Cystic fibrosis: Ferreting with fibroblasts for cystic fibrosis

Gene Therapy

Volumn 16, Issue 1, 2009, Pages 1-2

  Griesenbach, U ^a   Alton, E W F W ^a  

^a UK Cystic Fibrosis Gene Therapy Consortium ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL; PARVOVIRUS VECTOR; SINGLE STRANDED DNA; TRANSMEMBRANE CONDUCTANCE REGULATOR;

CELL NUCLEUS TRANSPLANTATION; CYSTIC FIBROSIS; DISEASE MODEL; EMBRYONIC STEM CELL; ENTEROPATHY; FIBROBLAST; GENE TARGETING; HETEROZYGOTE; HUMAN; ION TRANSPORT; LUNG DISEASE; NONHUMAN; NOTE; PANCREAS DISEASE; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; SOMATIC CELL GENETICS; SPECIES DIFFERENCE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; FERRETS; FIBROBLASTS; GENE EXPRESSION; HUMANS; MODELS, ANIMAL; MUTATION; ORGANISMS, GENETICALLY MODIFIED; SWINE;

EID: 58149475226     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2008.155     Document Type: Note

References (4)

1. Sun X, Yan Z, Yi Y, Li Z, Lei D, Rogers CS et al. Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets. J Clin Invest 2008; 118: 1578-1583.
2. Rogers CS, Hao Y, Rokhlina T, Samuel M, Stoltz DA, Li Y et al. Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer. J Clin Invest 2008; 118: 1571-1577.
3. Clarke LL, Grubb BR, Yankaskas JR, Cotton CU, McKenzie A, Boucher RC. Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/ -) mice. Proc Natl Acad Sci USA 1994; 91: 479-483.
4. Liu Y, Wang Y, Jiang Y, Zhu N, Liang H, Xu L et al. Mild processing defect of porcine DeltaF508-CFTR suggests that DeltaF508 pigs may not develop cystic fibrosis disease. Biochem Biophys Res Commun 2008; 373: 113-118.