Effects of the ligand sequence modifications on the retargeted transduction by the retroviral vector having a ligand-chimeric Env protein

Journal of General Virology

Volumn 89, Issue 12, 2008, Pages 3137-3143

  Miyakawa, Kei ^a,c   Fujita, Rika ^a   Katane, Masumi ^a,d   Kubo, Yoshinao ^b   Amanuma, Hiroshi ^a  

^a Japan Science and Technology Agency   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CHEMOKINE RECEPTOR CXCR4; CYSTEINE; MUTANT PROTEIN; RETROVIRUS VECTOR; VIRUS ENVELOPE PROTEIN; HYBRID PROTEIN; LIGAND; STROMAL CELL DERIVED FACTOR 1;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE TARGETING; GENETIC TRANSDUCTION; GLIOMA CELL; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MODIFICATION; RECEPTOR BINDING; VIRION; VIRUS CELL INTERACTION; CELL LINE; CHEMISTRY; FLOW CYTOMETRY; GENE VECTOR; GENETICS; METABOLISM; MUTATION; PATHOGENICITY; PHYSIOLOGY; RETROVIRUS;

MOLONEY MURINE LEUKEMIA VIRUS; MURINE LEUKEMIA VIRUS;

CELL LINE; CHEMOKINE CXCL12; FLOW CYTOMETRY; GENE PRODUCTS, ENV; GENETIC VECTORS; HUMANS; LIGANDS; MUTATION; RECEPTORS, CXCR4; RECOMBINANT FUSION PROTEINS; RETROVIRIDAE; TRANSDUCTION, GENETIC; VIRION;

EID: 58149376703     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.2008/006031-0     Document Type: Article

References (18)

1. Bahrami, S., Duch, M. & Pedersen, F. S. (2007). Ligand presentation on a synthetic flexible hinge in Moloney murine leukemia virus SU supports entry via a heterologous receptor. Virology 363, 303-309.
2. Baum, C., Schambach, A., Bohne, J. & Galla, M. (2006). Retrovirus vectors: toward the plentivirus? Mol Ther 13, 1050-1063.
3. Benedict, C. A., Tun, R. Y. M., Rubinstein, D. B., Guillaume, T., Cannon, P. M. & Anderson, W. F. (1999). Targeting retroviral vectors to CD34-expressing cells: binding to CD34 does not catalyze virus-cell fusion. Hum Gene Ther 10, 545-557.
4. Chen, C. & Okayama, H. (1987). High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7, 2745-2752.
5. Cosset, F.-L., Takeuchi, Y., Battini, J. L., Weiss, R. A. & Collins, M. K. L. (1995). High-titer packaging cells producing recombinant retroviruses resistant to human serum. J Virol 69, 7430-7436.
6. Crump, M. P., Gong, J.-H., Loetscher, P., Rajarathnam, K., Amara, A., Arenzana-Seisdedos, F., Virelizier, J.-L., Baggiolini, M., Sykes, B. D. & Clark-Lewis, I. (1997). Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1. EMBO J 16, 6996-7007.
7. Deng, H., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R. E. & other authors (1996). Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661-666.
8. Kadan, M. J., Sturm, S., Anderson, W. F. & Eglitis, M. A. (1992). Detection of receptor-specific murine leukemia virus binding to cells by immunofluorescence analysis. J Virol 66, 2281-2287.
9. Katane, M., Takao, E., Kubo, Y., Fujita, R. & Amanuma, H. (2002). Factors affecting the direct targeting of murine leukemia virus vectors containing peptide ligands in the envelope protein. EMBO Rep 3, 899-904.
10. Katane, M., Fujita, R., Takao, E., Kubo, Y., Aoki, Y. & Amanuma, H. (2004). An essential role for the His-8 residue of the SDF-1α-chimeric, tropism-redirected Env protein of the Moloney murine leukemia virus in regulating postbinding fusion events. J Gene Med 6, 260-267.
11. + cells emphasize limited transduction at low receptor levels. Gene Ther 8, 593-599.
12. MacKrell, A. J., Soong, N.-W., Curtis, C. M. & Anderson, W. F. (1996). Identification of a subdomain in the Moloney murine leukemia virus envelope protein involved in receptor binding. J Virol 70, 1768-1774.
13. Nelson, P. J. & Krensky, A. M. (2001). Chemokines, chemokine receptors, and allograft rejection. Immunity 14, 377-386.
14. Russell, S. J. & Cosset, F.-L. (1999). Modifying the host range properties of retroviral vectors. J Gene Med 1, 300-311.
15. Sandrin, V., Russell, S. J. & Cosset, F.-L. (2003). Targeting retroviral and lentiviral vectors. Curr Top Microbiol Immunol 281, 137-178.
16. Wu, B. W., Lu, J., Gallaher, T. K., Anderson, W. F. & Cannon, P. M. (2000). Identification of regions in the Moloney murine leukemia virus SU protein that tolerate the insertion of an integrin-binding peptide. Virology 269, 7-17.
17. Yamazaki, K. (1982). Tumorigenicity of established human glioma cell lines in lasat and nude mice: in relation to differentiation and anaplasia of glioma cells. Neuropathology 3, 29-38 (in Japanese).
18. Zhao, Y., Zhu, L., Lee, S., Li, L., Chang, E., Soong, N.-W., Douer, D. & Anderson, W. F. (1999). Identification of the block in targeted retroviral-mediated gene transfer. Proc Natl Acad Sci U S A 96, 4005-4010.