Sirolimus in unmanipulated haploidentical cell transplantation

Bone Marrow Transplantation

Volumn 42, Issue 11, 2008, Pages 765-766

  von Reyn Cream, L ^a   Ehmann, W C ^a   Rybka, W B ^a   Claxton, D F ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE; CYCLOPHOSPHAMIDE; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; LACTATE DEHYDROGENASE; METHOTREXATE; METHYLPREDNISOLONE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AGED; ANTINEOPLASTIC ACTIVITY; CANCER GROWTH; CANCER REGRESSION; CANCER SURVIVAL; CHIMERA; CLINICAL ARTICLE; DRUG DOSE REDUCTION; DRUG TOLERABILITY; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HERPES; HLA MATCHING; HODGKIN DISEASE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LETTER; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; LUNG ASPERGILLOSIS; LYMPHOCYTE DEPLETION; MULTIPLE CYCLE TREATMENT; MYELODYSPLASTIC SYNDROME; NEUTROPHIL COUNT; NONHODGKIN LYMPHOMA; NONMYELOABLATIVE STEM CELL TRANSPLANTATION; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; STEM CELL MOBILIZATION; SURVIVAL TIME; THROMBOCYTE COUNT; THROMBOTIC THROMBOCYTOPENIC PURPURA; VIRUS REACTIVATION;

ADULT; AGED; ANTIBIOTICS, ANTINEOPLASTIC; DISEASE-FREE SURVIVAL; GRAFT VS TUMOR EFFECT; HAPLOTYPES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LYMPHOMA; MEDICAL ONCOLOGY; MIDDLE AGED; RISK; SIROLIMUS; STEM CELLS; TREATMENT OUTCOME;

EID: 58149477881     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2008.242     Document Type: Letter

References (10)

1. Lacerda JF, Martins C, Carmo JA, Lourenco F, Juncal C, Ismail S et al Haploidentical stem cell transplantation with purified CD34 + cells after a chemotherapy-alone conditioning regimen in heavily transfused severe aplastic anemia. Biol Blood Marrow Transplant 2005; 11 399-400.
2. Uoshima N, Kamitsuji Y, Maruya E, Saji H. Successful reduced-intensity stem cell transplantation from an HLA haploidentical 3-loci-mismatched donor on the basis of fetomaternal microchimerism in a patient with advanced acute myeloid leukemia. Int J Hematol 2003; 78: 69-72.
3. Spitzer TR, McAfee SL, Dey BR, Colby C, Hope J, Grossberg H et al. Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies. Transplantation 2003; 75: 1748-1751.
4. O'Donnell PV, Luznik L, Jones RJ, Vogelsang GB, Leffell MS, Phelps M et al. Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide. Biol Blood Marrow Transplant 2002; 8: 377-386.
5. Chakrabarti S, Mackinnon S, Chopra R, Kottaridis PD, Peggs K, O'Gorman P et al. High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: Potential role of Campath-1H in delaying immune reconstitution. Blood 2002; 99: 4357-4363.
6. Jager MD, Liu JY, Timrott KF, Popp FC, Stoeltzing O, Lang SA et al Sirolimus promotes tolerance for donor and recipient antigens after MHC class II disparate bone marrow transplantation in rats. Exp Hematol 2007; 35: 164-170.
7. Cutler C, Kim HT, Hochberg E, Ho V, Alyea E, Lee SJ et al. Sirolimus and tacrolimus without methotrexate as graft-versus-host disease prophylaxis after matched related donor peripheral blood stem cell transplantation. Biol Blood Marrow Transplant 2004; 10: 328-336.
8. Claxton DF, Ehmann C, Rybka W, Claxton DF, Ehmann C, Rybka W. Control of advanced and refractory acute myelogenous leukaemia with sirolimus-based non-myeloablative allogeneic stem cell transplantation. Br J Haematol 2005; 130: 256-264.
9. Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med 2002; 8: 128-135.
10. Recher C, Beyne-Rauzy O, Demur C, Chicanne G, Dos SC, Mas VM et al Antileukemic activity of rapamycin in acute myeloid leukemia. Blood 2005; 105: 2527-2534.