-
1
-
-
20244364226
-
Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice
-
Abbas N, Bednar I, Mix E, Marie S, Paterson D, Ljungberg A, Morris C, Winblad B, Nordberg A, Zhu J (2002) Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice. J Neuroimmunol 126:50-57.
-
(2002)
J Neuroimmunol
, vol.126
, pp. 50-57
-
-
Abbas, N.1
Bednar, I.2
Mix, E.3
Marie, S.4
Paterson, D.5
Ljungberg, A.6
Morris, C.7
Winblad, B.8
Nordberg, A.9
Zhu, J.10
-
2
-
-
0029932195
-
Localization and cell association of C1q in Alzheimer's disease brain
-
Afagh A, Cummings BJ, Cribbs DH, Cotman CW, Tenner AJ (1996) Localization and cell association of C1q in Alzheimer's disease brain. Exp Neurol 138:22-32.
-
(1996)
Exp Neurol
, vol.138
, pp. 22-32
-
-
Afagh, A.1
Cummings, B.J.2
Cribbs, D.H.3
Cotman, C.W.4
Tenner, A.J.5
-
3
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783-801.
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
4
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T (2000) Inflammation and Alzheimer's disease. Neurobiol Aging 21:383-421.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 383-421
-
-
Akiyama, H.1
Barger, S.2
Barnum, S.3
Bradt, B.4
Bauer, J.5
Cole, G.M.6
Cooper, N.R.7
Eikelenboom, P.8
Emmerling, M.9
Fiebich, B.L.10
Finch, C.E.11
Frautschy, S.12
Griffin, W.S.13
Hampel, H.14
Hull, M.15
Landreth, G.16
Lue, L.17
Mrak, R.18
Mackenzie, I.R.19
McGeer, P.L.20
O'banion, M.K.21
Pachter, J.22
Pasinetti, G.23
Plata-Salaman, C.24
Rogers, J.25
Rydel, R.26
Shen, Y.27
Streit, W.28
Strohmeyer, R.29
Tooyoma, I.30
Van Muiswinkel, F.L.31
Veerhuis, R.32
Walker, D.33
Webster, S.34
Wegrzyniak, B.35
Wenk, G.36
Wyss-Coray, T.37
more..
-
5
-
-
0029999787
-
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
-
Alonso AC, Grundke-Iqbal I, Iqbal K (1996) Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 2:783-787.
-
(1996)
Nat Med
, vol.2
, pp. 783-787
-
-
Alonso, A.C.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
6
-
-
0000293742
-
Ueber eine eigenartige Erkrankung der Hirnrinde
-
Alzheimer A (1907) Ueber eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiat 64:146-148.
-
(1907)
Allg Z Psychiat
, vol.64
, pp. 146-148
-
-
Alzheimer, A.1
-
7
-
-
0035831189
-
Beta-amyloid-induced glial expression of both pro-and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology
-
Apelt J, Schliebs R (2001) Beta-amyloid-induced glial expression of both pro-and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology. Brain Res 894:21-30.
-
(2001)
Brain Res
, vol.894
, pp. 21-30
-
-
Apelt, J.1
Schliebs, R.2
-
8
-
-
0037468588
-
Aging-related down-regulation of neprilysin, a putative beta-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of beta-amyloid plaques
-
Apelt J, Ach K, Schliebs R (2003) Aging-related down-regulation of neprilysin, a putative beta-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of beta-amyloid plaques. Neurosci Lett 339:183-186.
-
(2003)
Neurosci Lett
, vol.339
, pp. 183-186
-
-
Apelt, J.1
Ach, K.2
Schliebs, R.3
-
9
-
-
8144223671
-
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice
-
Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Du Yan SS (2004) RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. EMBO J 23:4096-4105.
-
(2004)
EMBO J
, vol.23
, pp. 4096-4105
-
-
Arancio, O.1
Zhang, H.P.2
Chen, X.3
Lin, C.4
Trinchese, F.5
Puzzo, D.6
Liu, S.7
Hegde, A.8
Yan, S.F.9
Stern, A.10
Luddy, J.S.11
Lue, L.F.12
Walker, D.G.13
Roher, A.14
Buttini, M.15
Mucke, L.16
Li, W.17
Schmidt, A.M.18
Kindy, M.19
Hyslop, P.A.20
Stern, D.M.21
Du Yan, S.S.22
more..
-
10
-
-
2442587216
-
Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: Linkage of poorer cognitive performance to tau pathology in forebrain
-
Arendash GW, Lewis J, Leighty RE, McGowan E, Cracchiolo JR, Hutton M, Garcia MF (2004) Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: Linkage of poorer cognitive performance to tau pathology in forebrain. Brain Res 1012:29-41.
-
(2004)
Brain Res
, vol.1012
, pp. 29-41
-
-
Arendash, G.W.1
Lewis, J.2
Leighty, R.E.3
McGowan, E.4
Cracchiolo, J.R.5
Hutton, M.6
Garcia, M.F.7
-
11
-
-
0006300658
-
Microglia, amyloid and dementia in alzheimer disease. A correlative study
-
Arends YM, Duyckaerts C, Rozemuller JM, Eikelenboom P, Hauw JJ (2000) Microglia, amyloid and dementia in alzheimer disease. A correlative study. Neurobiol Aging 21:39-47.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 39-47
-
-
Arends, Y.M.1
Duyckaerts, C.2
Rozemuller, J.M.3
Eikelenboom, P.4
Hauw, J.J.5
-
12
-
-
0025341181
-
Women, myocardial infarction, and dementia in the very old
-
Aronson MK, Ooi WL, Morgenstern H, Hafner A, Masur D, Crystal H, Frishman WH, Fisher D, Katzman R (1990) Women, myocardial infarction, and dementia in the very old. Neurology 40:1102-1106.
-
(1990)
Neurology
, vol.40
, pp. 1102-1106
-
-
Aronson, M.K.1
Ooi, W.L.2
Morgenstern, H.3
Hafner, A.4
Masur, D.5
Crystal, H.6
Frishman, W.H.7
Fisher, D.8
Katzman, R.9
-
14
-
-
0037474447
-
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase
-
Asai M, Hattori C, Szabo B, Sasagawa N, Maruyama K, Tanuma S, Ishiura S (2003) Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase. Biochem Biophys Res Commun 301:231-235.
-
(2003)
Biochem Biophys Res Commun
, vol.301
, pp. 231-235
-
-
Asai, M.1
Hattori, C.2
Szabo, B.3
Sasagawa, N.4
Maruyama, K.5
Tanuma, S.6
Ishiura, S.7
-
16
-
-
0029852887
-
Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40)
-
Backstrom JR, Lim GP, Cullen MJ, Tokes ZA (1996) Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40). J Neurosci 16:7910-7919.
-
(1996)
J Neurosci
, vol.16
, pp. 7910-7919
-
-
Backstrom, J.R.1
Lim, G.P.2
Cullen, M.J.3
Tokes, Z.A.4
-
17
-
-
0033593027
-
Apolipoprotein e is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease
-
Bales KR, Verina T, Cummins DJ, Du Y, Dodel RC, Saura J, Fishman CE, DeLong CA, Piccardo P, Petegnief V, Ghetti B, Paul SM (1999) Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 96:15233-15238.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 15233-15238
-
-
Bales, K.R.1
Verina, T.2
Cummins, D.J.3
Du, Y.4
Dodel, R.C.5
Saura, J.6
Fishman, C.E.7
Delong, C.A.8
Piccardo, P.9
Petegnief, V.10
Ghetti, B.11
Paul, S.M.12
-
18
-
-
0037387147
-
A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation
-
Bamberger ME, Harris ME, McDonald DR, Husemann J, Landreth GE (2003) A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. J Neurosci 23:2665-2674.
-
(2003)
J Neurosci
, vol.23
, pp. 2665-2674
-
-
Bamberger, M.E.1
Harris, M.E.2
McDonald, D.R.3
Husemann, J.4
Landreth, G.E.5
-
19
-
-
0030610645
-
Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein e
-
Barger S, Harmon A (1997) Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388:878-881.
-
(1997)
Nature
, vol.388
, pp. 878-881
-
-
Barger, S.1
Harmon, A.2
-
20
-
-
0035146889
-
Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function
-
Barger SW, Basile AS (2001) Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. J Neurochem 76:846-854.
-
(2001)
J Neurochem
, vol.76
, pp. 846-854
-
-
Barger, S.W.1
Basile, A.S.2
-
21
-
-
0030268026
-
Chronic complement C3 gene expression in the CNS of transgenic mice with astrocyte-targeted interleukin-6 expression
-
Barnum SR, Jones JL, Muller-Ladner U, Samimi A, Campbell IL (1996) Chronic complement C3 gene expression in the CNS of transgenic mice with astrocyte-targeted interleukin-6 expression. Glia 18:107-117.
-
(1996)
Glia
, vol.18
, pp. 107-117
-
-
Barnum, S.R.1
Jones, J.L.2
Muller-Ladner, U.3
Samimi, A.4
Campbell, I.L.5
-
22
-
-
0032504710
-
Mitochondrial dysfunction in neurodegenerative diseases
-
Beal MF (1998) Mitochondrial dysfunction in neurodegenerative diseases. Biochim Biophys Acta 1366:211-223.
-
(1998)
Biochim Biophys Acta
, vol.1366
, pp. 211-223
-
-
Beal, M.F.1
-
23
-
-
0028233494
-
Hydrogen peroxide mediates amyloid beta protein toxicity
-
Behl C, Davis JB, Lesley R, Schubert D (1994) Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77:817-827.
-
(1994)
Cell
, vol.77
, pp. 817-827
-
-
Behl, C.1
Davis, J.B.2
Lesley, R.3
Schubert, D.4
-
24
-
-
0033370498
-
Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice
-
Benzing WC, Wujek JR, Ward EK, Shaffer D, Ashe KH, Younkin SG, Brunden KR (1999) Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice. Neurobiol Aging 20:581-589.
-
(1999)
Neurobiol Aging
, vol.20
, pp. 581-589
-
-
Benzing, W.C.1
Wujek, J.R.2
Ward, E.K.3
Shaffer, D.4
Ashe, K.H.5
Younkin, S.G.6
Brunden, K.R.7
-
25
-
-
0027468235
-
Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older
-
Berg L, McKeel DW, Jr., Miller JP, Baty J, Morris JC (1993) Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. Arch Neurol 50:349-358.
-
(1993)
Arch Neurol
, vol.50
, pp. 349-358
-
-
Berg, L.1
McKeel Jr., D.W.2
Miller, J.P.3
Baty, J.4
Morris, J.C.5
-
26
-
-
3142654210
-
Inferences, questions and possibilities in Toll-like receptor signaling
-
Beutler B (2004) Inferences, questions and possibilities in Toll-like receptor signaling. Nature 430:257-263.
-
(2004)
Nature
, vol.430
, pp. 257-263
-
-
Beutler, B.1
-
27
-
-
0034960228
-
CXCR4-activated astrocyte glutamate release via TNFalpha: Amplification by microglia triggers neurotoxicity
-
Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, Vescovi A, Bagetta G, Kollias G, Meldolesi J, Volterra A (2001) CXCR4-activated astrocyte glutamate release via TNFalpha: Amplification by microglia triggers neurotoxicity. Nat Neurosci 4:702-710.
-
(2001)
Nat Neurosci
, vol.4
, pp. 702-710
-
-
Bezzi, P.1
Domercq, M.2
Brambilla, L.3
Galli, R.4
Schols, D.5
De Clercq, E.6
Vescovi, A.7
Bagetta, G.8
Kollias, G.9
Meldolesi, J.10
Volterra, A.11
-
28
-
-
0032983334
-
Betaamyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease
-
Bianca VD, Dusi S, Bianchini E, Dal Pra I, Rossi F (1999) betaamyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease. J Biol Chem 274:15493-15499.
-
(1999)
J Biol Chem
, vol.274
, pp. 15493-15499
-
-
Bianca, V.D.1
Dusi, S.2
Bianchini, E.3
Dal Pra, I.4
Rossi, F.5
-
29
-
-
0027338266
-
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
-
Biernat J, Gustke N, Drewes G, Mandelkow EM, Mandelkow E (1993) Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding. Neuron 11:153-163.
-
(1993)
Neuron
, vol.11
, pp. 153-163
-
-
Biernat, J.1
Gustke, N.2
Drewes, G.3
Mandelkow, E.M.4
Mandelkow, E.5
-
30
-
-
0032621790
-
TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs
-
Blasko I, Marx F, Steiner E, Hartmann T, Grubeck-Loebenstein B (1999) TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs. FASEB J 13:63-68.
-
(1999)
FASEB J
, vol.13
, pp. 63-68
-
-
Blasko, I.1
Marx, F.2
Steiner, E.3
Hartmann, T.4
Grubeck-Loebenstein, B.5
-
31
-
-
0034523456
-
Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes
-
Blasko I, Veerhuis R, Stampfer-Kountchev M, Saurwein-Teissl M, Eikelenboom P, Grubeck-Loebenstein B (2000) Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes. Neurobiol Dis 7:682-689.
-
(2000)
Neurobiol Dis
, vol.7
, pp. 682-689
-
-
Blasko, I.1
Veerhuis, R.2
Stampfer-Kountchev, M.3
Saurwein-Teissl, M.4
Eikelenboom, P.5
Grubeck-Loebenstein, B.6
-
32
-
-
0030833055
-
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
-
Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19:939-945.
-
(1997)
Neuron
, vol.19
, pp. 939-945
-
-
Borchelt, D.R.1
Ratovitski, T.2
Van Lare, J.3
Lee, M.K.4
Gonzales, V.5
Jenkins, N.A.6
Copeland, N.G.7
Price, D.L.8
Sisodia, S.S.9
-
33
-
-
0031470830
-
Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia
-
Botchkina GI, Meistrell ME, 3rd, Botchkina IL, Tracey KJ (1997) Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia. Mol Med 3:765-781.
-
(1997)
Mol Med
, vol.3
, pp. 765-781
-
-
Botchkina, G.I.1
Meistrell III, M.E.2
Botchkina, I.L.3
Tracey, K.J.4
-
34
-
-
0029013727
-
Staging of Alzheimer's disease-related neurofibrillary changes
-
discussion 278-284
-
Braak H, Braak E (1995) Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16:271-278; discussion 278-284.
-
(1995)
Neurobiol Aging
, vol.16
, pp. 271-278
-
-
Braak, H.1
Braak, E.2
-
35
-
-
0027308924
-
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
-
Bramblett GT, Goedert M, Jakes R, Merrick SE, Trojanowski JQ, Lee VM (1993) Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10:1089-1099.
-
(1993)
Neuron
, vol.10
, pp. 1089-1099
-
-
Bramblett, G.T.1
Goedert, M.2
Jakes, R.3
Merrick, S.E.4
Trojanowski, J.Q.5
Lee, V.M.6
-
36
-
-
0347362913
-
Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain
-
Brionne TC, Tesseur I, Masliah E, Wyss-Coray T (2003) Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron 40:1133-1145.
-
(2003)
Neuron
, vol.40
, pp. 1133-1145
-
-
Brionne, T.C.1
Tesseur, I.2
Masliah, E.3
Wyss-Coray, T.4
-
37
-
-
0033850407
-
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
-
Buee L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 33:95-130.
-
(2000)
Brain Res Brain Res Rev
, vol.33
, pp. 95-130
-
-
Buee, L.1
Bussiere, T.2
Buee-Scherrer, V.3
Delacourte, A.4
Hof, P.R.5
-
38
-
-
0035112647
-
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
-
Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC (2001) BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci 4:233-234.
-
(2001)
Nat Neurosci
, vol.4
, pp. 233-234
-
-
Cai, H.1
Wang, Y.2
McCarthy, D.3
Wen, H.4
Borchelt, D.R.5
Price, D.L.6
Wong, P.C.7
-
39
-
-
4444223956
-
Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model
-
Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N, Jr., Ashe KH, Frautschy SA, Cole GM (2004) Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 43:633-645.
-
(2004)
Neuron
, vol.43
, pp. 633-645
-
-
Calon, F.1
Lim, G.P.2
Yang, F.3
Morihara, T.4
Teter, B.5
Ubeda, O.6
Rostaing, P.7
Triller, A.8
Salem Jr., N.9
Ashe, K.H.10
Frautschy, S.A.11
Cole, G.M.12
-
40
-
-
0029776850
-
Production of monocyte chemotactic protein-1 by rat brain macrophages
-
Calvo CF, Yoshimura T, Gelman M, Mallat M (1996) Production of monocyte chemotactic protein-1 by rat brain macrophages. Eur J Neurosci 8:1725-1734.
-
(1996)
Eur J Neurosci
, vol.8
, pp. 1725-1734
-
-
Calvo, C.F.1
Yoshimura, T.2
Gelman, M.3
Mallat, M.4
-
41
-
-
10044225937
-
Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide
-
Camacho IE, Serneels L, Spittaels K, Merchiers P, Dominguez D, De Strooper B (2004) Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. J Neurosci 24:10908-10917.
-
(2004)
J Neurosci
, vol.24
, pp. 10908-10917
-
-
Camacho, I.E.1
Serneels, L.2
Spittaels, K.3
Merchiers, P.4
Dominguez, D.5
De Strooper, B.6
-
42
-
-
33744477358
-
Inflammation, longevity, and cardiovascular diseases: Role of polymorphisms of TLR4
-
Candore G, Aquino A, Balistreri CR, Bulati M, Di Carlo D, Grimaldi MP, Listi F, Orlando V, Vasto S, Caruso M, Colonna-Romano G, Lio D, Caruso C (2006) Inflammation, longevity, and cardiovascular diseases: Role of polymorphisms of TLR4. Ann N Y Acad Sci 1067:282-287.
-
(2006)
Ann N y Acad Sci
, vol.1067
, pp. 282-287
-
-
Candore, G.1
Aquino, A.2
Balistreri, C.R.3
Bulati, M.4
Di Carlo, D.5
Grimaldi, M.P.6
Listi, F.7
Orlando, V.8
Vasto, S.9
Caruso, M.10
Colonna-Romano, G.11
Lio, D.12
Caruso, C.13
-
43
-
-
13544272944
-
Differential activation of astrocytes by innate and adaptive immune stimuli
-
Carpentier PA, Begolka WS, Olson JK, Elhofy A, Karpus WJ, Miller SD (2005) Differential activation of astrocytes by innate and adaptive immune stimuli. Glia 49:360-374.
-
(2005)
Glia
, vol.49
, pp. 360-374
-
-
Carpentier, P.A.1
Begolka, W.S.2
Olson, J.K.3
Elhofy, A.4
Karpus, W.J.5
Miller, S.D.6
-
44
-
-
0029620390
-
Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: Involvement of nitric oxide and of N-methyl-D-aspartate receptors
-
Chao C, Hu S, Erlich L, Peterson P (1995) Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: Involvement of nitric oxide and of N-methyl-D-aspartate receptors. Brain Behav Immun 9:355-365.
-
(1995)
Brain Behav Immun
, vol.9
, pp. 355-365
-
-
Chao, C.1
Hu, S.2
Erlich, L.3
Peterson, P.4
-
45
-
-
0028577356
-
Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures
-
Chao CC, Hu S (1994) Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures. Dev Neurosci 16:172-179.
-
(1994)
Dev Neurosci
, vol.16
, pp. 172-179
-
-
Chao, C.C.1
Hu, S.2
-
46
-
-
0028094017
-
Transforming growth factor beta in Alzheimer's disease
-
Chao CC, Hu S, Frey WH, 2nd, Ala TA, Tourtellotte WW, Peterson PK (1994a) Transforming growth factor beta in Alzheimer's disease. Clin Diagn Lab Immunol 1:109-110.
-
(1994)
Clin Diagn Lab Immunol
, vol.1
, pp. 109-110
-
-
Chao, C.C.1
Hu, S.2
Frey III, W.H.3
Ala, T.A.4
Tourtellotte, W.W.5
Peterson, P.K.6
-
47
-
-
0028465427
-
Serum cytokine levels in patients with Alzheimer's disease
-
Chao CC, Ala TA, Hu S, Crossley KB, Sherman RE, Peterson PK, Frey WH, 2nd (1994b) Serum cytokine levels in patients with Alzheimer's disease. Clin Diagn Lab Immunol 1:433-436.
-
(1994)
Clin Diagn Lab Immunol
, vol.1
, pp. 433-436
-
-
Chao, C.C.1
Ala, T.A.2
Hu, S.3
Crossley, K.B.4
Sherman, R.E.5
Peterson, P.K.6
Frey II, W.H.7
-
48
-
-
0033360356
-
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
-
Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TV, Hyman BT, Younkin SG, Hsiao KK (1999) Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 2:271-276.
-
(1999)
Nat Neurosci
, vol.2
, pp. 271-276
-
-
Chapman, P.F.1
White, G.L.2
Jones, M.W.3
Cooper-Blacketer, D.4
Marshall, V.J.5
Irizarry, M.6
Younkin, L.7
Good, M.A.8
Bliss, T.V.9
Hyman, B.T.10
Younkin, S.G.11
Hsiao, K.K.12
-
49
-
-
0028316908
-
Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails
-
Charo IF, Myers SJ, Herman A, Franci C, Connolly AJ, Coughlin SR (1994) Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci USA 91:2752-2756.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 2752-2756
-
-
Charo, I.F.1
Myers, S.J.2
Herman, A.3
Franci, C.4
Connolly, A.J.5
Coughlin, S.R.6
-
50
-
-
0034700480
-
A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease
-
Chen G, Chen KS, Knox J, Inglis J, Bernard A, Martin SJ, Justice A, McConlogue L, Games D, Freedman SB, Morris RG (2000) A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature 408:975-979.
-
(2000)
Nature
, vol.408
, pp. 975-979
-
-
Chen, G.1
Chen, K.S.2
Knox, J.3
Inglis, J.4
Bernard, A.5
Martin, S.J.6
Justice, A.7
McConlogue, L.8
Games, D.9
Freedman, S.B.10
Morris, R.G.11
-
51
-
-
0028178798
-
Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis
-
Cheng B, Christakos S, Mattson MP (1994) Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12:139-153.
-
(1994)
Neuron
, vol.12
, pp. 139-153
-
-
Cheng, B.1
Christakos, S.2
Mattson, M.P.3
-
52
-
-
0035877756
-
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
-
Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D (2001) Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 276:21562-21570.
-
(2001)
J Biol Chem
, vol.276
, pp. 21562-21570
-
-
Chishti, M.A.1
Yang, D.S.2
Janus, C.3
Phinney, A.L.4
Horne, P.5
Pearson, J.6
Strome, R.7
Zuker, N.8
Loukides, J.9
French, J.10
Turner, S.11
Lozza, G.12
Grilli, M.13
Kunicki, S.14
Morissette, C.15
Paquette, J.16
Gervais, F.17
Bergeron, C.18
Fraser, P.E.19
Carlson, G.A.20
George-Hyslop, P.S.21
Westaway, D.22
more..
-
53
-
-
33744465230
-
PKC{varepsilon} increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice
-
Choi DS, Wang D, Yu GQ, Zhu G, Kharazia VN, Paredes JP, Chang WS, Deitchman JK, Mucke L, Messing RO (2006) PKC{varepsilon} increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc Natl Acad Sci USA 103(21):8215-8220.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.21
, pp. 8215-8220
-
-
Choi, D.S.1
Wang, D.2
Yu, G.Q.3
Zhu, G.4
Kharazia, V.N.5
Paredes, J.P.6
Chang, W.S.7
Deitchman, J.K.8
Mucke, L.9
Messing, R.O.10
-
54
-
-
27644489474
-
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer's disease mouse model
-
Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM (2005) P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer's disease mouse model. J Clin Invest 115:3285-3290.
-
(2005)
J Clin Invest
, vol.115
, pp. 3285-3290
-
-
Cirrito, J.R.1
Deane, R.2
Fagan, A.M.3
Spinner, M.L.4
Parsadanian, M.5
Finn, M.B.6
Jiang, H.7
Prior, J.L.8
Sagare, A.9
Bales, K.R.10
Paul, S.M.11
Zlokovic, B.V.12
Piwnica-Worms, D.13
Holtzman, D.M.14
-
55
-
-
16644379264
-
Natural oligomers of the amyloidbeta protein specifically disrupt cognitive function
-
Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH (2005) Natural oligomers of the amyloidbeta protein specifically disrupt cognitive function. Nat Neurosci 8:79-84.
-
(2005)
Nat Neurosci
, vol.8
, pp. 79-84
-
-
Cleary, J.P.1
Walsh, D.M.2
Hofmeister, J.J.3
Shankar, G.M.4
Kuskowski, M.A.5
Selkoe, D.J.6
Ashe, K.H.7
-
56
-
-
28444452546
-
Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions
-
Cole GM, Lim GP, Yang F, Teter B, Begum A, Ma Q, Harris-White ME, Frautschy SA (2005) Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions. Neurobiol Aging 26:133-136.
-
(2005)
Neurobiol Aging
, vol.26
, pp. 133-136
-
-
Cole, G.M.1
Lim, G.P.2
Yang, F.3
Teter, B.4
Begum, A.5
Ma, Q.6
Harris-White, M.E.7
Frautschy, S.A.8
-
59
-
-
0033081796
-
Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system
-
Cuzner ML, Opdenakker G (1999) Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system. J Neuroimmunol 94:1-14.
-
(1999)
J Neuroimmunol
, vol.94
, pp. 1-14
-
-
Cuzner, M.L.1
Opdenakker, G.2
-
60
-
-
0028838289
-
Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury
-
D'Souza S, Alinauskas K, McCrea E, Goodyer C, Antel JP (1995) Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury. J Neurosci 15:7293-7300.
-
(1995)
J Neurosci
, vol.15
, pp. 7293-7300
-
-
D'souza, S.1
Alinauskas, K.2
McCrea, E.3
Goodyer, C.4
Antel, J.P.5
-
62
-
-
0028889206
-
Expression of the Alzheimer amyloidpromoting factor antichymotrypsin is induced in human astrocytes by IL-1
-
Das S, Potter H (1995) Expression of the Alzheimer amyloidpromoting factor antichymotrypsin is induced in human astrocytes by IL-1. Neuron 14:447-456.
-
(1995)
Neuron
, vol.14
, pp. 447-456
-
-
Das, S.1
Potter, H.2
-
63
-
-
4344688011
-
Targeting the neurotoxic species in Alzheimer's disease: Inhibitors of Abeta oligomerization
-
De Felice FG, Vieira MN, Saraiva LM, Figueroa-Villar JD, Garcia-Abreu J, Liu R, Chang L, Klein WL, Ferreira ST (2004) Targeting the neurotoxic species in Alzheimer's disease: Inhibitors of Abeta oligomerization. FASEB J 18:1366-1372.
-
(2004)
FASEB J
, vol.18
, pp. 1366-1372
-
-
De Felice, F.G.1
Vieira, M.N.2
Saraiva, L.M.3
Figueroa-Villar, J.D.4
Garcia-Abreu, J.5
Liu, R.6
Chang, L.7
Klein, W.L.8
Ferreira, S.T.9
-
64
-
-
0030831489
-
Correlates of p53-and Fas (CD95)-mediated apoptosis in Alzheimer's disease
-
de la Monte SM, Sohn YK, Wands JR (1997) Correlates of p53-and Fas (CD95)-mediated apoptosis in Alzheimer's disease. J Neurol Sci 152:73-83.
-
(1997)
J Neurol Sci
, vol.152
, pp. 73-83
-
-
De La Monte, S.M.1
Sohn, Y.K.2
Wands, J.R.3
-
65
-
-
0037431082
-
Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active gamma-Secretase Complex
-
De Strooper B (2003) Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active gamma-Secretase Complex. Neuron 38:9-12.
-
(2003)
Neuron
, vol.38
, pp. 9-12
-
-
De Strooper, B.1
-
66
-
-
0032101935
-
Interferon-gamma gene expresion in rat central nervous system glial cells
-
DeSimone R, Levi G, Aloisi F (1998) Interferon-gamma gene expresion in rat central nervous system glial cells. Cytokine 10:418-422.
-
(1998)
Cytokine
, vol.10
, pp. 418-422
-
-
Desimone, R.1
Levi, G.2
Aloisi, F.3
-
67
-
-
26244453309
-
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial in macroVascular Events): A randomised controlled trial
-
Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, Skene AM, Tan MH, Lefebvre PJ, Murray GD, Standl E, Wilcox RG, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine RJ, Koranyi L, Laakso M, Mokan M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): A randomised controlled trial. Lancet 366:1279-1289.
-
(2005)
Lancet
, vol.366
, pp. 1279-1289
-
-
Dormandy, J.A.1
Charbonnel, B.2
Eckland, D.J.3
Erdmann, E.4
Massi-Benedetti, M.5
Moules, I.K.6
Skene, A.M.7
Tan, M.H.8
Lefebvre, P.J.9
Murray, G.D.10
Standl, E.11
Wilcox, R.G.12
Wilhelmsen, L.13
Betteridge, J.14
Birkeland, K.15
Golay, A.16
Heine, R.J.17
Koranyi, L.18
Laakso, M.19
Mokan, M.20
Norkus, A.21
Pirags, V.22
Podar, T.23
Scheen, A.24
Scherbaum, W.25
Schernthaner, G.26
Schmitz, O.27
Skrha, J.28
Smith, U.29
Taton, J.30
more..
-
68
-
-
0030969575
-
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
-
Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (1997) MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89:297-308.
-
(1997)
Cell
, vol.89
, pp. 297-308
-
-
Drewes, G.1
Ebneth, A.2
Preuss, U.3
Mandelkow, E.M.4
Mandelkow, E.5
-
69
-
-
16044366039
-
Increased amyloidbeta42( 43) in brains of mice expressing mutant presenilin 1
-
Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S (1996) Increased amyloidbeta42( 43) in brains of mice expressing mutant presenilin 1. Nature 383:710-713.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-Tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
70
-
-
0037254083
-
Cellular expression of tumor necrosis factor a and its receptors in human ischemic stroke
-
Dziewulska D, Mossakowski MJ (2003) Cellular expression of tumor necrosis factor a and its receptors in human ischemic stroke. Clin Neuropathol 22:35-40.
-
(2003)
Clin Neuropathol
, vol.22
, pp. 35-40
-
-
Dziewulska, D.1
Mossakowski, M.J.2
-
72
-
-
0036850023
-
Neuroinflammation in Alzheimer's disease and prion disease
-
Eikelenboom P, Bate C, Van Gool WA, Hoozemans JJ, Rozemuller JM, Veerhuis R, Williams A (2002) Neuroinflammation in Alzheimer's disease and prion disease. Glia 40:232-239.
-
(2002)
Glia
, vol.40
, pp. 232-239
-
-
Eikelenboom, P.1
Bate, C.2
Van Gool, W.A.3
Hoozemans, J.J.4
Rozemuller, J.M.5
Veerhuis, R.6
Williams, A.7
-
73
-
-
0029787599
-
Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils
-
El Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD (1996) Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature 382:716-719.
-
(1996)
Nature
, vol.382
, pp. 716-719
-
-
El Khoury, J.1
Hickman, S.E.2
Thomas, C.A.3
Cao, L.4
Silverstein, S.C.5
Loike, J.D.6
-
74
-
-
0038204838
-
CD36 mediates the innate host response to beta-amyloid
-
El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD (2003) CD36 mediates the innate host response to beta-amyloid. J Exp Med 197:1657-1666.
-
(2003)
J Exp Med
, vol.197
, pp. 1657-1666
-
-
El Khoury, J.B.1
Moore, K.J.2
Means, T.K.3
Leung, J.4
Terada, K.5
Toft, M.6
Freeman, M.W.7
Luster, A.D.8
-
75
-
-
85047691727
-
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo
-
Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE (2003) NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest 112:440-449.
-
(2003)
J Clin Invest
, vol.112
, pp. 440-449
-
-
Eriksen, J.L.1
Sagi, S.A.2
Smith, T.E.3
Weggen, S.4
Das, P.5
McLendon, D.C.6
Ozols, V.V.7
Jessing, K.W.8
Zavitz, K.H.9
Koo, E.H.10
Golde, T.E.11
-
76
-
-
0032975114
-
Deaths attributable to Alzheimer's disease in the United States
-
Ewbank DC (1999) Deaths attributable to Alzheimer's disease in the United States. Am J Public Health 89:90-92.
-
(1999)
Am J Public Health
, vol.89
, pp. 90-92
-
-
Ewbank, D.C.1
-
77
-
-
0036233168
-
Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease
-
Fagan AM, Watson M, Parsadanian M, Bales KR, Paul SM, Holtzman DM (2002) Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol Dis 9:305-318.
-
(2002)
Neurobiol Dis
, vol.9
, pp. 305-318
-
-
Fagan, A.M.1
Watson, M.2
Parsadanian, M.3
Bales, K.R.4
Paul, S.M.5
Holtzman, D.M.6
-
78
-
-
0025807206
-
Elevated circulating tumor necrosis factor levels in Alzheimer's disease
-
Fillit H, Ding WH, Buee L, Kalman J, Altstiel L, Lawlor B, Wolf-Klein G (1991) Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neurosci Lett 129:318-320.
-
(1991)
Neurosci Lett
, vol.129
, pp. 318-320
-
-
Fillit, H.1
Ding, W.H.2
Buee, L.3
Kalman, J.4
Altstiel, L.5
Lawlor, B.6
Wolf-Klein, G.7
-
79
-
-
0027723223
-
TGF-beta 1 is an organizer of responses to neurodegeneration
-
Finch CE, Laping NJ, Morgan TE, Nichols NR, Pasinetti GM (1993) TGF-beta 1 is an organizer of responses to neurodegeneration. J Cell Biochem 53:314-322.
-
(1993)
J Cell Biochem
, vol.53
, pp. 314-322
-
-
Finch, C.E.1
Laping, N.J.2
Morgan, T.E.3
Nichols, N.R.4
Pasinetti, G.M.5
-
80
-
-
0034626735
-
Oxidants, oxidative stress and the biology of ageing
-
Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408:239-247.
-
(2000)
Nature
, vol.408
, pp. 239-247
-
-
Finkel, T.1
Holbrook, N.J.2
-
81
-
-
0016823810
-
Mini-mental state". A practical method for grading the cognitive state of patients for the clinician
-
Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198.
-
(1975)
J Psychiatr Res
, vol.12
, pp. 189-198
-
-
Folstein, M.F.1
Folstein, S.E.2
McHugh, P.R.3
-
82
-
-
3242766671
-
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease
-
Fonseca MI, Zhou J, Botto M, Tenner AJ (2004a) Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J Neurosci 24:6457-6465.
-
(2004)
J Neurosci
, vol.24
, pp. 6457-6465
-
-
Fonseca, M.I.1
Zhou, J.2
Botto, M.3
Tenner, A.J.4
-
84
-
-
0012748828
-
The transition from normal functioning to dementia in the aging population
-
Iqbal K, Sisodia SS, Winblad B, eds. West Sussex, UK: John Wiley & Sons Ltd.
-
Fratiglioni L, Small B, Winblad B, Backman L (2001) The transition from normal functioning to dementia in the aging population. In: Alzheimer's Disease: Advances in Etiology, Pathogenesis, and Therapeutics (Iqbal K, Sisodia SS, Winblad B, eds), pp 3-10. West Sussex, UK: John Wiley & Sons Ltd.
-
(2001)
Alzheimer's Disease: Advances in Etiology, Pathogenesis, and Therapeutics
, pp. 3-10
-
-
Fratiglioni, L.1
Small, B.2
Winblad, B.3
Backman, L.4
-
85
-
-
0031974406
-
Microglial response to amyloid plaques in APPsw transgenic mice
-
Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsaio K, Cole GM (1998) Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 152:307-317.
-
(1998)
Am J Pathol
, vol.152
, pp. 307-317
-
-
Frautschy, S.A.1
Yang, F.2
Irrizarry, M.3
Hyman, B.4
Saido, T.C.5
Hsaio, K.6
Cole, G.M.7
-
86
-
-
0027366571
-
Induction of IFN-g in macrophages by lipopolysaccharide
-
Fultz M, Barber S, Dieffenbach C, Vogel S (1993) Induction of IFN-g in macrophages by lipopolysaccharide. Int Immunol 5:1383-1392.
-
(1993)
Int Immunol
, vol.5
, pp. 1383-1392
-
-
Fultz, M.1
Barber, S.2
Dieffenbach, C.3
Vogel, S.4
-
87
-
-
0033045848
-
In vitro peroxidase oxidation induces stable dimers of beta-amyloid (1-42) through dityrosine bridge formation
-
Galeazzi L, Ronchi P, Franceschi C, Giunta S (1999) In vitro peroxidase oxidation induces stable dimers of beta-amyloid (1-42) through dityrosine bridge formation. Amyloid 6:7-13.
-
(1999)
Amyloid
, vol.6
, pp. 7-13
-
-
Galeazzi, L.1
Ronchi, P.2
Franceschi, C.3
Giunta, S.4
-
88
-
-
33749998363
-
Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease
-
Galimberti D, Fenoglio C, Lovati C, Venturelli E, Guidi I, Corra B, Scalabrini D, Clerici F, Mariani C, Bresolin N, Scarpini E (2005) Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease. Neurobiol Aging 27(12):1763-1768.
-
(2005)
Neurobiol Aging
, vol.27
, Issue.12
, pp. 1763-1768
-
-
Galimberti, D.1
Fenoglio, C.2
Lovati, C.3
Venturelli, E.4
Guidi, I.5
Corra, B.6
Scalabrini, D.7
Clerici, F.8
Mariani, C.9
Bresolin, N.10
Scarpini, E.11
-
89
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
-
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, et al. (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373:523-527.
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
Barbour, R.4
Berthelette, P.5
Blackwell, C.6
Carr, T.7
Clemens, J.8
Donaldson, T.9
Gillespie, F.10
-
90
-
-
0022922108
-
Characterization of ameboid microglia isolated from developing mammalian brain
-
Giulian D, Baker TJ (1986) Characterization of ameboid microglia isolated from developing mammalian brain. J Neurosci 6:2163-2178.
-
(1986)
J Neurosci
, vol.6
, pp. 2163-2178
-
-
Giulian, D.1
Baker, T.J.2
-
91
-
-
0028105846
-
Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture
-
Giulian D, Li J, Leara B, Keenen C (1994) Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture. Neurochem Int 25:227-233.
-
(1994)
Neurochem Int
, vol.25
, pp. 227-233
-
-
Giulian, D.1
Li, J.2
Leara, B.3
Keenen, C.4
-
92
-
-
0029931236
-
Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain
-
Glabinski AR, Balasingam V, Tani M, Kunkel SL, Strieter RM, Yong VW, Ransohoff RM (1996) Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. J Immunol 156:4363-4368.
-
(1996)
J Immunol
, vol.156
, pp. 4363-4368
-
-
Glabinski, A.R.1
Balasingam, V.2
Tani, M.3
Kunkel, S.L.4
Strieter, R.M.5
Yong, V.W.6
Ransohoff, R.M.7
-
93
-
-
0029902166
-
Evidence of neuronal oxidative damage in Alzheimer's disease
-
Good PF, Werner P, Hsu A, Olanow CW, Perl DP (1996) Evidence of neuronal oxidative damage in Alzheimer's disease. Am J Pathol 149:21-28.
-
(1996)
Am J Pathol
, vol.149
, pp. 21-28
-
-
Good, P.F.1
Werner, P.2
Hsu, A.3
Olanow, C.W.4
Perl, D.P.5
-
94
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
-
Gotz J, Chen F, van Dorpe J, Nitsch RM (2001a) Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 293:1491-1495.
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
95
-
-
0034948975
-
Oligodendroglial tau filament formation in transgenic mice expressing G272V tau
-
Gotz J, Tolnay M, Barmettler R, Chen F, Probst A, Nitsch RM (2001b) Oligodendroglial tau filament formation in transgenic mice expressing G272V tau. Eur J Neurosci 13:2131-2140.
-
(2001)
Eur J Neurosci
, vol.13
, pp. 2131-2140
-
-
Gotz, J.1
Tolnay, M.2
Barmettler, R.3
Chen, F.4
Probst, A.5
Nitsch, R.M.6
-
96
-
-
0035690770
-
Inflammatory factors are elevated in brain microvessels in Alzheimer's disease
-
Grammas P, Ovase R (2001) Inflammatory factors are elevated in brain microvessels in Alzheimer's disease. Neurobiol Aging 22:837-842.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 837-842
-
-
Grammas, P.1
Ovase, R.2
-
97
-
-
0027185651
-
Regulation of beta-amyloid precursor protein isoform mRNAs by transforming growth factor-beta 1 and interleukin-1 beta in astrocytes
-
Gray CW, Patel AJ (1993) Regulation of beta-amyloid precursor protein isoform mRNAs by transforming growth factor-beta 1 and interleukin-1 beta in astrocytes. Brain Res Mol Brain Res 19:251-256.
-
(1993)
Brain Res Mol Brain Res
, vol.19
, pp. 251-256
-
-
Gray, C.W.1
Patel, A.J.2
-
98
-
-
3343003470
-
Neuronal expression of myeloperoxidase is increased in Alzheimer's disease
-
Green PS, Mendez AJ, Jacob JS, Crowley JR, Growdon W, Hyman BT, Heinecke JW (2004) Neuronal expression of myeloperoxidase is increased in Alzheimer's disease. J Neurochem 90:724-733.
-
(2004)
J Neurochem
, vol.90
, pp. 724-733
-
-
Green, P.S.1
Mendez, A.J.2
Jacob, J.S.3
Crowley, J.R.4
Growdon, W.5
Hyman, B.T.6
Heinecke, J.W.7
-
99
-
-
0028926976
-
Interleukin-1 expression in different plaque types in Alzheimer's diseases: Significance in plaque evolution
-
Griffin W, Sheng J, Roberts G, Mrak R (1995) Interleukin-1 expression in different plaque types in Alzheimer's diseases: Significance in plaque evolution. J Neuropathol Exp Neurol 54:276-281.
-
(1995)
J Neuropathol Exp Neurol
, vol.54
, pp. 276-281
-
-
Griffin, W.1
Sheng, J.2
Roberts, G.3
Mrak, R.4
-
100
-
-
0001360461
-
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
-
Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, 3rd, Araoz C (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 86:7611-7615.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 7611-7615
-
-
Griffin, W.S.1
Stanley, L.C.2
Ling, C.3
White, L.4
Macleod, V.5
Perrot, L.J.6
White III, C.L.7
Araoz, C.8
-
101
-
-
0034724427
-
Head injury and the risk of AD in the MIRAGE study
-
Guo Z, Cupples LA, Kurz A, Auerbach SH, Volicer L, Chui H, Green RC, Sadovnick AD, Duara R, DeCarli C, Johnson K, Go RC, Growdon JH, Haines JL, Kukull WA, Farrer LA (2000) Head injury and the risk of AD in the MIRAGE study. Neurology 54:1316-1323.
-
(2000)
Neurology
, vol.54
, pp. 1316-1323
-
-
Guo, Z.1
Cupples, L.A.2
Kurz, A.3
Auerbach, S.H.4
Volicer, L.5
Chui, H.6
Green, R.C.7
Sadovnick, A.D.8
Duara, R.9
Decarli, C.10
Johnson, K.11
Go, R.C.12
Growdon, J.H.13
Haines, J.L.14
Kukull, W.A.15
Farrer, L.A.16
-
102
-
-
14644390310
-
Molecular mechanisms of TNF-alphainduced apoptosis in aging human T cell subsets
-
Gupta S, Gollapudi S (2005) Molecular mechanisms of TNF-alphainduced apoptosis in aging human T cell subsets. Int J Biochem Cell Biol 37:1034-1042.
-
(2005)
Int J Biochem Cell Biol
, vol.37
, pp. 1034-1042
-
-
Gupta, S.1
Gollapudi, S.2
-
103
-
-
23944449670
-
Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain
-
Hampel H, Haslinger A, Scheloske M, Padberg F, Fischer P, Unger J, Teipel SJ, Neumann M, Rosenberg C, Oshida R, Hulette C, Pongratz D, Ewers M, Kretzschmar HA, Moller HJ (2005) Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain. Eur Arch Psychiatry Clin Neurosci 255:269-278.
-
(2005)
Eur Arch Psychiatry Clin Neurosci
, vol.255
, pp. 269-278
-
-
Hampel, H.1
Haslinger, A.2
Scheloske, M.3
Padberg, F.4
Fischer, P.5
Unger, J.6
Teipel, S.J.7
Neumann, M.8
Rosenberg, C.9
Oshida, R.10
Hulette, C.11
Pongratz, D.12
Ewers, M.13
Kretzschmar, H.A.14
Moller, H.J.15
-
104
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy JA, Higgins GA (1992) Alzheimer's disease: The amyloid cascade hypothesis. Science 256:184-185.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
105
-
-
0030614627
-
Observation of metastable Abeta amyloid protofibrils by atomic force microscopy
-
Harper JD, Wong SS, Lieber CM, Lansbury PT (1997) Observation of metastable Abeta amyloid protofibrils by atomic force microscopy. Chem Biol 4:119-125.
-
(1997)
Chem Biol
, vol.4
, pp. 119-125
-
-
Harper, J.D.1
Wong, S.S.2
Lieber, C.M.3
Lansbury, P.T.4
-
106
-
-
0032535717
-
Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures
-
Harris-White ME, Chu T, Balverde Z, Sigel JJ, Flanders KC, Frautschy SA (1998) Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures. J Neurosci 18:10366-10374.
-
(1998)
J Neurosci
, vol.18
, pp. 10366-10374
-
-
Harris-White, M.E.1
Chu, T.2
Balverde, Z.3
Sigel, J.J.4
Flanders, K.C.5
Frautschy, S.A.6
-
107
-
-
0034666289
-
Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo
-
Heneka MT, Klockgether T, Feinstein DL (2000) Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. J Neurosci 20:6862-6867.
-
(2000)
J Neurosci
, vol.20
, pp. 6862-6867
-
-
Heneka, M.T.1
Klockgether, T.2
Feinstein, D.L.3
-
108
-
-
20444499367
-
Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice
-
Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE (2005) Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain 128:1442-1453.
-
(2005)
Brain
, vol.128
, pp. 1442-1453
-
-
Heneka, M.T.1
Sastre, M.2
Dumitrescu-Ozimek, L.3
Hanke, A.4
Dewachter, I.5
Kuiperi, C.6
O'banion, K.7
Klockgether, T.8
Van Leuven, F.9
Landreth, G.E.10
-
109
-
-
0037226680
-
Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease
-
Hof PR, Bussiere T, Gold G, Kovari E, Giannakopoulos P, Bouras C, Perl DP, Morrison JH (2003) Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease. J Neuropathol Exp Neurol 62:55-67.
-
(2003)
J Neuropathol Exp Neurol
, vol.62
, pp. 55-67
-
-
Hof, P.R.1
Bussiere, T.2
Gold, G.3
Kovari, E.4
Giannakopoulos, P.5
Bouras, C.6
Perl, D.P.7
Morrison, J.H.8
-
110
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4:97-100.
-
(1998)
Nat Med
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
McGowan, E.3
Yu, X.4
Benkovic, S.5
Jantzen, P.6
Wright, K.7
Saad, I.8
Mueller, R.9
Morgan, D.10
Sanders, S.11
Zehr, C.12
O'campo, K.13
Hardy, J.14
Prada, C.M.15
Eckman, C.16
Younkin, S.17
Hsiao, K.18
Duff, K.19
-
111
-
-
0033559412
-
Expression of human apolipoprotein e reduces amyloid-beta deposition in a mouse model of Alzheimer's disease
-
Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan AM, Chang LK, Sun Y, Paul SM (1999) Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J Clin Invest 103:R15-R21.
-
(1999)
J Clin Invest
, vol.103
-
-
Holtzman, D.M.1
Bales, K.R.2
Wu, S.3
Bhat, P.4
Parsadanian, M.5
Fagan, A.M.6
Chang, L.K.7
Sun, Y.8
Paul, S.M.9
-
112
-
-
4243215848
-
Apolipoprotein e isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
-
Holtzman DM, Bales KR, Tenkova T, Fagan AM, Parsadanian M, Sartorius LJ, Mackey B, Olney J, McKeel D, Wozniak D, Paul SM (2000) Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 97:2892-2897.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 2892-2897
-
-
Holtzman, D.M.1
Bales, K.R.2
Tenkova, T.3
Fagan, A.M.4
Parsadanian, M.5
Sartorius, L.J.6
Mackey, B.7
Olney, J.8
McKeel, D.9
Wozniak, D.10
Paul, S.M.11
-
113
-
-
0037975676
-
Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta
-
Hoshi M, Sato M, Matsumoto S, Noguchi A, Yasutake K, Yoshida N, Sato K (2003) Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta. Proc Natl Acad Sci USA 100:6370-6375.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 6370-6375
-
-
Hoshi, M.1
Sato, M.2
Matsumoto, S.3
Noguchi, A.4
Yasutake, K.5
Yoshida, N.6
Sato, K.7
-
114
-
-
13044287361
-
Plaqueindependent disruption of neural circuits in Alzheimer's disease mouse models
-
Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L (1999) Plaqueindependent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci USA 96:3228-3233.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3228-3233
-
-
Hsia, A.Y.1
Masliah, E.2
McConlogue, L.3
Yu, G.Q.4
Tatsuno, G.5
Hu, K.6
Kholodenko, D.7
Malenka, R.C.8
Nicoll, R.A.9
Mucke, L.10
-
115
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
116
-
-
0032732224
-
Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors
-
Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, Mucke L (1999) Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am J Pathol 155:1741-1747.
-
(1999)
Am J Pathol
, vol.155
, pp. 1741-1747
-
-
Huang, F.1
Buttini, M.2
Wyss-Coray, T.3
McConlogue, L.4
Kodama, T.5
Pitas, R.E.6
Mucke, L.7
-
117
-
-
0029986869
-
Occurrence of interleukin-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques
-
Hull M, Berger M, Volk B, Bauer J (1996) Occurrence of interleukin-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques. Ann N Y Acad Sci 777:205-212.
-
(1996)
Ann N y Acad Sci
, vol.777
, pp. 205-212
-
-
Hull, M.1
Berger, M.2
Volk, B.3
Bauer, J.4
-
118
-
-
0032543684
-
Association of missense and 5?-splice-site mutations in tau with the inherited dementia FTDP-17
-
Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P, Che LK, Norton J, Morris JC, Reed LA, Trojanowski J, Basun H, Lannfelt L, Neystat M, Fahn S, Dark F, Tannenberg T, Dodd PR, Hayward N, Kwok JB, Schofield PR, Andreadis A, Snowden J, Craufurd D, Neary D, Owen F, Oostra BA, Hardy J, Goate A, van Swieten J, Mann D, Lynch T, Heutink P (1998) Association of missense and 5?-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393:702-705.
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
Baker, M.4
Froelich, S.5
Houlden, H.6
Pickering-Brown, S.7
Chakraverty, S.8
Isaacs, A.9
Grover, A.10
Hackett, J.11
Adamson, J.12
Lincoln, S.13
Dickson, D.14
Davies, P.15
Petersen, R.C.16
Stevens, M.17
De Graaff, E.18
Wauters, E.19
Van Baren, J.20
Hillebrand, M.21
Joosse, M.22
Kwon, J.M.23
Nowotny, P.24
Che, L.K.25
Norton, J.26
Morris, J.C.27
Reed, L.A.28
Trojanowski, J.29
Basun, H.30
Lannfelt, L.31
Neystat, M.32
Fahn, S.33
Dark, F.34
Tannenberg, T.35
Dodd, P.R.36
Hayward, N.37
Kwok, J.B.38
Schofield, P.R.39
Andreadis, A.40
Snowden, J.41
Craufurd, D.42
Neary, D.43
Owen, F.44
Oostra, B.A.45
Hardy, J.46
Goate, A.47
Van Swieten, J.48
Mann, D.49
Lynch, T.50
Heutink, P.51
more..
-
119
-
-
0037573524
-
Amyloid precursor protein-processing products affect mononuclear phagocyte activation: Pathways for sAPP-and Abeta-mediated neurotoxicity
-
Ikezu T, Luo X, Weber GA, Zhao J, McCabe L, Buescher JL, Ghorpade A, Zheng J, Xiong H (2003) Amyloid precursor protein-processing products affect mononuclear phagocyte activation: Pathways for sAPP-and Abeta-mediated neurotoxicity. J Neurochem 85:925-934.
-
(2003)
J Neurochem
, vol.85
, pp. 925-934
-
-
Ikezu, T.1
Luo, X.2
Weber, G.A.3
Zhao, J.4
McCabe, L.5
Buescher, J.L.6
Ghorpade, A.7
Zheng, J.8
Xiong, H.9
-
120
-
-
0038064189
-
Pharmacologic agents associated with a preventive effect on Alzheimer's disease: A review of the epidemiologic evidence
-
in 't Veld BA, Launer LJ, Breteler MM, Hofman A, Stricker BH (2002) Pharmacologic agents associated with a preventive effect on Alzheimer's disease: A review of the epidemiologic evidence. Epidemiol Rev 24:248-268.
-
(2002)
Epidemiol Rev
, vol.24
, pp. 248-268
-
-
In 't Veld, B.A.1
Launer, L.J.2
Breteler, M.M.3
Hofman, A.4
Stricker, B.H.5
-
121
-
-
28744458578
-
CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein-coupled receptor mFPR2
-
Iribarren P, Chen K, Hu J, Gong W, Cho EH, Lockett S, Uranchimeg B, Wang JM (2005) CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein-coupled receptor mFPR2. FASEB J 19:2032-2034.
-
(2005)
FASEB J
, vol.19
, pp. 2032-2034
-
-
Iribarren, P.1
Chen, K.2
Hu, J.3
Gong, W.4
Cho, E.H.5
Lockett, S.6
Uranchimeg, B.7
Wang, J.M.8
-
122
-
-
0026619472
-
Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments
-
Ishiguro K, Omori A, Takamatsu M, Sato K, Arioka M, Uchida T, Imahori K (1992) Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments. Neurosci Lett 148:202-206.
-
(1992)
Neurosci Lett
, vol.148
, pp. 202-206
-
-
Ishiguro, K.1
Omori, A.2
Takamatsu, M.3
Sato, K.4
Arioka, M.5
Uchida, T.6
Imahori, K.7
-
123
-
-
0030988629
-
Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease
-
Ishizuka K, Kimura T, Igata-yi R, Katsuragi S, Takamatsu J, Miyakawa T (1997) Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry Clin Neurosci 51:135-138.
-
(1997)
Psychiatry Clin Neurosci
, vol.51
, pp. 135-138
-
-
Ishizuka, K.1
Kimura, T.2
Igata-Yi, R.3
Katsuragi, S.4
Takamatsu, J.5
Miyakawa, T.6
-
124
-
-
5444262511
-
Toll-like receptor control of the adaptive immune responses
-
Iwasaki A, Medzhitov R (2004) Toll-like receptor control of the adaptive immune responses. Nat Immunol 5:987-995.
-
(2004)
Nat Immunol
, vol.5
, pp. 987-995
-
-
Iwasaki, A.1
Medzhitov, R.2
-
125
-
-
0033621739
-
Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
-
Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, Saido TC (2000) Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition. Nat Med 6:143-150.
-
(2000)
Nat Med
, vol.6
, pp. 143-150
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Watanabe, K.4
Sekiguchi, M.5
Hosoki, E.6
Kawashima-Morishima, M.7
Lee, H.J.8
Hama, E.9
Sekine-Aizawa, Y.10
Saido, T.C.11
-
126
-
-
25444498280
-
TLR signaling tailors innate immune responses in human microglia and astrocytes
-
Jack CS, Arbour N, Manusow J, Montgrain V, Blain M, McCrea E, Shapiro A, Antel JP (2005) TLR signaling tailors innate immune responses in human microglia and astrocytes. J Immunol 175:4320-4330.
-
(2005)
J Immunol
, vol.175
, pp. 4320-4330
-
-
Jack, C.S.1
Arbour, N.2
Manusow, J.3
Montgrain, V.4
Blain, M.5
McCrea, E.6
Shapiro, A.7
Antel, J.P.8
-
127
-
-
33645520634
-
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
-
Jacobsen JS, Wu CC, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH, Bloom FE (2006) Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 103:5161-5166.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5161-5166
-
-
Jacobsen, J.S.1
Wu, C.C.2
Redwine, J.M.3
Comery, T.A.4
Arias, R.5
Bowlby, M.6
Martone, R.7
Morrison, J.H.8
Pangalos, M.N.9
Reinhart, P.H.10
Bloom, F.E.11
-
128
-
-
27744482552
-
Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice
-
Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ (2005) Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation 2:23.
-
(2005)
J Neuroinflammation
, vol.2
, pp. 23
-
-
Janelsins, M.C.1
Mastrangelo, M.A.2
Oddo, S.3
Laferla, F.M.4
Federoff, H.J.5
Bowers, W.J.6
-
129
-
-
0037088914
-
Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
-
Jantzen PT, Connor KE, DiCarlo G, Wenk GL, Wallace JL, Rojiani AM, Coppola D, Morgan D, Gordon MN (2002) Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J Neurosci 22:2246-2254.
-
(2002)
J Neurosci
, vol.22
, pp. 2246-2254
-
-
Jantzen, P.T.1
Connor, K.E.2
Dicarlo, G.3
Wenk, G.L.4
Wallace, J.L.5
Rojiani, A.M.6
Coppola, D.7
Morgan, D.8
Gordon, M.N.9
-
130
-
-
0034700471
-
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, St George-Hyslop P, Westaway D (2000) A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408:979-982.
-
(2000)
Nature
, vol.408
, pp. 979-982
-
-
Janus, C.1
Pearson, J.2
McLaurin, J.3
Mathews, P.M.4
Jiang, Y.5
Schmidt, S.D.6
Chishti, M.A.7
Horne, P.8
Heslin, D.9
French, J.10
Mount, H.T.11
Nixon, R.A.12
Mercken, M.13
Bergeron, C.14
Fraser, P.E.15
St George-Hyslop, P.16
Westaway, D.17
-
131
-
-
0029947089
-
Apolipoprotein e is highly susceptible to oxidation by myeloperoxidase, an enzyme present in the brain
-
Jolivalt C, Leininger-Muller B, Drozdz R, Naskalski JW, Siest G (1996) Apolipoprotein E is highly susceptible to oxidation by myeloperoxidase, an enzyme present in the brain. Neurosci Lett 210:61-64.
-
(1996)
Neurosci Lett
, vol.210
, pp. 61-64
-
-
Jolivalt, C.1
Leininger-Muller, B.2
Drozdz, R.3
Naskalski, J.W.4
Siest, G.5
-
132
-
-
2542444219
-
Epidemiology of Alzheimer's disease and dementia: Advances and challenges
-
Iqbal K, Sisodia SS, Winblad B, eds. West Sussex, UK: John Wiley & Sons Ltd
-
Katzman R (2001) Epidemiology of Alzheimer's disease and dementia: Advances and challenges. In: Alzheimer's Disease: Advances in Etiology, Pathogenesis, and Therapeutics (Iqbal K, Sisodia SS, Winblad B, eds), pp 11-21. West Sussex, UK: John Wiley & Sons Ltd.
-
(2001)
Alzheimer's Disease: Advances in Etiology, Pathogenesis, and Therapeutics
, pp. 11-21
-
-
Katzman, R.1
-
133
-
-
0002004673
-
The world wide impact of dementia in the next fifty years
-
Mayeux R, Christen Y, eds. Berlin: Springer
-
Katzman R, Fox P (1999) The world wide impact of dementia in the next fifty years. In: Epidemiology of Alzheimer's Disease: From Gene to Prevention (Mayeux R, Christen Y, eds), pp 1-17. Berlin: Springer.
-
(1999)
Epidemiology of Alzheimer's Disease: From Gene to Prevention
, pp. 1-17
-
-
Katzman, R.1
Fox, P.2
-
134
-
-
0001680872
-
Purification and characterization of a neurite extension factor from bovine brain
-
Kligman D, Marshak DR (1985) Purification and characterization of a neurite extension factor from bovine brain. Proc Natl Acad Sci USA 82:7136-7139.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 7136-7139
-
-
Kligman, D.1
Marshak, D.R.2
-
135
-
-
24744467358
-
Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines
-
Koenigsknecht-Talboo J, Landreth GE (2005) Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J Neurosci 25:8240-8249.
-
(2005)
J Neurosci
, vol.25
, pp. 8240-8249
-
-
Koenigsknecht-Talboo, J.1
Landreth, G.E.2
-
136
-
-
0031753157
-
Alzheimer's beta-amyloid peptide 1-42 induces a phagocytic response in murine microglia
-
Kopec KK, Carroll RT (1998) Alzheimer's beta-amyloid peptide 1-42 induces a phagocytic response in murine microglia. J Neurochem 71:2123-2131.
-
(1998)
J Neurochem
, vol.71
, pp. 2123-2131
-
-
Kopec, K.K.1
Carroll, R.T.2
-
137
-
-
1342333775
-
Cell cycle activation linked to neuronal cell death initiated by DNA damage
-
Kruman II, Wersto RP, Cardozo-Pelaez F, Smilenov L, Chan SL, Chrest FJ, Emokpae Jr R, Gorospe M, Mattson MP (2004) Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron 41:549-561.
-
(2004)
Neuron
, vol.41
, pp. 549-561
-
-
Kruman, I.I.1
Wersto, R.P.2
Cardozo-Pelaez, F.3
Smilenov, L.4
Chan, S.L.5
Chrest, F.J.6
Emokpae Jr., R.7
Gorospe, M.8
Mattson, M.P.9
-
138
-
-
21044458540
-
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production
-
Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE (2005) Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nat Med 11:545-550.
-
(2005)
Nat Med
, vol.11
, pp. 545-550
-
-
Kukar, T.1
Murphy, M.P.2
Eriksen, J.L.3
Sagi, S.A.4
Weggen, S.5
Smith, T.E.6
Ladd, T.7
Khan, M.A.8
Kache, R.9
Beard, J.10
Dodson, M.11
Merit, S.12
Ozols, V.V.13
Anastasiadis, P.Z.14
Das, P.15
Fauq, A.16
Koo, E.H.17
Golde, T.E.18
-
139
-
-
0029823454
-
Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice
-
LaFerla FM, Hall CK, Ngo L, Jay G (1996) Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice. J Clin Invest 98:1626-1632.
-
(1996)
J Clin Invest
, vol.98
, pp. 1626-1632
-
-
Laferla, F.M.1
Hall, C.K.2
Ngo, L.3
Jay, G.4
-
140
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL (1998) Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA 95:6448-6453.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
141
-
-
0033523480
-
Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice
-
Larson J, Lynch G, Games D, Seubert P (1999) Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice. Brain Res 840:23-35.
-
(1999)
Brain Res
, vol.840
, pp. 23-35
-
-
Larson, J.1
Lynch, G.2
Games, D.3
Seubert, P.4
-
142
-
-
0034703594
-
Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease
-
Leake A, Morris CM, Whateley J (2000) Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease. Neurosci Lett 291:201-203.
-
(2000)
Neurosci Lett
, vol.291
, pp. 201-203
-
-
Leake, A.1
Morris, C.M.2
Whateley, J.3
-
143
-
-
13844265969
-
BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo
-
Lee EB, Zhang B, Liu K, Greenbaum EA, Doms RW, Trojanowski JQ, Lee VM (2005) BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. J Cell Biol 168:291-302.
-
(2005)
J Cell Biol
, vol.168
, pp. 291-302
-
-
Lee, E.B.1
Zhang, B.2
Liu, K.3
Greenbaum, E.A.4
Doms, R.W.5
Trojanowski, J.Q.6
Lee, V.M.7
-
145
-
-
0346101885
-
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
-
Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ (2003) Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40:1087-1093.
-
(2003)
Neuron
, vol.40
, pp. 1087-1093
-
-
Leissring, M.A.1
Farris, W.2
Chang, A.Y.3
Walsh, D.M.4
Wu, X.5
Sun, X.6
Frosch, M.P.7
Selkoe, D.J.8
-
146
-
-
0029731662
-
Peroxisome proliferatoractivated receptors: A nuclear receptor signaling pathway in lipid physiology
-
Lemberger T, Desvergne B, Wahli W (1996) Peroxisome proliferatoractivated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12:335-363.
-
(1996)
Annu Rev Cell Dev Biol
, vol.12
, pp. 335-363
-
-
Lemberger, T.1
Desvergne, B.2
Wahli, W.3
-
147
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440:352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesne, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
Gallagher, M.7
Ashe, K.H.8
-
148
-
-
34247471687
-
Innate immune receptor expression in normal brain aging
-
Letiembre M, Hao W, Liu Y, Walter S, Mihaljevic I, Rivest S, Hartmann T, Fassbender K (2007) Innate immune receptor expression in normal brain aging. Neuroscience 146(1):248-254.
-
(2007)
Neuroscience
, vol.146
, Issue.1
, pp. 248-254
-
-
Letiembre, M.1
Hao, W.2
Liu, Y.3
Walter, S.4
Mihaljevic, I.5
Rivest, S.6
Hartmann, T.7
Fassbender, K.8
-
149
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K, et al. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973-977.
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
Yu, C.E.7
Jondro, P.D.8
Schmidt, S.D.9
Wang, K.10
-
150
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, Dickson DW, Davies P, Hutton M (2000) Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet 25:402-405.
-
(2000)
Nat Genet
, vol.25
, pp. 402-405
-
-
Lewis, J.1
McGowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
Van Slegtenhorst, M.6
Gwinn-Hardy, K.7
Paul Murphy, M.8
Baker, M.9
Yu, X.10
Duff, K.11
Hardy, J.12
Corral, A.13
Lin, W.L.14
Yen, S.H.15
Dickson, D.W.16
Davies, P.17
Hutton, M.18
-
151
-
-
1242274383
-
Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death
-
Li R, Yang L, Lindholm K, Konishi Y, Yue X, Hampel H, Zhang D, Shen Y (2004) Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death. J Neurosci 24:1760-1771.
-
(2004)
J Neurosci
, vol.24
, pp. 1760-1771
-
-
Li, R.1
Yang, L.2
Lindholm, K.3
Konishi, Y.4
Yue, X.5
Hampel, H.6
Zhang, D.7
Shen, Y.8
-
152
-
-
0034254924
-
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
-
Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, Cole GM (2000) Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci 20:5709-5714.
-
(2000)
J Neurosci
, vol.20
, pp. 5709-5714
-
-
Lim, G.P.1
Yang, F.2
Chu, T.3
Chen, P.4
Beech, W.5
Teter, B.6
Tran, T.7
Ubeda, O.8
Ashe, K.H.9
Frautschy, S.A.10
Cole, G.M.11
-
153
-
-
0035503597
-
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
-
Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21:8370-8377.
-
(2001)
J Neurosci
, vol.21
, pp. 8370-8377
-
-
Lim, G.P.1
Chu, T.2
Yang, F.3
Beech, W.4
Frautschy, S.A.5
Cole, G.M.6
-
154
-
-
16244416174
-
A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
-
Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N, Jr., Frautschy SA, Cole GM (2005) A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci 25:3032-3040.
-
(2005)
J Neurosci
, vol.25
, pp. 3032-3040
-
-
Lim, G.P.1
Calon, F.2
Morihara, T.3
Yang, F.4
Teter, B.5
Ubeda, O.6
Salem Jr., N.7
Frautschy, S.A.8
Cole, G.M.9
-
155
-
-
22244456028
-
Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and-4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures
-
Lotz M, Ebert S, Esselmann H, Iliev AI, Prinz M, Wiazewicz N, Wiltfang J, Gerber J, Nau R (2005) Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and-4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures. J Neurochem 94:289-298.
-
(2005)
J Neurochem
, vol.94
, pp. 289-298
-
-
Lotz, M.1
Ebert, S.2
Esselmann, H.3
Iliev, A.I.4
Prinz, M.5
Wiazewicz, N.6
Wiltfang, J.7
Gerber, J.8
Nau, R.9
-
157
-
-
3042631024
-
Gene regulation and DNA damage in the ageing human brain
-
Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA (2004) Gene regulation and DNA damage in the ageing human brain. Nature 429:883-891.
-
(2004)
Nature
, vol.429
, pp. 883-891
-
-
Lu, T.1
Pan, Y.2
Kao, S.Y.3
Li, C.4
Kohane, I.5
Chan, J.6
Yankner, B.A.7
-
158
-
-
0037308834
-
C1qcalreticulin induced oxidative neurotoxicity: Relevance for the neuropathogenesis of Alzheimer's disease
-
Luo X, Weber GA, Zheng J, Gendelman HE, Ikezu T (2003) C1qcalreticulin induced oxidative neurotoxicity: Relevance for the neuropathogenesis of Alzheimer's disease. J Neuroimmunol 135:62-71.
-
(2003)
J Neuroimmunol
, vol.135
, pp. 62-71
-
-
Luo, X.1
Weber, G.A.2
Zheng, J.3
Gendelman, H.E.4
Ikezu, T.5
-
159
-
-
0030898724
-
An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease
-
Lyras L, Cairns NJ, Jenner A, Jenner P, Halliwell B (1997) An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J Neurochem 68:2061-2069.
-
(1997)
J Neurochem
, vol.68
, pp. 2061-2069
-
-
Lyras, L.1
Cairns, N.J.2
Jenner, A.3
Jenner, P.4
Halliwell, B.5
-
160
-
-
2342628596
-
Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: Implications for early mitochondrial dysfunction and oxidative damage
-
Manczak M, Park BS, Jung Y, Reddy PH (2004) Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: Implications for early mitochondrial dysfunction and oxidative damage. Neuromolecular Med 5:147-162.
-
(2004)
Neuromolecular Med
, vol.5
, pp. 147-162
-
-
Manczak, M.1
Park, B.S.2
Jung, Y.3
Reddy, P.H.4
-
161
-
-
0012473279
-
The nuclear receptor superfamily: The second decade
-
Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM (1995) The nuclear receptor superfamily: The second decade. Cell 83:835-839.
-
(1995)
Cell
, vol.83
, pp. 835-839
-
-
Mangelsdorf, D.J.1
Thummel, C.2
Beato, M.3
Herrlich, P.4
Schutz, G.5
Umesono, K.6
Blumberg, B.7
Kastner, P.8
Mark, M.9
Chambon, P.10
Evans, R.M.11
-
162
-
-
0032902974
-
Oxidative alterations in Alzheimer's disease
-
Markesbery WR, Carney JM (1999) Oxidative alterations in Alzheimer's disease. Brain Pathol 9:133-146.
-
(1999)
Brain Pathol
, vol.9
, pp. 133-146
-
-
Markesbery, W.R.1
Carney, J.M.2
-
163
-
-
0022480081
-
Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress
-
Martins RN, Harper CG, Stokes GB, Masters CL (1986) Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress. J Neurochem 46:1042-1045.
-
(1986)
J Neurochem
, vol.46
, pp. 1042-1045
-
-
Martins, R.N.1
Harper, C.G.2
Stokes, G.B.3
Masters, C.L.4
-
164
-
-
0025985434
-
Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease
-
Masliah E, Mallory M, Hansen L, Alford M, Albright T, Terry R, Shapiro P, Sundsmo M, Saitoh T (1991) Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease. Acta Neuropathol (Berl) 83:12-20.
-
(1991)
Acta Neuropathol (Berl)
, vol.83
, pp. 12-20
-
-
Masliah, E.1
Mallory, M.2
Hansen, L.3
Alford, M.4
Albright, T.5
Terry, R.6
Shapiro, P.7
Sundsmo, M.8
Saitoh, T.9
-
165
-
-
21144447065
-
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases
-
Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D (2005) Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Natl Acad Sci USA 102:8972-8977.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8972-8977
-
-
Mastrangelo, P.1
Mathews, P.M.2
Chishti, M.A.3
Schmidt, S.D.4
Gu, Y.5
Yang, J.6
Mazzella, M.J.7
Coomaraswamy, J.8
Horne, P.9
Strome, B.10
Pelly, H.11
Levesque, G.12
Ebeling, C.13
Jiang, Y.14
Nixon, R.A.15
Rozmahel, R.16
Fraser, P.E.17
St George-Hyslop, P.18
Carlson, G.A.19
Westaway, D.20
more..
-
166
-
-
0029811901
-
Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
-
McGeer P, Schulzer M, McGeer E (1996) Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies. Neurology 47:425-432.
-
(1996)
Neurology
, vol.47
, pp. 425-432
-
-
McGeer, P.1
Schulzer, M.2
McGeer, E.3
-
167
-
-
0035693924
-
Inflammation, autotoxicity and Alzheimer disease
-
McGeer PL, McGeer EG (2001) Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging 22:799-809.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 799-809
-
-
McGeer, P.L.1
McGeer, E.G.2
-
168
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
-
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939-944.
-
(1984)
Neurology
, vol.34
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
Katzman, R.4
Price, D.5
Stadlan, E.M.6
-
169
-
-
25144479446
-
In response to pathogens, glial cells dynamically and differentially regulate Toll-like receptor gene expression
-
McKimmie CS, Fazakerley JK (2005) In response to pathogens, glial cells dynamically and differentially regulate Toll-like receptor gene expression. J Neuroimmunol 169:116-125.
-
(2005)
J Neuroimmunol
, vol.169
, pp. 116-125
-
-
McKimmie, C.S.1
Fazakerley, J.K.2
-
170
-
-
0028953529
-
Activation of microglial cells by bamyloid protein and interferon-g
-
Meda L, Cassatella MA, Szendrei GI, Jr LO, Baron P, Villalba M, Ferrari D, Rossi F (1995) Activation of microglial cells by bamyloid protein and interferon-g. Nature 374:647-650.
-
(1995)
Nature
, vol.374
, pp. 647-650
-
-
Meda, L.1
Cassatella, M.A.2
Szendrei Jr., G.I.L.O.3
Baron, P.4
Villalba, M.5
Ferrari, D.6
Rossi, F.7
-
171
-
-
0032891880
-
Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with betaamyloid[ 25-35]
-
Meda L, Baron P, Prat E, Scarpini E, Scarlato G, Cassatella MA, Rossi F (1999) Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with betaamyloid[ 25-35]. J Neuroimmunol 93:45-52.
-
(1999)
J Neuroimmunol
, vol.93
, pp. 45-52
-
-
Meda, L.1
Baron, P.2
Prat, E.3
Scarpini, E.4
Scarlato, G.5
Cassatella, M.A.6
Rossi, F.7
-
172
-
-
18944389722
-
Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation
-
Medina MG, Ledesma MD, Dominguez JE, Medina M, Zafra D, Alameda F, Dotti CG, Navarro P (2005) Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation. EMBO J 24:1706-1716.
-
(2005)
EMBO J
, vol.24
, pp. 1706-1716
-
-
Medina, M.G.1
Ledesma, M.D.2
Dominguez, J.E.3
Medina, M.4
Zafra, D.5
Alameda, F.6
Dotti, C.G.7
Navarro, P.8
-
173
-
-
1542313772
-
Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology
-
Mohajeri MH, Saini KD, Nitsch RM (2004) Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology. J Neural Transm 111:413-425.
-
(2004)
J Neural Transm
, vol.111
, pp. 413-425
-
-
Mohajeri, M.H.1
Saini, K.D.2
Nitsch, R.M.3
-
174
-
-
0028353284
-
Transforming growth factor beta mediates increase of mature transmembrane amyloid precursor protein in microglial cells
-
Monning U, Sandbrink R, Banati RB, Masters CL, Beyreuther K (1994) Transforming growth factor beta mediates increase of mature transmembrane amyloid precursor protein in microglial cells. FEBS Lett 342:267-272.
-
(1994)
FEBS Lett
, vol.342
, pp. 267-272
-
-
Monning, U.1
Sandbrink, R.2
Banati, R.B.3
Masters, C.L.4
Beyreuther, K.5
-
175
-
-
0347635258
-
L-serine-mediated release of apolipoprotein e and lipids from microglial cells
-
Mori K, Yokoyama A, Yang L, Maeda N, Mitsuda N, Tanaka J (2004) L-serine-mediated release of apolipoprotein E and lipids from microglial cells. Exp Neurol 185:220-231.
-
(2004)
Exp Neurol
, vol.185
, pp. 220-231
-
-
Mori, K.1
Yokoyama, A.2
Yang, L.3
Maeda, N.4
Mitsuda, N.5
Tanaka, J.6
-
176
-
-
0037263789
-
P53-dependent cell death signaling in neurons
-
Morrison RS, Kinoshita Y, Johnson MD, Guo W, Garden GA (2003) p53-dependent cell death signaling in neurons. Neurochem Res 28:15-27.
-
(2003)
Neurochem Res
, vol.28
, pp. 15-27
-
-
Morrison, R.S.1
Kinoshita, Y.2
Johnson, M.D.3
Guo, W.4
Garden, G.A.5
-
178
-
-
0025913996
-
Head trauma as a risk factor for Alzheimer's disease: A collaborative re-analysis of case-control studies
-
EURODEM Risk Factors Research Group
-
Mortimer JA, van Duijn CM, Chandra V, Fratiglioni L, Graves AB, Heyman A, Jorm AF, Kokmen E, Kondo K, Rocca WA, et al. (1991) Head trauma as a risk factor for Alzheimer's disease: A collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol 20 Suppl 2:S28-35.
-
(1991)
Int J Epidemiol 20 Suppl
, vol.2
-
-
Mortimer, J.A.1
Van Duijn, C.M.2
Chandra, V.3
Fratiglioni, L.4
Graves, A.B.5
Heyman, A.6
Jorm, A.F.7
Kokmen, E.8
Kondo, K.9
Rocca, W.A.10
-
179
-
-
0031661968
-
The cell division cycle and the pathophysiology of Alzheimer's disease
-
Nagy Z, Esiri MM, Smith AD (1998) The cell division cycle and the pathophysiology of Alzheimer's disease. Neuroscience 87:731-739.
-
(1998)
Neuroscience
, vol.87
, pp. 731-739
-
-
Nagy, Z.1
Esiri, M.M.2
Smith, A.D.3
-
180
-
-
0038117796
-
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
-
Naslund J, Haroutunian V, Mohs R, Davis KL, Davies P, Greengard P, Buxbaum JD (2000) Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 283: 1571-1577.
-
(2000)
JAMA
, vol.283
, pp. 1571-1577
-
-
Naslund, J.1
Haroutunian, V.2
Mohs, R.3
Davis, K.L.4
Davies, P.5
Greengard, P.6
Buxbaum, J.D.7
-
181
-
-
0042697305
-
Tripletransgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Tripletransgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction. Neuron 39:409-421.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
Laferla, F.M.10
-
182
-
-
4644232615
-
Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
-
Olson JK, Miller SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J Immunol 173:3916-3924.
-
(2004)
J Immunol
, vol.173
, pp. 3916-3924
-
-
Olson, J.K.1
Miller, S.D.2
-
184
-
-
0032764016
-
Diabetes mellitus and the risk of dementia: The Rotterdam Study
-
Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM (1999) Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology 53:1937-1942.
-
(1999)
Neurology
, vol.53
, pp. 1937-1942
-
-
Ott, A.1
Stolk, R.P.2
Van Harskamp, F.3
Pols, H.A.4
Hofman, A.5
Breteler, M.M.6
-
185
-
-
0030248270
-
Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
-
Paresce DM, Ghosh RN, Maxfield FR (1996) Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron 17:553-565.
-
(1996)
Neuron
, vol.17
, pp. 553-565
-
-
Paresce, D.M.1
Ghosh, R.N.2
Maxfield, F.R.3
-
186
-
-
0030664076
-
Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells
-
Paresce DM, Chung H, Maxfield FR (1997) Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells. J Biol Chem 272:29390-29397.
-
(1997)
J Biol Chem
, vol.272
, pp. 29390-29397
-
-
Paresce, D.M.1
Chung, H.2
Maxfield, F.R.3
-
187
-
-
0033540060
-
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
-
Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH (1999) Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402:615-622.
-
(1999)
Nature
, vol.402
, pp. 615-622
-
-
Patrick, G.N.1
Zukerberg, L.2
Nikolic, M.3
De La Monte, S.4
Dikkes, P.5
Tsai, L.H.6
-
188
-
-
0036227542
-
Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study
-
Peila R, Rodriguez BL, Launer LJ (2002) Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes 51:1256-1262.
-
(2002)
Diabetes
, vol.51
, pp. 1256-1262
-
-
Peila, R.1
Rodriguez, B.L.2
Launer, L.J.3
-
189
-
-
0026743059
-
Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines
-
Piani D, Spranger M, Frei K, Schaffner A, Fontana A (1992) Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines. Eur J Immunol 22:2429-2436.
-
(1992)
Eur J Immunol
, vol.22
, pp. 2429-2436
-
-
Piani, D.1
Spranger, M.2
Frei, K.3
Schaffner, A.4
Fontana, A.5
-
190
-
-
0027447286
-
Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state
-
Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW (1993) Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state. J Neurosci 13:1676-1687.
-
(1993)
J Neurosci
, vol.13
, pp. 1676-1687
-
-
Pike, C.J.1
Burdick, D.2
Walencewicz, A.J.3
Glabe, C.G.4
Cotman, C.W.5
-
191
-
-
0023080585
-
Astrocytes synthesize apolipoprotein e and metabolize apolipoprotein E-containing lipoproteins
-
Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW (1987) Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim Biophys Acta 917:148-161.
-
(1987)
Biochim Biophys Acta
, vol.917
, pp. 148-161
-
-
Pitas, R.E.1
Boyles, J.K.2
Lee, S.H.3
Foss, D.4
Mahley, R.W.5
-
192
-
-
0036660263
-
Role of GSK-3ß in Alzheimer's disease pathology
-
Planel E, Sun X, Takashima A (2002) Role of GSK-3ß in Alzheimer's disease pathology. Drug Dev Res 56:491-510.
-
(2002)
Drug Dev Res
, vol.56
, pp. 491-510
-
-
Planel, E.1
Sun, X.2
Takashima, A.3
-
193
-
-
85047690140
-
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
-
Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz F (2004) A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J Clin Invest 113:1456-1464.
-
(2004)
J Clin Invest
, vol.113
, pp. 1456-1464
-
-
Postina, R.1
Schroeder, A.2
Dewachter, I.3
Bohl, J.4
Schmitt, U.5
Kojro, E.6
Prinzen, C.7
Endres, K.8
Hiemke, C.9
Blessing, M.10
Flamez, P.11
Dequenne, A.12
Godaux, E.13
Van Leuven, F.14
Fahrenholz, F.15
-
195
-
-
22144451172
-
The age-dependent relation of blood pressure to cognitive function and dementia
-
Qiu C, Winblad B, Fratiglioni L (2005) The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol 4:487-499.
-
(2005)
Lancet Neurol
, vol.4
, pp. 487-499
-
-
Qiu, C.1
Winblad, B.2
Fratiglioni, L.3
-
196
-
-
0000398342
-
Insulindegrading enzyme regulates extracellular levels of amyloid betaprotein by degradation
-
Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ (1998) Insulindegrading enzyme regulates extracellular levels of amyloid betaprotein by degradation. J Biol Chem 273:32730-32738.
-
(1998)
J Biol Chem
, vol.273
, pp. 32730-32738
-
-
Qiu, W.Q.1
Walsh, D.M.2
Ye, Z.3
Vekrellis, K.4
Zhang, J.5
Podlisny, M.B.6
Rosner, M.R.7
Safavi, A.8
Hersh, L.B.9
Selkoe, D.J.10
-
197
-
-
27944491109
-
Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)
-
Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH (2005) Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci 25:10637-10647.
-
(2005)
J Neurosci
, vol.25
, pp. 10637-10647
-
-
Ramsden, M.1
Kotilinek, L.2
Forster, C.3
Paulson, J.4
McGowan, E.5
Santacruz, K.6
Guimaraes, A.7
Yue, M.8
Lewis, J.9
Carlson, G.10
Hutton, M.11
Ashe, K.H.12
-
198
-
-
0037197836
-
Tau is essential to beta-amyloid-induced neurotoxicity
-
Rapoport M, Dawson HN, Binder LI, Vitek MP, Ferreira A (2002) Tau is essential to beta-amyloid-induced neurotoxicity. Proc Natl Acad Sci USA 99:6364-6369.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 6364-6369
-
-
Rapoport, M.1
Dawson, H.N.2
Binder, L.I.3
Vitek, M.P.4
Ferreira, A.5
-
199
-
-
0033004381
-
Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease
-
Reynolds WF, Rhees J, Maciejewski D, Paladino T, Sieburg H, Maki RA, Masliah E (1999) Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease. Exp Neurol 155:31-41.
-
(1999)
Exp Neurol
, vol.155
, pp. 31-41
-
-
Reynolds, W.F.1
Rhees, J.2
Maciejewski, D.3
Paladino, T.4
Sieburg, H.5
Maki, R.A.6
Masliah, E.7
-
200
-
-
0024157709
-
Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease
-
Rogers J, Luber-Narod J, Styren SD, Civin WH (1988) Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease. Neurobiol Aging 9:339-349.
-
(1988)
Neurobiol Aging
, vol.9
, pp. 339-349
-
-
Rogers, J.1
Luber-Narod, J.2
Styren, S.D.3
Civin, W.H.4
-
201
-
-
0033525735
-
Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5?-untranslated region sequences
-
Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN (1999) Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5?-untranslated region sequences. J Biol Chem 274:6421-6431.
-
(1999)
J Biol Chem
, vol.274
, pp. 6421-6431
-
-
Rogers, J.T.1
Leiter, L.M.2
McPhee, J.3
Cahill, C.M.4
Zhan, S.S.5
Potter, H.6
Nilsson, L.N.7
-
202
-
-
9444245809
-
Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease
-
Roher AE, Chaney MO, Kuo YM, Webster SD, Stine WB, Haverkamp LJ, Woods AS, Cotter RJ, Tuohy JM, Krafft GA, Bonnell BS, Emmerling MR (1996) Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease. J Biol Chem 271:20631-20635.
-
(1996)
J Biol Chem
, vol.271
, pp. 20631-20635
-
-
Roher, A.E.1
Chaney, M.O.2
Kuo, Y.M.3
Webster, S.D.4
Stine, W.B.5
Haverkamp, L.J.6
Woods, A.S.7
Cotter, R.J.8
Tuohy, J.M.9
Krafft, G.A.10
Bonnell, B.S.11
Emmerling, M.R.12
-
203
-
-
4344659648
-
A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice
-
Sadowski M, Pankiewicz J, Scholtzova H, Ripellino JA, Li Y, Schmidt SD, Mathews PM, Fryer JD, Holtzman DM, Sigurdsson EM, Wisniewski T (2004) A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. Am J Pathol 165:937-948.
-
(2004)
Am J Pathol
, vol.165
, pp. 937-948
-
-
Sadowski, M.1
Pankiewicz, J.2
Scholtzova, H.3
Ripellino, J.A.4
Li, Y.5
Schmidt, S.D.6
Mathews, P.M.7
Fryer, J.D.8
Holtzman, D.M.9
Sigurdsson, E.M.10
Wisniewski, T.11
-
204
-
-
22344438508
-
Tau suppression in a neurodegenerative mouse model improves memory function
-
Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M, Ashe KH (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Science 309:476-481.
-
(2005)
Science
, vol.309
, pp. 476-481
-
-
Santacruz, K.1
Lewis, J.2
Spires, T.3
Paulson, J.4
Kotilinek, L.5
Ingelsson, M.6
Guimaraes, A.7
Deture, M.8
Ramsden, M.9
McGowan, E.10
Forster, C.11
Yue, M.12
Orne, J.13
Janus, C.14
Mariash, A.15
Kuskowski, M.16
Hyman, B.17
Hutton, M.18
Ashe, K.H.19
-
205
-
-
0036830458
-
Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells
-
Sato S, Tatebayashi Y, Akagi T, Chui DH, Murayama M, Miyasaka T, Planel E, Tanemura K, Sun X, Hashikawa T, Yoshioka K, Ishiguro K, Takashima A (2002) Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells. J Biol Chem 277:42060-42065.
-
(2002)
J Biol Chem
, vol.277
, pp. 42060-42065
-
-
Sato, S.1
Tatebayashi, Y.2
Akagi, T.3
Chui, D.H.4
Murayama, M.5
Miyasaka, T.6
Planel, E.7
Tanemura, K.8
Sun, X.9
Hashikawa, T.10
Yoshioka, K.11
Ishiguro, K.12
Takashima, A.13
-
206
-
-
33746879943
-
Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation
-
Sato S, Cerny RL, Buescher JL, Ikezu T (2006) Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem 98:1573-1584.
-
(2006)
J Neurochem
, vol.98
, pp. 1573-1584
-
-
Sato, S.1
Cerny, R.L.2
Buescher, J.L.3
Ikezu, T.4
-
207
-
-
0038810288
-
Microglial apolipoprotein e and astroglial apolipoprotein J expression in vitro: Opposite effects of lipopolysaccharide
-
Saura J, Petegnief V, Wu X, Liang Y, Paul SM (2003) Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: Opposite effects of lipopolysaccharide. J Neurochem 85:1455-1467.
-
(2003)
J Neurochem
, vol.85
, pp. 1455-1467
-
-
Saura, J.1
Petegnief, V.2
Wu, X.3
Liang, Y.4
Paul, S.M.5
-
208
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2:864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
209
-
-
0030822470
-
Low education is a genuine risk factor for accelerated memory decline and dementia
-
Schmand B, Smit J, Lindeboom J, Smits C, Hooijer C, Jonker C, Deelman B (1997) Low education is a genuine risk factor for accelerated memory decline and dementia. J Clin Epidemiol 50:1025-1033.
-
(1997)
J Clin Epidemiol
, vol.50
, pp. 1025-1033
-
-
Schmand, B.1
Smit, J.2
Lindeboom, J.3
Smits, C.4
Hooijer, C.5
Jonker, C.6
Deelman, B.7
-
210
-
-
0033845932
-
Preclinical" AD revisited: Neuropathology of cognitively normal older adults
-
Schmitt FA, Davis DG, Wekstein DR, Smith CD, Ashford JW, Markesbery WR (2000) "Preclinical" AD revisited: Neuropathology of cognitively normal older adults. Neurology 55:370-376.
-
(2000)
Neurology
, vol.55
, pp. 370-376
-
-
Schmitt, F.A.1
Davis, D.G.2
Wekstein, D.R.3
Smith, C.D.4
Ashford, J.W.5
Markesbery, W.R.6
-
211
-
-
0028170818
-
Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease
-
Selkoe DJ (1994) Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu Rev Cell Biol 10:373-403.
-
(1994)
Annu Rev Cell Biol
, vol.10
, pp. 373-403
-
-
Selkoe, D.J.1
-
212
-
-
0031038918
-
Alzheimer's disease: Genotypes, phenotypes, and treatments
-
Selkoe DJ (1997) Alzheimer's disease: Genotypes, phenotypes, and treatments. Science 275:630-631.
-
(1997)
Science
, vol.275
, pp. 630-631
-
-
Selkoe, D.J.1
-
213
-
-
84879647862
-
Mechanism of Abeta production and Abeta degradation: Routes to the treatment of Alzheimer's disease
-
New York: John Wiley & Sons Ltd. Iqbal K, Sisodia SS, Winblad B, eds
-
Selkoe DJ, Xia W, Kimberly WT, Vekrellis K, Walsh D, Esler WP, Wolfe MS (2001) Mechanism of Abeta production and Abeta degradation: Routes to the treatment of Alzheimer's disease. In: Alzheimer's disease: Advances in Ethology, Pathogenesis and Therapeutics (Iqbal K, Sisodia SS, Winblad B, eds), pp 421-432. New York: John Wiley & Sons Ltd.
-
(2001)
Alzheimer's Disease: Advances in Ethology, Pathogenesis and Therapeutics
, pp. 421-432
-
-
Selkoe, D.J.1
Xia, W.2
Kimberly, W.T.3
Vekrellis, K.4
Walsh, D.5
Esler, W.P.6
Wolfe, M.S.7
-
214
-
-
33947314641
-
Natural Oligomers of the Alzheimer Amyloidß Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway
-
Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL (2007) Natural Oligomers of the Alzheimer Amyloidß Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway. J Neurosci 27:2866-2875.
-
(2007)
J Neurosci
, vol.27
, pp. 2866-2875
-
-
Shankar, G.M.1
Bloodgood, B.L.2
Townsend, M.3
Walsh, D.M.4
Selkoe, D.J.5
Sabatini, B.L.6
-
215
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
-
216
-
-
0032698746
-
Series introduction: Alzheimer's disease: Perspectives for the new millennium
-
Sisodia SS (1999) Series introduction: Alzheimer's disease: Perspectives for the new millennium. J Clin Invest 104:1169-1170.
-
(1999)
J Clin Invest
, vol.104
, pp. 1169-1170
-
-
Sisodia, S.S.1
-
217
-
-
0031981072
-
Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress
-
Smith MA, Hirai K, Hsiao K, Pappolla MA, Harris PL, Siedlak SL, Tabaton M, Perry G (1998) Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. J Neurochem 70:2212-2215.
-
(1998)
J Neurochem
, vol.70
, pp. 2212-2215
-
-
Smith, M.A.1
Hirai, K.2
Hsiao, K.3
Pappolla, M.A.4
Harris, P.L.5
Siedlak, S.L.6
Tabaton, M.7
Perry, G.8
-
218
-
-
0033551712
-
Cell cycle-related protein expression in vascular dementia and Alzheimer's disease
-
Smith MZ, Nagy Z, Esiri MM (1999) Cell cycle-related protein expression in vascular dementia and Alzheimer's disease. Neurosci Lett 271:45-48.
-
(1999)
Neurosci Lett
, vol.271
, pp. 45-48
-
-
Smith, M.Z.1
Nagy, Z.2
Esiri, M.M.3
-
219
-
-
0025242640
-
Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease
-
Sparks DL, Hunsaker JC, 3rd, Scheff SW, Kryscio RJ, Henson JL, Markesbery WR (1990) Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease. Neurobiol Aging 11:601-607.
-
(1990)
Neurobiol Aging
, vol.11
, pp. 601-607
-
-
Sparks, D.L.1
Hunsaker III, J.C.2
Scheff, S.W.3
Kryscio, R.J.4
Henson, J.L.5
Markesbery, W.R.6
-
220
-
-
26844449402
-
Transgenic models of Alzheimer's disease: Learning from animals
-
Spires TL, Hyman BT (2005) Transgenic models of Alzheimer's disease: Learning from animals. NeuroRx 2:423-437.
-
(2005)
NeuroRx
, vol.2
, pp. 423-437
-
-
Spires, T.L.1
Hyman, B.T.2
-
221
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA 94:13287-13292.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.H.4
Mistl, C.5
Rothacher, S.6
Ledermann, B.7
Burki, K.8
Frey, P.9
Paganetti, P.A.10
Waridel, C.11
Calhoun, M.E.12
Jucker, M.13
Probst, A.14
Staufenbiel, M.15
Sommer, B.16
-
222
-
-
0025077080
-
Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain
-
Styren SD, Civin WH, Rogers J (1990) Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain. Exp Neurol 110:93-104.
-
(1990)
Exp Neurol
, vol.110
, pp. 93-104
-
-
Styren, S.D.1
Civin, W.H.2
Rogers, J.3
-
223
-
-
0038115686
-
Inflammatory markers in matched plasma and cerebrospinal fluid from patients with Alzheimer's disease
-
Sun YX, Minthon L, Wallmark A, Warkentin S, Blennow K, Janciauskiene S (2003) Inflammatory markers in matched plasma and cerebrospinal fluid from patients with Alzheimer's disease. Dement Geriatr Cogn Disord 16:136-144.
-
(2003)
Dement Geriatr Cogn Disord
, vol.16
, pp. 136-144
-
-
Sun, Y.X.1
Minthon, L.2
Wallmark, A.3
Warkentin, S.4
Blennow, K.5
Janciauskiene, S.6
-
224
-
-
0027240081
-
Tau protein kinase i is essential for amyloid beta-protein-induced neurotoxicity
-
Takashima A, Noguchi K, Sato K, Hoshino T, Imahori K (1993) Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity. Proc Natl Acad Sci USA 90:7789-7793.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7789-7793
-
-
Takashima, A.1
Noguchi, K.2
Sato, K.3
Hoshino, T.4
Imahori, K.5
-
225
-
-
0031778629
-
Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain
-
Takeda A, Yasuda T, Miyata T, Goto Y, Wakai M, Watanabe M, Yasuda Y, Horie K, Inagaki T, Doyu M, Maeda K, Sobue G (1998) Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain. Acta Neuropathol (Berl) 95:555-558.
-
(1998)
Acta Neuropathol (Berl)
, vol.95
, pp. 555-558
-
-
Takeda, A.1
Yasuda, T.2
Miyata, T.3
Goto, Y.4
Wakai, M.5
Watanabe, M.6
Yasuda, Y.7
Horie, K.8
Inagaki, T.9
Doyu, M.10
Maeda, K.11
Sobue, G.12
-
226
-
-
0033579382
-
Microglial activation resulting from CD40-CD40L interaction after b-amyloid stimulation
-
Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Flavell RA, Mullan M (1999) Microglial activation resulting from CD40-CD40L interaction after b-amyloid stimulation. Science 286:2352-2355.
-
(1999)
Science
, vol.286
, pp. 2352-2355
-
-
Tan, J.1
Town, T.2
Paris, D.3
Mori, T.4
Suo, Z.5
Crawford, F.6
Mattson, M.P.7
Flavell, R.A.8
Mullan, M.9
-
227
-
-
0034711317
-
CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway
-
Tan J, Town T, Mullan M (2000a) CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway. J Biol Chem 275:37224-37231.
-
(2000)
J Biol Chem
, vol.275
, pp. 37224-37231
-
-
Tan, J.1
Town, T.2
Mullan, M.3
-
228
-
-
0034667558
-
CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase
-
Tan J, Town T, Mori T, Wu Y, Saxe M, Crawford F, Mullan M (2000b) CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase. J Neurosci 20:7587-7594.
-
(2000)
J Neurosci
, vol.20
, pp. 7587-7594
-
-
Tan, J.1
Town, T.2
Mori, T.3
Wu, Y.4
Saxe, M.5
Crawford, F.6
Mullan, M.7
-
229
-
-
0036900076
-
Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice
-
Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA, Mullan MJ (2002) Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nat Neurosci 5:1288-1293.
-
(2002)
Nat Neurosci
, vol.5
, pp. 1288-1293
-
-
Tan, J.1
Town, T.2
Crawford, F.3
Mori, T.4
Delledonne, A.5
Crescentini, R.6
Obregon, D.7
Flavell, R.A.8
Mullan, M.J.9
-
230
-
-
0036138044
-
Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau
-
Tanemura K, Murayama M, Akagi T, Hashikawa T, Tominaga T, Ichikawa M, Yamaguchi H, Takashima A (2002) Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci 22:133-141.
-
(2002)
J Neurosci
, vol.22
, pp. 133-141
-
-
Tanemura, K.1
Murayama, M.2
Akagi, T.3
Hashikawa, T.4
Tominaga, T.5
Ichikawa, M.6
Yamaguchi, H.7
Takashima, A.8
-
231
-
-
0032868874
-
Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia
-
Tarkowski E, Blennow K, Wallin A, Tarkowski A (1999) Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia. J Clin Immunol 19:223-230.
-
(1999)
J Clin Immunol
, vol.19
, pp. 223-230
-
-
Tarkowski, E.1
Blennow, K.2
Wallin, A.3
Tarkowski, A.4
-
232
-
-
33750591957
-
Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology
-
Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T (2006) Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest 116:3060-3069.
-
(2006)
J Clin Invest
, vol.116
, pp. 3060-3069
-
-
Tesseur, I.1
Zou, K.2
Esposito, L.3
Bard, F.4
Berber, E.5
Can, J.V.6
Lin, A.H.7
Crews, L.8
Tremblay, P.9
Mathews, P.10
Mucke, L.11
Masliah, E.12
Wyss-Coray, T.13
-
233
-
-
3042511847
-
Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice
-
Todd Roach J, Volmar CH, Dwivedi S, Town T, Crescentini R, Crawford F, Tan J, Mullan M (2004) Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice. Brain Res 1015:161-168.
-
(2004)
Brain Res
, vol.1015
, pp. 161-168
-
-
Todd Roach, J.1
Volmar, C.H.2
Dwivedi, S.3
Town, T.4
Crescentini, R.5
Crawford, F.6
Tan, J.7
Mullan, M.8
-
234
-
-
0034571241
-
Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases
-
Togo T, Akiyama H, Kondo H, Ikeda K, Kato M, Iseki E, Kosaka K (2000) Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases. Brain Res 885:117-121.
-
(2000)
Brain Res
, vol.885
, pp. 117-121
-
-
Togo, T.1
Akiyama, H.2
Kondo, H.3
Ikeda, K.4
Kato, M.5
Iseki, E.6
Kosaka, K.7
-
235
-
-
0027450057
-
Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies
-
van der Wal EA, Gomez-Pinilla F, Cotman CW (1993) Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies. Neuroreport 4:69-72.
-
(1993)
Neuroreport
, vol.4
, pp. 69-72
-
-
Van Der Wal, E.A.1
Gomez-Pinilla, F.2
Cotman, C.W.3
-
236
-
-
0033595706
-
Betasecretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (1999) Betasecretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
237
-
-
0034161516
-
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
-
Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ (2000) Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci 20:1657-1665.
-
(2000)
J Neurosci
, vol.20
, pp. 1657-1665
-
-
Vekrellis, K.1
Ye, Z.2
Qiu, W.Q.3
Walsh, D.4
Hartley, D.5
Chesneau, V.6
Rosner, M.R.7
Selkoe, D.J.8
-
238
-
-
33646089457
-
Gene expression changes by amyloid {beta} peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes
-
Walker DG, Link J, Lue LF, Dalsing-Hernandez JE, Boyes BE (2006) Gene expression changes by amyloid {beta} peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes. J Leukoc Biol 79:596-610.
-
(2006)
J Leukoc Biol
, vol.79
, pp. 596-610
-
-
Walker, D.G.1
Link, J.2
Lue, L.F.3
Dalsing-Hernandez, J.E.4
Boyes, B.E.5
-
239
-
-
0032969285
-
Tumor necrosis factor receptor and Fas signaling mechanisms
-
Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP (1999) Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol 17:331-367.
-
(1999)
Annu Rev Immunol
, vol.17
, pp. 331-367
-
-
Wallach, D.1
Varfolomeev, E.E.2
Malinin, N.L.3
Goltsev, Y.V.4
Kovalenko, A.V.5
Boldin, M.P.6
-
240
-
-
0030799122
-
Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate
-
Walsh DM, Lomakin A, Benedek GB, Condron MM, Teplow DB (1997) Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. J Biol Chem 272:22364-22372.
-
(1997)
J Biol Chem
, vol.272
, pp. 22364-22372
-
-
Walsh, D.M.1
Lomakin, A.2
Benedek, G.B.3
Condron, M.M.4
Teplow, D.B.5
-
241
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-539.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
242
-
-
3042798841
-
Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide
-
Wang Q, Rowan MJ, Anwyl R (2004a) Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide. J Neurosci 24:6049-6056.
-
(2004)
J Neurosci
, vol.24
, pp. 6049-6056
-
-
Wang, Q.1
Rowan, M.J.2
Anwyl, R.3
-
243
-
-
1842610852
-
Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5
-
Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R (2004b) Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. J Neurosci 24:3370-3378.
-
(2004)
J Neurosci
, vol.24
, pp. 3370-3378
-
-
Wang, Q.1
Walsh, D.M.2
Rowan, M.J.3
Selkoe, D.J.4
Anwyl, R.5
-
244
-
-
0034050540
-
Complement component C1q modulates the phagocytosis of Abeta by microglia
-
Webster SD, Yang AJ, Margol L, Garzon-Rodriguez W, Glabe CG, Tenner AJ (2000) Complement component C1q modulates the phagocytosis of Abeta by microglia. Exp Neurol 161:127-138.
-
(2000)
Exp Neurol
, vol.161
, pp. 127-138
-
-
Webster, S.D.1
Yang, A.J.2
Margol, L.3
Garzon-Rodriguez, W.4
Glabe, C.G.5
Tenner, A.J.6
-
245
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
-
Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH (2001) A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414:212-216.
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
Findlay, K.A.7
Smith, T.E.8
Murphy, M.P.9
Bulter, T.10
Kang, D.E.11
Marquez-Sterling, N.12
Golde, T.E.13
Koo, E.H.14
-
246
-
-
33745860362
-
Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity. A quantitative study
-
White AR, Du T, Laughton KM, Volitakis I, Sharples RA, Hoke DE, Holsinger RM, Evin G, Cherny RA, Hill AF, Barnham KJ, Li QX, Bush AI, Masters CL (2006) Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity. A quantitative study. J Biol Chem 281(26):17670-17680.
-
(2006)
J Biol Chem
, vol.281
, Issue.26
, pp. 17670-17680
-
-
White, A.R.1
Du, T.2
Laughton, K.M.3
Volitakis, I.4
Sharples, R.A.5
Hoke, D.E.6
Holsinger, R.M.7
Evin, G.8
Cherny, R.A.9
Hill, A.F.10
Barnham, K.J.11
Li, Q.X.12
Bush, A.I.13
Masters, C.L.14
-
247
-
-
0019935804
-
Plaques, tangles and dementia
-
Wilcock GK, Esiri MM (1982) Plaques, tangles and dementia. J Neurol Sci 56:343-356.
-
(1982)
J Neurol Sci
, vol.56
, pp. 343-356
-
-
Wilcock, G.K.1
Esiri, M.M.2
-
248
-
-
33746377015
-
Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia
-
Wilkinson B, Koenigsknecht-Talboo J, Grommes C, Lee CY, Landreth G (2006) Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia. J Biol Chem 281:20842-20850.
-
(2006)
J Biol Chem
, vol.281
, pp. 20842-20850
-
-
Wilkinson, B.1
Koenigsknecht-Talboo, J.2
Grommes, C.3
Lee, C.Y.4
Landreth, G.5
-
249
-
-
7244234177
-
Beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice
-
Willem M, Dewachter I, Smyth N, Van Dooren T, Borghgraef P, Haass C, Van Leuven F (2004) beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice. Am J Pathol 165:1621-1631.
-
(2004)
Am J Pathol
, vol.165
, pp. 1621-1631
-
-
Willem, M.1
Dewachter, I.2
Smyth, N.3
Van Dooren, T.4
Borghgraef, P.5
Haass, C.6
Van Leuven, F.7
-
250
-
-
23944449575
-
Protection of human cerebral neurons from neurodegenerative insults by gene delivery of soluble tumor necrosis factor p75 receptor
-
Williams MA, Turchan J, Lu Y, Nath A, Drachman DB (2005) Protection of human cerebral neurons from neurodegenerative insults by gene delivery of soluble tumor necrosis factor p75 receptor. Exp Brain Res 165:383-391.
-
(2005)
Exp Brain Res
, vol.165
, pp. 383-391
-
-
Williams, M.A.1
Turchan, J.2
Lu, Y.3
Nath, A.4
Drachman, D.B.5
-
251
-
-
0036685522
-
Inflammation in neurodegenerative disease-A double-edged sword
-
Wyss-Coray T, Mucke L (2002) Inflammation in neurodegenerative disease-A double-edged sword. Neuron 35:419-432.
-
(2002)
Neuron
, vol.35
, pp. 419-432
-
-
Wyss-Coray, T.1
Mucke, L.2
-
252
-
-
0030764732
-
Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease
-
Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Lin C, Mucke L (1997) Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature 389:603-606.
-
(1997)
Nature
, vol.389
, pp. 603-606
-
-
Wyss-Coray, T.1
Masliah, E.2
Mallory, M.3
McConlogue, L.4
Johnson-Wood, K.5
Lin, C.6
Mucke, L.7
-
253
-
-
0034103604
-
Alzheimer's disease-like cerebrovascular pathology in transforming growth factor-beta 1 transgenic mice and functional metabolic correlates
-
Wyss-Coray T, Lin C, von Euw D, Masliah E, Mucke L, Lacombe P (2000) Alzheimer's disease-like cerebrovascular pathology in transforming growth factor-beta 1 transgenic mice and functional metabolic correlates. Ann N Y Acad Sci 903:317-323.
-
(2000)
Ann N y Acad Sci
, vol.903
, pp. 317-323
-
-
Wyss-Coray, T.1
Lin, C.2
Von Euw, D.3
Masliah, E.4
Mucke, L.5
Lacombe, P.6
-
254
-
-
0034744296
-
TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice
-
Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L (2001) TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat Med 7:612-618.
-
(2001)
Nat Med
, vol.7
, pp. 612-618
-
-
Wyss-Coray, T.1
Lin, C.2
Yan, F.3
Yu, G.Q.4
Rohde, M.5
McConlogue, L.6
Masliah, E.7
Mucke, L.8
-
255
-
-
0036679142
-
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice
-
Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, Masliah E (2002) Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc Natl Acad Sci USA 99:10837-10842.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10837-10842
-
-
Wyss-Coray, T.1
Yan, F.2
Lin, A.H.3
Lambris, J.D.4
Alexander, J.J.5
Quigg, R.J.6
Masliah, E.7
-
256
-
-
0037394788
-
Adult mouse astrocytes degrade amyloid-beta in vitro and in situ
-
Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, Silverstein SC, Husemann J (2003) Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat Med 9:453-457.
-
(2003)
Nat Med
, vol.9
, pp. 453-457
-
-
Wyss-Coray, T.1
Loike, J.D.2
Brionne, T.C.3
Lu, E.4
Anankov, R.5
Yan, F.6
Silverstein, S.C.7
Husemann, J.8
-
257
-
-
0030951449
-
Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease
-
Xia M, Qin S, McNamara M, Mackay C, Hyman BT (1997) Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease. Am J Pathol 150:1267-1274.
-
(1997)
Am J Pathol
, vol.150
, pp. 1267-1274
-
-
Xia, M.1
Qin, S.2
McNamara, M.3
Mackay, C.4
Hyman, B.T.5
-
258
-
-
0032917904
-
Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease
-
Xia MQ, Hyman BT (1999) Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. J Neurovirol 5:32-41.
-
(1999)
J Neurovirol
, vol.5
, pp. 32-41
-
-
Xia, M.Q.1
Hyman, B.T.2
-
259
-
-
0031848322
-
Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains
-
Xia MQ, Qin SX, Wu LJ, Mackay CR, Hyman BT (1998) Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am J Pathol 153:31-37.
-
(1998)
Am J Pathol
, vol.153
, pp. 31-37
-
-
Xia, M.Q.1
Qin, S.X.2
Wu, L.J.3
Mackay, C.R.4
Hyman, B.T.5
-
260
-
-
0034256053
-
Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: In vitro ERK1/2 activation and role in Alzheimer's disease
-
Xia MQ, Bacskai BJ, Knowles RB, Qin SX, Hyman BT (2000) Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: In vitro ERK1/2 activation and role in Alzheimer's disease. J Neuroimmunol 108:227-235.
-
(2000)
J Neuroimmunol
, vol.108
, pp. 227-235
-
-
Xia, M.Q.1
Bacskai, B.J.2
Knowles, R.B.3
Qin, S.X.4
Hyman, B.T.5
-
261
-
-
33646911081
-
Profile and regulation of apolipoprotein e (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus
-
Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW, Huang Y (2006) Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. J Neurosci 26:4985-4994.
-
(2006)
J Neurosci
, vol.26
, pp. 4985-4994
-
-
Xu, Q.1
Bernardo, A.2
Walker, D.3
Kanegawa, T.4
Mahley, R.W.5
Huang, Y.6
-
262
-
-
17844375420
-
Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition
-
Yamamoto M, Horiba M, Buescher JL, Huang D, Gendelman HE, Ransohoff RM, Ikezu T (2005) Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. Am J Pathol 166:1475-1485.
-
(2005)
Am J Pathol
, vol.166
, pp. 1475-1485
-
-
Yamamoto, M.1
Horiba, M.2
Buescher, J.L.3
Huang, D.4
Gendelman, H.E.5
Ransohoff, R.M.6
Ikezu, T.7
-
263
-
-
34247512968
-
Kinetic analysis of aggregated amyloid-peptide clearance in adult bone-marrowderived macrophages from APP and CCL2 transgenic mice
-
Yamamoto M, Kiyota T, Walsh SM, Ikezu T (2007a) Kinetic analysis of aggregated amyloid-peptide clearance in adult bone-marrowderived macrophages from APP and CCL2 transgenic mice. J Neuroimmune Pharm 2:213-227.
-
(2007)
J Neuroimmune Pharm
, vol.2
, pp. 213-227
-
-
Yamamoto, M.1
Kiyota, T.2
Walsh, S.M.3
Ikezu, T.4
-
264
-
-
33947512432
-
Interferon-{gamma} and Tumor Necrosis Factor-{alpha} Regulate Amyloid-{beta} Plaque Deposition and {beta}-Secretase Expression in Swedish Mutant APP Transgenic Mice
-
Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T (2007b) Interferon-{gamma} and Tumor Necrosis Factor-{alpha} Regulate Amyloid-{beta} Plaque Deposition and {beta}-Secretase Expression in Swedish Mutant APP Transgenic Mice. Am J Pathol 170:680-692.
-
(2007)
Am J Pathol
, vol.170
, pp. 680-692
-
-
Yamamoto, M.1
Kiyota, T.2
Horiba, M.3
Buescher, J.L.4
Walsh, S.M.5
Gendelman, H.E.6
Ikezu, T.7
-
265
-
-
0033603328
-
Metalloendopeptidase EC 3. 4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation
-
Yamin R, Malgeri EG, Sloane JA, McGraw WT, Abraham CR (1999) Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation. J Biol Chem 274:18777-18784.
-
(1999)
J Biol Chem
, vol.274
, pp. 18777-18784
-
-
Yamin, R.1
Malgeri, E.G.2
Sloane, J.A.3
McGraw, W.T.4
Abraham, C.R.5
-
266
-
-
0041921071
-
Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease
-
Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G (2003) Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. J Neurosci 23:7504-7509.
-
(2003)
J Neurosci
, vol.23
, pp. 7504-7509
-
-
Yan, Q.1
Zhang, J.2
Liu, H.3
Babu-Khan, S.4
Vassar, R.5
Biere, A.L.6
Citron, M.7
Landreth, G.8
-
267
-
-
0013615899
-
RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
-
Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM (1996) RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature 382:685-691.
-
(1996)
Nature
, vol.382
, pp. 685-691
-
-
Yan, S.D.1
Chen, X.2
Fu, J.3
Chen, M.4
Zhu, H.5
Roher, A.6
Slattery, T.7
Zhao, L.8
Nagashima, M.9
Morser, J.10
Migheli, A.11
Nawroth, P.12
Stern, D.13
Schmidt, A.M.14
-
268
-
-
20044370990
-
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
-
Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM (2005) Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 280:5892-5901.
-
(2005)
J Biol Chem
, vol.280
, pp. 5892-5901
-
-
Yang, F.1
Lim, G.P.2
Begum, A.N.3
Ubeda, O.J.4
Simmons, M.R.5
Ambegaokar, S.S.6
Chen, P.P.7
Kayed, R.8
Glabe, C.G.9
Frautschy, S.A.10
Cole, G.M.11
-
269
-
-
0033950591
-
Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain
-
Yoshiyama Y, Asahina M, Hattori T (2000) Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain. Acta Neuropathol (Berl) 99:91-95.
-
(2000)
Acta Neuropathol (Berl)
, vol.99
, pp. 91-95
-
-
Yoshiyama, Y.1
Asahina, M.2
Hattori, T.3
-
270
-
-
0028848472
-
Role of interferon-gamma in immune cell regulation
-
Young H, Hardy K (1995) Role of interferon-gamma in immune cell regulation. J Leukoc Biol 58:373-381.
-
(1995)
J Leukoc Biol
, vol.58
, pp. 373-381
-
-
Young, H.1
Hardy, K.2
-
271
-
-
0025306076
-
The prevalence of dementia and Alzheimer's disease in Shanghai, China: Impact of age, gender, and education
-
Zhang MY, Katzman R, Salmon D, Jin H, Cai GJ, Wang ZY, Qu GY, Grant I, Yu E, Levy P, et al. (1990) The prevalence of dementia and Alzheimer's disease in Shanghai, China: Impact of age, gender, and education. Ann Neurol 27:428-437.
-
(1990)
Ann Neurol
, vol.27
, pp. 428-437
-
-
Zhang, M.Y.1
Katzman, R.2
Salmon, D.3
Jin, H.4
Cai, G.J.5
Wang, Z.Y.6
Qu, G.Y.7
Grant, I.8
Yu, E.9
Levy, P.10
-
272
-
-
0242414463
-
Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho
-
Zhou Y, Su Y, Li B, Liu F, Ryder JW, Wu X, Gonzalez-DeWhitt PA, Gelfanova V, Hale JE, May PC, Paul SM, Ni B (2003) Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. Science 302:1215-1217.
-
(2003)
Science
, vol.302
, pp. 1215-1217
-
-
Zhou, Y.1
Su, Y.2
Li, B.3
Liu, F.4
Ryder, J.W.5
Wu, X.6
Gonzalez-Dewhitt, P.A.7
Gelfanova, V.8
Hale, J.E.9
May, P.C.10
Paul, S.M.11
Ni, B.12
-
273
-
-
0034144269
-
Chemokines: A new classification system and their role in immunity
-
Zlotnik A, Yoshie O (2000) Chemokines: A new classification system and their role in immunity. Immunity 12:121-127.
-
(2000)
Immunity
, vol.12
, pp. 121-127
-
-
Zlotnik, A.1
Yoshie, O.2
|