A novel method for the estimation of podocyte injury: Podocalyxin-positive elements in urine

Folia Biologica

Volumn 54, Issue 5, 2008, Pages 162-167

  Habara, Peter ^a   Mareckova H ^a   Sopkova Z ^a   Malickova K ^a   Zivorova D ^a   Zima, T ^a   Tesar V ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

PODOCALYXIN;

ADULT; AGED; ARTICLE; CHRONIC GLOMERULONEPHRITIS; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE SEVERITY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GLOMERULONEPHRITIS; HEMATURIA; HUMAN; MAJOR CLINICAL STUDY; MALE; PODOCYTE; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEIN URINE LEVEL; PROTEINURIA; REMISSION; SENSITIVITY AND SPECIFICITY; URINALYSIS;

EID: 58149516347     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Bariety, J., Mandet, Ch., Hill, G. S., Bruneval P. (2006) Parietal podocytes in normal human glomeruli. J. Am. Soc. Nephrol. 17, 2770-2780.
2. Barisoni, L., Schnaper, H. W., Kopp, J. B. (2007) A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases. Clin. J. Am. Soc. Nephrol. 2, 529-542.
3. Economou, C. G., Kitsiou, P. V., Tzinia, A. K., Panagopoulou, E., Marinos, E., Kershaw, D. B., Kerjaschki, D., Tsilibary, E. C. (2004) Enhanced podocalyxin expression alters the structure of podocyte basal surface. J. Cell Sci. 117, 3281-3294.
4. Hara, M., Yamamoto, T., Yanagihara, T., Takada, T., Itoh, M., Adachi, Y., Yoshizumi, A., Kawasaki, K., Kihara, I. (1995) Urinary excretion of podocalyxin indicates glomerular epithelial cell injuries in glomerulonephritis. Nephron 69, 397-403.
5. Hara, M., Yanagihara, T., Kihara, I. (2001) Urinary podocytes in primary focal segmental glomerulosclerosis. Nephron 89, 342-347.
6. Hara, M., Yanagihara, T., Kihara, I., Higashi, K., Fujimoto, K., Kajita, T. (2005) Apical cell membranes are shed into urine from injured podocytes: A novel phenomenon of podocyte injury. J. Am. Soc. Nephrol. 16, 408-416.
7. Kanno, K., Kawachi, H., Uchida, Y., Hara, M., Shimizu, F., Uchiyama, M. (2003) Urinary sediment podocalyxin in children with glomerular disease. Nephron Clin. Pract. 95, 91-99.
8. Kouri, T., Vuotari, L., Pohjavaara, S., Laippala, P. (2002) Preservation of urine for flow cytometric and visual microscopic testing. Clin. Chem. 48, 900-905.
9. Lemley, K. V. (2007) An introduction to biomarkers: applications to chronic kidney disease. Pediatr. Nephrol. 22, 1849-1859.
10. Mundel, P., Shankland, S. J. (2002) Podocyte biology and response to injury. J. Am. Soc. Nephrol. 13, 3005-3015
11. Petermann, A., Floege, J. (2007) Podocyte damage resulting in podocyturia: a potential diagnostic marker to assess glomerular disease activity. Nephron Clin. Pract. 106, c61-c66.
12. Shankland, S. J., Pippin, J. W., Couser, W. G. (1999) Complement (C5b-9) induces glomerular epithelial cell DNA synthesis but not proliferation in vitro. Kidney Int. 56, 538-548.
13. Somasiri, A., Nielsen, J. S., Makretsov, N., McCoy, M. L., Prentice, L., Gliks, C. B., Chia, S. K., Gelmon, K. A., Kershaw, D. B., Hunstamn, D. G., McNagny, K. M., Roskelley, C. D. (2004) Overexpresion of the anti-adhesin podocalyxin is an independent predictor of breast cancer progresion. Cancer Res. 64, 5068-5073.
14. Yu, D., Petermann, A., Kunter, U., Rong, Shankland, S. J., Floege, J. (2005) Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria. J. Am. Soc. Nephrol. 16, 1733-1741.