Do human {gamma}{delta} T cells respond to M tuberculosis protein antigens?

Blood

Volumn 112, Issue 12, 2008, Pages 4776-4777

  Casetti, Rita ^a   Martino, Angelo ^b   Sacchi, Alessandra ^b   Agrati, Chiara ^b   Goletti, Delia ^b   Martini, Federico ^b  

^a NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALKYL AMINE; AMINE; AMINOBISPHOSPHONATE; ANTIGEN; APOLIPOPROTEIN A; BISPHOSPHONIC ACID DERIVATIVE; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; HYDROXYMETHYLBUTYL PYROPHOSPHATE; ISOPENTENYL DIPHOSPHATE; ISOPRENOID; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEVALONIC ACID; MYCOBACTERIUM ANTIGEN; NONPETIDIC PHOSPHOANTIGEN; PYROPHOSPHORIC ACID DERIVATIVE; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; ESAT 6 ANTIGEN, MYCOBACTERIUM LEPRAE; ESAT-6 ANTIGEN, MYCOBACTERIUM LEPRAE; LYMPHOCYTE ANTIGEN RECEPTOR; MYCOBACTERIUM TUBERCULOSIS ANTIGENS;

CELL ACTIVATION; CELL PROLIFERATION; CROSS LINKING; CYTOKINE PRODUCTION; HUMAN; IMMUNE RESPONSE; IN VITRO STUDY; INFECTION; LETTER; MAMMAL; MITOCHONDRION; MOLECULAR RECOGNITION; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; REGULATORY MECHANISM; T LYMPHOCYTE; TUBERCULOSIS; CD4+ T LYMPHOCYTE; DRUG EFFECT; IMMUNOLOGY; LUNG TUBERCULOSIS; LYMPHOCYTE ACTIVATION; METABOLISM; NOTE;

ANTIGENS, BACTERIAL; CD4-POSITIVE T-LYMPHOCYTES; HUMANS; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; TUBERCULOSIS, PULMONARY;

EID: 58149380843     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-07-167619     Document Type: Letter

References (9)

1. Li L, Wu CY. CD4+ CD25+ Treg cells inhibit human memory gammadelta T cells to produce IFN-gamma in response to M tuberculosis antigen ESAT-6. Blood. 2008;111:5629-5636.
2. Hayday AC. [gamma][delta] cells: a right time and a right place for a conserved third way of protection. Annu Rev Immunol. 2000;18:975-1026.
3. Chien YH, Konigshofer Y Antigen recognition by gammadeltaT cells. Immunol Rev. 2007;215:46-58.
4. Morita CT, Jin C, Sarikonda G, Wang H. Nonpeptide antigens, presentation mechanisms, and immunologic memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol Rev. 2007;215:59-76.
5. Gober HJ, Kistowska M, Angman L, et al. Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. J Exp Med. 2003;197:163-168.
6. Kabelitz D. Small molecules for the activation of human gammadelta T cell responses against infection. Recent Patents Anti-Infect Drug Disc. 2008;3:1-9.
7. Scotet E, Martinez LO, Grant E, et al. Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I. Immunity. 2005;22:71-80.
8. Russano AM, Bassotti G, Agea E, et al. CD1-restricted recognition of exogenous and self-lipid antigens by duodenal gammadelta+ T lymphocytes. J Immunol. 2007;178:3620-3626.
9. Goletti D, Butera O, Bizzoni F, et al. Region of difference 1 antigen-specific CD4+ memory T cells correlate with a favorable outcome of tuberculosis. J Infect Dis. 2006;194:984-992.