Preclinical toxicological assessment of a phytotherapeutic product - CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.)

Phytotherapy Research

Volumn 23, Issue 1, 2009, Pages 33-40

  Tabach, Ricardo ^a   Rodrigues, Eliana ^a   Carlini, E A ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Association of plants; Crataegus; Passiflora; Preclinical toxicity; Valeriana

Indexed keywords

CRATAEGUS OXYACANTHA EXTRACT; PASSIFLORA INCARNATA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; VALERIAN;

AMES TEST; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRATAEGUS OXYACANTHA; DOG; DRUG SCREENING; ESTRUS CYCLE; FEMALE; FERTILITY; FLUID INTAKE; FOOD INTAKE; LD 50; MALE; MEDICINAL PLANT; MOTOR ACTIVITY; MOTOR COORDINATION; MOUSE; MUTAGENIC ACTIVITY; NONHUMAN; PARAMETER; PASSIFLORA INCARNATA; PASSION FRUIT; PATHOLOGICAL ANATOMY; PHYTOTHERAPY; RAT; TERATOGENESIS; TOXICOLOGY; VALERIANA OFFICINALIS; WEIGHT GAIN; WEIGHT REDUCTION;

ACUTE TOXICITY TESTS; ANIMALS; CRATAEGUS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRUS; FEMALE; FERTILITY; LETHAL DOSE 50; MALE; MICE; MOTOR ACTIVITY; MUTAGENICITY TESTS; PASSIFLORA; PLANT EXTRACTS; RATS; RATS, WISTAR; TOXICITY TESTS, CHRONIC; VALERIAN; WEIGHT GAIN; WEIGHT LOSS;

CANIS FAMILIARIS; CRATAEGUS; CRATAEGUS MONOGYNA; MUS; PASSIFLORA; PASSIFLORA INCARNATA; RATTUS; VALERIANA; VALERIANA OFFICINALIS;

EID: 58149523224     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2499     Document Type: Article

References (39)

1. Ames BN, McCann J, Yamasaky E. 1975. Methods for detecting carcinogens and mutagens with samonella/mammalian-microsome mutegenicity test. Mutat Res 11: 347-364.
2. Andreatini R, Sartori VA, Seabra ML, Leite JR. 2002. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study. Phytother Res 16: 650-654.
3. Carlini EA. 1972. Screening farmacológico de plantas brasileiras. Rev Bras Biol 32: 265-275.
4. Carlini EA, Burgos U. 1979. Screening farmacológico de ansioĺticos: metodologia laboratorial e comparação entre diazepam e clorobenzepam. Rev Assoc Bras Psiquiat 2: 25-31.
5. Coleman JH, Johnston JA. 1979. Handbook of psychoactive drug prescribing information. Physicians Postgraduate Press: Memphis, USA.
6. Degenring FH, Suter A, Weber M, Saller R. 2003. A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan) in the treatment of patients with congestive heart failure NYHA II. Phytomedicine 10: 363-9.
7. Dhawan K, Kumar S, Sharma A. 2001a. Anxiolitic activity of aerial and underground parts of Passiflora incarnata. Fitoterapia 72: 922-926.
8. Dhawan K, Kumar S, Sharma A. 2001b. Comparative biological activity study on Passiflora incarnata and P. edulis. Fitoterapia 72: 698-702.
9. Dhingra D, Parle M, Kulkarni SK. 2004. Memory enhancing activity of Glycirrhyza glabra in mice. J Ethnopharmacol 91: 361-365.
10. Fehri B, Aiache JM, Boukef K, Memmi A, Hizaoui B. 1991. Valeriana officinalis and Crataegus oxyacantha: toxicity from repeated administration and pharmacologic investigations. J Pharm Belg 46: 165-176.
11. Fernandez S, Wasowski C, Paladini AC, Marder M. 2004. Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacol Biochem Behav 77: 399-404.
12. Fisher AA, Purcell P, Couteur DGL. 2000. Toxicity of Passiflora incarnata L. J Toxico Clin Toxicol 38: 63-66.
13. Formigoni MLO, Lodder HM, Gianotti-Filho O, Ferreira TMS, Carlini EA. 1998. Pharmacology of lemongrass (Cymbopo-gon citratus stapf). II Effects of daily two months administration in male and in female rats and in offspring exposed "in utero". J. Ethnopharmacol 17: 65-74.
14. Gilbert B, Alves LF. 2003. Synergy in plant medicines. Curr Med Chem 10: 13-20.
15. Giri AK, Banerjee S. 1996. Genetic toxicology of four commonly used benzodiazepines: a review. Mutat Res 340: 93-108.
16. Grieve M. 1994. A modern herbal: The medicinal, culinary, cosmetic and economic proprieties, cultivation and folklore of herbs, grasses, fungi, shrubs and trees with all their modern scientific uses. Tiger: London.
17. Guo Y, Kong L, Wang Y, Huang Z. 2004. Antidepressant evaluation of polysaccharides from a Chinese herbal medicine Banxia-houpu decoction. Phytother Res 18: 204-207.
18. Hanus M, Lafon J, Mathieu M. 2004. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Curr Med Res Opin 20: 63-71.
19. Hodgson E. 2000. Introduction to toxicology. In Textbook of modern toxicology Second Edition, Hodson E, Levi PE (eds). McGraw-Hill Companies: Singapore, 1-25.
20. Jardim MC, Guimarães FS. 2004. Role of glutamate ionotropic receptors in the dorsomedial hypothalamic nucleus on anxiety and locomotor behavior. Pharmacol Biochem Behav 79: 541-546.
21. Krenn L. 2002. [Passion Flower (Passiflora incarnata L.) - A reliable herbal sedative]. Wien Med Wochenschr 152: 404-406.
22. Kuribara H, Tomioka H, Takahashi R, Onozato K, Murohashi N, Numajiri T, Iwata H, Koya S. 2004. An antidepressant effect of sho-ju-sem, a Japanese herbal medicine, assessed by learned helplessness model in mice. Phytother Res 18: 173-176.
23. Mendes FR, Mattei, R, Carlini, EA. 2002. Activity of Hypericum brasiliense and Hypericum cordatumon the central nervous system in rodents. Fitoterapia 73: 462- 471.
24. Morazzoni P, Bombardelli E. 1995. Valeriana officinalis: traditional use and recent evaluation of activity. Fitoterapia 66: 99-112.
25. Oliveira MG, Monteiro MG, Macaúbas C, Barbosa VP, Carlini EA. 1991. Pharmacologic and toxicologic effects of two Maytenus species in laboratory animals. J Ethnopharmacol 34: 29-41.
26. Prut L, Belzung C. 2003. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol 463: 3-33.
27. Rajendran S, Deepalakshimi PD, Parasakthy K, Devaraj H, Devaraj SN. 1996. Effect of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet. Atherosclerosis 123: 235-241.
28. Ryan C, Pappas, BA. 1986. Intrauterine diazepam exposure: eefects on physical and neurobehavioral development in rat. Neurobehav Toxicol Teratol 8: 279-286.
29. Savic MM, Obradovic DI, Ugresic ND, Bokonjic DR. 2003. The influence of diazepam on atropine reversal of behavioural impairment in dichlorvos-treated rats. Pharmacol Toxicol 93: 211-218.
30. Schmid W. 1976. The micronucleus test for cytogenetic analysis. In Chemical mutagens principles and method for their detection. Hollaender A (ed.). Plenum Press: New York, 31-53.
31. Shanthi R, Parasakthy K, Deepalakshmi PD, Niranjali DS. 1996. Protective effect of tincture of crataegus on oxidative stress in experimental atherosclerosis in rats. J Clin Biochem Nutr 20: 211-223.
32. Shivalingappa H, Satyanarayan ND, Purohit MG, Sharanabasappa A, Patil SB. 2002. Effect of ethanol extract of Rivea hypocrateriformis on the estrous cycle of the rat. J Ethnopharmacol 82: 11 -17.
33. Siemiatkowski M, Sienkiewicz-Jarosz H, Czlonkowska AI, Bidznski A, Plaznik A. 2000. Effects of buspirone, diazepam and zolpidem on open field behavior, and brain [3H] muscimol binding after buspirone pretreatment. Pharmacol Biochem Behav 66: 645-651.
34. Soulimani R, Younos C, Jarmouni S, Bousta D, Misslin R, Mortier F. 1997. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol 57: 11-20.
35. Sousa FCF, Melo CTV, Monteiro AP, Lima VTM, Gutierrez SJC, Pereira BA, Barbosa-Filho JM, Vasconcelos SMM, Fonteles MF, Viana GSB. 2004. Antianxiety and antidepressant effects of riparin III from Aniba riparia (Nees) Mez (Lauraceae) in mice. Pharmacol Biochem Behav 78: 27-33.
36. Tabach R, Mattei R, Carlini EA. 2008. Pharmacological evaluation of a phytotherapeutic product-CPV (dry extract of Crataegus Oxyacantha L, Passiflora Incarnata L, and Valeriana Officinalis L) in Laboratory Animals (Submitted).
37. Williamson EM. 2001. Synergy and other interactions in phytomedicines. Phytomedicine 8: 401-409.
38. Williamson EM. 2002. Major herbs of Ayurveda. Churchill Livingstone: London.
39. Wu Y, Zhang Y, Na Wu J, Lowell T, Gu M, Yuan CS. 1998. Effects of Erkang, a modified formulation of Chinese folk medicine Shi-Qua-Da-Bu-Tang, on mice. J Ethnopharmacol 61: 153-159.