A functional genomics approach to identify and characterize oxidation resistance genes

Methods in Molecular Biology

Volumn 477, Issue , 2008, Pages 331-342

  Volkert, Michael R ^a   Wang, Jen Yeu ^b   Elliott, Nathan A ^c  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^c NANOSTRING TECHNOLOGIES   (United States)

Author keywords

8 oxoguanine; DNA repair; Fluorescence microscopy; Functional gene cloning; Mitochondrial localization; Mutagenesis; Oxidative DNA damage

Indexed keywords

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

COMPLEMENTARY DNA; HYDROGEN PEROXIDE; ORGANIC COMPOUND; OXR1 PROTEIN, HUMAN; PROTEIN; REACTIVE OXYGEN METABOLITE; RED DYE CMXROS; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENE; GENETICS; GENOMICS; HELA CELL; HUMAN; METABOLISM; METHODOLOGY; MITOCHONDRION; MUTAGENESIS; MUTATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; STAINING;

BIOLOGICAL ASSAY; DNA, COMPLEMENTARY; FLUORESCENT ANTIBODY TECHNIQUE; GENES; GENOMICS; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; MITOCHONDRIA; MUTAGENESIS; MUTATION; ORGANIC CHEMICALS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEINS; REACTIVE OXYGEN SPECIES; STAINING AND LABELING;

EID: 58149376845     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60327-517-0_25     Document Type: Article

References (11)

1. Wyrzykowski, J., Volkert, M. R. (2003) The Escherichia coli methyl-directed mismatch repair system repairs base pairs containing oxidative lesions. J. Bacteriol. 185, 1701-1704.
2. Tchou, J., Kasai, H., Shibutani, S., Chung, M., Laval, J., Grollman, A. P., et al. (1991) 8-oxoguanine (8-hydroxyguanine) DNA glyxosylase and its substrate specificity. Proc. Natl. Acad. Sci. USA 88, 4690-4694.
3. Au, K. G., Cabrera, M., Miller, J. H., Modrich, P. (1988) Escherichia coli mutY gene product is required for specific AG → CG mismatch correction. Proc. Natl. Acad. Sci. USA 85, 9163-9166.
4. Cupples, C. G., Miller, J. H. (1989) A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions. Proc. Natl. Acad. Sci. USA 86, 5345-5349.
5. Volkert, M. R., Elliott, N. A., Housman, D. E. (2000) Functional genomics reveals a family of eukaryotic oxidation protection genes. Proc. Natl. Acad. Sci. USA 97, 14530-14535.
6. Elliott, N. A., Volkert, M. R. (2004) Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans. Molec. Cell Biol. 24, 3180-3187.
7. Nghiem, Y., Cabrera, M., Cupples, C. G., Miller, J. H. (1988) The mutY gene: A mutator locus in Escherichia coli that generates GC → TA transversions. Proc. Natl. Acad. Sci. USA 85, 2709-2713.
8. Fischer, H., Zhang, X. U., O'Brien, K. P., Kylsten, P., Engvall, E. (2001) C7, a novel nucleolar protein, is the mouse homologue of the Drosophila late puff product L82 and an isoform of human oxr1. Biochem. Biophys. Res. Commun. 281, 795-803.
9. Shao, W., Halachmi, S., Brown, M. (2002) Erap140, a conserved tissue-specific nuclear receptor coactivator. Mol. Cell Biol. 22, 3358-3372.
10. Durand, M., Kolpak, A., Farrell, T., Elliott, N. A., Shao, W., Brown, M., et al. (2007) The Oxr domain defines a conserved family of eukaryotic oxidation resistance proteins. BMC Cell Biol. 8, 13.
11. Wang, J.-Y., Sarker, A. H., Cooper, P. K., Volkert, M. R. (2004) The single-strand DNA binding activity of human PC4 functions to prevent mutagenesis and killing by oxidative DNA damage. Mol. Cell Biol. 24, 6084-6093.