Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters

Anais da Academia Brasileira de Ciencias

Volumn 81, Issue 1, 2009, Pages 67-72

  Kanashiro, Alexandre ^a   andrade, Daiani C O ^a   Kabeya, Luciana M ^a   Turato, Walter M ^a   Faccioli, Lucia H ^a   Uyemura, Sérgio A ^a   Lucisano Valim, Yara M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Apoptosis; Atherosclerosis; Dimorphandra mollis; Golden syrian hamster; Hypercholesterolemia; Rutin

Indexed keywords

ANIMALIA; DIMORPHANDRA MOLLIS; MESOCRICETUS AURATUS;

EID: 58149200439     PISSN: 00013765     EISSN: 16782690     Source Type: Journal    
DOI: 10.1590/S0001-37652009000100009     Document Type: Article

References (26)

1. Auger C, Teissedre PL, Gerain P, Lequeux N, Bornet A, Serisier S, Besançon P, Caporiccio B, Cristol JP and Rouanet JM. 2005. Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation. J Agric Food Chem 53: 2015-2021.
2. Batista-Pereira LG, Petacci F, Fernandez JB, Correa AG, Vieira PC, da Silva MFGF and Malaspina O. 2002. Biological activity of astilbin from Dimorphandra mollis against Anticarsia gemmatalis and Spodoptera frugiperda. Pest Manag Sci 58: 503-507.
3. Bizerril MXA, Rodrigues FHG and Hass A. 2005. Fruit consumption and seed dispersal of Dimorphandra mollis Benth. (Leguminosae) by the lowland tapir in the cerrado of Central Brazil. Braz J Biol 65: 407-413.
4. Clardy J and Walsh C. 2004. Lessons from natural molecules. Nature 432: 729-737.
5. Enkhmaa B, Shiwaku K, Katsube T, Kitajima K, Anuurad E, Yamasaki M and Yamane Y. 2005. Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr 135: 729-734.
6. Glässer G, Graefe EU, Struck F, Veit M and Gebhardt R. 2002. Comparison of antioxidative and inhibitory effects on cholesterol biosynthesis of quercetin and potential metabolites. Phytomedicine 9: 33-40.
7. Hasumura M, Yasuhara K, Tamura T, Imai T, Mitsumori K and Hirose M. 2004. Evaluation of the toxicity of enzymatically decomposed rutin with 13-weeks dietary administration to Wistar rats. Food Chem Toxicol 42: 439-444.
8. Kanashiro A, Kabeya LM, Martinello F, Turato WM, Paula FS, Polizello ACM, Uyemura SA and Lucisano-Valim YM. 2007. Effect of rutin on polymorphonuclear leukocytes oxidative metabolism in hypercholesterolemic Golden Syrianhamsters: evaluation by chemiluminescence and flow cytometry. Pharmazie 62: 295-298.
9. Kourounakis AP, Victoratos P, Peroulis N, Stefanou N, Yiangou M, Hadjipetrou L and Kourounakis PN. 2002. Experimental hyperlipidemia and the effect of NSAIDs. Exp Mol Pathol 73: 135-138.
10. Lauridsen ST and Mortensen A. 1999. Probucolselectively increases oxidation of atherogenic lipoproteins in cholesterol-fed mice and in Watanabe heritable hyperlipidemic rabbits. Atherosclerosis 142: 169-178.
11. Macedo ML, Matos DGC, Machado OLT, Marangoni S and Novello JC. 2000. Trypsininhibitor from Dimorphandra mollis seeds: purification and properties. Phytochemistry 54: 553-558.
12. Manach C, Morand C, Demigne O, Regerat F and Remesy C. 1997. Bioavailability of rutin and quercetin in rats. FEBS Letters 409: 12-16.
13. Martinello F, Soares SM, Franco JJ, Santos AC, Sugohara A, Garcia SB, Curti C and Uyemura SA. 2006. Hypolipemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamsters. Food Chem Toxicol 44: 810-8.
14. Middleton-Junior E, Kandaswami C and Theoharides TC.2000. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 52: 673-751.
15. Moghadasian MH. 2002. Experimental atherosclerosis: a historical overview. Life Sci 70: 855-865.
16. Nistor A, Bulla A, Filip DA and Radu A. 1987. The hyperlipidemic hamster as a model of experimental atherosclerosis. Atherosclerosis 68: 159-173.
17. Park SY, Bok SH, Jeon SM, Park YB, Soon-Jae Lee SJ, Tae-Sook Jeong TS and Choi MS. 2002. Effect of rutin and tannic acid supplements on cholesterol metabolism in rats. Nutr Res 22: 283-295.
18. Parker RA, Sabrah T, Cap M and Gill BT. 1995. Relation of vascular oxidative stress, α-tocoferol, and hypercholesterolemia to early atherosclerosis in hamsters. Arterioscler Thromb Vasc Biol 15: 349-358.
19. Rice-Evans C, Miller NJ and Paganga G.1996. Structure-antioxidant activity relationship of flavonoids and phenolic acids. Free Radic Biol Med 20: 933-956.
20. Ross R. 1999. Atherosclerosis - an inflammatory disease. N Engl J Med 340: 115-126.
21. Santos KF, Oliveira TT, Nagem TJ, Pinto AS and Oliveira MG. 1999. Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations. Pharmacol Res 40: 493-6.
22. Selloum L, Bouriche H, Tigrine C and Boudoukha C. 2003. Anti-inflammatory effect of rutin on rat pawoedema, and on neutrophils chemotaxis and degranulation. Exp Toxicol Pathol 54: 313-318.
23. Stocker R and Keaney-Junior JF. 2004. Role of oxidative modifications in atherosclerosis. Physiol Ver 84: 1381-1478.
24. Verpoorte R. 1999. Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development. Drug Discov Today 3: 232-238.
25. Walle T. 2004. Absorption and metabolism of flavonoids. Free Radic Biol Med 36: 829-837.
26. Yuan G, Al-Shali KZ and Hegele RA. 2007. Hypertriglyceridemia: itsetiology, effectsandtreatment. CMAJ 176: 1113-1120.