Methemoglobin Effects on Coagulation: A Dose-Response Study With HBOC-200 (Oxyglobin) in a Thrombelastogram Model

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 23, Issue 1, 2009, Pages 41-47

  Moallempour, Mojgan ^a   Jahr, Jonathan S ^a   Lim, Jennifer C ^a   Weeks, David ^b   Butch, Anthony ^a   Driessen, Bernd ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

Author keywords

coagulation; HBOC 200; hemoglobin based oxygen carrier; methemoglobin; Oxyglobin; thromboelastography

Indexed keywords

HBOC 200; HEMOGLOBIN GLUTAMER 200; METHEMOGLOBIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; DOSE RESPONSE; HEMODILUTION; HEMORRHAGIC SHOCK; HUMAN; PRIORITY JOURNAL; RESUSCITATION; THROMBOELASTOGRAPHY;

BLOOD COAGULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; HEMOGLOBINS; HUMANS; METHEMOGLOBIN; THROMBELASTOGRAPHY;

EID: 58149517990     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2008.06.006     Document Type: Article

References (9)

1. TEG 5000 User's Manual (2005), Haemoscope Inc, Niles, IL 178
2. Yeh L.H., and Alayash A.I. Redox side reactions of haemoglobin and cell signaling mechanisms. J Int Med 258 (2003) 518-526
3. Essex D.W., and Li M. Redox modification of platelet glycoproteins. Current Drug Targets 7 (2006) 1233-1241
4. Sprung J., Kindscher J.D., Wahr J.A., et al. The use of Bovine Hemoglobin Glutamer-250 (Hemopure®) in surgical patients: Results of a muticenter, randomized, single-blinded trial. Anesth Analg 94 (2002) 799-808
5. Jahr J.S., Weeks D., Desai P., et al. Does Oxyvita, a new generation hemoglobin-based oxygen carrier, or Oxyglobin acutely interfere with coagulation compared with normal saline or 6% Hetastarch?. An ex vivo thromboelastography preliminary study. J Cardiothorac Vasc Anesth 22 (2008) 34-39
6. Osgood S.L., Jahr J.S., Desai P., et al. Does methemoglobin from oxidized hemoglobin-based oxygen carrier (Hemoglobin Glutamer-200) interfere with lactate measurement (YSI 2700 SELECT™ Biochemistry Analyzer). Anesth Analg 100 (2005) 437-439
7. Iselin B.M., Willimann P.F.X., Seifert B.M., et al. Isolated reduction of haematocrit does not compromise in vitro blood coagulation. Br J Anaesth 87 (2001) 246-249
8. Jahr J.S., Lurie F., Gosselin R., et al. Effects of Hemoglobin-250 (Bovine) (HBOC-201, Hemopure) on coagulation testing. Am J Ther 9 (2002) 431-436
9. James M.F., Potgieter H.E., and Ellis P. The effect of Hemopure® on coagulation in clinically relevant concentrations. Anesth Analg 99 (2004) 1593-1597