Central nervous system infections associated with human immunodeficiency virus infection: Radiologicpathologic correlation

Radiographics

Volumn 28, Issue 7, 2008, Pages 2033-2058

  Smith, Alice B ^a,b   Smirniotopoulos, James G ^b   Rushing, Elisabeth J ^a,c  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER ASSISTED TOMOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; REVIEW; VIRUS ENCEPHALITIS;

ENCEPHALITIS, VIRAL; HIV INFECTIONS; HUMANS; MAGNETIC RESONANCE IMAGING; TOMOGRAPHY, X-RAY COMPUTED;

EID: 58149392585     PISSN: 02715333     EISSN: 15271323     Source Type: Journal    
DOI: 10.1148/rg.287085135     Document Type: Article

References (103)

1. World Health Organization, Joint United Nations Programme on HIV/AIDS. AIDS epidemic update: December 2006. Geneva, Switzerland: World Health Organization, 2006.
2. Gray F, Scaravilli F, Everall I, et al. Neuropathology of early HIV-1 infection. Brain Pathol 1996;6 (1):1-15.
3. An SF, Giometto B, Scaravilli F. HIV-1 DNA in brains in AIDS and pre-AIDS: correlation with the stage of disease. Ann Neurol 1996;40(4):611-617.
4. Levy RM, Bredesen DE, Rosenblum ML. Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. J Neurosurg 1985;62(4): 475-495.
5. de la Monte SM, Ho DD, Schooley RT, Hirsch MS, Richardson EP Jr. Subacute encephalomyelitis of AIDS and its relation to HTLV-III infection. Neurology 1987;37(4):562-569.
6. Chiodi F, Keys B, Albert J, et al. Human immunodeficiency virus type 1 is present in the cerebrospinal fluid of a majority of infected individuals. J Clin Microbiol 1992;30(7):1768-1771.
7. Garcia F, Plana M, Vidal C, et al. Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy. AIDS 1999; 13(11):F79-F86.
8. Saito Y, Sharer LR, Epstein LG, et al. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 1994;44(3 pt 1):474-481.
9. Tornatore C, Chandra R, Berger JR, Major EO. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 1994;44 (3 pt 1):481-487.
10. Kaplan JE, Masur H, Holmes KK. Guidelines for preventing opportunistic infections among HIV-infected persons-2002: recommendations of the U.S. Public Health Service and the Infectious Diseases Society of America. MMWR Recomm Rep 2002;51 (RR-8):1-52.
11. Brodt HR, Kamps BS, Gute P, Knupp B, Staszewski S, Helm EB. Changing incidence of AIDS-defining illnesses in the era of antiretroviral combination therapy. AIDS 1997;11(14):1731-1738.
12. Maschke M, Kastrup O, Esser S, Ross B, Hengge U, Hufnagel A. Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART). J Neurol Neurosurg Psychiatry 2000;69 (3):376-380.
13. McArthur JC, Sacktor N, Selnes O. Human immunodeficiency virus-associated dementia. Semin Neurol 1999;19(2):129-150.
14. Bouwman FH, Skolasky RL, Hes D, et al. Variable progression of HIV-associated dementia. Neurology 1998;50(6):1814-1820.
15. Achim CL, Wang R, Miners DK, Wiley CA. Brain viral burden in HIV infection. J Neuropathol Exp Neurol 1994;53(3):284-294.
16. Bhaskaran K, Mussini C, Antinori A, et al. Changes in the incidence and predictors of human immunodeficiency virus-associated dementia in the era of highly active antiretroviral therapy. Ann Neurol 2008;63(2):213-221.
17. Langford TD, Letendre SL, Larrea GJ, Masliah E. Changing patterns in the neuropathogenesis of HIV during the HAART era. Brain Pathol 2003; 13(2):195-210.
18. Persidsky Y, Stins M, Way D, et al. A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. J Immunol 1997; 158(7):3499-3510.
19. Masliah E, Achim CL, Ge N, DeTeresa R, Terry RD, Wiley CA. Spectrum of human immunodeficiency virus-associated neocortical damage. Ann Neurol 1992;32(3):321-329.
20. Lackner AA, Smith MO, Munn RJ, et al. Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys. Am J Pathol 1991;139(3):609-621.
21. Budka H. Neuropathology of human immunodeficiency virus infection. Brain Pathol 1991;1(3): 163-175.
22. Scaravilli F, Bazille C, Gray F. Neuropathologic contributions to understanding AIDS and the central nervous system. Brain Pathol 2007;17(2):197-208.
23. Ciardi A, Sinclair E, Scaravilli F, Harcourt-Webster NJ, Lucas S. The involvement of the cerebral cortex in human immunodeficiency virus encephalopathy: a morphological and immunohistochemical study. Acta Neuropathol 1990;81(1):51-59.
24. Patel SH, Inglese M, Glosser G, Kolson DL, Grossman RI, Gonen O. Whole-brain N-acetylaspartate level and cognitive performance in HIV infection. AJNR Am J Neuroradiol 2003;24(8):1587-1591.
25. Laubenberger J, Haussinger D, Bayer S, et al. HIV-related metabolic abnormalities in the brain: depiction with proton MR spectroscopy with short echo times. Radiology 1996;199(3):805-810.
26. Thurnher MM, Post MJ, Rieger A, Kleibl-Popov C, Loewe C, Schindler E. Initial and follow-up MR imaging findings in AIDS-related progressive multifocal leukoencephalopathy treated with highly active antiretroviral therapy. AJNR Am J Neuroradiol 2001;22(5):977-984.
27. Pomara N, Crandall DT, Choi SJ, Johnson G, Lim KO. White matter abnormalities in HIV-1 infection: a diffusion tensor imaging study. Psychiatry Res 2001;106(1):15-24.
28. Filippi CG, Ulug AM, Ryan E, Ferrando SJ, van Gorp W. Diffusion tensor imaging of patients with HIV and normal-appearing white matter on MR images of the brain. AJNR Am J Neuroradiol 2001; 22(2):277-283.
29. Dore GJ, McDonald A, Li Y, Kaldor JM, Brew BJ. Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS 2003;17(10):1539-1545.
30. Hogan TF, Padgett BL, Walker DL, Borden EC, McBain JA. Rapid detection and identification of JC virus and BK virus in human urine by using immunofluorescence microscopy. J Clin Microbiol 1980;11(2):178-183.
31. Petito CK, Cho ES, Lemann W, Navia BA, Price RW. Neuropathology of acquired immunodeficiency syndrome (AIDS): an autopsy review. J Neuropathol Exp Neurol 1986;45(6):635-646.
32. Berger JR, Levy RM, Flomenhoft D, Dobbs M. Predictive factors for prolonged survival in acquired immunodeficiency syndrome-associated progressive multifocal leukoencephalopathy. Ann Neurol 1998; 44(3):341-349.
33. McGuire D, Barhite S, Hollander H, Miles M. JC virus DNA in cerebrospinal fluid of human immunodeficiency virus-infected patients: predictive value for progressive multifocal leukoencephalopathy. Ann Neurol 1995;37(3):395-399.
34. Fong IW, Britton CB, Luinstra KE, Toma E, Mahony JB. Diagnostic value of detecting JC virus DNA in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy. J Clin Microbiol 1995;33(2):484-486.
35. Marzocchetti A, Di Giambenedetto S, Cingolani A, Ammassari A, Cauda R, De Luca A. Reduced rate of diagnostic positive detection of JC virus DNA in cerebrospinal fluid in cases of suspected progressive multifocal leukoencephalopathy in the era of potent antiretroviral therapy. J Clin Microbiol 2005;43(8):4175-4177.
36. Whiteman ML, Post MJ, Berger JR, Tate LG, Bell MD, Limonte LP. Progressive multifocal leukoencephalopathy in 47 HIV-seropositive patients: neuroimaging with clinical and pathologic correlation. Radiology 1993;187(1):233-240.
37. Wheeler AL, Truwit CL, Kleinschmidt-DeMasters BK, Byrne WR, Hannon RN. Progressive multifocal leukoencephalopathy: contrast enhancement on CT scans and MR images. AJR Am J Roentgenol 1993;161(5):1049-1051.
38. Port JD, Miseljic S, Lee RR, et al. Progressive multifocal leukoencephalopathy demonstrating contrast enhancement on MRI and uptake of thallium-201: a case report. Neuroradiology 1999;41(12):895-898.
39. Kotecha N, George MJ, Smith TW, Corvi F, Litofsky NS. Enhancing progressive multifocal leukoencephalopathy: an indicator of improved immune status? Am J Med 1998;105(6):541-543.
40. Arbusow V, Strupp M, Pfister HW, Seelos KC, Bruckmann H, Brandt T. Contrast enhancement in progressive multifocal leukoencephalopathy: a predictive factor for long-term survival? J Neurol 2000;247(4):306-308.
41. Collazos J, Mayo J, Martinez E, Blanco MS. Contrast-enhancing progressive multifocal leukoencephalopathy as an immune reconstitution event in AIDS patients. AIDS 1999;13(11):1426-1428.
42. Ohta K, Obara K, Sakauchi M, Obara K, Takane H, Yogo Y. Lesion extension detected by diffusion-weighted magnetic resonance imaging in progressive multifocal leukoencephalopathy. J Neurol 2001;248(9):809-811.
43. Usiskin SI, Bainbridge A, Miller RF, Jager HR. Progressive multifocal leukoencephalopathy: serial high-b-value diffusion-weighted MR imaging and apparent diffusion coefficient measurements to assess response to highly active antiretroviral therapy. AJNR Am J Neuroradiol 2007;28(2):285-286.
44. Levy RM, Mills CM, Posin JP, Moore SG, Rosenblum ML, Bredesen DE. The efficacy and clinical impact of brain imaging in neurologically symptomatic AIDS patients: a prospective CT/MRI study. J Acquir Immune Defic Syndr 1990;3(5):461-471.
45. Cornford ME, Holden JK, Boyd MC, Berry K, Vinters HV. Neuropathology of the acquired immune deficiency syndrome (AIDS): report of 39 autopsies from Vancouver, Br Columbia. Can J Neurol Sci 1992;19(4):442-452.
46. Wright D, Schneider A, Berger JR. Central nervous system opportunistic infections. Neuroimaging Clin N Am 1997;7(3):513-525.
47. Ammassari A, Cingolani A, Pezzotti P, et al. AIDS-related focal brain lesions in the era of highly active antiretroviral therapy. Neurology 2000;55(8): 1194-1200.
48. Luft BJ, Remington JS. Toxoplasmic encephalitis in AIDS. Clin Infect Dis 1992;15(2):211-222.
49. Zufferey J, Sugar A, Rudaz P, Bille J, Glauser MP, Chave JP. Prevalence of latent toxoplasmosis and serological diagnosis of active infection in HIV-positive patients. Eur J Clin Microbiol Infect Dis 1993;12(8):591-595.
50. Colombo FA, Vidal JE, Penalva de Oliveira AC, et al. Diagnosis of cerebral toxoplasmosis in AIDS patients in Brazil: importance of molecular and immunological methods using peripheral blood samples. J Clin Microbiol 2005;43(10):5044-5047.
51. Navia BA, Petito CK, Gold JW, Cho ES, Jordan BD, Price RW. Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: clinical and neuropathological findings in 27 patients. Ann Neurol 1986;19(3):224-238.
52. Trenkwalder P, Trenkwalder C, Feiden W, Vogl TJ, Einhaupl KM, Lydtin H. Toxoplasmosis with early intracerebral hemorrhage in a patient with the acquired immunodeficiency syndrome. Neurology 1992;42(2):436-438.
53. Fischbein NJ, Dillon WP, Barkovich AJ. Teaching atlas of brain imaging. New York, NY: Thieme, 2000.
54. Lee HJ, Williams R, Kalnin A, Wolansky L. Toxoplasmosis of the corpus callosum: another butterfly. AJR Am J Roentgenol 1996;166(6):1280-1281.
55. Dina TS. Primary central nervous system lymphoma versus toxoplasmosis in AIDS. Radiology 1991;179 (3):823-828.
56. Skiest DJ, Erdman W, Chang WE, Oz OK, Ware A, Fleckenstein J. SPECT thallium-201 combined with Toxoplasma serology for the presumptive diagnosis of focal central nervous system mass lesions in patients with AIDS. J Infect 2000;40(3):274-281.
57. Lorberboym M, Wallach F, Estok L, et al. Thallium-201 retention in focal intracranial lesions for differential diagnosis of primary lymphoma and nonmalignant lesions in AIDS patients. J Nucl Med 1998; 39(8):1366-1369.
58. Licho R, Litofsky NS, Senitko M, George M. Inaccuracy of Tl-201 brain SPECT in distinguishing cerebral infections from lymphoma in patients with AIDS. Clin Nucl Med 2002;27(2):81-86.
59. Pomper MG, Constantinides CD, Barker PB, et al. Quantitative MR spectroscopic imaging of brain lesions in patients with AIDS: correlation with [11C-methyl]thymidine PET and thallium-201 SPECT. Acad Radiol 2002;9(4):398-409.
60. Chang L, Miller BL, McBride D, et al. Brain lesions in patients with AIDS: H-1 MR spectroscopy. Radiology 1995;197(2):525-531.
61. Ionita C, Wasay M, Balos L, Bakshi R. MR imaging in toxoplasmosis encephalitis after bone marrow transplantation: paucity of enhancement despite fulminant disease. AJNR Am J Neuroradiol 2004; 25(2):270-273.
62. Schroeder PC, Post MJ, Oschatz E, Stadler A, Bruce-Gregorios J, Thurnher MM. Analysis of the utility of diffusion-weighted MRI and apparent diffusion coefficient values in distinguishing central nervous system toxoplasmosis from lymphoma. Neuroradiology 2006;48(10):715-720.
63. Arribas JR, Storch GA, Clifford DB, Tselis AC. Cytomegalovirus encephalitis. Ann Intern Med 1996;125(7):577-587.
64. McNeil MM, Nash SL, Hajjeh RA, et al. Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997. Clin Infect Dis 2001; 33(5):641-647.
65. Kume H, Yamazaki T, Abe M, Tanuma H, Okudaira M, Okayasu I. Increase in aspergillosis and severe mycotic infection in patients with leukemia and MDS: comparison of the data from the Annual of the Pathological Autopsy Cases in Japan in 1989, 1993 and 1997. Pathol Int 2003;53(11):744-750.
66. Pagano L, Gleissner B, Fianchi L. Breakthrough zygomycosis and voriconazole. J Infect Dis 2005; 192(8):1496-1497; author reply 1497.
67. Sabetta JR, Andriole VT. Cryptococcal infection of the central nervous system. Med Clin North Am 1985;69(2):333-344.
68. Zuger A, Louie E, Holzman RS, Simberkoff MS, Rahal JJ. Cryptococcal disease in patients with the acquired immunodeficiency syndrome: diagnostic features and outcome of treatment. Ann Intern Med 1986;104(2):234-240.
69. Eng RH, Bishburg E, Smith SM, Kapila R. Cryptococcal infections in patients with acquired immune deficiency syndrome. Am J Med 1986;81(1):19-23.
70. Mamidi A, DeSimone JA, Pomerantz RJ. Central nervous system infections in individuals with HIV-1 infection. J Neurovirol 2002;8(3):158-167.
71. Mathews VP, Alo PL, Glass JD, Kumar AJ, McArthur JC. AIDS-related CNS cryptococcosis: radiologic-pathologic correlation. AJNR Am J Neuroradiol 1992;13(5):1477-1486.
72. Takasu A, Taneda M, Otuki H, Okamoto Y, Oku K. Gd-DTPA-enhanced MR imaging of cryptococcal meningoencephalitis. Neuroradiology 1991;33(5): 443-446.
73. Ho TL, Lee HJ, Lee KW, Chen WL. Diffusion-weighted and conventional magnetic resonance imaging in cerebral cryptococcoma. Acta Radiol 2005; 46(4):411-414.
74. Vender JR, Miller DM, Roth T, Nair S, Reboli AC. Intraventricular cryptococcal cysts. AJNR Am J Neuroradiol 1996;17(1):110-113.
75. Tien RD, Chu PK, Hesselink JR, Duberg A, Wiley C. Intracranial cryptococcosis in immunocompromised patients: CT and MR findings in 29 cases. AJNR Am J Neuroradiol 1991;12(2):283-289.
76. Mathews M, Pare L, Hasso A. Intraventricular cryptococcal cysts masquerading as racemose neurocysticercosis. Surg Neurol 2007;67(6):647-649.
77. Robinson PA, Bauer M, Leal MA, et al. Early mycological treatment failure in AIDS-associated cryptococcal meningitis. Clin Infect Dis 1999;28 (1): 82-92.
78. Ashdown BC, Tien RD, Felsberg GJ. Aspergillosis of the brain and paranasal sinuses in immunocompromised patients: CT and MR imaging findings. AJR Am J Roentgenol 1994;162(1):155-159.
79. DeLone DR, Goldstein RA, Petermann G, et al. Disseminated aspergillosis involving the brain: distribution and imaging characteristics. AJNR Am J Neuroradiol 1999;20(9):1597-1604.
80. Luthra G, Parihar A, Nath K, et al. Comparative evaluation of fungal, tubercular, and pyogenic brain abscesses with conventional and diffusion MR imaging and proton MR spectroscopy. AJNR Am J Neuroradiol 2007;28(7):1332-1338.
81. Lin SJ, Schranz J, Teutsch SM. Aspergillosis case-fatality rate: systematic review of the literature. Clin Infect Dis 2001;32(3):358-366.
82. Steinbach WJ, Stevens DA, Denning DW. Combination and sequential antifungal therapy for invasive aspergillosis: review of published in vitro and in vivo interactions and 6281 clinical cases from 1966 to 2001. Clin Infect Dis 2003;37(suppl 3): S188-S224.
83. World Health Organization. Global tuberculosis control: surveillance, planning, financing. Geneva, Switzerland: World Health Organization, 2006.
84. Whiteman M, Espinoza L, Post MJ, Bell MD, Falcone S. Central nervous system tuberculosis in HIV-infected patients: clinical and radiographic findings. AJNR Am J Neuroradiol 1995;16(6): 1319-1327.
85. Villoria MF, de la Torre J, Fortea F, Munoz L, Hernandez T, Alarcon JJ. Intracranial tuberculosis in AIDS: CT and MRI findings. Neuroradiology 1992;34(1):11-14.
86. Bishburg E, Sunderam G, Reichman LB, Kapila R. Central nervous system tuberculosis with the acquired immunodeficiency syndrome and its related complex. Ann Intern Med 1986;105(2): 210-213.
87. Katrak SM, Shembalkar PK, Bijwe SR, Bhandarkar LD. The clinical, radiological and pathological profile of tuberculous meningitis in patients with and without human immunodeficiency virus infection. J Neurol Sci 2000;181(1-2):118-126.
88. Gupta RK, Vatsal DK, Husain N, et al. Differentiation of tuberculous from pyogenic brain abscesses with in vivo proton MR spectroscopy and magnetization transfer MR imaging. AJNR Am J Neuroradiol 2001;22(8):1503-1509.
89. Sheller JR, Des Prez RM. CNS tuberculosis. Neurol Clin 1986;4(1):143-158.
90. Thwaites GE, Tran TH. Tuberculous meningitis: many questions, too few answers. Lancet Neurol 2005;4(3):160-170.
91. Garg RK. Tuberculosis of the central nervous system. Postgrad Med J 1999;75(881):133-140.
92. Johns DR, Tierney M, Felsenstein D. Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus. N Engl J Med 1987;316(25):1569-1572.
93. Holland BA, Perrett LV, Mills CM. Meningovascular syphilis: CT and MR findings. Radiology 1986; 158(2):439-442.
94. Brightbill TC, Ihmeidan IH, Post MJ, Berger JR, Katz DA. Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings. AJNR Am J Neuroradiol 1995;16(4):703-711.
95. Harris DE, Enterline DS, Tien RD. Neurosyphilis in patients with AIDS. Neuroimaging Clin N Am 1997;7(2):215-221.
96. Bash S, Hathout GM, Cohen S. Mesiotemporal T2-weighted hyperintensity: neurosyphilis mimicking herpes encephalitis. AJNR Am J Neuroradiol 2001;22(2):314-316.
97. Simon RP. Neurosyphilis. Arch Neurol 1985;42 (6): 606-613.
98. Berger JR, Waskin H, Pall L, Hensley G, Ihmedian I, Post MJ. Syphilitic cerebral gumma with HIV infection. Neurology 1992;42(7):1282-1287.
99. Denays R, Collier A, Rubinstein M, Atsama P. A 51-year-old woman with disorientation and amnesia. Lancet 1999;354(9192):1786.
100. Angus F, Maysuria H, Bryan CS. Neurosyphilis mimicking herpes simplex encephalitis. J S C Med Assoc 1998;94(7):315-317.
101. Autran B, Carcelain G, Li TS, et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 1997;277(5322):112-116.
102. Shelburne SA 3rd, Hamill RJ, Rodriguez-Barradas MC, et al. Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy. Medicine (Baltimore) 2002;81(3):213-227.
103. Michailidis C, Pozniak AL, Mandalia S, Basnayake S, Nelson MR, Gazzard BG. Clinical characteristics of IRIS syndrome in patients with HIV and tuberculosis. Antivir Ther 2005;10(3):417-422.