Early relapses in primary CNS lymphoma after response to polychemotherapy without intraventricular treatment: Results of a phase II study

Journal of Neuro-Oncology

Volumn 91, Issue 3, 2009, Pages 299-305

  Pels, Hendrik ^a   Juergens, Annika ^a   Glasmacher, Axel ^b   Schulz, Holger ^c   Engert, Andreas ^c   Linnebank, Michael ^d   Schackert, Gabriele ^e   Reichmann, Heinz ^e   Kroschinsky, Frank ^e   Vogt Schaden, Marlies ^f   Egerer, Gerlinde ^g   Bode, Udo ^b   Schaller, Carlo ^b,h   Lamprecht, Monika ^g   Hau, Peter ⁱ   Deckert, Martina ^c   Fimmers, Rolf ^b   Bangard, Christopher ^c   Schmidt Wolf, Ingo G H ^b   Schlegel, Uwe ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^f UNIVERSITY OF HEIDELBERG   (Germany)

^g UNIVERSITY OF KIEL   (Germany)

^h GENEVA UNIVERSITY HOSPITALS   (Switzerland)

ⁱ UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Chemotherapy; Intraventricular treatment; Neurotoxicity; Primary CNS lymphoma

Indexed keywords

CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; IFOSFAMIDE; METHOTREXATE; VINCA ALKALOID; VINCRISTINE; VINDESINE;

ADULT; ARTICLE; BLOOD DISEASE; BLOOD TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CANCER RELAPSE; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG EFFICACY; DRUG MEGADOSE; DRUG RESPONSE; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; FOLLOW UP; HUMAN; INFECTION; LEUKOPENIA; LIVER TOXICITY; MUCOSA INFLAMMATION; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; NEPHROTOXICITY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL; PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA; RECURRENCE RISK; SYSTEMIC DISEASE; SYSTEMIC THERAPY; THROMBOCYTOPENIA;

ADULT; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CENTRAL NERVOUS SYSTEM NEOPLASMS; DRUG ADMINISTRATION ROUTES; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIERS ESTIMATE; KARNOFSKY PERFORMANCE STATUS; LYMPHOMA; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 58149460977     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-008-9712-4     Document Type: Article

References (31)

1. Central Brain Tumor Registry of the United States (2005) Statistical report: Primary brain tumors in the United States. Chicago, IL
2. Harris NL, Jaffe ES, Diebold J et al (2000) Lymphoma classification - from controversy to consensus: The REAL and WHO Classification of lymphoid neoplasms. Ann Oncol 11(Suppl 1):3-10. doi: 10.1023/ A:1008383406103
3. Pels H, Schmidt-Wolf IG, Glasmacher A et al (2003) Primary central nervous system lymphoma: Results of a pilot and phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy. J Clin Oncol 21:4489-4495. doi: 10.1200/JCO.2003.04.056
4. Ferreri AJ, Reni M, Pasini F et al (2002) A multicenter study of treatment of primary CNS lymphoma. Neurology 58:1513-1520
5. Khan RB, Shi W, Thaler HT et al (2002) Is intrathecal methotrexate necessary in the treatment of primary CNS lymphoma? J Neurooncol 58:175-178. doi: 10.1023/A:1016077907952
6. Harris NL, Jaffe ES, Stein H et al (1994) A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 84:1361-1392
7. Gatter KCWR (2001) Diffuse large cell lymphoma. IARC Press, Lyon, France
8. Abrey LE, Batchelor TT, Ferreri AJ et al (2005) Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma. J Clin Oncol 23:5034-5043. doi: 10.1200/JCO.2005.13.524
9. Macdonald DR, Cascino TL, Schold SC Jr et al (1990) Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 8:1277-1280
10. World Health Organization (1979) WHO handbook for reporting results of cancer treatment. In: WHO offset publication no 48. World Health Organization, Geneva, Switzerland, pp 14-21
11. Ferreri AJ, Blay JY, Reni M et al (2003) Prognostic scoring system for primary CNS lymphomas: The International Extranodal Lymphoma Study Group experience. J Clin Oncol 21:266-272. doi: 10.1200/JCO.2003.09.139
12. Abrey LE, Ben-Porat L, Panageas KS et al (2006) Primary central nervous system lymphoma: The Memorial Sloan-Kettering Cancer Center prognostic model. J Clin Oncol 24:5711-5715. doi: 10.1200/JCO.2006.08.2941
13. Kaplan ELMP (1958) Non parametric estimations from complete observations. J Am Stat Assoc 53:163-179. doi: 10.2307/2281868
14. Soussain C, Hoang-Xuan K, Levy V (2004) Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma. Bull Cancer 91:189-192
15. Batchelor T, Carson K, O'Neill A et al (2003) Treatment of primary CNS lymphoma with methotrexate and deferred radiotherapy: A report of NABTT 96-07. J Clin Oncol 21:1044-1049. doi: 10.1200/JCO.2003.03.036
16. Herrlinger U, Kuker W, Uhl M et al (2005) NOA-03 trial of high-dose methotrexate in primary central nervous system lymphoma: Final report. Ann Neurol 57:843-847. doi: 10.1002/ana.20495
17. Guha-Thakurta N, Damek D, Pollack C et al (1999) Intravenous methotrexate as initial treatment for primary central nervous system lymphoma: Response to therapy and quality of life of patients. J Neurooncol 43:259-268. doi: 10.1023/A:1006210703827
18. Hoang-Xuan K, Taillandier L, Chinot O et al (2003) Chemotherapy alone as initial treatment for primary CNS lymphoma in patients older than 60 years: A multicenter phase II study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group. J Clin Oncol 21:2726-2731. doi: 10.1200/JCO.2003.11.036
19. DeAngelis LM, Seiferheld W, Schold SC et al (2002) Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: Radiation Therapy Oncology Group Study 93-10. J Clin Oncol 20:4643-4648. doi: 10.1200/JCO.2002.11.013
20. O'Brien P, Roos D, Pratt G et al (2000) Phase II multicenter study of brief single-agent methotrexate followed by irradiation in primary CNS lymphoma. J Clin Oncol 18:519-526
21. Abrey LE, Yahalom J, DeAngelis LM (2000) Treatment for primary CNS lymphoma: The next step. J Clin Oncol 18:3144-3150
22. Bessell EM, Lopez-Guillermo A, Villa S et al (2002) Importance of radiotherapy in the outcome of patients with primary CNS lymphoma: An analysis of the CHOD/BVAM regimen followed by two different radiotherapy treatments. J Clin Oncol 20:231-236. doi: 10.1200/JCO.20.1.231
23. Poortmans PM, Kluin-Nelemans HC, Haaxma-Reiche H et al (2003) High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962. J Clin Oncol 21:4483-4488. doi: 10.1200/JCO.2003.03.108
24. Batchelor T (2005) Neuro-oncology update: 2005. Curr Opin Neurol 18:631. doi: 10.1097/01.wco.0000189873.92362.dc
25. Batchelor T, Loeffler JS (2006) Primary CNS lymphoma. J Clin Oncol 24:1281-1288. doi: 10.1200/JCO.2005.04.8819
26. Harder H, Holtel H, Bromberg JE et al (2004) Cognitive status and quality of life after treatment for primary CNS lymphoma. Neurology 62:544-547
27. Fisher B, Seiferheld W, Schultz C et al (2005) Secondary analysis of Radiation Therapy Oncology Group study (RTOG) 9310: An intergroup phase II combined modality treatment of primary central nervous system lymphoma. J Neurooncol 74:201-205. doi: 10.1007/s11060-004-6596-9
28. O'Brien PC, Roos DE, Pratt G et al (2006) Combined-modality therapy for primary central nervous system lymphoma: Long-term data from a phase II multicenter study (Trans-Tasman Radiation Oncology Group). Int J Radiat Oncol Biol Phys 64:408-413. doi: 10.1016/j.ijrobp.2005.07.958
29. Correa DD, DeAngelis LM, Shi W et al (2004) Cognitive functions in survivors of primary central nervous system lymphoma. Neurology 62:548-555
30. Fliessbach K, Helmstaedter C, Urbach H et al (2005) Neuropsychological outcome after chemotherapy for primary CNS lymphoma: A prospective study. Neurology 64:1184-1188
31. Neuwelt EA, Guastadisegni PE, Varallyay P et al (2005) Imaging changes and cognitive outcome in primary CNS lymphoma after enhanced chemotherapy delivery. AJNR Am J Neuroradiol 26:258-265