The 21st century hepatologist and a systems biology based approach to liver diseases

Hepatology

Volumn 48, Issue 6, 2008, Pages 1731-1733

  Mishra, Lopa ^a,b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA 1 ANTITRYPSIN; CALCIUM; HEPATITIS B VACCINE; HEPCIDIN; HFE PROTEIN; INTERFERON; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 4; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; VITAMIN D; WNT PROTEIN;

ALZHEIMER DISEASE; AMINOTRANSFERASE BLOOD LEVEL; CANCER RISK; COLORECTAL CARCINOMA; DIABETES MELLITUS; DISEASE EXACERBATION; DISEASE SURVEILLANCE; EPIGASTRIC PAIN; EPIGENETICS; GENE ACTIVATION; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENE SEQUENCE; GENE SILENCING; GENOTYPE; GLYCOGEN STORAGE DISEASE; HEPATITIS; HISTORY OF MEDICINE; HUMAN; HYSTERECTOMY; LIVER DISEASE; MEDICAL SPECIALIST; NOTE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SCREENING TEST; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH FUNDUS; SYSTEMS BIOLOGY; TREATMENT PLANNING; TUMOR SUPPRESSOR GENE; ARTICLE; GASTROENTEROLOGY; GENETICS; LIVER TUMOR; RISK FACTOR;

GASTROENTEROLOGY; HUMANS; LIVER DISEASES; LIVER NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SYSTEMS BIOLOGY;

EID: 58149382654     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22625     Document Type: Note

References (15)

1. Williams CS, Smalley W, DuBois RN. Aspirin use and potential mechanisms for colorectal cancer prevention. J Clin Invest 1997;100:1325-1329.
2. Laferla G, Kaye SB, Crean GP. Hepatocellular and gastric carcinoma associated with familial polyposis coli. J Surg Oncol 1988;38:19-21.
3. Tang Y, Kitisin K, Jogunoori W, Li C, Deng CX, Mueller SC, et al. Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci U S A 2008;105:2445-2450.
4. Byers S, Shah S. Vitamin D and the regulation of Wnt/beta-catenin signaling and innate immunity in colorectal cancer. Nutr Rev 2007;65:S118-S120.
5. Shah S, Islam MN, Dakshanamurthy S, Rizvi I, Rao M, Herrell R, et al. The molecular basis of vitamin D receptor and beta-catenin crossregulation. Mol Cell 2006;21:799-809.
6. Chin L, Gray JW. Translating insights from the cancer genome into clinical practice. Nature 2008;452:553-563.
7. Chen S, Wang W, Lee S, Nafa K, Lee J, Romans K, et al. Colon Cancer Family Registry. Prediction of germline mutations and cancer risk in the Lynch syndrome. JAMA 2006;296:1479-1487.
8. Schuppan D, Jia J, Brinkhaus B, Hahn E. Herbal products for liver diseases: a therapeutic challenge for the new millennium. HEPATOLOGY 1999; 30:1099-1104.
9. Bell J. Predicting disease using genomics. Nature 2004;429:453-456.
10. Feder J, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy D, Basava A, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996;13:399-408.
11. Taddei T, Mistry P, Schilsky ML. Inherited metabolic disease of the liver. Curr Opin Gastroenterol 2008;24:278-286.
12. Alissa FT, Jaffe R, Shneider BL. Update on progressive familial intrahepatic cholestasis. J Pediatr Gastroenterol Nutr 2008;46:241-252.
13. Zapater P, Moreu R, Horga JF. The diagnosis of drug-induced liver disease. Curr Clin Pharmacol 2006;1:207-217.
14. Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science 2005;310:68-71.
15. Lee I, Lehner B, Crombie C, Fraser A, Marcotte E, Wong W. A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans. Nat Genet 2008;40:181-188.