Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 50, 2008, Pages 19962-19967

  Chen, Suzhen ^a   Charness, Michael E ^a  

^a NONE

Author keywords

Cerebellum; Crk associated substrate; Fetal alcohol spectrum disorders; Fyn kinase

Indexed keywords

ACTIVITY DEPENDENT NEUROPROTECTIVE PROTEIN; ALCOHOL; ASPARAGINYLALANYLPROLYLVALYLSERYLISOLEUCYLPROLYLGLUTAMINE; BRAIN PROTEIN; CRK ASSOCIATED SUBSTRATE PROTEIN; OCTAPEPTIDE; PROTEIN KINASE FYN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ADNP PROTEIN, RAT; FYN PROTEIN, RAT; HOMEODOMAIN PROTEIN; NERVE PROTEIN;

ANIMAL CELL; ARTICLE; CELL INTERACTION; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; DRINKING BEHAVIOR; GLIA CELL; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENE SILENCING; GENETICS; METABOLISM; NERVE FIBER; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; AXONS; CELL DIFFERENTIATION; CELLS, CULTURED; CEREBELLUM; CRK-ASSOCIATED SUBSTRATE PROTEIN; ETHANOL; GENE KNOCKDOWN TECHNIQUES; HOMEODOMAIN PROTEINS; NERVE TISSUE PROTEINS; NEURONS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-FYN; RATS; SIGNAL TRANSDUCTION;

EID: 58149384440     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0807758105     Document Type: Article

References (37)

1. Sowell ER, et al. (1996) Abnormal development of the cerebellar vermis in children prenatally exposed to alcohol: Size reduction in lobules I-V. Alcohol Clin Exp Res 20:31-34.
2. Riley EP, McGee CL, Sowell ER (2004) Teratogenic effects of alcohol: A decade of brain imaging. Am J Med Genet 127C:35-41.
3. Miller MW (1996) Mechanisms of ethanol induced neuronal death during development: From the molecule to behavior. Alcohol Clin Exp Res 20:128A-132A.
4. Goodlett CR, Horn KH, Zhou FC (2005) Alcohol teratogenesis: Mechanisms of damage and strategies for intervention. Exp Biol Med 230:394-406.
5. Olney JW (2004) Fetal alcohol syndrome at the cellular level. Addict Biol 9:137-149 and discussion 151.
6. Conforti L, Adalbert R, Coleman MP (2007) Neuronal death: Where does the end begin? Trends Neurosci 30:159-166.
7. Dow KE, Riopelle RJ (1985) Ethanol neurotoxicity: Effects on neurite formation and neurotrophic factor production in vitro. Science 228:591-593.
8. Bouquet C, Nothias F (2007) Molecular mechanisms of axonal growth. Adv Exp Med Biol 621:1-16.
9. Bassan M, et al. (1999) Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. J Neurochem 72:1283-1293.
10. Pinhasov A, et al. (2003) Activity-dependent neuroprotective protein: A novel gene essential for brain formation. Brain Res Dev Brain Res 144:83-90.
11. Gozes I (2007) Activity-dependent neuroprotective protein: From gene to drug candidate. Pharmacol Ther 114:146-154.
12. Charness ME, Simon RP, Greenberg DA (1989) Ethanol and the nervous system. N Engl J Med 321:442-454.
13. Spong CY, Abebe DT, Gozes I, Brenneman DE, Hill JM (2001) Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome. J Pharmacol Exp Ther 297:774-779.
14. Pascual M, Guerri C (2007) The peptide NAP promotes neuronal growth and differentiation through extracellular signal-regulated protein kinase and Akt pathways and protects neurons cocultured with astrocytes damaged by ethanol. J Neurochem 103:567-568.
15. Binder LI, Frankfurter A, Rebhun LI (1985) The distribution of tau in the mammalian central nervous system. J Cell Biol 101:1371-1378.
16. Loers G, Chen S, Grumet M, Schachner M (2005) Signal transduction pathways implicated in neural recognition molecule L1 triggered neuroprotection and neuritogenesis. J Neurochem 92:1463-1476.
17. Hanke JH, et al. (1996) Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem 271:695-701.
18. Liu G, et al. (2004) Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat Neurosci 7:1222-1232.
19. Huang J, Sakai R, Furuichi T (2006) The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons. Mol Biol Cell 17:3187-3196.
20. Gennet N, Herden C, Bubb VJ, Quinn JP, Kipar A (2008) Expression of activity-dependent neuroprotective protein in the brain of adult rats. Histol Histopathol 23:309-317.
21. Zamostiano R, et al. (2001) Cloning and characterization of the human activity-dependent neuroprotective protein. J Biol Chem 276:708-714.
22. Lagreze WA, et al. (2005) The peptides ADNF-9 and NAP increase survival and neurite outgrowth of rat retinal ganglion cells in vitro. Invest Ophthalmol Visual Sci 46:93393-93398.
23. Smith-Swintosky VL, Gozes I, Brenneman DE, D'Andrea MR, Plata-Salaman CR (2005) Activity-dependent neurotrophic factor-9 and NAP promote neurite outgrowth in rat hippocampal and cortical cultures. J Mol Neurosci 25:225-238.
24. Visochek L, et al. (2005) PolyADP-ribosylation is involved in neurotrophic activity. J Neurosci 25:7420-7428.
25. Divinski I, Mittelman L, Gozes I (2004) A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication. J Biol Chem 279:28531-28538.
26. Santuccione A, Sytnyk V, Leshchyns'ka I, Schachner M (2005) Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth. J Cell Biol 169:341-354.
27. Chen S, Mange A, Dong L, Lehmann S, Schachner M (2003) Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival. Mol Cell Neurosci 22:227-233.
28. Beggs HE, Soriano P, Maness PF (1994) NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice. J Cell Biol 127:825-833.
29. Meriane M, et al. (2004) Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance. J Cell Biol 167:687-698.
30. Morita A, et al. (2006) Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling. J Neurosci 26:2971-2980.
31. Defilippi P, Di Stefano P, Cabodi S (2006) p130Cas: A versatile scaffold in signaling networks. Trends Cell Biol 16:257-263.
32. Liu G, et al. (2007) p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci 27:957-968.
33. Wilkemeyer MF, et al. (2003) Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity. Proc Natl Acad Sci USA 100:8543-8548.
34. Wilkemeyer MF, Menkari CE, Spong CY, Charness ME (2002) Peptide antagonists of ethanol inhibition of l1-mediated cell- cell adhesion. J Pharmacol Exp Ther 303:110-116.
35. Chen S, Mantei N, Dong L, Schachner M (1999) Prevention of neuronal cell death by neural adhesion molecules L1 and CHL1. J Neurobiol 38:428-439.
36. Dityateva G, et al. (2003) Rapid and efficient electroporation-based gene transfer into primary dissociated neurons. J Neurosci Methods 130:65-73.
37. Kovacs G, et al. (2004) NR2B containing NMDA receptor-dependent windup of single spinal neurons. Neuropharmacology 46:23-30.