No impact of NOD2/CARD15 on outcome after SCT: A reply

Bone Marrow Transplantation

Volumn 42, Issue 12, 2008, Pages 837-838

  Mayor, N P ^a,b   Shaw, B E ^a,c   Madrigal, J A ^a,b   Marsh, S G E ^a,b  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Royal Marsden Hospital   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15;

ACUTE LEUKEMIA; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; CANCER RELAPSE; CORRELATION ANALYSIS; DISEASE FREE SURVIVAL; DONOR; HUMAN; INCIDENCE; LETTER; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; RESEARCH SUBJECT; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; T CELL DEPLETION; TREATMENT OUTCOME;

COHORT STUDIES; GENETIC PREDISPOSITION TO DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; NEOPLASM RECURRENCE, LOCAL; NOD2 SIGNALING ADAPTOR PROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SURVIVAL ANALYSIS; TRANSPLANTATION, HOMOLOGOUS;

EID: 58149201269     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2008.251     Document Type: Letter

References (9)

1. Sairafi D, Uzunel M, Remberger M, Ringden O, Mattsson J. No impact of NOD2/CARD15 on outcome after SCT. Bone Marrow Transplant 2008; 41: 961-964.
2. Mayor NP, Shaw BE, Hughes DA, Maldonado-Torres H, Madrigal JA, Keshav S et al. Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors. J Clin Oncol 2007; 25: 4262-4269.
3. Holler E, Rogler G, Brenmoehl J, Hahn J, Herfarth H, Greinix H et al Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: Effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 2006; 107 4189-4193.
4. Holler E, Rogler G, Herfarth H, Brenmoehl J, Wild PJ, Hahn J et al Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 2004; 104: 889-894.
5. Granell M, Urbano-Ispizua A, Arostegui JI, Fernandez-Aviles F, Martinez C, Rovira M et al. Effect of NOD2/CARD15 variants in T-cell depleted allogeneic stem cell transplantation. Haematologica 2006; 91: 1372-1376.
6. Elmaagacli AH, Koldehoff M, Hindahl H, Steckel NK, Trenschel R, Peceny R et al. Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation. Transplantation 2006; 81: 247-254.
7. Holler E, Hahn J, Andreesen R, Rogler G, Brenmoehl J, Greinix H et al NOD2/CARD15 polymorphisms in allogeneic stem-cell transplantation from unrelated donors: T depletion matters. J Clin Oncol 2008; 26: 338-339.
8. Mayor NP, Shaw BE, Hughes DA, Maldonado-Torres H, Madrigal JA, Keshav S et al. In Reply. J Clin Oncol 2008; 26: 339.
9. Hugot JP, Zaccaria I, Cavanaugh J, Yang H, Vermeire S, Lappalainen M et al. Prevalence of CARD15/NOD2 mutations in Caucasian healthy people. Am J Gastroenterol 2007; 102: 1259-1267.