Zinc chloride stimulates DNA synthesis of mouse embryonic stem cells: Involvement of PI3K/Akt, MAPKs, and mTOR

Journal of Cellular Physiology

Volumn 218, Issue 3, 2009, Pages 558-567

  Jung, Min Ryu ^a   Min, Young Lee ^a   Seung, Pil Yun ^a   Ho, Jae Han ^a  

^a Chonnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLIN DEPENDENT KINASE; DNA; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; THYMIDINE; WORTMANNIN; ZINC CHLORIDE; CELL CYCLE PROTEIN; CHLORIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; ZINC DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; EMBRYONIC STEM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL LINE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION;

MAMMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CELL PROLIFERATION; CHLORIDES; DNA; EMBRYONIC STEM CELLS; ENZYME ACTIVATION; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; ZINC COMPOUNDS;

EID: 58149399133     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21628     Document Type: Article

References (44)

1. + exchange in colonocytes mediated by the zinc-sensing receptor. J Biol Chem 279:51804-51816.
2. Bao S, Knoell DL. 2006. Zinc modulates airway epithelium susceptibility to death receptor-mediated apoptosis. Am J Physiol Lung Cell Mol Physiol 290:L433-L441.
3. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM. 1993. Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney. Pharm Res 10:423-426.
5. Cano E, Mahadevan LC. 1995. Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20:117-122.
6. Carter JW, Lancaster H, Hardman WE, Cameron IL. 1997. Zinc deprivation promotes progression of 1,2-dimethylhydrazine-induced colon tumors but reduces malignant invasion in mice. Nutr Cancer 27:217-221.
7. Chambers I. 2004. The molecular basis of pluripotency in mouse embryonic stem cells. Cloning Stem Cells 6:386-391.
8. Chesters JK. 1991. Trace element-gene interactions with particular reference to zinc. Proc Nutr Soc 50:123-129.
9. Choi DW, Koh JY. 1998. Zinc and brain injury. Annu Rev Neurosci 21:347-375.
10. Dufourny B, Alblas J, van Teeffelen HA, van Schaik FM, van der Burg B, Steenbergh PH, Sussenbach JS. 1997. Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. J Biol Chem 272:31163-31171.
11. 2+ induces stimulation of the c-Jun N-terminal kinase signaling pathway through phosphoinositide 3-kinase. Mol Pharmacol 59:981-986.
12. Hansson A. 1996. Extracellular zinc ions induces mitogen-activated protein kinase activity and protein tyrosine phosphorylation in bombesin-sensitive Swiss 3T3 fibroblasts. Arch Biochem Biophys 328:233-238.
13. Hashemolhosseini S, Nagamine Y, Morley SJ, Desrivieres S, Mercep L, Ferrari S. 1998. Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability. J Biol Chem 273:14424-14429.
14. 2+ and regulates ion transport. Proc Natl Acad Sci USA 98:11749-11754.
15. Hershfinkel M, Silverman WF, Sekler I. 2007. The zinc sensing receptor, a link between zinc and cell signaling. Mol Med 13:331-336.
16. Hsieh TJ, Fustier P, Zhang SL, Filep JG, Tang SS, Ingelfinger JR, Fantus IG, Hamet P, Chan JS. 2003. High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells. Endocrinology 144:4338-4349.
17. Hurley LS. 1981. Teratogenic aspects of manganese, zinc, and copper nutrition. Physiol Rev 61:249-295.
18. Ip YT, Davis RJ. 1998. Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development. Curr Opin Cell Biol 10:205-219.
19. Kanda S, Hodgkin MN, Woodfield RJ, Wakelam MJ, Thomas G, Claesson-Welsh L. 1997. Phosphatidylinositol 3′-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells. J Biol Chem 272:23347-23353.
20. Kip1 by rapamycin results in G1 arrest in exponentially growing T-cell lines. Blood 91:561-569.
21. Kim S, Jung Y, Kim D, Koh H, Chung J. 2000. Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway. J Biol Chem 275:25979-25984.
22. Kim YH, Heo JS, Han HJ. 2006. High glucose increase cell cycle regulatory proteins level of mouse embryonic stem cells via PI3-K/Akt and MAPKs signal pathways. J Cell Physiol 209:94-102.
23. Luo J, Manning BD, Cantley LC. 2003. Targeting the PI3K-Akt pathway in human cancer: Rationale and promise. Cancer Cell 4:257-262.
24. MacDonald RS. 2000. The role of zinc in growth and cell proliferation. J Nutr 130:1500S-1508S.
25. Mills BJ, Broghamer WL, Higgins PJ, Lindeman RD. 1984. Inhibition of tumor growth by zinc depletion of rats. J Nutr 114:746-752.
26. Min YK, Lee JE, Chung KC. 2007. Zinc induces cell death in immortalized embryonic hippocampal cells via activation of Akt-GSK-3β signaling. Exp Cell Res 313:312-321.
27. Minden A, Karin M. 1997. Regulation and function of the JNK subgroup of MAP kinases. Biochim Biophys Acta 1333:F85-F104.
28. Muise-Helmericks RC, Grimes HL, Bellacosa A, Malstrom SE, Tsichlis PN, Rosen N. 1998. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 273:29864-29872.
29. Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570-573.
30. Cip/WAF1 and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells. Exp Mol Med 34:27-31.
31. O'Shea KS. 2004. Self-renewal vs. differentiation of mouse embryonic stem cells. Biol Reprod 71:1755-1765.
32. mapk are required for fibroblast proliferation. Proc Natl Acad Sci USA 90:8319-8323.
33. Cip/WAF1 and inhibits proliferation of colorectal cancer cells. Br J Pharmacol 137:597-607.
34. Pellegatta F, Chierchia SL, Zocchi MR. 1998. Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils. J Biol Chem 273:27768-27771.
35. Pumiglia KM, Decker SJ. 1997. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 94:448-452.
36. Samet JM, Graves LM, Quay J, Dailey LA, Devlin RB, Ghio AJ, Wu W, Bromberg PA, Reed W. 1998. Activation of MAPKs in human bronchial epithelial cells exposed to metals. Am J Physiol 275:L551-L558.
37. Schaeffer HJ, Weber MJ. 1999. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers. Mol Cell Biol 19:2435-2444.
38. Cip1. Mol Cell Biol 17:5588-5597.
39. Sherr CJ. 1993. Mammalian G1 cyclins. Cell 73:1059-1065.
40. Sherr CJ. 1994. G1 phase progression: Cycling on cue. Cell 79:551-555.
41. Thornton WH, Jr., MacDonald RS, Wollard-Biddle LC, Browning JD, O'Dell BL. 1998. Chelation of extracellular zinc inhibits proliferation in 3T3 cells independent of insulin-like growth factor-I receptor expression. Proc Soc Exp Biol Med 219:64-68.
42. Walter PL, Kampkotter A, Eckers A, Barthel A, Schmoll D, Sies H, Klotz LO. 2006. Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions. Arch Biochem Biophys 454:107-113.
43. Cip1. Mol Cell Biol 17:5598-5611.
44. Wullschleger S, Loewith R, Hall MN. 2006. TOR signaling in growth and metabolism. Cell 124:471-484.