Sub-acute occupational hypersensitivity pneumonitis due to low-level exposure to diisocyanates in a secretary

European Respiratory Journal

Volumn 32, Issue 3, 2008, Pages 807-811

  Schreiber, J ^a   Knolle, J ^b   Sennekamp, J ^c   Schulz, K T ^a   Hahn, J U ^d   Hering, K G ^e   Raulf Heimsoth, M ^f   Merget, R ^f  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b DESSAU MEDICAL CENTER   (Germany)

^c Institute of Lung Diseases and Allergy   (Germany)

^d INSTITUT FÜR ARBEITSSCHUTZ DER DEUTSCHEN GESETZLICHEN UNFALLVERSICHERUNG IFA   (Germany)

^e Knappschaftskrankenhaus ^*  (Germany)

^f INSTITUT DER RUHR UNIVERSITÄT BOCHUM IPA   (Germany)

Author keywords

Diisocyanates; Hypersensitivity pneumonitis; Occupational exposure

Indexed keywords

4,4 METHYLENEDIPHENYL DIISOCYANATE; ISOCYANIC ACID DERIVATIVE; PREDNISOLONE; UNCLASSIFIED DRUG; PAINT;

ADULT; ALLERGIC PNEUMONITIS; ANAMNESIS; ARTICLE; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DRUG DOSE REDUCTION; FEMALE; HUMAN; HUMAN TISSUE; LUNG BIOPSY; LUNG LAVAGE; OCCUPATIONAL DISEASE; PRIORITY JOURNAL; TREATMENT OUTCOME; EXPOSURE; MAXIMUM ALLOWABLE CONCENTRATION; MIDDLE AGED; OCCUPATIONAL EXPOSURE;

ALVEOLITIS, EXTRINSIC ALLERGIC; FEMALE; HUMANS; INHALATION EXPOSURE; ISOCYANATES; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PAINT; THRESHOLD LIMIT VALUES;

EID: 58149382507     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00060507     Document Type: Article

References (20)

1. Bakke JE, Olof Norén J, Thorud S, Aasen TB, eds, International Consensus Report on: Isocyanates - Risk assessment and management. November 20-22, 2001, Furnes, Norway. www.arbeidstilsynet.no/binfil/download.php? tid527871 Date last accessed: June 22, 2008.
2. Baur X. Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates. J Allergy Clin Immunol 1995; 95: 1004-1010.
3. Vandenplas O, Malo JL, Dugas M, et al. Hypersensitivity pneumonitis-like pneumonitis reaction among workers exposed to diphenylmethane [correction to pipheylmethane] diisocyanate (MDI). Am Rev Respir Dis 1993; 147: 338-346.
4. Bernstein DI, Korbee L, Stauder T, et al. The low prevalence of occupational asthma and antibody-dependent sensitization to diphenylmethane diisocyanate in a plant engineered for minimal exposure to diisocyanates. J Allergy Clin Immunol 1993; 92: 387-396.
5. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardisation of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Repir J 1993; 6: Suppl. 16, 5-40.
6. Hahn JU, Assenmacher-Maiworm H. Isocyanates. In: BG Institute for Occupational Safety and Health, ed. BGIA-Arbeitsmappe - Messung von Gefahrstoffen. [BGIA workbook measurements of hazardous substances.] Erich Schmidt, Berlin, 1989; Suppl. 47, 7670.
7. Tiesler A, Eben A. Hexamethylene diisocyanate (HDI), 2,4-and 2,6-Toluylene diisocyanate (TDI; toluene-2,4- and 2,6-diisocyanate). In: Deutsche Forschungsgemeinschaft Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, ed. Analyses of Hazardous Substances in Air. Volume 1. New York, Wiley and Sons, 1991; pp. 67-83.
8. Yoshizawa Y, Ohtani Y, Hayakawa H, Sato A, Suga M, Ando M. Chronic hypersensitivity pneumonitis in Japan: a nationwide epidemiologic survey. J Allergy Clin Immunol 1999; 103: 315-320.
9. Charles J, Bernstein A, Jones B, et al. Hypersensitivity pneumonitis after exposure to isocyanates. Thorax 1976; 31: 127-136.
10. Zacharisen MC, Schlueter DP, Kurup VP, Fink JN. The long-term outcome in acute, subacute, and chronic forms of pigeon breeder's disease hypersensitivity pneumonitis. Ann Allergy Asthma Immunol 2002; 88: 175-182.
11. Akimoto T, Tamura N, Uchida K, Dambara T, Nukiwa T, Kira S. [A case of hypersensitivity pneumonitis due to isocyanate exposure showing progression even two months after removal of the antigen.]. Nihon Kyobu Shikkan Gakkai Zasshi 1992; 30: 458-463.
12. Grammer LC, Harris KE, Malo JL, Cartier A, Patterson R. The use of an immunoassay index for antibodies against isocyanate human protein conjugates and application to human isocyanate disease. J Allergy Clin Immunol 1990; 86: 94-98.
13. Baur X. Immunologic cross-reactivity between different albumin-bound isocyanates. J Allergy Clin Immunol 1983; 71: 197-205.
14. Innocenti A, Cirla AM, Pisati G, Mariano A. Cross reactions between aromatic isocyanates (TDI and MDI): a specific bronchial provocation test study. Clin Allergy 1988; 18: 323-329.
15. Suzuki N, Matsuzaki G, Arai Y, et al. [A case of hypersensitivity pneumonitis in which serum specific antibodies for three species of isocyanate molecules were demonstrated.]. Nihon Kyobu Shikkan Gakkai Zasshi 1992; 30: 478-484.
16. Aul DJ, Bhaumik A, Kennedy AL, Brown WE, Lesage J, Malo JL. Specific IgG response to monomeric and polymeric diphenylmethane diisocyanate conjugates in subjects with respiratory reactions to isocyanates. J Allergy Clin Immunol 1999; 103: 749-755.
17. Baur X, Chen Z, Flagge A, Posch A, Raulf-Heimsoth M. EAST and CAP specificity for the evaluation of IgE and IgG antibodies to diisocyanate-HSA conjugates. Int Arch Allergy Immunol 1996; 110: 332-338.
18. Pronk A, Tielemans E, Skarping G, et al. Inhalation exposure to isocyanates of car body repair shop workers and industrial spray painters. Ann Occup Hyg 2006; 50: 1-14.
19. Health and Safety Executive, EDS. Isocyanates: Health Hazards and Precautionary Measures. Guidance Note EH 16. Suffolk, HSE Books, 1999.
20. Sennekamp J, ed, Extrinsic Allergic Alveolitis. Hypersensitivity Pneumonitis. Munich, Orlando, Dustri Verlag, 2004.