High prevalence and early complication of symptomatic vertebral fracture in elderly people treated with high-dose glucocorticoids

Journal of the American Geriatrics Society

Volumn 57, Issue 1, 2009, Pages 188-189

  Tatsuno, Ichiro ^a,b   Suzuki, Sawako ^a,b   Yoshida, Tomohiko ^a,b   Tanaka, Tomoaki ^a,b   Sueishi, Makoto ^c   Sugiyama, Takao ^c  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CHIBA UNIVERSITY HOSPITAL   (Japan)

^c SHIMOSHIZU HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; PREDNISOLONE;

AGE DISTRIBUTION; BACKACHE; BONE FRAGILITY; COHORT ANALYSIS; DISEASE ACTIVITY; DISEASE ASSOCIATION; DRUG DOSE INCREASE; DRUG MEGADOSE; DRUG PULSE THERAPY; GERIATRIC ASSESSMENT; GERIATRIC PATIENT; HOSPITAL; HUMAN; INCIDENCE; KAPLAN MEIER METHOD; LETTER; LONG TERM CARE; MIDDLE AGED; MORBIDITY; OSTEOPOROSIS; PREVALENCE; PROPORTIONAL HAZARDS MODEL; RADIODIAGNOSIS; RISK FACTOR; SEX RATIO; SPINE RADIOGRAPHY; SYMPTOMATOLOGY; THORACOLUMBAR SPINE; TREATMENT DURATION; VERTEBRA FRACTURE; VERTEBRA MALFORMATION;

AGED; FEMALE; GLUCOCORTICOIDS; HUMANS; MALE; PREVALENCE; SPINAL FRACTURES;

EID: 58149242741     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2009.02077.x     Document Type: Letter

References (10)

1. Canalis E, Mazziotti G, Giustina A et al. Glucocorticoid-induced osteoporosis: Pathophysiology and therapy. Osteoporos Int 2007 18 : 1319 1328.
2. Mazziotti G, Angeli A, Bilezikian JP et al. Glucocorticoid-induced osteoporosis: An update. Trends Endocrinol Metab 2006 17 : 144 149.
3. Shaker JL, Lukert BP. Osteoporosis associated with excess glucocorticoids. Endocrinol Metab Clin North Am 2005 34 : 341 356, viii-ix.
4. van Staa TP. The pathogenesis, epidemiology and management of glucocorticoid-induced osteoporosis. Calcif Tissue Int 2006 79 : 129 137.
5. Naganathan V, Jones G, Nash P et al. Vertebral fracture risk with long-term corticosteroid therapy: Prevalence and relation to age, bone density, and corticosteroid use. Arch Intern Med 2000 160 : 2917 2922.
6. van Staa TP, Leufkens HG, Cooper C. The epidemiology of corticosteroid-induced osteoporosis: A meta-analysis. Osteoporos Int 2002 13 : 777 787.
7. Raisz LG. Pathogenesis of osteoporosis: Concepts, conflicts, and prospects. J Clin Invest 2005 115 : 3318 3325.
8. Chan GK, Duque G. Age-related bone loss: Old bone, new facts. Gerontology 2002 48 : 62 71.
9. Angeli A, Guglielmi G, Dovio A et al. High prevalence of asymptomatic vertebral fractures in post-menopausal women receiving chronic glucocorticoid therapy: A cross-sectional outpatient study. Bone 2006 39 : 253 259.
10. de Nijs RN, Jacobs JW, Lems WF et al. Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis. N Engl J Med 2006 355 : 675 684.