International Normalized Ratio of Prothrombin Time in the Model for End-stage Liver Disease Score: An Unreliable Measure

Clinics in Liver Disease

Volumn 13, Issue 1, 2009, Pages 67-71

  Arjal, Russ ^a   Trotter, James F ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Allocation; INR; Liver transplant; MELD; Outcomes

Indexed keywords

ANTIVITAMIN K; BILIRUBIN; CREATININE; THROMBOPLASTIN;

ANTICOAGULATION; BILIRUBIN BLOOD LEVEL; CALIBRATION; CLINICAL ASSESSMENT; CREATININE BLOOD LEVEL; GRAFT RECIPIENT; INTERNATIONAL NORMALIZED RATIO; KIDNEY DISEASE; LABORATORY DIAGNOSIS; LIVER DISEASE; LIVER TRANSPLANTATION; MODEL FOR END STAGE LIVER DISEASE SCORE; PARAMETER; PROTHROMBIN TIME; REVIEW; SURVIVAL; TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT;

CADAVER; DONOR SELECTION; HUMANS; INTERNATIONAL NORMALIZED RATIO; LIVER FAILURE; LIVER TRANSPLANTATION; MODELS, BIOLOGICAL; PROTHROMBIN TIME; SEVERITY OF ILLNESS INDEX; WAITING LISTS;

EID: 58149505850     PISSN: 10893261     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cld.2008.09.009     Document Type: Review

References (21)

1. Malinchoc M., Kamath P.S., Gordon F.D., et al. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology 31 (2000) 864-871
2. Institute of Medicine Committee on Organ Procurement and Policy. Organ procurement and transplantation: assessing current policies and the potential impact of the DHHS final rule (1999), National Academy Press, Washington, DC 1-29
3. Kamath P.S., Wiesner R.H., Malinchoc M., et al. A model to predict survival in patients with end-stage liver disease. Hepatology 33 (2001) 464-470
4. Wiesner R., Edwards E., Freeman R., et al. Model for end-stage liver disease (MELD) and allocation of donor liver. Gastroenterology 124 (2003) 91-96
5. Freeman R.B., Wiesner R., Harper A., et al. The new allocation system: moving toward evidence-based transplantation policy. Liver Transpl 8 (2002) 851-858
6. Kamath P.S., and Kim W.R. The model for end-stage liver disease (MELD). Hepatology 45 (2007) 797-805
7. Cholongitas E., Marelli L., Kerry A., et al. Different methods of creatinine measurement significantly affect MELD scores. Liver Transpl 13 (2007) 523-529
8. Cholongitas E., Marelli L., Kerry A., et al. Female liver transplant recipients with the same GFR as male recipients have lower MELD scores-a systematic bias. Am J Transplant 7 (2007) 685-692
9. Trotter J.F., Brimhall B., Arjal R., et al. Specific laboratory methodologies achieve higher model for end-stage liver disease (MELD) scores for patients listed for liver transplantation. Liver Transpl 10 (2004) 995-1000
10. Trotter J.F., Olson J., Lefkowitz J., et al. Changes in international normalized ratio (INR) and model for endstage liver disease (MELD) based on selection of clinical laboratory. Am J Transplant 7 (2007) 1624-1628
11. Hirsh J., and Poller L. The international normalized ratio. Arch Intern Med 154 (1994) 282-288
12. Kirkwood T.B. Calibration of reference thromboplastins and standardization of the prothrombin time ratio. Thromb Haemost 49 (1983) 238-244
13. Olson J.D., Brandt J.T., Chandler W.L., et al. Laboratory reporting for the international normalized ratio: progress and problems. Arch Pathol Lab Med 131 (2007) 1641-1647
14. Kovacs M.H., Wong A., MacKinnon K., et al. Assessment of the validity of the INR system for patients with liver impairment. Thromb Haemost 71 (1994) 727-730
15. Denson K.W.E., Reed S.V., Haddon M.E., et al. Comparative studies of rabbit and human recombinant tissue factor reagents. Thromb Res 94 (1999) 255-261
16. Robert A., and Chazouilleres O. Prothrombin time in liver failure: time, ratio, activity percentage, or international normalized ratio. Hepatology 24 (1996) 1392-1394
17. liver) normalizes prothrombin time results for model for end-stage liver disease calculation. Hepatology 46 (2007) 528-534
18. Bellest L., Eschwege V., Poupon R., et al. A modified international normalized ratio of prothrombin time standardization in hepatology. Hepatology 46 (2007) 520-527
19. Marlar R. Determining the model for end-stage liver disease with better accuracy: neutralizing the international normalized ratio pitfalls. Hepatology 46 (2007) 295-296
20. Heuman D.M., Mihas A.A., Habib A., et al. MELD-XI: a rational approach to "sickest first" liver transplantation in cirrhotic patients requiring anticoagulant therapy. Liver Transpl 13 (2007) 30-37
21. United Network for Organ Sharing. Available at:. http://www.unos.org/SharedContentDocumens/Revised_MELDPELD_2003(2).pdf Accessed December 20, 2005