Capecitabine-based combination therapy for breast cancer: Implications for nurses

Oncology Nursing Forum

Volumn 36, Issue 1, 2009, Pages 105-113

  Frye, Debra K ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; CAPECITABINE; DEOXYCYTIDINE; DRUG DERIVATIVE; FLUOROURACIL; PRODRUG;

ALOPECIA; BONE MARROW DISEASE; BREAST TUMOR; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; DOSE RESPONSE; DRUG INTERACTION; FEMALE; GASTROINTESTINAL DISEASE; HUMAN; NURSING; PARESTHESIA; PATHOLOGY; PATIENT COMPLIANCE; PATIENT EDUCATION; PERIPHERAL NEUROPATHY; PSYCHOLOGICAL ASPECT; REVIEW;

ALOPECIA; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW DISEASES; BREAST NEOPLASMS; CLINICAL TRIALS AS TOPIC; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; FLUOROURACIL; GASTROINTESTINAL DISEASES; HUMANS; PARESTHESIA; PATIENT COMPLIANCE; PATIENT EDUCATION AS TOPIC; PERIPHERAL NERVOUS SYSTEM DISEASES; PRODRUGS;

EID: 58149513886     PISSN: 0190535X     EISSN: 15380688     Source Type: Journal    
DOI: 10.1188/09.ONF.105-113     Document Type: Review

References (72)

1. Abraxis Oncology. (2005). Abraxane® [Prescribing information]. Los Angeles: Author.
2. Bartsch, R., Wenzel, C., Altorjai, G., Pluschnig, U., Rudas, M., Mader, R.M., et al. (2007). Capecitabine and trastuzumab in heavily pretreated patients with metastatic breast cancer. Journal of Clinical Oncology, 25(25), 3853-3858.
3. Berg, D.T. (2006). Capecitabine: A new adjuvant option for colorectal cancer. Clinical Journal of Oncology Nursing, 10(4), 479-486.
4. Berton-Rigaud, J., Roche, F., Penault-Llorca, Tubiana-Mathieu, N., Ferrerro, B., Coudert, G., et al. (2008). Benefit of neoadjuvant capecitabine + epirubicin + cyclophosphamide (CEX) versus 5-FU + epirubicin + cyclophosphamide (FEC) for operable breast cancer (BC) followed by adjuvant docetaxel (T) [Abstract 598]. Retrieved December 16, 2008, from http://www.asco.org/ASCO/ Abstracts+&+Virtual+Meeting/Abstracts?&vmview=abst-detail- view&confID=55&abstractID=35640
5. Beslija, S., Obralic, N., Basic, H., Tatarevic, A., Naila, M., Banjin, M., et al. (2006). Randomized trial of sequence versus combination of capecitabine and docetaxel: Capecitabine and docetaxel versus docetaxel followed by capecitabine after progression as first-line therapy for patients with metastatic breast cancer [Abstract 571]. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings, 24(18, Suppl.), 20S.
6. Blum, J.L., Dees, E.C., Chacko, A., Doane, L., Ethirajan, S., Hopkins, J., et al. (2006). Phase II trial of capecitabine and weekly paclitaxel as first-line therapy for metastatic breast cancer. Journal of Clinical Oncology, 24(27), 4384-4390.
7. Blum, J.L., Dees, E.C., Vukelja, S.J., Amare, M., Gill, D.P., McMahon, R.T., et al. (2007). Phase II trial of capecitabine and weekly paclitaxel in patients with metastatic breast cancer previously treated with every-three-week taxane therapy. Clinical Breast Cancer, 7(6), 465-470.
8. Blum, J.L., Dieras, V., LoRusso, P.M., Horton, J., Rutman, O., Buzdar, A., et al. (2001). Multicenter, phase II study of capecitabine in taxane-pretreated metastatic breast carcinoma patients. Cancer, 92(7), 1759-1768.
9. Boehmke, M.M., & Dickerson, S.S. (2005). Symptom, symptom experiences, and symptom distress encountered by women with breast cancer undergoing current treatment modalities. Cancer Nursing, 28(5), 382-389.
10. Borner, M.M., Schoffski, P., de Wit, R., Caponigro, F., Comella, G., Sulkes, A., et al. (2002). Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: A randomized crossover trial in advanced colorectal cancer. European Journal of Cancer, 38(3), 349-358.
11. Bristol-Myers Squibb Company. (2007). Paclitaxel [Prescribing information]. Princeton, NJ: Author.
12. Cawley, M.M., & Benson, L.M. (2005). Current trends in managing oral mucositis. Clinical Journal of Oncology Nursing, 9(5), 584-592.
13. Chan, A., Ganju, V., Becquart, D., Conte, P.F., Petruzelka, L., Gil, M., et al. (2008). Multicenter international phase II study of oral vinorelbine (NVBo), capecitabine (X) and trastuzumab (H) triple combination in HER2-positive metastatic breast cancer (MBC) [Abstract 3151]. Cancer Research, 69(Suppl., 2), 253S.
14. Chau, I., Legge, S., & Fumoleau, P. (2004). The vital role of education and information in patients receiving capecitabine (Xeloda®). European Journal of Oncology Nursing, 8(Suppl. 1), S41-S53.
15. Chin, S.F., Tchen, N., Oza, A.M., Moore, M.J., Warr, D., & Siu, L.L. (2001). Use of "Bag Balm" as topical treatment of palmar-plantar erythrodysesthesia syndrome in patients receiving selected chemotherapeutic agents [Abstract 1632]. Proceedings of the American Society of Clinical Oncology, 20, 409a.
16. Cole, T. (2006). Risks and benefits of needle use in patients after axillary node surgery. British Journal of Nursing, 15(18), 969-979.
17. Cox, A.C., & Fallowfield, L.J. (2007). After going through chemotherapy I can't see another needle. European Journal of Oncology Nursing, 11(1), 43-48.
18. Dibble, S.L., Casey, K., Nussey, B., Israel, J., & Luce, J. (2004). Chemotherapy-induced vomiting in women treated for breast cancer [Online exclusive]. Oncology Nursing Forum, 31(1), E1-E8. Retrieved November 21, 2008, from http://ons.metapress.com/content/j2w3070617x1r707/fulltext.pdf
19. Faithfull, S., & Deery, P. (2004). Implementation of capecitabine (Xeloda®) into a cancer centre: UK experience. European Journal of Oncology Nursing, 8(Suppl. 1), S54-S62.
20. Gerbrecht, B.M. (2003). Current Canadian experience with capecitabine: Partnering with patients to optimize therapy. Cancer Nursing, 26(2), 161-167.
21. Gerbrecht, B.M., & Kangas, T. (2004). Implications of capecitabine (Xeloda® ) for cancer nursing practice. European Journal of Oncology Nursing, 8(Suppl. 1), S63-S71.
22. Geyer, C.E., Forster, J., Lindquist, D., Chan, S., Romieu, C.G., Pienkowski, T., et al. (2006). Lapatinib plus capecitabine for HER2-positive advanced breast cancer. New England Journal of Medicine, 355(26), 2733-2743.
23. Ghosn, M., Kattan, J., Farhat, F., Younes, F., & Gasmi, J. (2006). Phase II trial of capecitabine and vinorelbine as first-line chemotherapy for metastatic breast cancer patients. Anticancer Research, 26(3B), 2451-2456.
24. Ghosn, M., Kattan, J., Farhat, F., Younes, F., Nasr, F., Moukadem, W., et al. (2008). Sequential vinorelbine-capecitabine followed by docetaxel in advanced breast cancer: Long-term results of a pilot phase II trial. Cancer Chemotherapy and Pharmacology, 62(1), 11-18.
25. Gopal, R.L., Beaver, K., Barnett, T., & Ismail, N.S. (2005). A comparison of the information needs of women newly diagnosed with breast cancer in Malaysia and the United Kingdom. Cancer Nursing, 28(2), 132-140.
26. Gradishar, W.J., Meza, L.A., Amin, B., Samid, D., Hill, T., Chen, Y.M., et al. (2004). Capecitabine plus paclitaxel as front-line combination therapy for metastatic breast cancer: A multicenter phase II study. Journal of Clinical Oncology, 22(12), 2321-2327.
27. Haller, D.G., Cassidy, J., Clarke, S., Cunningham, D., Van Cutsem, E., Hoff, P., et al. (2008).Potential regional differences for the tolerability profiles of fluoropyrimidines. Journal of Clinical Oncology, 26(13, Suppl.), 2118-2123.
28. Hartigan, K. (2003). Patient education: The cornerstone of successful oral chemotherapy treatment. Clinical Journal Oncology Nursing, 7(6, Suppl.), 21-24.
29. Hortobagyi, G.N., Perez, E., Vrdoljak, C., Medina, B., Xu, P., Conte, H., Peck, V., et al. (2008). Analysis of overall survival (OS) among patients (pts) with metastatic breast cancer (MBC) receiving either ixabepilone (I) plus capecitabine (C) or C alone [Abstract 186]. Retrieved December 16, 2008, from http://www.asco.org/ASCO/Abstracts+&+Virtual+Meeting/Abstracts?&vmview= abst-detail-view&confID=58&abstractID=40389
30. Ishikawa, T., Utoh, M., Sawada, N., Nishida, M., Fukase, Y., Sekiguchi, F., et al. (1998). Tumor selective delivery of 5-fluorouracil by capecitabine, a new oral fluoropyrimidine carbamate, in human cancer xenografts. Biochemical Pharmacology, 55(7), 1091-1097.
31. Joensuu, H., Hemminki, A., Huovinen, R., Tanner, M., Kokko, R., Asola, R., et al. (2007). The FinXX trial: Safety results in 600 patients (pts) randomized to either docetaxel (T) followed by cyclophosphamide (C) + epirubicin (E) + 5-FU (F) (CEF) or T + capecitabine (X) followed by CEX as adjuvant therapy for early breast cancer (BC) [Abstract 11035]. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings, 25(18, Suppl.), 596.
32. Lassere, Y., & Hoff, P. (2004). Management of hand-foot syndrome in patients treated with capecitabine (Xeloda). European Journal of Oncology Nursing, 8(Suppl. 1), S31-S40.
33. Lee, K.S., Ro, J., Nam, B.H., Lee, E.S., Kwon, Y., Kwon, H.S., et al. (2008). A randomized phase-III trial of docetaxel/capecitabine versus doxorubicin/cyclophosphamide as primary chemotherapy for patients with stage II/III breast cancer. Breast Cancer Research and Treatment, 109(3), 481-489.
34. Leonard, R., O'Shaughnessy, J., Vukelja, S., Gorbounova, V., Chan-Navarro, C.A., Maraninchi, D., et al. (2006). Detailed analysis of a randomized phase III trial: Can the tolerability of capecitabine plus docetaxel be improved without compromising its survival advantage? Annals of Oncology, 17(9), 1379-1385.
35. Liu, G., Franssen, E., Fitch, M.I., & Warner, E. (1997). Patient preferences for oral versus intravenous palliative chemotherapy. Journal of Clinical Oncology, 15(1), 110-115.
36. Lorusso, V., Spada, M., Giampaglia, M., Misino, A., Calabrese, R., Latorre, A., et al. (2006). Oral vinorelbine plus capecitabine (oral vincap) combination in patients with advanced breast cancer. A phase II study of the GOIM (Gruppo Oncologico dell'Italia Meridionale). Annals of Oncology, 17(Suppl. 7), vii15-vii17.
37. Lueck, H.J., du Bois, A., Schrader, I., Huober, J., Heilmann, V., Fasching, P.A., et al. (2007). Final results of the AGO breast cancer study group MAMMA-3 trial [Abstract 1076]. Breast Cancer Research and Treatment, 106(Suppl. 1), 67S.
38. Luker, K.A., Beaver, K., Leinster, S.J., Owens, R.G., Degner, L.F., & Sloan, J.A. (1995). The information needs of women newly diagnosed with breast cancer. Journal of Advanced Nursing, 22(1), 134-141.
39. Markman, M. (2003). Management of toxicities associated with the administration of taxanes. Expert Opinion on Drug Safety, 2(2), 141-146.
40. Marse, H., Van Cutsem, E., Grothey, A., & Valverde, S. (2004). Management of adverse events and other practical considerations in patients receiving capecitabine (Xeloda® ). European Journal of Oncology Nursing, 8(Suppl. 1), S16-S30.
41. Mavroudis, D., Papakotoulas, P., Ardavanis, A., Kakolyris, S., Kouroussis, C.H., Malamos, N., et al. (2008). Docetaxel plus epirubicin versus docetaxel plus capecitabine as first line treatment in patients with advanced breast cancer [Abstract 1360]. Annals of Oncology, 19(Suppl. 8), viii63.
42. McGinn, K., & Moore, J. (2001). Metastatic breast cancer: Understanding current management options. Oncology Nursing Forum, 28(3), 507-512.
43. Miller, K.D., Chap, L.I., Holmes, F.A., Cobleigh, M.A., Marcom, P.K., Fehrenbacher, L., et al. (2005). Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. Journal of Clinical Oncology, 23(4), 792-799.
44. Miwa, M., Ura, M., Nishida, M., Sawada, N., Ishikawa, T., Mori, K., et al. (1998). Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. European Journal of Cancer, 34(8), 1274-1281.
45. Moore, S. (2007). Facilitating oral chemotherapy treatment and compliance through patient/family-focused education. Cancer Nursing, 30(2), 112-122.
46. Mrozek-Orlowski, M.E., Frye, D.K., & Sanborn, H.M. (1999). Capecitabine: Nursing implications of a new oral chemotherapeutic agent. Oncology Nursing Forum, 26(4), 753-762.
47. O'Shaughnessy, J., Miles, D., Vukelja, S., Moiseyenko, V., Ayoub, J.P., Cervantes, G., et al. (2002). Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: Phase III trial results. Journal of Clinical Oncology, 20(12), 2812-2823.
48. Paley, M., Love, N., Carlson, R., Tripathy, D., Kaderman, R., Paley, D., et al. (2005). Preferences for oral and parenteral antitumor therapy: A survey of 260 patients with metastatic breast cancer [Abstract 619]. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings, 23(16, Suppl.), 33S.
49. Partridge, A.H., Avorn, J., Wang, P.S., & Winer, E.P. (2002). Adherence to therapy with oral antineoplastic agents. Journal of the National Cancer Institute, 94(9), 652-661.
50. Perez, E.A., Hillman, D.W., Kugler, J.W., Steen, P.D., Fitch, T.R., & Rowland, K.M. (2006). North central cancer treatment group (NCCTG) N0432: Phase II trial of docetaxel with capecitabine and bevacizumab as first line chemotherapy for patients with metastatic breast cancer [Abstract 2069]. Breast Cancer Research and Treatment, 100(Suppl. 1), S104.
51. Pierre-Fabre Pharmaceuticals, Inc. (2005). Vinorelbine [Prescribing information]. Parsippany, NJ: Author.
52. Roche Laboratories, Inc. (2006). Capecitabine [Prescribing information]. Nutley, NJ: Author.
53. Rough, A., MacLeod, A., Cassidy, J., & McDonald, L. (2004). Questionnaire audit assessing compliance in colon cancer patients taking adjuvant capecitabine as part of the X-ACT trial [Abstract 283P]. Annals of Oncology, 15(Suppl. 3), iii75.
54. sanofi-aventis U.S. LLC. (2007). Docetaxel [Prescribing information]. Bridgewater, NJ: Author.
55. Schaller, G., Fuchs, I., Gonsch, T., Weber, J., Kleine-Tebbe, A., Klare, P., et al. (2007). Phase II study of capecitabine plus trastuzumab in human epidermal growth factor receptor 2-overexpressing metastatic breast cancer pretreated with anthracyclines or taxanes. Journal of Clinical Oncology, 25(22), 3246-3250.
56. Sledge, G., Miller, K., Moisa, C., & Gradishar, W. (2007). Safety and efficacy of capecitabine plus bevacizumab as first-line in metastatic breast cancer [Abstract 1013]. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings, 25(Suppl. 18), 35S.
57. Smith, J.A., Kindo, C.C., Kurian, S., Whitaker, L.M., Burke, C., Wachel, B., et al. (2004). Evaluation of patient chemotherapy education in a gynecology oncology center. Supportive Care in Cancer, 12(8), 577-583.
58. Somer, B.G., Schwartzberg, L.S., Arena, F., Epperson, D., Fu, D., & Fortner, B.V. (2007). Phase II trial of nab-paclitaxel (nanoparticle albumin-bound paclitaxel) plus capecitabine in first line treatment of metastatic breast cancer [Abstract 1053]. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings, 25(18, Suppl.), 45S.
59. Soto, C., Torrecillas, L., Reyes, S., Ramirez, M., Perez, L., Cervantes, G., et al. (2006). Capecitabine and taxanes in patients with anthracycline-pretreated metastatic breast cancer: Sequential versus combined therapy results from a MOSG randomized phase III trial [Abstract 570]. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings, 24(18, Suppl.), 20S.
60. Thomas, E.S., Gomez, H.L., Li, R.K., Chung, H.C., Fein, L.E., Chan, V.F., et al. (2007). Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. Journal of Clinical Oncology, 25(33), 5210-5217.
61. Timmerman, D. (2001). Capecitabine (Xeloda®). Clinical Journal of Oncology Nursing, 5(1), 36-37.
62. Tubiana-Mathieu, N., Bougnoux, P., Becquart, D., Chan, A., Majois, F., Espie, M., et al. (2008). All-oral combination of oral vinorelbine (NVBo) and capecitabine (X) in HER2-negative metastatic breast cancer (MBC) [Abstract 6125]. Cancer Research, 69(Suppl., 2), 397s.
63. Viale, P.H., Fung, A., & Zitella, L. (2005). Advanced colorectal cancer: Current treatment and nursing management with economic considerations. Clinical Journal of Oncology Nursing, 9(5), 541-552.
64. von Minckwitz, G., Rezai, M., Loibl, S., Fasching, P., Huober, J., Tesch, H., et al. (2007). GeparQuattro: First interim safety analysis of a phase III trial exploring the efficacy of capecitabine and trastuzumab given concomitantly or in sequence to EC-Doc as neoadjuvant treatment of primary breast cancer [Abstract 222]. Retrieved November 24, 2008, from http://gicancers.asco.org/ ASCO/Abstracts+&+Virtual+Meeting/Abstracts?&vmview=abst-detail- view&confID=52&abstractID=40300
65. von Minckwitz, G., Zielinski, C., Maarteense, P., Vogel, M., Schmidt, H., Eidtmann, T., et al. (2008). Capecitabine vs. capecitabine + trastuzumab in patients with HER2-positive metastatic breast cancer progressing during trastuzumab treatment [Abstract 1025]. Retrieved December 16, 2008, from http://meeting.ascopubs.org/cgi/content/abstract/26/15-suppl/1025
66. Wardley, A., Anton-Torres, A., Pivot, X., Morales-Vasquez, F., Zetina, L., de Fatima Dias Gaui, M., et al. (2008). Trastuzumab plus docetaxel with or without capecitabine as first-line therapy for HER2-positive locally advanced or metastatic breast cancer [Abstract 209]. European Journal of Cancer, 7(Suppl.), 109.
67. Webster-Gandy, J.D., How, C., & Harrold, K. (2007). Palmar-plantar erythrodysesthesia: A literature review with commentary on experience in a cancer centre. European Journal of Oncology Nursing, 11(3), 238-246.
68. Wildiers, H., Neven, P., Christiaens, M.R., Fesneau, G., Amant, F., Weltens, C., et al. (2008). Multicenter phase II study of neoadjuvant capecitabine (X), docetaxel (T) plus trastuzumab (H) for patients (pts) with locally advanced breast cancer (LABC) [Abstract 5115]. Cancer Research, 69(Suppl., 2), 343s.
69. Wilkes, G.M., & Doyle, D. (2005). Palmar-plantar erythrodysesthesia. Clinical Journal of Oncology Nursing, 9(1), 103-106.
70. Williams, S.A., & Schreier, A.M. (2004). The effect of education in managing side effects in women receiving chemotherapy for treatment of breast cancer [Online exclusive]. Oncology Nursing Forum, 31(1), E16-E23. Retrieved November 21, 2008, from http://ons.metapress.com/content/ b366435101rv1712/fulltext.pdf
71. Yamamoto, D., Iwase, S., Kitamura, K., Odagiri, H., Yamamoto, C., & Nagumo, Y. (2008). A phase II study of trastuzumab and capecitabine for patients with HER2-overexpressing metastatic breast cancer. Cancer Chemotherapy and Pharmacology, 61(3), 509-514.
72. Zambetti, M., Mansutti, A., Llunch, C., Zamagni, E., De Benedictis, P., Gomez, L., et al. (2008). First report of the European Cooperative Trial in Operable Breast Cancer II (ECTO II): Effects of primary chemo-endocrine therapy on local-regional disease in ER-positive breast cancer [Abstract 588]. Retrieved December 16, 2008, from http://meeting.ascopubs.org/cgi/content/abstract/26/15- suppl/588