Hepatoprotective activity of daucus Carota L. Aqueous extract against paracetamol, isoniazid and alcohol induced hepatotoxicity in male wistar rats

Pharmacologyonline

Volumn 3, Issue , 2008, Pages 776-787

  Shoba, S ^a   Patil, P A ^b   Vivek, V ^b  

^a K L E S S COLLEGE OF PHARMACY   (India)

^b JAWAHARLAL NEHRU MEDICAL COLLEGE   (India)

Author keywords

Alcohol; Carrot extract; Hepatic enzymes; Hepatoprotection; Isoniazid; Paracetamol

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; DAUCUS CAROTA EXTRACT; ISONIAZID; PARACETAMOL; PLANT EXTRACT; SODIUM CHLORIDE; UNCLASSIFIED DRUG; WATER;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CARROT; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HISTOPATHOLOGY; LIVER FUNCTION TEST; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; PROTHROMBIN TIME; RAT; TREATMENT RESPONSE;

EID: 58149267657     PISSN: None     EISSN: 18278620     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Ward FM and Daly MJ, 1999. Hepatic disease, chapter 14 in clinical pharmacy and therapeutics. Walker B., Edwards C., 2nd edition, Harcourt Brace and company limited, Churchill livingstone, London: 195.
2. Dienstag JL and Issebacher KJ, 2001. Toxic and drug induced hepatitis, chapter 296, Harrison's principals of internal medicine. Braunwald E, et.al., 15th edition. The McGraw-Hill companies, Inc., New york: 1737-42.
3. Bhanwra S, Singh J and Khosla P, 2000. Effect of Azadirachta indica leaf aqueous extract on paracetamol induced liver damage in rats. J. Physiol. Phrmacol., 44(1): 64-8.
4. Saraswathi SD, et al., 1998. Effect of Liv-100 against antitubercular drugs (Isoniazid, Rifampicin and Pyrazinamide) induced hepatotoxicty in rats. Indian. J. Pharmacol., 30: 233-8.
5. Gulati RK, Agarwal S and Agarwal SS, 1995. Hepatoprotective studies on Phyllanthus emblica Linn and Quercetin. Indian. J. Exp. Biol. 1995: 261-8.
6. Chattopadhyay RF, et al., 1992. Hepatoprotective activity of Ocimum sanctum leaf extract against paracetamol induced hepatic damage in rats. Indian. J. Pharmacol., 24: 163-5.
7. Chattopadhyay RR, et al., 1992. Hepatoprotective activity of Azadirachta indica leaves on paracetamol induced hepatic damage in rats. Indian. J. Exp. Biol., 30: 738-40.
8. Nadkarni KM, 1976. Indian Materia Medica, Vol. I. Popular Prokashan, Bombay : 442.
9. Kirtikar KR and Basu BD, 1933. Indian Medicinal Plants, Vol. II. L.M. Basu, Allahabad: 1229-31.
10. Bishayee A, Sarkar A and Chatterjee M, 1995. Hepatoprotective activity of carrot (Daucus carota L) against carbon tetrachloride intoxication in mouse liver. J. of Ethnopharmacol., 47: 69-74.
11. Balasubramaniam P, Pari L and Menin VP, 1998. Protective effect of carrot (Daucus carota L) against lindane induced hepatotoxicity in rats. Phytother. Res., 12: 434-6.
12. Dass EE and Shah KK, 2000. Paracetamol and conventional antimalarial drugs induced hepatotoxicty and its protection by methionine in rats. Ind. J. Exp. Biol. :1138-42.
13. Nimbkar SR, Juvekar AR and Jogalekar SN, 2000. Hepatoprotective activity of Fumaria indica in hepatotoxicty induced by anti-tubercular drugs treatment. Indian Drugs, 37(11): 537-42.
14. Kapoor V, 1994. Hepatoprotective activity of Jigrine on liver damage caused by alcohol, carbontetrachloride and paracetamol in rats. Ind. J. Pharmacol., 26: 35-40.
15. Reitman S and Frankel S, 1957. A colorimetrio method for the determination of serum glutamic oxaloacetate and glutamic pyruvic transaminases. Am. J. Clin. Pathol., 28: 56-63.
16. Malloy HT and Evelyn KA, 1937. The determination of bilirubin with photoelectric colorimeter. J. Biochem. :481-5.
17. Hull R, Hirsh H, Jay R, et al., 1982. Different intensities of oral anticoagulant therapy in the treatment of proximal vein thrombosis. New. Eng. J. Med., 307:1676-81.
18. Straub O, 1987. In: F. Pfander (Ed.), Key to Carotenoids, 2nd Edn., Birkhauser Verlag, Basel: 296.
19. Olson JA, 1989. Provitamin A function of carotenoids: the conversion of β-carotene into vitamin A. Journal of Nutrition, 119: 105-8.
20. Burton GW, 1989. Antioxidant action of carotenoids. Journal of Nutrition, 119:109-11.
21. Bishayee A and Chatterjee M, 1993. Carrot aqueous extract protection against hepatic oxidative stress and lipid peroxidation induced by acute carbon tetrachloride intoxication in mice. Fitoterapia, 64: 261-5.