Parathyroid carcinoma with anaplastic feature: Association of a p53 gene mutation with anaplastic transformation

Pathology International

Volumn 59, Issue 2, 2009, Pages 107-110

  Tamura, Gen ^a   Miyoshi, Hiroaki ^a   Ogata, Shin Ya ^a,b   Sasou, Shun Ichi ^a   Kudoh, Shun ^a   Kikuchi, Jun ^a   Yanagawa, Naoki ^b   Motoyama, Teiichi ^b  

^a Yamagata Prefectural Central Hospital   (Japan)

^b YAMAGATA UNIVERSITY   (Japan)

Author keywords

Anaplastic carcinoma; p53 gene mutation; Parathyroid carcinoma

Indexed keywords

CALCIUM; PARAFFIN; PARATHYROID HORMONE; PROTEIN P53;

AGED; ANAPLASTIC CARCINOMA; ARTICLE; BLOOD ANALYSIS; CALCIUM BLOOD LEVEL; CANCER CELL; CANCER SURGERY; CASE REPORT; CELL NUCLEUS; CELL TRANSFORMATION; CLINICAL FEATURE; CODON; COMPUTER ASSISTED TOMOGRAPHY; DISEASE ASSOCIATION; DNA EXTRACTION; GENE; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC TRANSFORMATION; HISTOPATHOLOGY; HORMONE BLOOD LEVEL; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; MALE; MISSENSE MUTATION; P53 GENE; PARATHYROID CARCINOMA; POLYMERASE CHAIN REACTION; PRIMARY HYPERPARATHYROIDISM; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RADIODIAGNOSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; SUBTOTAL THYROIDECTOMY; TREATMENT OUTCOME; WILD TYPE;

AGED; CARCINOMA; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; DNA MUTATIONAL ANALYSIS; GENES, P53; HUMANS; HYPERPARATHYROIDISM; MALE; MUTATION, MISSENSE; PARATHYROID NEOPLASMS; PARATHYROIDECTOMY; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; TUMOR SUPPRESSOR PROTEIN P53;

EID: 58149308216     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2008.02337.x     Document Type: Article

References (9)

1. Koea JB, Shaw JH. Parathyroid cancer: Biology and management. Surg Oncol 1999 8 : 155 65.
2. Naccarato AG, Marcocci C, Miccoli P et al. Bcl-2, p53 and MIB-1 expression in normal and neoplastic parathyroid tissues. J Endocrinol Invest 1998 21 : 136 41.
3. Levine AJ, Momand J, Finlay CA. The p53 tumour suppressor gene. Nature 1991 351 : 453 6.
4. Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol 1995 147 : 545 60.
5. Buglioni S, D'Agnano I, Cosimelli M et al. Evaluation of multiple bio-pathological factors in colorectal adenocarcinomas: Independent prognostic role of p53 and bcl-2. Int J Cancer 1999 84 : 545 52.
6. Nikiforov YE. Genetic alterations involved in the transition from well-differentiated to poorly differentiated and anaplastic thyroid carcinomas. Endocr Pathol 2004 15 : 319 27.
7. Akiyama S, Tamura G, Endoh Y et al. Histogenesis of hepatoid adenocarcinoma of the stomach: Molecular evidence of identical origin with coexistent tubular adenocarcinoma. Int J Cancer 2003 106 : 510 15.
8. Fagin JA, Matsuo K, Karmakar A et al. High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J Clin Invest 1993 91 : 179 84.
9. Pace V, Scarsella S, Perentes E. Parathyroid gland carcinoma in a Wistar rat. Vet Pathol 2003 40 : 203 6.