Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells

Oncology Reports

Volumn 20, Issue 5, 2008, Pages 1053-1059

  Huang, Shu ^a   Zhang, Faming ^a,b   Miao, Lin ^a   Zhang, Huijie ^a   Fan, Zhining ^a   Wang, Xuehao ^a   Ji, Guozhong ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase 3; Hepatocellular carcinoma; p16; Proliferation; RNA interference; Smad4; Transforming growth factor

Indexed keywords

CASPASE 3; LENTIVIRUS VECTOR; PROTEIN P16; PROTEIN P21; PROTEIN P53; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; SMAD4 PROTEIN, HUMAN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; GENE EXPRESSION REGULATION; GENETICS; LENTIVIRINAE; LIVER TUMOR; METABOLISM; NICK END LABELING; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU NICK-END LABELING; LENTIVIRUS; LIVER NEOPLASMS; POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 58149346113     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000109     Document Type: Article

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