Sulfate-conjugated methylprednisolone: Evaluation as a colon-specific methylprednisolone prodrug and comparison with sulfate-conjugated prednisolone and dexamethasone

Journal of Drug Targeting

Volumn 17, Issue 2, 2009, Pages 159-167

  Kong, Hyesik ^a   Kim, Youngsoo ^b   Lee, Yonghyun ^b   Choi, Boim ^b   Jung, Sunhwa ^b   Jung, Yunjin ^b   Kim, Young Mi ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Pusan National University   (South Korea)

Author keywords

Colon specific prodrug; Drug delivery; Glucocorticoid; Methylprednisolone; Sulfate conjugates; Sulfation

Indexed keywords

DEXAMETHASONE; DEXAMETHASONE 21 SULFATE SODIUM; GLUCOCORTICOID; METHYLPREDNISOLONE; METHYLPREDNISOLONE 21 SULFATE SODIUM; OXIDOREDUCTASE; PREDNISOLONE; PREDNISOLONE 21 SULFATE SODIUM; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG METABOLISM; DRUG SCREENING; DRUG SENSITIVITY; DRUG SPECIFICITY; DRUG STABILITY; DRUG SYNTHESIS; DRUG URINE LEVEL; INTESTINE; MALE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; RAT; TISSUE HOMOGENATE;

ADMINISTRATION, ORAL; ANIMALS; COLON; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; GLUCOCORTICOIDS; INTESTINAL ABSORPTION; MALE; METHYLPREDNISOLONE; PREDNISOLONE; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SULFATES; TISSUE DISTRIBUTION;

EID: 58149469929     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860802546637     Document Type: Article

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