A unified mathematical model for the prediction of controlled release from surface and bulk eroding polymer matrices

Biomaterials

Volumn 30, Issue 8, 2009, Pages 1657-1664

  Rothstein, Sam N ^a,b   Federspiel, William J ^a,b,c   Little, Steven R ^a,b,d  

^a University of Pittsburgh   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Biodegradation; Controlled drug release; Modeling; Polyanhydride; Polyorthoester

Indexed keywords

CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATIONS; CONTROLLED RELEASES; DESIGN PARAMETERS; EMPIRICAL DATUMS; EXPERIMENTAL DATUMS; MASS LOSSES; MODELING; POLYANHYDRIDE; POLYMER DEGRADATIONS; POLYMER MATRIX.; POLYORTHOESTER; RELEASE PROFILES; SPATIAL DISTRIBUTIONS; UNIFIED MODELS;

BIOCHEMISTRY; BIODEGRADATION; DEGRADATION; DISSOLUTION; FORECASTING; FUNCTIONS; HYDRATION; MICROBIOLOGY; PHOTORESISTS; POLYMERS;

MATHEMATICAL MODELS;

POLY(ORTHO ESTER); POLYANHYDRIDE;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG DEGRADATION; DRUG SOLUBILITY; MATHEMATICAL MODEL; PRIORITY JOURNAL; THEORETICAL MODEL;

DELAYED-ACTION PREPARATIONS; HYDROLYSIS; KINETICS; MODELS, THEORETICAL; MOLECULAR WEIGHT; POLYMERS; SOLUBILITY; SURFACE PROPERTIES; TIME FACTORS;

EID: 58249091982     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2008.12.002     Document Type: Article

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