Percutaneous nonviral delivery of hepatocyte growth factor in an osteotomy gap promotes bone repair in rabbits: A preliminary study

Clinical Orthopaedics and Related Research

Volumn 466, Issue 12, 2008, Pages 2962-2972

  Matsubara, Hidenori ^a   Tsuchiya, Hiroyuki ^a   Watanabe, Koji ^a   Takeuchi, Akihiko ^a   Tomita, Katsuro ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; SCATTER FACTOR; LIPOSOME; VIRUS ENVELOPE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE RADIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FRACTURE HEALING; FRACTURE TREATMENT; GENE EXPRESSION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OSTEOTOMY; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENDAI VIRUS; TIBIA; VIRUS ENVELOPE; ANIMAL; BONE DENSITY; DRUG EFFECT; FEMALE; GENE TRANSFER; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALS; BONE DENSITY; FEMALE; FRACTURE HEALING; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEPATOCYTE GROWTH FACTOR; IMMUNOHISTOCHEMISTRY; LIPOSOMES; OSTEOTOMY; PLASMIDS; RABBITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SENDAI VIRUS; TRANSFECTION; VIRAL ENVELOPE PROTEINS;

EID: 58149289888     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-008-0493-z     Document Type: Article

References (52)

1. TD Alden DD Pittman GR Hankins EJ Beres JA Engh S Das SB Hudson KM Kerns DF Kallmes GA Helm 1999 In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector Hum Gene Ther. 10 2245 2253
2. YM Alkhiary LC Gerstenfeld E Krall M Westmore M Sato BH Mitlak TA Einhorn 2005 Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34) J Bone Joint Surg Am. 87 731 741
3. MJ Al-Sayyad 2006 Taylor Spatial Frame in the treatment of pediatric and adolescent tibial shaft fractures J Pediatr Orthop. 26 164 170
4. I Aoyama J Anzai T Nakamura Y Hiyama M Tamura 2001 Acceleration of fracture healing in nonhuman primates by fibroblast growth factor-2 J Clin Endocrinol Metab. 86 875 880
5. J Azuma Y Taniyama Y Takeya K Iekushi M Aoki N Dosaka K Matsumoto T Nakamura T Ogihara R Morishita 2006 Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy Gene Ther. 13 1206 1213
6. AW Baltzer C Lattermann JD Whalen S Ghivizzani P Wooley R Krauspe PD Robbins CH Evans 2000 Potential role of direct adenoviral gene transfer in enhancing fracture repair Clin Orthop Relat Res. 379 S120 125
7. AL Bertone DD Pittman ML Bouxsein J Li B Clancy HJ Seeherman 2004 Adenoviral-mediated transfer of human BMP-6 gene accelerates healing in a rabbit ulnar osteotomy model J Orthop Res. 22 1261 1270
8. OB Betz VM Betz A Nazarian CG Pilapil MS Vrahas ML Bouxsein LC Gerstenfeld TA Einhorn CH Evans 2006 Direct percutaneous gene delivery to enhance healing of segmental bone defect J Bone Joint Surg Am. 88 355 365
9. F Blanquaert AM Delany E Canalis 1999 Fibroblast growth factor-2 induces hepatocyte growth factor/scatter factor expression in osteoblasts Endocrinology. 140 1069 1074
10. WJ Chen S Jingushi I Aoyama J Anzai G Hirata M Tamura Y Iwamoto 2004 Effects of FGF-2 on metaphyseal fracture repair in rabbit tibiae J Bone Miner Metab. 22 303 309
11. Y Chen KM Cheung HF Kung JC Leong WW Lu KD Luk 2002 In vivo new bone formation by direct transfer of adenoviral-mediated bone morphogenetic protein-4 gene Biochem Biophys Res Commun. 298 121 127
12. G D'Ippolito PC Schiller C Perez-stable W Balkan BA Roos GA Howard 2002 Cooperative actions of hepatocyte growth factor and 1, 25-dihydroxyvitamin D3 in osteoblastic differentiation of human vertebral bone marrow stromal cell Bone. 31 269 275
13. H Eckardt M Ding M Lind ES Hansen KS Christensen I Hvid 2005 Recombinant human vascular endothelial growth factor enhances bone healing in an experimental nonunion model J Bone Joint Surg Br. 87 1434 1438
14. M Egermann J Goldhahn E Schneider 2005 Animal models for fracture treatment in osteoporosis Osteoporos Int. 16 S129 138
15. M Egermann CA Lill K Griesbeck CH Evans PD Robbins E Schneider AW Baltzer 2006 Effect of BMP-2 gene transfer on bone healing in sheep Gene Ther. 13 1290 1299
16. TA Einhorn 1995 Enhancement of fracture-healing J Bone Joint Surg Am. 77 940 956
17. TA Einhorn RJ Majeska A Mohaideen EM Kagel ML Bouxsein TJ Turek JM Wozney 2003 A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair J Bone Joint Surg Am. 85 1425 1435
18. RT Franceschi S Yang RB Rutherford PH Krebsbach M Zhao D Wang 2004 Gene therapy approaches for bone regeneration Cells Tissues Organs. 176 95 108
19. PV Giannoudis CC Tzioupis E Tsiridis 2006 Gene therapy in orthopaedics Injury. 37 S30 40
20. RM Greiwe MT Archdeacon 2007 Locking plate technology: current concepts J Knee Surg. 20 50 55
21. S Hirano DM Bless B Rousseau N Welham D Montequin RW Chan CN Ford 2004 Prevention of vocal fold scarring by topical injection of hepatocyte growth factor in a rabbit model Laryngoscope. 114 548 556
22. M Hossain R Irwin MJ Baumann LR McCabe 2005 Hepatocyte growth factor (HGF) adsorption kinetics and enhancement of osteoblast differentiation on hydroxyapatite surfaces Biomaterials. 26 2595 2602
23. A Ido A Moriuchi I Kim M Numata Y Nagata S Hasuike H Uto H Tsubouchi 2004 Pharmacokinetic study of recombinant human hepatocyte growth factor administered in a bolus intravenously or via portal vein Hepatology Research. 30 175 181
24. Y Imai H Terai C Nomura-Furuwatari S Mizuno K Matsumoto T Nakamura K Takaoka 2005 Hepatocyte growth factor contributes to fracture repair by upregulating the expression of BMP receptors J Bone Miner Res. 20 1723 1730
25. M Jin Y Chen S He SJ Ryan DR Hinton 2004 Hepatocyte growth factor and its role in the pathogenesis of retinal detachment Invest Ophthalmol Vis Sci. 45 323 329
26. Y Kaneda T Nakajima T Nishikawa S Yamamoto H Ikegami N Suzuki H Nakamura R Morishita H Kotani 2002 Hemagglutinating virus of Japan (HVJ) envelope vector as a versatile gene delivery system Mol Ther. 6 219 226
27. N Kato K Nemoto K Nakanishi R Morishita Y Kaneda M Uenoyama T Ikeda K Fujikawa 2005 Nonviral HVJ (hemagglutinating virus of Japan) liposome-mediated retrograde gene transfer of human hepatocyte growth factor into rat nervous system promotes functional and histological recovery of the crushed nerve Neurosci Res. 52 299 310
28. H Koike R Morishita S Iguchi M Aoki K Matsumoto T Nakamura C Yokoyama T Tanabe T Ogihara Y Kaneda 2003 Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene FASEB J. 17 779 781
29. JM Lane 2005 Bone morphogenic protein science and studies J Orthop Trauma. 19 S17 22
30. JR Lieberman A Daluiski TA Einhorn 2002 The role of growth factors in the repair of bone. Biology and clinical applications J Bone Joint Surg Am. 84 1032 1044
31. JR Lieberman A Daluiski S Stevenson L Wu P McAllister YP Lee JM Kabo GA Finerman AJ Berk ON Witte 1999 The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats J Bone Joint Surg Am. 81 905 917
32. J Luo MH Sun Q Kang Y Peng W Jiang HH Luu Q Luo JY Park Y Li RC Haydon TC He 2005 Gene therapy for bone regeneration Curr Gene Ther. 5 167 179
33. T Matsushita T Kurokawa 1998 Comparison of cyclic compression, cyclic distraction and rigid fixation. Bone healing in rabbits Acta Orthop Scand. 69 95 98
34. R Morishita M Aoki N Hashiya H Makino K Yamasaki J Azuma Y Sawa H Matsuda Y Kaneda T Ogihara 2004 Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease Hypertension. 44 203 209
35. DS Musgrave P Bosch S Ghivizzani PD Robbins CH Evans J Huard 1999 Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone Bone. 24 541 547
36. T Nakamura K Nawa A Ichihara N Kaise T Nishino 1987 Purification and subunit structure of hepatocyte growth factor from rat platelets FEBS Lett. 224 311 316
37. T Nakamura T Nishizawa M Hagiya T Seki M Shimonishi A Sugimura K Tashiro S Shimizu 1989 Molecular cloning and expression of human hepatocyte growth factor Nature. 342 440 443
38. C Niyibizi A Baltzer C Lattermann M Oyama JD Whalen PD Robbins CH Evans 1998 Potential role for gene therapy in the enhancement of fracture healing Clin Orthop Relat Res. 355 S148 153
39. K Oshima M Shimamura S Mizuno K Tamai K Doi R Morishita T Nakamura T Kubo Y Kaneda 2004 Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats FASEB J. 18 212 214
40. SH Park K O'Connor R Sung H McKellop A Sarmiento 1999 Comparison of healing process in open osteotomy model and closed fracture model J Orthop Trauma. 13 114 120
41. SH Park M Silva 2003 Effect of intermittent pneumatic soft-tissue compression on fracture-healing in an animal model J Bone Joint Surg Am. 85 1446 1453
42. ML Radomsky TB Aufdemorte LD Swain WC Fox RC Spiro JW Poser 1999 Novel formulation of fibroblast growth factor-2 in a hyaluronan gel accelerates fracture healing in nonhuman primates J Orthop Res. 17 607 614
43. CH Rundle N Miyakoshi Y Kasukawa ST Chen MH Sheng JE Wergedal KH Lau DJ Baylink 2003 In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4 Bone. 32 591 601
44. B Sekalska A Ciechanowicz B Dolegowska M Naruszewicz 2006 Optimized RT-PCR method for assaying expression of monocyte chemotactic protein type 1 (MCP-1) in rabbit aorta Biochem Genet. 44 133 143
45. E Shi X Jiang T Kazui N Washiyama K Yamashita H Terada AH Bashar 2006 Nonviral gene transfer of hepatocyte growth factor attenuates neurologic injury after spinal cord ischemia in rabbits J Thorac Cardiovasc Surg. 132 941 947
46. M Shimamura R Morishita M Endoh K Oshima M Aoki S Waguri Y Uchiyama Y Kaneda 2003 HVJ-envelope vector for gene transfer into central nervous system Biochem Biophys Res Commun. 300 464 471
47. M Shimamura N Sato K Oshima M Aoki H Kurinami S Waguri Y Uchiyama T Ogihara Y Kaneda R Morishita 2004 Novel therapeutic strategy to treat brain ischemia: overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model Circulation. 109 424 431
48. LL Southwood DD Frisbie CE Kawcak CW McIlwraith 2004 Delivery of growth factors using gene therapy to enhance bone healing Vet Surg. 33 565 578
49. Y Taniyama R Morishita M Aoki H Nakagami K Yamamoto K Yamazaki K Matsumoto T Nakamura Y Kaneda T Ogihara 2001 Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease Gene Ther. 8 181 189
50. Y Taniyama R Morishita K Hiraoka M Aoki H Nakagami K Yamasaki K Matsumoto T Nakamura Y Kaneda T Ogihara 2001 Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes Circulation. 104 2344 2350
51. RD Welch AL Jones RW Bucholz CM Reinert JS Tjia WA Pierce JM Wozney XJ Li 1998 Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model J Bone Miner Res. 13 1483 1490
52. S Yoshimura R Morishita K Hayashi J Kokuzawa M Aoki K Matsumoto T Nakamura T Ogihara N Sakai Y Kaneda 2002 Gene transfer of hepatocyte growth factor to subarachnoid space in cerebral hypoperfusion model Hypertension. 39 1028 1034