Vicks VapoRub induces mucin secretion, decreases ciliary beat frequency, and increases tracheal mucus transport in the ferret trachea

Chest

Volumn 135, Issue 1, 2009, Pages 143-148

  Abanses, Juan Carlos ^a   Arima, Shinobu ^a   Rubin, Bruce K ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Airway disease; Aromatics; Camphor; Lung water; Menthol; Mucin; Mucociliary clearance; Mucus

Indexed keywords

DECONGESTIVE AGENT; MUCIN; UNCLASSIFIED DRUG; VAPORUB;

ANIMAL TISSUE; ARTICLE; CILIARY MOTILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FERRET; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; TRACHEA MUCUS;

EID: 58249102078     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.08-0095     Document Type: Article

References (28)

1. Protcor & Gamble. Vicks VapoRub. Available at: http://www.vicks.com/ products/vaporub. Accessed December 1, 2008
2. Burrow A, Eccles R, Jones AS. The effects of camphor, eucalyptus and menthol vapour on nasal resistance to airflow and nasal sensation. Acta Otolaryngol 1983; 96:157-161
3. Kishioka C, Okamoto K, Kim JS, et al. Regulation of secretion from mucous and serous cells in the excised ferret trachea. Respir Physiol 2001; 126:163-171
4. Okamoto K, Kim J-S, Rubin BK. Secretory phospholipases A2 stimulate mucus secretion, induce airway inflammation, and produce secretory hyperresponsiveness to neutrophil elastase in the ferret trachea. Am J Physiol Lung Cell Mol Physiol 2007; 292:L62-L67
5. Faul F, Erdfelder E, Lang A-G, et al. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39:175-191
6. Berger H, Madreiter H, Jarosch E. Effect of VapoRub on the restlessness of children with acute bronchitis. J Int Med Res 1978; 6:491-493
7. Jaiwal A. Vick's VapoRub induced dermokerato conjunctivitis: a case report. Indian J Ophthalmol 1989; 37:154
8. Ferrando RL, McCorvey E Jr, Simon WA et al. Bizarre behavior following the ingestion of levo-desoxyephedrine. Drug Intell Clin Pharm 1988; 22:214-217
9. Gattuso P, Reddy VB, Castelli MJ. Exogenous lipoid pneumonitis due to Vicks VapoRub inhalation diagnosed by fine needle aspiration cytology. Cytopathology 1991; 2:315-316
10. Schaller M, Korting HC. Allergic airborne contact dermatitis from essential oils used in aromatherapy. Clin Exp Dermatol 1995; 20:143-145
11. Uc A, Bishop WP, Sanders KD. Camphor hepatotoxicity. South Med J 2000; 93:596-598
12. McBride B, Whitelaw WA. A physiological stimulus to upper airway receptors in humans. J Appl Physiol 1981; 51:1189-1197
13. Orani GP, Anderson JW, Sant'Ambrogio G, et al. Upper airway cooling and l-menthol reduce ventilation in the guinea pig. J Appl Physiol 1991; 70:2080-2086
14. Sant'Ambrogio FB, Anderson JW, Sant'Ambrogio G. Menthol in the upper airway depresses ventilation in newborn dogs. Respir Physiol 1992; 89:299-307
15. Seybold ZV, Mariassy AT, Stroh D, et al. Mucociliary interaction in vitro: effects of physiological and inflammatory stimuli. J Pharm Pharmacol 1994; 46:618-630
16. Fox N. Effects of camphor, eucalyptol, and menthol on the vascular state of the mucous membrane. Arch Otolaryngol Head Neck Surg 1927; 6:112-122
17. Harkema JR, Hotchkiss JA. In vivo effects of endotoxin on intraepithelial mucosubstances in rat pulmonary airways: quantitative histochemistry. Am J Pathol 1992; 141:307-317
18. Harkema JR, Hotchkiss JA. In vivo effects of endotoxin on nasal epithelial mucosubstances: quantitative histochemistry. Exp Lung Res 1991; 17:743-761
19. Riechelmann H, Brommer C, Hinni M, Martin C. Response of human ciliated respiratory cells to a mixture of menthol, eucalyptus oil and pine needle oil. Arzneimittelforschung 1997; 47:1035-1039
20. Das PK, Rathor RS, Sinha PS, et al. Effect on ciliary movements of some agents which come in contact with the respiratory tract. Indian J Physiol Pharmacol 1970; 14:297-303
21. Eccles R. Menthol and related cooling compounds. J Pharm Pharmacol 1994; 46:618-630
22. Jones AS, Crosher R, Wight RG, et al. The effect of local anaesthesia of the nasal vestibule on nasal sensation of airflow and nasal resistance. Clin Otolaryngol 1987; 12:461-464
23. Jordt SC, Mckeny DD, Julius D. Lessons from pepper and peppermint: the molecular logic of thermal sensation. Curr Opin Neurobiol 2003; 13:487-492
24. Schafer K, Braun HA, Hensel H. Static and dynamic activity of cold receptors at various calcium levels. J Neurophysiol 1982; 47:1017-1028
25. Butler DB, Ivy AC. Effects of nasal inhalers on erectile tissues of the nose. Arch Otolaryngol Head Neck Surg 1943; 38:309-317
26. Eccles R, Lancashire B, Tolley NS. The effect of aromatics on inspiratory and expiratory nasal resistance to airflow. Clin Otolaryngol 1987; 12:11-14
27. Eccles R, Griffiths DH, Newton CG, et al. The effects of D and L isomers of menthol upon nasal sensation of airflow. J Laryngol Otol 1988; 102:506-508
28. Eccles R, Griffiths DH, Newton CG, et al. The effects of menthol isomers on nasal sensation of airflow. Clin Otolaryngol 1988; 13:25-29