Serum autoantibodies measured by immunofluorescence confirm a failure to differentiate PANDAS and Tourette syndrome from controls

Journal of the Neurological Sciences

Volumn 276, Issue 1-2, 2009, Pages 45-48

  Morris, Christina M ^a   Pardo Villamizar, Carlos ^b   Gause, Colin D ^a   Singer, Harvey S ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Anti striatal antibodies; Autoimmunity; Immunofluorescent histochemistry; PANDAS; Tourette syndrome; Western immunoblotting

Indexed keywords

AUTOANTIBODY; FRUCTOSE BISPHOSPHATE ALDOLASE; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; MUSCARINIC M1 RECEPTOR; PYRUVATE KINASE;

ADOLESCENT; ANTIBODY BLOOD LEVEL; ANTIGEN ANTIBODY REACTION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CAUDATE NUCLEUS; CHILD; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIFFERENTIATION; DISEASE SEVERITY; FEMALE; GILLES DE LA TOURETTE SYNDROME; HUMAN; IMMUNOASSAY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PEDIATRIC AUTOIMMUNE NEUROPSYCHIATRIC DISORDERS ASSOCIATED STREPTOCOCCAL INFECTION; PRIORITY JOURNAL; STAINING; STREPTOCOCCUS INFECTION; TIC; TISSUE DISTRIBUTION; WESTERN BLOTTING;

ADOLESCENT; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BASAL GANGLIA; CHILD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; LOGISTIC MODELS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; STREPTOCOCCAL INFECTIONS; TOURETTE SYNDROME;

EID: 58149267592     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2008.08.032     Document Type: Article

References (26)

1. Kiessling L.S., Marcotte A.C., and Culpepper L. Antineuronal antibodies in movement disorders. Pediatrics 92 1 (1993) 39-43
2. Church A.J., Dale R.C., Lees A.J., Giovannoni G., and Robertson M.M. Tourette's syndrome: a cross sectional study to examine the PANDAS hypothesis. J Neurol Neurosurg Psychiatry 74 5 (2003) 602-607
3. Swedo S.E., Leonard H.L., Garvey M., Mittleman B., Allen A.J., Perlmutter S., et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry 155 2 (1998) 264-271
4. Edwards M.J., Trikouli E., Martino D., Bozi M., Dale R.C., Church A.J., et al. Anti-basal ganglia antibodies in patients with atypical dystonia and tics: a prospective study. Neurology 63 1 (2004) 156-158
5. DiFazio M.P., Morales J., and Davis R. Acute myoclonus secondary to group A beta-hemolytic streptococcus infection: A PANDAS variant. J Child Neurol 13 10 (1998) 516-518
6. Ben-Pazi H., Livne A., Shapira Y., and Dale R.C. Parkinsonian features after streptococcal pharyngitis. J Pediatr 143 2 (2003) 267-269
7. Dale R.C., Church A.J., Surtees R.A., Thompson E.J., Giovannoni G., and Neville B.G. Post-streptococcal autoimmune neuropsychiatric disease presenting as paroxysmal dystonic choreoathetosis. Mov Disord 17 4 (2002) 817-820
8. Edwards M.J., Dale R.C., Church A.J., Trikouli E., Quinn N.P., Lees A.J., et al. Adult-onset tic disorder, motor stereotypies, and behavioural disturbance associated with antibasal ganglia antibodies. Mov Disord 19 10 (2004) 1190-1196
9. Dale R.C., Church A.J., and Heyman I. Striatal encephalitis after varicella zoster infection complicated by Tourettism. Move Disord 18 12 (2003) 1554-1556
10. Husby G., van de Rijn I., Zabriskie J.B., Abdin Z.H., and Williams Jr. R.C. Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever. J Exp Med 144 4 (1976) 1094-1110
11. Singer H.S., Hong J.J., Yoon D.Y., and Williams P.N. Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls. Neurology 65 (2005) 1701-1707
12. Church A.J., Dale R.C., and Giovannoni G. Anti-basal ganglia antibodies: a possible diagnostic utility in idiopathic movement disorders?. Arch Dis Child 89 7 (2004) 611-614
13. Dale R.C., Church A.J., Candler P.M., Chapman M., Martino D., and Giovannoni G. Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls. Neurology 66 10 (2006) 1612 ; author reply 1612.
14. Hoekstra P.J., Kallenberg C.G., Korf J., and Minderaa R.B. Is Tourette's syndrome an autoimmune disease?. Mol Psychiatry 7 5 (2002) 437-445
15. Rizzo R., Gulisano M., Pavone P., Fogliani F., and Robertson M.M. Increased antistreptococcal antibody titers and anti-basal ganglia antibodies in patients with Tourette syndrome: controlled cross-sectional study. J Child Neurol 21 9 (2006) 747-753
16. Morshed S.A., Parveen S., Leckman J.F., Mercadante M.T., Bittencourt Kiss M.H., Miguel E.C., et al. Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette's syndrome, Sydenham's chorea, and autoimmune disorders. Biol Psychiatry 50 8 (2001) 566-577
17. Pavone P., Bianchini R., Parano E., Incorpora G., Rizzo R., Mazzone L., et al. Anti-brain antibodies in PANDAS versus uncomplicated streptococcal infection. Pediatr Neurol 30 2 (2004) 107-110
18. Diagnostic and statistical manual of mental disorders: DSM-IV. 4th ed. (1994), American Psychiatric Association, Washington, D.C.
19. DuPaul G. Parent and teacher ratings of ADHD symptoms: psychometric properties in a community based sample. J Clin Child Psychol 20 (1991) 243-253
20. Scahill L., Riddle M.A., McSwiggin-Hardin M., Ort S.I., King R.A., Goodman W.K., et al. Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 36 6 (1997) 844-852
21. Kaplan E.L., Rothermel C.D., and Johnson D.R. Antistreptolysin O and anti-deoxyribonuclease B titers: normal values for children ages 2 to 12 in the United States. Pediatrics 101 1 Pt 1 (1998) 86-88
22. Archelos J.J., and Hartung H.P. Pathogenetic role of autoantibodies in neurological diseases. Trends Neurosci 23 7 (2000) 317-327
23. Vianello M., Vitaliani R., Pezzani R., Nicolao P., Betterle C., Keir G., et al. The spectrum of antineuronal autoantibodies in a series of neurological patients. J Neurol Sci 220 1-2 (2004) 29-36
24. Antunes N.L., Khakoo Y., Matthay K.K., Seeger R.C., Stram D.O., Gerstner E., et al. Antineuronal antibodies in patients with neuroblastoma and paraneoplastic opsoclonus-myoclonus. J Pediatr Hematol Oncol 22 4 (2000) 315-320
25. Kotby A.A., El Badawy N., El Sokkary S., Moawad H., and El Shawarby M. Antineuronal antibodies in rheumatic chorea. Clin Diagn Lab Immunol 5 6 (1998) 836-839
26. Swedo S.E., Leonard H.L., Schapiro M.B., Casey B.J., Mannheim G.B., Lenane M.C., et al. Sydenham's chorea: physical and psychological symptoms of St Vitus dance. Pediatrics 91 4 (1993) 706-713