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Volumn 6, Issue 6, 2008, Pages 544-554

HIV pharmacogenetics in clinical practice: Recent achievements and future challenges

Author keywords

Antiretroviral therapy; HIV; Hypersensitivity reactions; Pharmacogenetics

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; APOLIPOPROTEIN; ATAZANAVIR; CYTOCHROME P450 2B6; DIDANOSINE; EFAVIRENZ; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 2B7; GLYCINE; GLYCOPROTEIN P; HLA B ANTIGEN; HLA B5701 ANTIGEN; INDINAVIR; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; NELFINAVIR; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TENOFOVIR; THREONINE; TRANSMEMBRANE CONDUCTANCE REGULATOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZALCITABINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

EID: 58149214287     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016208786501535     Document Type: Review
Times cited : (10)

References (60)
  • 1
    • 0035163638 scopus 로고    scopus 로고
    • Hypersensitivity reactions during therapy with the nucleoside reverse trancriptase inhibitor abacavir
    • Hetherington S, McGuirk S, Powell G, et al. Hypersensitivity reactions during therapy with the nucleoside reverse trancriptase inhibitor abacavir. Clin Ther 2001; 23: 1603-14.
    • (2001) Clin Ther , vol.23 , pp. 1603-1614
    • Hetherington, S.1    McGuirk, S.2    Powell, G.3
  • 2
    • 0036811774 scopus 로고    scopus 로고
    • The abacavir hypersensitivity reaction: A review
    • Clay PG. The abacavir hypersensitivity reaction: a review. Clin Ther 2002; 24: 1502-14.
    • (2002) Clin Ther , vol.24 , pp. 1502-1514
    • Clay, P.G.1
  • 5
    • 12144287198 scopus 로고    scopus 로고
    • Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
    • Martin AM, Nolan D, Gaudieri S, et al. Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Proc Natl Acad Sci USA 2004; 101: 4180-5.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4180-4185
    • Martin, A.M.1    Nolan, D.2    Gaudieri, S.3
  • 6
    • 0037006623 scopus 로고    scopus 로고
    • Association between presence of HLA-B*5701, HLA-DR7 and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    • Mallal S, Nolan D, Witt C, et al. Association between presence of HLA-B*5701, HLA-DR7 and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet 2002; 359: 727-32.
    • (2002) Lancet , vol.359 , pp. 727-732
    • Mallal, S.1    Nolan, D.2    Witt, C.3
  • 7
    • 0037197044 scopus 로고    scopus 로고
    • Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
    • Hetherington S, Hughes AR, Mosteller M, et al. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet 2002; 359: 1121-2.
    • (2002) Lancet , vol.359 , pp. 1121-1122
    • Hetherington, S.1    Hughes, A.R.2    Mosteller, M.3
  • 8
    • 12144291646 scopus 로고    scopus 로고
    • Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations
    • Hughes AR, Mosteller M, Bansal AT, et al. Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations. Pharmacogenomics 2004; 5: 203-11.
    • (2004) Pharmacogenomics , vol.5 , pp. 203-211
    • Hughes, A.R.1    Mosteller, M.2    Bansal, A.T.3
  • 9
    • 33745295856 scopus 로고    scopus 로고
    • Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study
    • Rauch A, Nolan D, Martin A, McKinnon E, Almeida C, Mallal S. Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study. Clin Infect Dis 2006; 43: 99-102.
    • (2006) Clin Infect Dis , vol.43 , pp. 99-102
    • Rauch, A.1    Nolan, D.2    Martin, A.3    McKinnon, E.4    Almeida, C.5    Mallal, S.6
  • 11
    • 38949196447 scopus 로고    scopus 로고
    • HLA-B*5701 screening for hypersensitivity to abacavir
    • Mallal S, Phillips E, Carosi G, et al. HLA-B*5701 screening for hypersensitivity to abacavir. N Engl J Med 2008; 358: 568-79.
    • (2008) N Engl J Med , vol.358 , pp. 568-579
    • Mallal, S.1    Phillips, E.2    Carosi, G.3
  • 14
    • 1542327563 scopus 로고    scopus 로고
    • Drug-induced liver injury associated with the use of nonnucleoside reverse-transcriptase inhibitors
    • Dieterich DT, Robinson PA, Love J, Stern JO. Drug-induced liver injury associated with the use of nonnucleoside reverse-transcriptase inhibitors. Clin Infect Dis 2004; 38: S80-9.
    • (2004) Clin Infect Dis , vol.38
    • Dieterich, D.T.1    Robinson, P.A.2    Love, J.3    Stern, J.O.4
  • 15
    • 33646797442 scopus 로고    scopus 로고
    • Nevirapine toxicity
    • Taiwo BO. Nevirapine toxicity. Int J STD AIDS 2006; 17: 364-70.
    • (2006) Int J STD AIDS , vol.17 , pp. 364-370
    • Taiwo, B.O.1
  • 16
    • 12144260460 scopus 로고    scopus 로고
    • Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts
    • Martin AM, Nolan D, James I, et al. Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts. AIDS 2005; 19: 97-9.
    • (2005) AIDS , vol.19 , pp. 97-99
    • Martin, A.M.1    Nolan, D.2    James, I.3
  • 17
    • 33746767604 scopus 로고    scopus 로고
    • HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients
    • Littera R, Carcassi C, Masala A, et al. HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients. AIDS 2006; 20: 1621-6.
    • (2006) AIDS , vol.20 , pp. 1621-1626
    • Littera, R.1    Carcassi, C.2    Masala, A.3
  • 18
    • 33845945094 scopus 로고    scopus 로고
    • HLA-Cw8 primarily associated with hypersensitivity to nevirapine
    • Gatanaga H, Yazaki H, Tamuna J, et al. HLA-Cw8 primarily associated with hypersensitivity to nevirapine. AIDS 2007; 21: 264-5.
    • (2007) AIDS , vol.21 , pp. 264-265
    • Gatanaga, H.1    Yazaki, H.2    Tamuna, J.3
  • 19
    • 33748288115 scopus 로고    scopus 로고
    • Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse transcriptase inhibitor hepatotoxicity
    • Ritchie MD, Haas DW, Motsinger AA, et al. Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse transcriptase inhibitor hepatotoxicity. Clin Inf Dis 2006; 43: 779-82.
    • (2006) Clin Inf Dis , vol.43 , pp. 779-782
    • Ritchie, M.D.1    Haas, D.W.2    Motsinger, A.A.3
  • 20
    • 33748328070 scopus 로고    scopus 로고
    • Pharmacogenetics of nevirapine-associated hepatotoxicity: An Adult AIDS Clinical Trials Group collaboration
    • Haas DW, Bartlett JA, Andersen JW, et al. Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration. Clin Inf Dis 2006; 43: 783-6
    • (2006) Clin Inf Dis , vol.43 , pp. 783-786
    • Haas, D.W.1    Bartlett, J.A.2    Andersen, J.W.3
  • 21
    • 19944428456 scopus 로고    scopus 로고
    • Pharmacogenetics of efavirenz and central nervous sistem side effects: An Adult AIDS Clinical Trials Group study
    • Haas DW, Ribaudo HJ, Kim RB, et al. Pharmacogenetics of efavirenz and central nervous sistem side effects: an Adult AIDS Clinical Trials Group study. AIDS 2004; 18: 2391-400.
    • (2004) AIDS , vol.18 , pp. 2391-2400
    • Haas, D.W.1    Ribaudo, H.J.2    Kim, R.B.3
  • 22
    • 0035808574 scopus 로고    scopus 로고
    • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
    • Marzolini C, Telenti A, Decosterd LA, Greub G, Biollaz J, Buclin T. Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS 2001; 15: 1192-4.
    • (2001) AIDS , vol.15 , pp. 1192-1194
    • Marzolini, C.1    Telenti, A.2    Decosterd, L.A.3    Greub, G.4    Biollaz, J.5    Buclin, T.6
  • 23
    • 20244364148 scopus 로고    scopus 로고
    • Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients
    • Rotger M, Colombo S, Furrer H, et al. Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients. Pharmacogenet Genomics 2005; 15: 1-5.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 1-5
    • Rotger, M.1    Colombo, S.2    Furrer, H.3
  • 24
    • 34347356504 scopus 로고    scopus 로고
    • Efavirenzz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516-T polymorphism
    • Saitoh A, Fletcher CV, Brundage R, et al. Efavirenzz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516-T polymorphism. J Acquir Immune Defic Syndr 2007; 45: 280-5.
    • (2007) J Acquir Immune Defic Syndr , vol.45 , pp. 280-285
    • Saitoh, A.1    Fletcher, C.V.2    Brundage, R.3
  • 25
    • 33947382259 scopus 로고    scopus 로고
    • Predictive value of know and novel alleles of CYP2B6 for Efavirenz plasma concentrations in HIV-infected individuals
    • Rotger M, Tegude H, Colombo S, et al. Predictive value of know and novel alleles of CYP2B6 for Efavirenz plasma concentrations in HIV-infected individuals. Clin Pharmacol Ther 2007; 81: 557-66.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 557-566
    • Rotger, M.1    Tegude, H.2    Colombo, S.3
  • 26
    • 2942551228 scopus 로고    scopus 로고
    • Homozygous CYP2B6 *6 (Q172h and K262R) correlates with high plasma efavirenz concentration in HIV-1 patients treated with standard efavirenz-containing regimens
    • Tsuchiya K, Gatanaga H, Tachikawa N, et al. Homozygous CYP2B6 *6 (Q172h and K262R) correlates with high plasma efavirenz concentration in HIV-1 patients treated with standard efavirenz-containing regimens. Biochem Biophys Res Commun 2004; 319: 1322-6.
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 1322-1326
    • Tsuchiya, K.1    Gatanaga, H.2    Tachikawa, N.3
  • 27
    • 33644588715 scopus 로고    scopus 로고
    • Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz
    • Wang J, Sonnerborg A, Rane A, et al. Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz. Pharmacogenet Genomics 2006; 16: 191-8.
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 191-198
    • Wang, J.1    Sonnerborg, A.2    Rane, A.3
  • 28
    • 31044456584 scopus 로고    scopus 로고
    • Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: An Adult AIDS Clinical Trials Group Study
    • Ribaudo HJ, Haas DW, Tierney C, et al. Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study. Clin Inf Dis 2006; 42: 401-7.
    • (2006) Clin Inf Dis , vol.42 , pp. 401-407
    • Ribaudo, H.J.1    Haas, D.W.2    Tierney, C.3
  • 29
    • 0037022006 scopus 로고    scopus 로고
    • Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: A pharmacogenetics study
    • Fellay J, Marzolini C, Meaden ER, et al. Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Lancet 2002; 359: 30-6.
    • (2002) Lancet , vol.359 , pp. 30-36
    • Fellay, J.1    Marzolini, C.2    Meaden, E.R.3
  • 30
    • 23144442403 scopus 로고    scopus 로고
    • No influence of the Pglycoprotein polymorphisms MDR1 G2677T/A and C3435T on the virological and immunological response in treatment naive HIV-positive patients
    • Winzer R, Langmann P, Zylli M, et al. No influence of the Pglycoprotein polymorphisms MDR1 G2677T/A and C3435T on the virological and immunological response in treatment naive HIV-positive patients. Ann Clin Microbiol Antimicrob 2005; 4: 3.
    • (2005) Ann Clin Microbiol Antimicrob , vol.4 , pp. 3
    • Winzer, R.1    Langmann, P.2    Zylli, M.3
  • 31
    • 3142751539 scopus 로고    scopus 로고
    • No influence of the Pglycoprotein genotype (MDR1 C3435T) on plasma levels of lopinavir and efavirenz during antiretroviral treatment
    • Winzer R, Langmann P, Zylli M, et al. No influence of the Pglycoprotein genotype (MDR1 C3435T) on plasma levels of lopinavir and efavirenz during antiretroviral treatment. Eur J Med Res 2003; 8: 531-4.
    • (2003) Eur J Med Res , vol.8 , pp. 531-534
    • Winzer, R.1    Langmann, P.2    Zylli, M.3
  • 32
    • 27944460707 scopus 로고    scopus 로고
    • Pharmacogenetics of long-term responses to antirewtroviral regimens containing Efavirenz and/ or Nelfinavir: An Adult AIDS Clinical Trials Group Study
    • Haas DW, Smeaton LM, Shafer RW, et al. Pharmacogenetics of long-term responses to antirewtroviral regimens containing Efavirenz and/ or Nelfinavir: an Adult AIDS Clinical Trials Group Study. J Infect Dis 2005; 192: 1931-42.
    • (2005) J Infect Dis , vol.192 , pp. 1931-1942
    • Haas, D.W.1    Smeaton, L.M.2    Shafer, R.W.3
  • 33
    • 33750312905 scopus 로고    scopus 로고
    • Multilocus genetic interactions and response to efavirenz-containing regimens: An adult AIDS clinical trials group study
    • Motsinger AA, Ritchie MD, Shafer RW, et al. Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study. Pharmacogenet Genomics 2006; 16: 837-45.
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 837-845
    • Motsinger, A.A.1    Ritchie, M.D.2    Shafer, R.W.3
  • 34
    • 9644268882 scopus 로고    scopus 로고
    • Atazanavir for the treatment of human immunodeficiency virus infection
    • Busti AJ, Hali RG, Margolis DM. Atazanavir for the treatment of human immunodeficiency virus infection. Pharmacotherapy 2004; 24: 1732-47.
    • (2004) Pharmacotherapy , vol.24 , pp. 1732-1747
    • Busti, A.J.1    Hali, R.G.2    Margolis, D.M.3
  • 35
    • 33845495422 scopus 로고    scopus 로고
    • Genetic factors influencing atazanavir plasma concentrations and the risk of severe hyperbilirubinemia
    • Rodriguez-Novoa S, Martin-Carbonero L, Barreiro P, et al. Genetic factors influencing atazanavir plasma concentrations and the risk of severe hyperbilirubinemia. AIDS 2007; 21: 41-6.
    • (2007) AIDS , vol.21 , pp. 41-46
    • Rodriguez-Novoa, S.1    Martin-Carbonero, L.2    Barreiro, P.3
  • 36
    • 33745929357 scopus 로고    scopus 로고
    • Pharmacogenetics characteristics of indinavir, zidovudine and lamivudine therapy in HIV-infected adults: A pilot study
    • Anderson PL, Lamba J, Aquilante CL, Shuetz E, Fletcher CV. Pharmacogenetics characteristics of indinavir, zidovudine and lamivudine therapy in HIV-infected adults: a pilot study. J Acquir Immune Defic Syndr 2006; 42: 441-9.
    • (2006) J Acquir Immune Defic Syndr , vol.42 , pp. 441-449
    • Anderson, P.L.1    Lamba, J.2    Aquilante, C.L.3    Shuetz, E.4    Fletcher, C.V.5
  • 37
    • 25844446183 scopus 로고    scopus 로고
    • Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia
    • Rotger M, Taffe P, Bleiber G, et al. Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia. J Infect Dis 2005; 192: 1381-6.
    • (2005) J Infect Dis , vol.192 , pp. 1381-1386
    • Rotger, M.1    Taffe, P.2    Bleiber, G.3
  • 38
    • 30144438738 scopus 로고    scopus 로고
    • Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C/ T polymorphism at the multidrug resistance gene 1
    • Rodriguez-Novoa S, Barreiro P, Rendon A, et al. Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C/ T polymorphism at the multidrug resistance gene 1. Clin Infect Dis 2006; 42: 291-5.
    • (2006) Clin Infect Dis , vol.42 , pp. 291-295
    • Rodriguez-Novoa, S.1    Barreiro, P.2    Rendon, A.3
  • 40
    • 1442351728 scopus 로고    scopus 로고
    • The cellular pharmacology of nucleoside and nucleotide-analogue reverse transcriptase inhibitors and its relationship to clinical toxicities
    • Anderson PL, Kakuda TN, Lichtenstein KA. The cellular pharmacology of nucleoside and nucleotide-analogue reverse transcriptase inhibitors and its relationship to clinical toxicities. Clin Infect Dis 2004; 38: 734-53.
    • (2004) Clin Infect Dis , vol.38 , pp. 734-753
    • Anderson, P.L.1    Kakuda, T.N.2    Lichtenstein, K.A.3
  • 41
    • 29144452191 scopus 로고    scopus 로고
    • Mitochondrial haplogroups and peripheral neuropathy during antiretrovirals therapy: An adult AIDS clinical trials group study
    • Hulgan T, Haas DW, Haines JL, et al. Mitochondrial haplogroups and peripheral neuropathy during antiretrovirals therapy: an adult AIDS clinical trials group study. AIDS 2005; 19: 1341-9.
    • (2005) AIDS , vol.19 , pp. 1341-1349
    • Hulgan, T.1    Haas, D.W.2    Haines, J.L.3
  • 42
    • 38349127924 scopus 로고    scopus 로고
    • The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy
    • Canter JA, Haas DW, Kallinpur AR, et al. The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy. Pharmacogenomics J 2008; 8: 71-7.
    • (2008) Pharmacogenomics J , vol.8 , pp. 71-77
    • Canter, J.A.1    Haas, D.W.2    Kallinpur, A.R.3
  • 43
    • 33746211636 scopus 로고    scopus 로고
    • Hemocromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy
    • Kallianpur AR, Hulgan T, Canter JA, et al. Hemocromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy. AIDS 2006; 20: 1503-13.
    • (2006) AIDS , vol.20 , pp. 1503-1513
    • Kallianpur, A.R.1    Hulgan, T.2    Canter, J.A.3
  • 44
    • 34748835839 scopus 로고    scopus 로고
    • No evidence of relation between peripheral neuropathy and presence of hemochromatosis gene mutations in HIV-1-positive patients
    • Costarelli S, Torti C, Gatta LB, et al. No evidence of relation between peripheral neuropathy and presence of hemochromatosis gene mutations in HIV-1-positive patients. J Acquir Immuno Defic Syndr 2007; 46: 255-6.
    • (2007) J Acquir Immuno Defic Syndr , vol.46 , pp. 255-256
    • Costarelli, S.1    Torti, C.2    Gatta, L.B.3
  • 45
    • 39549113449 scopus 로고    scopus 로고
    • Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts individual's NRTI-SN risk
    • Cherry CL, Rosenow A, Affandi JS, McArthur JC, Wesselingh SL, Price P. Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts individual's NRTI-SN risk. AIDS Res Hum Retroviruses 2008; 24: 117-23.
    • (2008) AIDS Res Hum Retroviruses , vol.24 , pp. 117-123
    • Cherry, C.L.1    Rosenow, A.2    Affandi, J.S.3    McArthur, J.C.4    Wesselingh, S.L.5    Price, P.6
  • 46
    • 0033396957 scopus 로고    scopus 로고
    • Fat distribution and metabolic changes in patient with HIV infection
    • Safrin S, Grunfeld C. Fat distribution and metabolic changes in patient with HIV infection. AIDS 1999; 13: 2493-505.
    • (1999) AIDS , vol.13 , pp. 2493-2505
    • Safrin, S.1    Grunfeld, C.2
  • 47
    • 33747605338 scopus 로고    scopus 로고
    • Current concepts in the diagnosis and management of metabolic complications of HIV infection and its therapy
    • Wohl DA, McComsey G, Tebas P, et al. Current concepts in the diagnosis and management of metabolic complications of HIV infection and its therapy. Clin Infect Dis 2006; 43: 645-53.
    • (2006) Clin Infect Dis , vol.43 , pp. 645-653
    • Wohl, D.A.1    McComsey, G.2    Tebas, P.3
  • 48
    • 36348984420 scopus 로고    scopus 로고
    • Metabolic syndrome, cardiovascular disease and type 2 diabetes mellitus after initiation of antiretroviral therapy in HIV infection
    • Wand H, Calmy A, Carey DL, et al. Metabolic syndrome, cardiovascular disease and type 2 diabetes mellitus after initiation of antiretroviral therapy in HIV infection. AIDS 2007; 21: 2445-53.
    • (2007) AIDS , vol.21 , pp. 2445-2453
    • Wand, H.1    Calmy, A.2    Carey, D.L.3
  • 49
    • 0033583977 scopus 로고    scopus 로고
    • Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: A cohort study
    • Carr A, Samaras K, Thorisdottir A, et al. Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study. Lancet 1999; 353: 2093-9.
    • (1999) Lancet , vol.353 , pp. 2093-2099
    • Carr, A.1    Samaras, K.2    Thorisdottir, A.3
  • 50
    • 0037233820 scopus 로고    scopus 로고
    • Incidence of and risk factors for lipoatrophy (abnormal fat loss) in ambulatory HIV-1-infected patients
    • Lichtenstein KA, Delaney KM, Armon C, et al. Incidence of and risk factors for lipoatrophy (abnormal fat loss) in ambulatory HIV-1-infected patients. J Acquir Immune Defic Syndr 2003; 32: 48-56.
    • (2003) J Acquir Immune Defic Syndr , vol.32 , pp. 48-56
    • Lichtenstein, K.A.1    Delaney, K.M.2    Armon, C.3
  • 51
    • 0037131198 scopus 로고    scopus 로고
    • TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy
    • Maher B, Alfirevic A, Vilar FJ, Wilkins EG, Park BK, Pirmohamed M. TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy. AIDS 2002; 16: 2013-8.
    • (2002) AIDS , vol.16 , pp. 2013-2018
    • Maher, B.1    Alfirevic, A.2    Vilar, F.J.3    Wilkins, E.G.4    Park, B.K.5    Pirmohamed, M.6
  • 52
    • 0037415033 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha gene -238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy
    • Nolan D, Moore C, Castley A, et al. Tumor necrosis factor-alpha gene -238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy. AIDS 2003; 17: 121-3.
    • (2003) AIDS , vol.17 , pp. 121-123
    • Nolan, D.1    Moore, C.2    Castley, A.3
  • 53
    • 20244375708 scopus 로고    scopus 로고
    • Modeling the influence of APOC3, APOE, and TNF polymorphisms on the risk of antiretroviral therapy-associated lipid disorders
    • Tarr PE, Taffe P, Bleiber G, et al. Modeling the influence of APOC3, APOE, and TNF polymorphisms on the risk of antiretroviral therapy-associated lipid disorders. J Infect Dis 2005; 191: 1419-26.
    • (2005) J Infect Dis , vol.191 , pp. 1419-1426
    • Tarr, P.E.1    Taffe, P.2    Bleiber, G.3
  • 54
    • 0035824763 scopus 로고    scopus 로고
    • An interaction between apoC-III variants and protease inhibitors contributes to high triglyceride/low HDL levels in treated HIV patients
    • Fauvel J, Bonnet E, Ruidavets JB, et al. An interaction between apoC-III variants and protease inhibitors contributes to high triglyceride/low HDL levels in treated HIV patients. AIDS 2001; 15: 2397-406.
    • (2001) AIDS , vol.15 , pp. 2397-2406
    • Fauvel, J.1    Bonnet, E.2    Ruidavets, J.B.3
  • 55
    • 33645329876 scopus 로고    scopus 로고
    • Association among race/ ethnicity, APOC-III genotypes, and lipids in HIV-1-infected individuals on antiretrovirals therapy
    • Foulkes AS, Wohl DA, Frank I, et al. Association among race/ ethnicity, APOC-III genotypes, and lipids in HIV-1-infected individuals on antiretrovirals therapy. PLos Med 2006; 3: 337-47.
    • (2006) PLos Med , vol.3 , pp. 337-347
    • Foulkes, A.S.1    Wohl, D.A.2    Frank, I.3
  • 56
    • 33749132365 scopus 로고    scopus 로고
    • Protease inhibitor-associated dyslipidemia in HIV-infected patients is strongly influenced by the APOA5-1131T->C gene variation
    • Guardiola M, Ferre R, Salazar J, et al. Protease inhibitor-associated dyslipidemia in HIV-infected patients is strongly influenced by the APOA5-1131T->C gene variation. Clin Chem 2006; 52: 1914-9.
    • (2006) Clin Chem , vol.52 , pp. 1914-1919
    • Guardiola, M.1    Ferre, R.2    Salazar, J.3
  • 57
    • 15444370017 scopus 로고    scopus 로고
    • The Efavirenz induced increase in HDL-cholesterol is influenced by the multidrug resistance gene 1 C3435T polymorphism
    • Alonso-Villaverde C, Coll B, Gomez F, et al. The Efavirenz induced increase in HDL-cholesterol is influenced by the multidrug resistance gene 1 C3435T polymorphism. AIDS 2005; 19: 341-2.
    • (2005) AIDS , vol.19 , pp. 341-342
    • Alonso-Villaverde, C.1    Coll, B.2    Gomez, F.3
  • 58
    • 38049006331 scopus 로고    scopus 로고
    • Tenofovir renal safety in HIV-infected patients: Results from the SCOLTA Project
    • Madeddu G, BonfantiP, De Socio GV, et al. Tenofovir renal safety in HIV-infected patients: results from the SCOLTA Project. Biomed Pharmacother 2008; 62: 6-11.
    • (2008) Biomed Pharmacother , vol.62 , pp. 6-11
    • Madeddu, G.1    BonfantiP, D.2    Socio, G.V.3
  • 59
    • 33845226137 scopus 로고    scopus 로고
    • Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy
    • Izzedine H, Hulot JS, Villard E, et al. Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. J Infect Dis 2006; 194: 1481-91.
    • (2006) J Infect Dis , vol.194 , pp. 1481-1491
    • Izzedine, H.1    Hulot, J.S.2    Villard, E.3
  • 60
    • 3843137250 scopus 로고    scopus 로고
    • The role of CFTR and SPINK-1 mutations in pancreatic disorders in HIV-positive patients: A case control study
    • Felley C, Morris MA, Wonkam A, et al. The role of CFTR and SPINK-1 mutations in pancreatic disorders in HIV-positive patients: a case control study. AIDS 2004; 18: 1521-7.
    • (2004) AIDS , vol.18 , pp. 1521-1527
    • Felley, C.1    Morris, M.A.2    Wonkam, A.3


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