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1
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0038053724
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A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
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Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 2000; 87:E1-E9.
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(2000)
Circ Res
, vol.87
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Donoghue, M.1
Hsieh, F.2
Baronas, E.3
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2
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0034721906
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A human homolog of angiotensinconverting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase
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Tipnis SR, Hooper NM, Hyde R, et al. A human homolog of angiotensinconverting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 2000; 275:33238-33243.
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(2000)
J Biol Chem
, vol.275
, pp. 33238-33243
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Tipnis, S.R.1
Hooper, N.M.2
Hyde, R.3
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3
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18544378161
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Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
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Vickers C, Hales P, Kaushik V, et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem 2002; 277:14838-14843.
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(2002)
J Biol Chem
, vol.277
, pp. 14838-14843
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Vickers, C.1
Hales, P.2
Kaushik, V.3
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4
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0037341501
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Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy
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Tikellis C, Johnson Cl, Formbes JM, et al. Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy. Hypertension 2003; 41:392-397.
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(2003)
Hypertension
, vol.41
, pp. 392-397
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Tikellis, C.1
Johnson, C.2
Formbes, J.M.3
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5
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42649115768
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Santos RAS, Ferreira AJ, Simōes e Silva AC. Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)- Mas axis. Exp Physiol 2008; 93:519-527.
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Santos RAS, Ferreira AJ, Simōes e Silva AC. Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)- Mas axis. Exp Physiol 2008; 93:519-527.
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42649108710
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• Soler MJ, Wysocki J, Batlle D. Angiotensin-converting enzyme 2 and the kidney. Exp Physiol 2008; 93:549-556. This paper provides a very useful review of ACE2 in the kidney.
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• Soler MJ, Wysocki J, Batlle D. Angiotensin-converting enzyme 2 and the kidney. Exp Physiol 2008; 93:549-556. This paper provides a very useful review of ACE2 in the kidney.
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7
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34248597758
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• Hamming I, Cooper ME, Haagmans BL, et al. The emerging role of ACE2 in physiology and disease. J Pathol 2007; 212:1-11. This paper provides a very useful review of ACE2 in health and disease.
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• Hamming I, Cooper ME, Haagmans BL, et al. The emerging role of ACE2 in physiology and disease. J Pathol 2007; 212:1-11. This paper provides a very useful review of ACE2 in health and disease.
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8
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42649141954
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• Alenina N, Xu P, Rentzsch B, et al. Genetically altered animal models for Mas and angiotensin-(1-7). Exp Physiol 2008; 93:528-537. Discusses the angiotensin-(1-7) pathways and their relevance to blood pressure and regulation of the vasculature.
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• Alenina N, Xu P, Rentzsch B, et al. Genetically altered animal models for Mas and angiotensin-(1-7). Exp Physiol 2008; 93:528-537. Discusses the angiotensin-(1-7) pathways and their relevance to blood pressure and regulation of the vasculature.
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9
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48449094131
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• Lu C-Y, Huang H-Y, Yang T-H, et al. siRNA silencing of angiotensin-converting enzyme 2 reduced severe acute respiratory syndrome-associated coronavirus replications in Vero E6 cells. Eur J Clin Microbiol Infect Dis 2008; 27:709-715. Both summarizes the role of ACE2 as a cellular receptor for SARS-coronavirus and shows by siRNA targeting of ACE2 how this could be a strategy for therapy. Further, the results have implications for renal and vascular research.
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• Lu C-Y, Huang H-Y, Yang T-H, et al. siRNA silencing of angiotensin-converting enzyme 2 reduced severe acute respiratory syndrome-associated coronavirus replications in Vero E6 cells. Eur J Clin Microbiol Infect Dis 2008; 27:709-715. Both summarizes the role of ACE2 as a cellular receptor for SARS-coronavirus and shows by siRNA targeting of ACE2 how this could be a strategy for therapy. Further, the results have implications for renal and vascular research.
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10
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42649139218
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• Imai Y, Kuba K, Penninger JM. The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Exp Physiol 2008; 93:543-548. This paper reviews ACE2 in terms of its roles in acute lung injury. This review should be helpful for those interested in ACE2 research in other tissues and organs.
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• Imai Y, Kuba K, Penninger JM. The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Exp Physiol 2008; 93:543-548. This paper reviews ACE2 in terms of its roles in acute lung injury. This review should be helpful for those interested in ACE2 research in other tissues and organs.
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11
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85119747915
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1-ERK/p38 MAP kinase pathway.
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1-ERK/p38 MAP kinase pathway.
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12
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58149402305
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•• Soler MJ, Barrios C, Oliva R, Batlle D. Pharmacologic modulation of ACE2 expression. Curr Hypertens Rep 2008; 10:410-414. This is a very useful review that summarizes modulation of ACE2 expression by pharmacological means.
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•• Soler MJ, Barrios C, Oliva R, Batlle D. Pharmacologic modulation of ACE2 expression. Curr Hypertens Rep 2008; 10:410-414. This is a very useful review that summarizes modulation of ACE2 expression by pharmacological means.
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13
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0141988867
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Angiotensin-(1-7) formation in the intact human heart: In vivo dependence on angiotensin II as substrate
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Zisman LS, Meixell GE, Bristow MR, Canver CC. Angiotensin-(1-7) formation in the intact human heart: in vivo dependence on angiotensin II as substrate. Circulation 2003; 108:1679-1681.
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(2003)
Circulation
, vol.108
, pp. 1679-1681
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Zisman, L.S.1
Meixell, G.E.2
Bristow, M.R.3
Canver, C.C.4
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14
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0037142101
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Angiotensin-converting enzyme 2 is an essential regulator of heart function
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Crackower MA, Sarao R, Oudit GY, et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 2002; 417:822-828.
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(2002)
Nature
, vol.417
, pp. 822-828
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Crackower, M.A.1
Sarao, R.2
Oudit, G.Y.3
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15
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42649108055
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• Gurley SB, Coffman TM. Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages. Exp Physiol 2008; 93:538-542. Excellent summary of studies ablating ACE2 and also of physiology of ACE2.
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• Gurley SB, Coffman TM. Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages. Exp Physiol 2008; 93:538-542. Excellent summary of studies ablating ACE2 and also of physiology of ACE2.
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16
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85120591024
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• Guy JL, Lambert DW, Turner AJ, Porter KE. Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts. Exp Physiol 2008; 93:579-588. This paper examines functional expression of ACE2 in human cardiac myofibroblasts and describes coexpression of ACE and ACE2 in these cells.
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• Guy JL, Lambert DW, Turner AJ, Porter KE. Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts. Exp Physiol 2008; 93:579-588. This paper examines functional expression of ACE2 in human cardiac myofibroblasts and describes coexpression of ACE and ACE2 in these cells.
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17
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39749202869
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• Der Sarkissian S, Grobe JL, Yuan L, et al. Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology. Hypertension 2008; 51:712-718. This paper demonstrates that overexpression of ACE2 protects the heart during ischemic injury.
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• Der Sarkissian S, Grobe JL, Yuan L, et al. Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology. Hypertension 2008; 51:712-718. This paper demonstrates that overexpression of ACE2 protects the heart during ischemic injury.
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•• Epelman S, Tang WH, Chen SY, et al. Detection of soluble angiotensin- converting enzyme 2 in heart failure: insights into the endogenous counterregulatory pathway of the renin-angiotensin-aldosterone system. J Am Coll Cardiol 2008; 52:750-754. These authors have developed an assay for ACE2 and have examined it in heart failure.
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•• Epelman S, Tang WH, Chen SY, et al. Detection of soluble angiotensin- converting enzyme 2 in heart failure: insights into the endogenous counterregulatory pathway of the renin-angiotensin-aldosterone system. J Am Coll Cardiol 2008; 52:750-754. These authors have developed an assay for ACE2 and have examined it in heart failure.
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19
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40149086849
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•• Koitka A, Cooper ME, Thomas MC, Tikellis C. Angiotensin converting enzyme 2 in the kidney. Clin Exp Pharmacol Physiol 2008; 35:420-425. This paper is a superb review of the role of the RAS in the kidney.
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•• Koitka A, Cooper ME, Thomas MC, Tikellis C. Angiotensin converting enzyme 2 in the kidney. Clin Exp Pharmacol Physiol 2008; 35:420-425. This paper is a superb review of the role of the RAS in the kidney.
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20
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34047193877
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Overexpression of angiotensinconverting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats
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Yamazato M, Yamazato Y, Sun C, et al. Overexpression of angiotensinconverting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension 2007; 49:926-931.
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(2007)
Hypertension
, vol.49
, pp. 926-931
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Yamazato, M.1
Yamazato, Y.2
Sun, C.3
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48249151833
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• Zulli A, Burrell LM, Buxton BF, Hare DL ACE2 and AT4R are present in diseased human blood vessels. Eur J Histochem 2008; 52:39-44. This paper demonstrates the presence of ACE2 in human blood vessels in health and disease.
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• Zulli A, Burrell LM, Buxton BF, Hare DL ACE2 and AT4R are present in diseased human blood vessels. Eur J Histochem 2008; 52:39-44. This paper demonstrates the presence of ACE2 in human blood vessels in health and disease.
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85120589315
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•• Diz Dl, Garcia-Espinosa MA, Gegick S, et al. Injections of angiotensin- converting enzyme 2 inhibitor MLN4760 into nucleus tractus solrtarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol 2008; 93:694-700. This paper shows that within the brain, in the nucleus tractus solitarius (NTS), Ang- (1-7) is locally synthesized from Ang II, and that normal sensitivity of the baroreflex control of heart rate requires this to respond to hypertension.
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•• Diz Dl, Garcia-Espinosa MA, Gegick S, et al. Injections of angiotensin- converting enzyme 2 inhibitor MLN4760 into nucleus tractus solrtarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol 2008; 93:694-700. This paper shows that within the brain, in the nucleus tractus solitarius (NTS), Ang- (1-7) is locally synthesized from Ang II, and that normal sensitivity of the baroreflex control of heart rate requires this to respond to hypertension.
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41449089986
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•• Feng Y, Yue X, Xia H, et al. Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin ll-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation. Circ Research 2008; 102:729-736. This paper shows that overexpressing ACE2 in the subfornical organ of the brain prevented the angiotensin ll-mediated pressor and drinking responses.
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•• Feng Y, Yue X, Xia H, et al. Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin ll-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation. Circ Research 2008; 102:729-736. This paper shows that overexpressing ACE2 in the subfornical organ of the brain prevented the angiotensin ll-mediated pressor and drinking responses.
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85120586947
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• Ji H, Menini S, Zheng W, et al. Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17 beta-oestradiol regulation of renal pathology in renal wrap hypertension. Exp Physiol 2008; 93:648-657. This paper shows that 17-beta estradiol both increases ACE2 protein and prevents tubular and glomerular injury in the renal wrap hypertension model.
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• Ji H, Menini S, Zheng W, et al. Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17 beta-oestradiol regulation of renal pathology in renal wrap hypertension. Exp Physiol 2008; 93:648-657. This paper shows that 17-beta estradiol both increases ACE2 protein and prevents tubular and glomerular injury in the renal wrap hypertension model.
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25
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3042596693
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No association of angiotensin- converting enzyme gene (ACE2) polymorphisms with hypertension
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Benjafield AV, Wang WY, Morris BJ. No association of angiotensin- converting enzyme gene (ACE2) polymorphisms with hypertension. Am J Hypertens 2004; 17:624-628.
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(2004)
Am J Hypertens
, vol.17
, pp. 624-628
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Benjafield, A.V.1
Wang, W.Y.2
Morris, B.J.3
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Association of angiotensin- converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiography substudy
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Lieb W, Graf J, Gotz A, et al. Association of angiotensin- converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiography substudy. J Mol Med 2006; 84:88-96.
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(2006)
J Mol Med
, vol.84
, pp. 88-96
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Lieb, W.1
Graf, J.2
Gotz, A.3
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27
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33751251070
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Association of angiotensin-converting enzyme gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese
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Huang W, Yang W, Wang Y, et al. Association of angiotensin-converting enzyme gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese. J Hum Hypertens 2006; 20:968-971.
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(2006)
J Hum Hypertens
, vol.20
, pp. 968-971
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Huang, W.1
Yang, W.2
Wang, Y.3
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31944448010
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Association of angiotensin- converting enzyme gene (ACE2) A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome
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Zhong J, Yan Z, Liu D, et al. Association of angiotensin- converting enzyme gene (ACE2) A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome. J Lab Clin Med 2006; 147:91-95.
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(2006)
J Lab Clin Med
, vol.147
, pp. 91-95
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Zhong, J.1
Yan, Z.2
Liu, D.3
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36049047073
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Correlation of angiotensin-converting enzyme 2 gene polymorphisms with stage 2 hypertension in Han Chinese
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Niu W, Qi YS, Zhou W, Qui C. Correlation of angiotensin-converting enzyme 2 gene polymorphisms with stage 2 hypertension in Han Chinese. Translational Res 2007; 150:374-380.
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(2007)
Translational Res
, vol.150
, pp. 374-380
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Niu, W.1
Qi, Y.S.2
Zhou, W.3
Qui, C.4
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46849105087
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• Sluimer JC, Gasc JM, Hamming I, et al. Angiotensin- converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions. J Pathol 2008; 215:273-279. These authors examined ACE2 expression and activity in human carotid lesions, observing that expression varies with the extent of disease.
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• Sluimer JC, Gasc JM, Hamming I, et al. Angiotensin- converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions. J Pathol 2008; 215:273-279. These authors examined ACE2 expression and activity in human carotid lesions, observing that expression varies with the extent of disease.
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31
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42649136964
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• Igase M, Kohara K, Nagai T, et al. Increased expression of angiotensin converting enzyme 2 in conjunction with reduction of neointima by angiotensin II type 1 receptor blockade. Hypertens Res 2008; 31:553-559. This paper indicates that ACE2 is regulated by factors other than blood pressure in the SHR.
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• Igase M, Kohara K, Nagai T, et al. Increased expression of angiotensin converting enzyme 2 in conjunction with reduction of neointima by angiotensin II type 1 receptor blockade. Hypertens Res 2008; 31:553-559. This paper indicates that ACE2 is regulated by factors other than blood pressure in the SHR.
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46249090611
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• Dong B, Zhang C, Feng JB, et al. Over-expression of ACE2 enhances plaque stability in a rabbit model of atherosclerosis. Arterioscler Thromb Vasc Biol 2008; 28:1270-1276. These authors used a rabbit model of atherosclerosis to show that overexpression of ACE2 may help to stabilize atherosclerotic plaques.
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• Dong B, Zhang C, Feng JB, et al. Over-expression of ACE2 enhances plaque stability in a rabbit model of atherosclerosis. Arterioscler Thromb Vasc Biol 2008; 28:1270-1276. These authors used a rabbit model of atherosclerosis to show that overexpression of ACE2 may help to stabilize atherosclerotic plaques.
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33846241330
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Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: Evidence for ACE2dependent processing of angiotensin II
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Shaltout HA, Westwood BM, Averill DB. et al. Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2dependent processing of angiotensin II. Am J Physiol Renal Physiol 2007; 292:F82-F91.
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(2007)
Am J Physiol Renal Physiol
, vol.292
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Shaltout, H.A.1
Westwood, B.M.2
Averill, D.B.3
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33750722109
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Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: Implications for albuminuria in diabetes
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doi: 10.1681
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Ye M, Wysocki J, William J, et al. Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes. J Am Soc Nephrol 2006; 17:3067-3075; doi: 10.1681.
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(2006)
J Am Soc Nephrol
, vol.17
, pp. 3067-3075
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Ye, M.1
Wysocki, J.2
William, J.3
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42449140640
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• Tikellis C, Bialkowski K, Pete J, et al. ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes. Diabetes 2008; 57:1018-1025. This study indicates that diabetes modifies ACE2 expression, which influences the development of renal injury and responsiveness to blocking ACE2.
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• Tikellis C, Bialkowski K, Pete J, et al. ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes. Diabetes 2008; 57:1018-1025. This study indicates that diabetes modifies ACE2 expression, which influences the development of renal injury and responsiveness to blocking ACE2.
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ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice
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Soler MJ, Wysocki J, Ye M, et al. ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice. Kidney Int 2007; 72:614-623.
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(2007)
Kidney Int
, vol.72
, pp. 614-623
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Soler, M.J.1
Wysocki, J.2
Ye, M.3
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Loss of angiotensin-converting enzyme- 2 accelerates diabetic kidney injury
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Wong DW, Oudit GY, Reich H, et al. Loss of angiotensin-converting enzyme- 2 accelerates diabetic kidney injury. Am J Pathol 2007; 171:438-451.
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(2007)
Am J Pathol
, vol.171
, pp. 438-451
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Wong, D.W.1
Oudit, G.Y.2
Reich, H.3
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Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury
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Shao Y, He M, Zhou L, et al. Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury. Acta Pharmacol Sin 2008; 29:829-837.
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(2008)
Acta Pharmacol Sin
, vol.29
, pp. 829-837
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Shao, Y.1
He, M.2
Zhou, L.3
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40
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40849127119
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• Mizuiri S, Hemmi H, Arita M, et al. Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls. Am J Kidney Dis 2008; 51:613-623. This study compares ACE and ACE2 expression in kidneys of normal subjects and in those with diabetes. They conclude that the high ACE/ACE2 ratio in the kidneys of patients with type 2 diabetes may contribute to renal injury.
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• Mizuiri S, Hemmi H, Arita M, et al. Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls. Am J Kidney Dis 2008; 51:613-623. This study compares ACE and ACE2 expression in kidneys of normal subjects and in those with diabetes. They conclude that the high ACE/ACE2 ratio in the kidneys of patients with type 2 diabetes may contribute to renal injury.
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41
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43049103449
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• Wang G, Lai FM-M, Lai K-B, et al. Urinary mRNA expression of ACE and ACE2 in human type 2 diabetic nephropathy. Diabetologia 2008; 51:1062-1067. This study showed that urinary expression of ACE2 mRNA correlated with proteinuria.
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• Wang G, Lai FM-M, Lai K-B, et al. Urinary mRNA expression of ACE and ACE2 in human type 2 diabetic nephropathy. Diabetologia 2008; 51:1062-1067. This study showed that urinary expression of ACE2 mRNA correlated with proteinuria.
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•• Hernandez Prada JA, Ferreira AJ, Katovich MJ, et al. Structure-based identi-fication of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension 2008; 51:1312-1317. This study suggests that ACE2 activators may be useful as a strategy to treat hypertension.
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•• Hernandez Prada JA, Ferreira AJ, Katovich MJ, et al. Structure-based identi-fication of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension 2008; 51:1312-1317. This study suggests that ACE2 activators may be useful as a strategy to treat hypertension.
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43
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85120140215
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1' subsite. Bioorganic Med Chem Lett 2008; 18:1681-1687. This study explores potential ACE2 inhibitors.
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1' subsite. Bioorganic Med Chem Lett 2008; 18:1681-1687. This study explores potential ACE2 inhibitors.
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44
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85120590970
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• Lew RA, Warner FJ, Hanchapola I, et al. Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor. Exp Physiol 2008; 93:685-693. This study demonstrates that an endogenous inhibitor may mask ACE2 activity in human plasma.
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• Lew RA, Warner FJ, Hanchapola I, et al. Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor. Exp Physiol 2008; 93:685-693. This study demonstrates that an endogenous inhibitor may mask ACE2 activity in human plasma.
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