble enhanced transrectal ultrasound as a tool for monitoring hormonal treatment of prostate carcinoma. The Prostate 51 (2002) 256-267
9. Foster F.S., Pavlin C.J., Harasiewicz K.A., Christopher D.A., and Turnbull D.H. Advances in ultrasound biomicroscopy. Ultrasound Med Biol 26 (2000) 1-27
10. Goertz D.E., Wong S.W.S., Chin C.T., Cherin E., Burns P.N., and Foster F.S. Nonlinear scattering from microbubble contrast agents in the 14 to 40 MHz range. IEEE Ultrason Symp (2001) 1747-1750
11. Goertz D.E., Frijlink M., Bouakaz A., Chin C.T., de Jong N., and van der Steen A.W.F. The effect of bubble size on nonlinear scattering from microbubbles. IEEE Ultrason Symp (2003) 1503-1506
12. Goertz D.E., Cherin E., Needles A., Karshafian R., Brown A.S., Burns P.N., and Foster F.S. High frequency nonlinear b-scan imaging of microbubbles contrast agents. IEEE Trans Ultrason Ferroelectr Freq Control 52 (2005) 65-79
13. Goertz D.E., Needles A., Burns P.N., and Foster F.S. High frequency nonlinear flow imaging of microbubbles contrast agents. IEEE Trans Ultrason Ferroelectr Freq Control 52 (2005) 495-502
14. Goertz D.E., Frijlink M.E., Tempel D., van Damme L.C.A., Krams R., Schaar J.A., ten Cate F.J., Serruys P.W., de Jong N., and van der Steen A.F.W. Contrast harmonic intravascular ultrasound: A feasibility study for vasa vasorum imaging. Investig Radiol 41 (2006) 631-638
15. Goertz D.E., Frijlink M.E., de Jong N., and van der Steen A.F.W. High frequency nonlinear scattering from a micrometer to submicrometer sized lipid encapsulated contrast agent. Ultrasound Med Biol 32 (2006) 569-577
16. Goertz D.E., de Jong N., and van der Steen A.F.W. Attenuation and size distribution measurements of Definity and manipulated Definity populations. Ultrasound Med Biol 33 (2007) 1376-1388
17. Janssen B.J., and Smits J.F.M. Autonomic control of blood pressure in mice: Basic physiology and effects of genetic modification. Am J Physiol Regul Integr Comp Physiol 282 (2002) R1545-R1564
18. Li J.K.-J. Dynamics of the vascular system (2004), World Scientific, River Edge, NJ
19. Lindner J.R., Song J., Jayaweera A.R., SKlenar J., and Kaul S. Microvascular rheology of Definity microbubbles after intra-arterial and intravenous administration. J Am Soc Echocardiogr 15 (2002) 396-403
20. Moran C.M., Watson R.J., Fox K.A.A., and McDicken W.N. In vitro acoustic characterisation of four intravenous ultrasonic contrast agents at 30 MHz. Ultrasound Med Biol 28 (2002) 785-791
21. Pavlin C.J., Burns P.N., and Foster F.S. Use of microbubble ultrasound contrast agent to demonstrate the iris valve effect in human eye bank eyes. Am J Ophthalmol 126 (1998) 719-720
22. Schutt E.G., Klein D.H., Mattrey R.M., and Riess J.G. Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: The key role of perfluoro-chemicals. Angewandte Chemie Int Ed 42 (2003) 3218-3235
23. Schwarz K.Q., Chen X., Bezante G.P., Phillips D., and Schlief R. The Doppler kinetic of microbubbles echo contrast. Ultrasound Med Biol 22 (1996) 453-462
24. Stapleton S., Goodman H., Zhou Y.Q., Cherin E., Burns P.N., and Foster F.S. In vivo characterisation of microbubbles using high frequency ultrasound. IEEE Ultrason Symp (2006) 305-308
25. Stapleton S., Needles A., Henderson E., and Foster F.S. Concentration requirements for subharmonic quantitative contrast enhanced high frequency ultrasound flow studies. IEEE Ultrason Symp (2007) 1061-1064
26. Uhlendorf V., Scholle F.-D., and Reinhardt M. Acoustic behaviour of current ultrasound contrast agents. Ultrasonics 38 (2000) 81-86
27. Wilson S.R., and Burns P.N. Microbubble contrast for radiological imaging: 2. applications. Ultrasound Q 22 (2006) 15-18
28. Yeh C.-K., Ferrara K.W., and Kruse D.E. High-resolution functional vascular assessment with ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control 23 (2004) 1263-1275