Estimation of no effect concentrations from exposure experiments when values scatter among individuals

Ecological Modelling

Volumn 220, Issue 3, 2009, Pages 411-418

  Baas, J ^a   Jager, T ^a   Kooijman, S A L M ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Individual tolerance distribution; Monte Carlo simulation; No effect concentration; Survival; Toxicity

Indexed keywords

EXPERIMENTS; MONTE CARLO METHODS; RISK ASSESSMENT; RISK MANAGEMENT; RISK PERCEPTION; STANDARDS; STATISTICS; TOXICITY; UNCERTAINTY ANALYSIS;

HIGH ACCURACIES; INDIVIDUAL DIFFERENCES; INDIVIDUAL TOLERANCE DISTRIBUTION; MONTE CARLO SIMULATION; NO EFFECT CONCENTRATION; NO OBSERVED EFFECT CONCENTRATIONS; PROCESS-BASED MODELS; STANDARD DEVIATIONS; STANDARD MODELS; SURVIVAL;

NORMAL DISTRIBUTION;

ACCURACY ASSESSMENT; COHORT ANALYSIS; CONCENTRATION (COMPOSITION); ECOLOGICAL MODELING; EXPERIMENTAL STUDY; MONTE CARLO ANALYSIS; PHYSIOLOGY; POLLUTION EXPOSURE; RISK ASSESSMENT; SURVIVAL; TOLERANCE; TOXICITY;

EID: 58149339625     PISSN: 03043800     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ecolmodel.2008.10.008     Document Type: Article

References (32)

1. Andersen J.S., Bedaux J.J.M., Kooijman S.A.L.M., and Holst H. The influence of design parameters on statistical inference in non-linear estimation; a simulation study based on survival data and hazard modelling. J. Agric. Biol. Environ. Stat. 5 (2000) 323-341
2. Aldridge W.N. The biological basis and measurement of thresholds. Ann. Rev. Pharmacol. Toxicol. 26 (1986) 39-58
3. Ashauer R., and Brown C.D. Toxicodynamic assumptions in ecotoxicological hazard models. Environ. Toxicol. Chem. 27 (2008) 1817-1821
4. Beckvar N., Dillon T.M., and Read L.B. Approaches for linking whole-body fish tissue residues of mercury or DDT to biological effects thresholds. Environ. Toxicol. Chem. 24 (2005) 2094-2105
5. Bedaux J.J.M., and Kooijman S.A.L.M. Statistical analysis of bioassays, based on hazard modeling. Environ. Ecol. Stat. 1 (1994) 303-314
6. Brooke L.T., Call D.J., Geiger D.L., and Northcott C.E. Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas) (1984), Center for Lake Superior Environmental Studies, University of Wisconsin-Superior, Superior, WI, USA
7. De Bruijn J.H.M., and Hof M. How to measure no effect. Part IV. How acceptable is the ECx from an environmental policy point of view?. Environmetrics 8 (1997) 263-267
8. Chapman P.M., Caldwell R.S., and Chapman P.F. A warning: NOECs are inappropriate for regulatory use. Environ. Toxicol. Chem. 15 (1996) 77-79
9. Chen C.W., and Selleck R.E. A kinetic model of fish toxicity threshold. J. Water Poll. Control Fed. 41 (1969) 294-308
10. Chèvre N., Becker-van Slooten K., Tarradellas J., Brazzale A.R., Behra R., and Guettinger H. Effects of dinoseb on the life cycle of daphnia magna: modeling survival time and a proposal for an alternative to the no-observed-effect concentration. Environ. Toxicol. Chem. 21 (2002) 828-833
11. Cox C. Threshold dose-response models in toxicology. Biometrics 43 (1987) 511-523
12. Crane M., and Newman M.C. What level of effect is a no observed effect?. Environ. Toxicol. Chem. 19 (2000) 516-519
13. Hoekstra J.A., and van Ewijk P.H. Alternatives for the no-observed-effect level. Environ. Toxicol. Chem. 12 (1993) 187-194
14. Van der Hoeven N., Noppert F., and Leopold A. How to measure no effect. Part I. Towards a new measure of chronic toxicity in ecotoxicology. Introduction and workshop results. Environmetrics 8 (1997) 241-248
15. Van der Hoeven N. Current issues in statistics and models for ecotoxicological risk assessment. Acta Biotheor. 52 (2004) 201-217
16. ISO, 1999. Effects of soil pollutants on Collembola (Folsomia candida): Method for determination of effects on reproduction. ISO 11267, International Standard Organisation, Geneva, 6.
17. Jager T., Heugens T.H.W., and Kooijman S.A.L.M. Making sense of ecotoxicological test results: towards process-based models. Ecotoxicology 15 (2006) 305-314
18. Klepper O., and Bedaux J.J.M. Nonlinear parameter estimation for toxicological threshold models. Ecol. Model. 102 (1997) 315-324
19. Kooijman S.A.L.M. Parametric analyses of mortality rates in bioassays. Water Res. 15 (1981) 107-119
20. Kooijman S.A.L.M., Bedaux J.J.M., and Slob W. No-effect concentration as a basis for ecological risk assessment. Risk Anal. 16 (1996) 445-447
21. Kooijman S.A.L.M., and Bedaux J.J.M. Some statistical properties of estimates of no-effects levels. Water Res. 30 (1996) 1724-1728
22. Laskowski R. Some good reasons to ban the use of NOEC. LOEC and related concepts in ecotoxicology. OIKOS 73 (1995) 140-144
23. McCullagh P., and Nelder J.A. Generalized Linear Models (1989), Chapman and Hall, London
24. Newman M.C., and McCloskey J.T. The individual tolerance concept is not the sole explanation for the probit dose-effect model. Environ. Toxicol. Chem. 19 (2000) 520-526
25. OECD, 1998. Report of the OECD workshop on statistical analysis of aquatic toxicity data. OECD environmental health and safety publications. Series on testing and assessment no 10, ENV/MC/CHEM(98) 18, Organisation for Economic Cooperation and Development Paris.
26. OECD, 2006. Current approaches in the statistical analysis of ecotoxicity data: a guidance to application Document No 54 of Series on Testing Assessment, Organisation for Economic Cooperation and Development Paris.
27. Péry A.R.R., Flammarion P., Vollat B., Bedaux J.J.M., Kooijman S.A.L.M., and Garric J. Using a biology-based model (DEBtox) to analyse bioassays in ecotoxicology: opportunities & recommendations. Environ. Toxicol. Chem. 21 (2002) 459-465
28. Pires A.M., Branco J.A., Picado A., and Mendonca E. Models for the estimation of a 'no effect concentration'. Environmetrics 13 (2002) 15-27
29. Schwartz P.F., Gennings C., and Chinchili V.M. Threshold models for combination data from reproductive and developmental experiments. J. Am. Stat. Assoc. 90 (1995) 862-870
30. Van Straalen N.M. How to measure no effect. II. Threshold effects in ecotoxicology. Environmetrics 8 (1997) 249-253
31. Suter G.W. Abuse of hypothesis testing statistics in ecological risk assessment. Hum. Ecol. Risk Assess. 2 (1996) 331-347
32. Ulm K.W. Threshold models in occupational epidemiology. Comput. Model. 14 (1990) 619-652