Assessment of ileal epithelial P-glycoprotein dysfunction induced by ischemia/reperfusion using in vivo animal model

Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 5, 2008, Pages 356-363

  Tomita, Mikio ^a   Takizawa, Yusuke ^a   Kishimoto, Hisanao ^a   Hayashi, Masahiro ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Barrier dysfunction; In vivo ischemia reperfusion model; Lipid peroxidation; Mdr1a; P glycoprotein

Indexed keywords

CLAUDIN 7; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1A; MULTIDRUG RESISTANCE PROTEIN 1B; MULTIDRUG RESISTANCE PROTEIN 2; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; CLAUDIN 7 PROTEIN, RAT; CLAUDIN-7 PROTEIN, RAT; MEMBRANE PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 3; P GLYCOPROTEIN 2; P-GLYCOPROTEIN 2; RHODAMINE 123;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; ILEUM MUCOSA; INTESTINE ISCHEMIA; LIPID PEROXIDATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SUPERIOR MESENTERIC ARTERY OBSTRUCTION; SUPERIOR MESENTERIC VEIN; SURVIVAL RATE; ANIMAL; DRUG EFFECT; GENETICS; ILEUM; INTESTINE MUCOSA; MESENTERIC VEIN; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SUPERIOR MESENTERIC ARTERY; VASCULARIZATION; WISTAR RAT;

ANIMALS; ILEUM; INTESTINAL MUCOSA; LIPID PEROXIDATION; MALE; MEMBRANE PROTEINS; MESENTERIC ARTERY, SUPERIOR; MESENTERIC VEINS; MODELS, ANIMAL; P-GLYCOPROTEIN; P-GLYCOPROTEINS; RATS; RATS, WISTAR; REPERFUSION INJURY; RHODAMINE 123; RNA, MESSENGER; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 58149316284     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.23.356     Document Type: Article

References (22)

1. Masuda, S., Uemoto, S., Hashida, T., Inomata, Y., Tanaka, K. and Inui, K.: Effect of intestinal P-glycoprotein on daily tacrolimus trough level in a living-donor small bowel recipirnt. Clin. Pharmacol. Ther., 68: 98-103 (2000)
2. Tomita, M., Nagira, M., Hotta, Y., Kobayashi, C., Ohkubo, R. and Hayashi, M.: Assessment using monolayers of human intestinal epithelia cell Caco-2 for ischemia/reperfusion-induced epithelial dysfunction. Organ Biology, 7: 87-94 (2000).
3. Tomita, M., Nagira, M., Haga, M. and Hayashi, M.: Clarification of the mechanism of structural change induced by reoxygenation following the induction of lipid peroxidation in caco-2 cell monolayers. Drug Metab. and Pharmacokinet., 17: 83-91 (2002).
4. Nagira, M., Tomita, M., Mizuno, S., Kumata, M., Ayabe, T. and Hayashi, M.: Ischemia/reperfusion injury in the monolayers of human intestinal epithelial cell line Caco-2 and its recoverey by antioxidants. Drug Metab. and Pharmacokinet., 21: 230-237 (2006).
5. Iida, A., Tomita, M., Idota, Y., Takizawa, Y. and Hayashi, M.: Improvement of intestinal absorption of P-glycoprotein substrate by D-tartaric acid. Drug Metab. and Pharmacokinet., 21: 424-428 (2006).
6. Iida, A., Tomita, M. and Hayashi, M.: Regional difference in P-glycoprotein function in rat intestine. Drug Metab. and Pharmacokinet., 20: 100-106 (2005).
7. Buege, J. and Aust, S. D.: Microsomal lipid peroxidation. In Pardridge, Fleischer, S. and Packer, J. (eds.), NY, Academic Press, 1977, 52: pp 302-310
8. Stieger, B. and Murer, H.: Heterogeneity of brush border membrane vesicles from rat intestine prepared by a precipitation method using Mg/ EGTA. Eur. J. Biochem., 135: 95-101 (1983).
9. Hsing, S., Gatmaitan, Z. and Arias, I. M.: The function of Gp170, the multidrug- resistance gene product, in the brush border of rat small intestinal mucosa. Gastroenterol., 102: 879-885 (1992).
10. Fujita, H., Chiba, H., Yokozaki, H., Sakai, N., Sugimoto, K., Wada, T., Kojima, T., Yamashita, T. and Sawada, N.: Differential expression and subcellular localization of claudin-7, -8, -12, -13 and -15 along the mouse intestine. J. Histochem. Cytochem., 54: 933-944 (2006).
11. Omae, T., Goto, M., Shimomura, M., Masuda, S., Ito, K., Okuda, M. and Inui, K.: Transient up-regulation of P-glycoprotein reduces tacrolimus absorption after ischemia-reperfusion injury in rat ileum. Biochem. Pharmacol., 69: 561-568 (2005).
12. Troutman, M. D. and Thakker, D. R.: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm. Res., 20: 1210-1224 (2003).
13. Kunimoto, M., Inoue, K. and Nojima, S.: Effects of ferrous and ascorbate-induced lipid peroxidation on liposomal membranes. Biochim. Biophys. Acta, 646: 169-178 (1981).
14. Tetik, C., Ozden, A., Calli, N., Bilgiham, A., Bostanci, B., Yis, O. and Bayramoglu, H.: Cytoprotective effect of trimetazidine on 60 minutes of intestinal ischemia-reperfusion injury in rats. Transpl. Int., 12: 108-112 (1999).
15. Ozturk, C., Avlan, D., Cinel, I., Cinel, L., Unlu, A., Camdeviren, H., Atik, U. and Oral, U.: Selenium pretreatment prevents bacterial translocation in rat intestinal ischemia/reperfusion model. Pharmacol. Res., 46: 171-175 (2002).
16. Ziemann, C., Burkle, A., Kahl, G. F. and Ernst, K. I. H.: Reactive oxygen species participate in mdr1b mRNA and P-glycoprotein overexpression in primary rat hepatocyte cultures. Carcinogenesis, 20(3): 407-414 (1999).
17. Ikeda, H., Suzuki, Y., Koike, M., Tamura, J., Tong, J., Nomura, M. and Itih, G.: Apoptosis is a major mode of cell death caused by ischemia and ischemia/reperfusion injury to the rat intestinal epithelium. Gut, 42: 530-537 (1998).
18. Kunihara, M., Nagai, J., Murakami, T. and Takano, M.: Renal excretion of rhodamine123, a P-glycoprotein substrate, in rats with glycerol-induced acute renal failure. J. Pharm. Pharmacol., 50: 1161-1165 (1998).
19. Yumoto, R., Murakami, T., Nakamoto, Y., Hasegawa, R., Nagai, J. and Takano, M.: Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds. J. Pharmacol. Exp. Ther., 289: 149-155 (1999).
20. Yumoto, R., Murakami, T., Sanemasa, M., Nasu, R., Nagai, J. and Takano, M.: Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone. Drug Metab. Dispos., 29: 145-151 (2001).
21. Yumoto, R., Murakami, T. and Takano, M.: Differential effect of acute hepatic failure on in vivo and in vitro P-glycoprotein functions in the intestine. Pharm. Res., 20: 765-71 (2003).
22. Molina, A. J., Prieto, J. G., Merino, G., Mendoza, G., Real, R., Pulido, M. M. and Alvarez, A. I.: Effects of ischemia-reperfusion on the absorption and esterase metabolism of diltiazem in rat intestine. Life Sci., 80: 397-407 (2007).