The life and times of John Beard, DSc (1858-1924)

Integrative Cancer Therapies

Volumn 7, Issue 4, 2008, Pages 229-251

  Moss, Ralph W ^a,b  

^a Cancer Communications   (United States)

^b Cancer Communications Inc   (United States)

Author keywords

Beard; Cancer; Enzymes; Pancreas; Trophoblast; Trypsin

Indexed keywords

TRYPSIN;

ALTERNATIVE MEDICINE; CANCER RESEARCH; CANCER STEM CELL; CANCER THERAPY; CHRONIC PANCREATITIS; CYSTIC FIBROSIS; PRIORITY JOURNAL; REVIEW; TROPHOBLAST;

ANIMALS; COMPLEMENTARY THERAPIES; EMBRYOLOGY; GREAT BRITAIN; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HUMANS; NEOPLASMS; PANCREAS; PEPTIDE HYDROLASES;

EID: 58149193434     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735408326174     Document Type: Review

References (107)

1. Race culture and parenthood. New York Times, Oct. 9, 1909, p. BR590.
2. Beard J. The Enzyme Treatment of Cancer and Its Scientific Basis. London, England: Chatto and Windus, 1911.
3. Lee FS The functions of the ear and the lateral line in fishes. Am J Physiol. 1898 ; 1: 128-144.
4. Beard J. The morphological continuity of the germ cells in Raja batis. Anat Anz. 1900 ; 18: 465-485.
5. Claypole AM Cytology, embryology and microscopical methods: current literature. J Appl Microscop. 1900 ; 3: 1095-1097.
6. Rohon JV Zur Anatomie der Hirnwindungen bei den Primaten. München, Germany: I. V. Williamson Fund ; 1884.
7. Hughes A. The development of the primary sensory system in Xenopus laevis (Daudin). J Anat. 1957 ; 91: 323-338.
8. Eichler VB, Porter RA Rohon-Beard cells in frog development: a study of temporal and spatial changes in a transient cell population. J Comp Neurol. 1981 ; 203: 121-130.
9. Fox H. Amphibian Morphogenesis. Clifton, NJ: Humana Press ; 1984.
10. Sebastian A. A Dictionary of the History of Medicine. New York, NY: Parthenon ; 1999.
11. Clarke PG, Clarke S. Nineteenth century research on naturally occurring cell death and related phenomena. Anat Embryol (Berl). 1996 ; 193: 81-99.
12. Anonymous. Dr John Beard. Nature. 1924 ; 114: 904.
13. Sell S. Stem Cell Handbook. Totowa, NJ: Humana Press ; 2003.
14. Ferretti C., Bruni L., Dangles-Marie V., Pecking AP, Bellet D. Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts. Hum Reprod Update. 2007 ; 13: 121-141.
15. Beaconsfield P., Birdwood G., Beaconsfield R. The placenta. Sci Am. 1980 ; 243: 94-103.
16. Ohlsson R., Glaser A., Holmgren L., Franklin G. Human placental development: a molecular and cellular approach to its "pseudomalignancy. " In: Redmond C, Sargent I, Starkey P, eds. The Placenta. Oxford: Blackwell Scientific Publications Ltd ; 1989.
17. Product approval information: new drug application. US Food and Drug Administration Web site. http://www.fda.gov/cder/foi/appletter/2002/ urokabb101002L.htm. Accessed August 31, 2008.
18. de Fost M., Aerts JM, Groener JE, et al. Low frequency maintenance therapy with imiglucerase in adult type I Gaucher disease: a prospective randomized controlled trial. Haematologica. 2007 ; 92: 215-221.
19. Beard J. The treatment of cancer. Br Med J. 1913 ; 1: 260-261.
20. Beard J. The Enzyme Treatment of Cancer. London: Chatto and Windus ; 1911.
21. Mayr E. The Growth of Biological Thought. Cambridge, MA: The Belknap Press ; 1985.
22. Beard J. Cancer genesis. Lancet. 1905 ; 1: 58.
23. Florey E. The Naples Zoological Station and the Marine Biological Laboratory: one hundred years of biology. Biol Bull. 1985 ; 168: 137-152.
24. Beard J. The System of Branchial Sense Organs and their Associated Ganglia in Ichthyopsida: A Contribution to the Ancestral History of Vertebrates. London: J. E. Adlard ; 1885.
25. Beard J. On the life-history and development of the Genus Myzostoma (F. S. Leuckart). Leipzig, Germany: William Engelmann; 1884.
26. Beard J. On the early development of Lepidosteus osseus - Preliminary notice. Proc Roy Soc. 1889 ; 46: 108-118.
27. Beard J. The history of a transient nervous apparatus in certain Ichthyopsida: an account of the development and degeneration of ganglion-cells and nerve-fibres. Zool Jahrb Morph Abteil. 1896 ; 8: 1-106.
28. Balfour FM On the phenomena accompanying the maturation and impregnation of the ovum. Q Jour Microscop Sci. 1887 ; 18: 109-131.
29. Rohon JV Zur histogenese des Rükenmarkes der Forelle. Sitzungsber der Math-Phys Munich, Germany: Klasse der Bayer Akademie d. Wiss., Bd. 14, 1884.
30. Neal HV The histogenesis of the "transient" (Rohon-Beard) cells in selacian embryos. Science. 1911 ; 33: 273.
31. Hughes A. The development of the primary sensory system in Xenopus laevis (Daudin). J Anat. 1957 ; 91: 323-338.
32. Beard J. The Enzyme Treatment of Cancer and Its Scientific Basis. London, England: Chatto and Windus, 1911.
33. Stewart WN, Rothwell GW Paleobotany and the Evolution of Plants. 2 nd ed. Cambridge, UK: Cambridge University Press ; 1993.
34. Hegner RW College Zoology. New York, NY: Macmillan ; 1918.
35. Gurchot C. The trophoblast theory of cancer (John Beard, 1857-1924) revisited. Oncology. 1975 ; 31: 310-333.
36. Beard J. The cancer problem and cancer research. Lancet. 1905 ; 1: 385-386.
37. Hickson FJ James Hartley Ashworth, Obituary Notices of Fellows of the Royal Society. 1936 ; 2: 204-211.
38. The third natural history collection: the early years and the founding of the Chair of Zoology (1876-1919). University of Edinburgh: The Natural History Collection Web site. http://www.nhc.ed.ac.uk/index.php?page=4.9. Accessed August 30, 2008.
39. Beard J. Professor George Bond Howes, F.R.S. J Anat Physiol. 1905 ; 39: 364-367.
40. Saleeby CW The Conquest of Cancer, New York, NY: Frederick A. Stokes ; 1907.
41. Dr John Beard [obituary]. Nature. 1924: 114: 904.
42. Beard J. The pancreatic treatment of relapse malaria. Br Med J. 1915 ; 1: 449-450.
43. Young AR Freud's friend Fliess. J Laryngol Otol. 2002 ; 116: 992-995.
44. Osler W. Science and Immortality. London: Archibald Constable ; 1906.
45. Haterius HO The female sex hormones. Ohio J Sci. 1937 ; 37: 394-407.
46. Smith MF, McIntush EW, Smith GW Mechanisms associated with corpus luteum development. J Anim Sci 1994 ; 72: 1857-1872.
47. Beard J., Minot CS On certain problems of vertebrate embryology. Science. 1897 ; 5: 107-109.
48. Warthin AS Embyological aspects and etiology of carcinoma. Physician and Surgeon. 1902 ; 24: 282-283.
49. Tietze H. Papaya: The Healthy Fruit. Burnaby, BC: Alive Books ; 2002.
50. Weismann A. The Germ-Plasm, A Theory of Heredity. New York, NY: Charles Scribner Sons ; 1893.
51. Shimkin MB Contrary to Nature-Cancer. Bethesda, MD: US Department of Health, Education and Welfare, Public Health Service, National Institutes of Health ; 1977.
52. Williams WR Cancer genesis. Lancet, 1904 ; 2: 1613.
53. Williams WR The Principles of Cancer and Tumour Formation. London: John Bale & Sons; 1888.
54. Williams WR The Natural History of Cancer. New York, NY: William Wood ; 1908.
55. Beard J. Cancer genesis. Lancet. 1904 ; 1: 1447-1448.
56. Anonymous. Reviews and notices of books: The Span of Gestation and the Cause of Birth. Lancet. 1898 (Jan. 29); 1: 306-307.
57. Anonymous. Cancer patients cured by trypsin injections. New York Times, December 23, 1906, p. 5.
58. Bainbridge WS The Cancer Problem, New York, NY: Macmillan ; 1911.
59. Niederhuber JE Developmental biology, self-renewal, and cancer. Lancet Oncol. 2007 ; 8: 456-457.
60. NCI Cancer Bulletin. National Cancer Institute Web site. http://www.cancer.gov/ncicancerbulletin/NCI_Cancer_Bulletin_080806/page3. Accessed August 30, 2008.
61. Bainbridge WS Trypsin in cancer. A preliminary statement. NY Med Jour. 1907 ; 85: 385.
62. Leighton G. The etiology of cancer: some aspects of modern views. J Comp Pathol Ther. 1903 ; 16: 257-263.
63. Carlson B. Human Embryology and Developmental Biology. 2 nd ed. St. Louis, MO: Mosby ; 1999.
64. Fukayama M., Hayashi Y., Koike M., Ogawa M., Kosaki G. Immunohistochemical localization of pancreatic secretory trypsin inhibitor in fetal and adult pancreatic and extrapancreatic tissues. J Histochem Cytochem. 1986 ; 34: 227-235.
65. Anonymous. Dr. John Beard on cancer. The Scotsman. Jan. 21, 1905, p. 7
66. Shaw-Mackenzie JA Trypsin in cancer [letter]. Medical Press and Circular. 1905 ; 82: 676.
67. Shaw-Mackenzie JA Some Methods of Hypodermic Medication in the Treatment of Cancer [pamphlet]. 1904 ;Vol. XI.5.68, 5. Located at: Cambridge University Library Rare Book Room, Cambridge, England.
68. Anonymous. The encouragement of biological research into the nature of disease. Lancet. 1905 (Feb. 4); 165 (4249). 303-304.
69. Saleeby CB Worry, The Disease of the Age, New York, NY: Stokes; 1907.
70. Saleeby CW Cancer, can it be cured? McClure's Monthly (Published by S.S. McClure, Ltd., London and New York). August 1906.
71. Anonymous. The Nomination Database for the Nobel Prize in Physiology or Medicine, 1901-1951. Web site of the Nobel Prize committee, www.nobelprize.org, accessed October 16, 2008.
72. Beard J. The action of trypsin upon the living cells of Jensen's mouse tumour: a preliminary note upon a research made (with a grant from the Carnegie Fund). Br Med J. 1906 ; 1: 140-141.
73. Beard J. Alternation of generations and its bearing upon cancer. Dublin J Med Sci. 1919 ; 147: 217-219.
74. Evans DME. Constancy of Purpose: An Account of the Foundation and History of the Hong Kong College of Medicine and the Faculty of Medicine of the University of Hong Kong, 1887-1987. Aberdeen, Hong Kong ; Hong Kong University Press: 1987.
75. Beard J. The scientific criterion of a malignant tumor. Med Rec. 1907 ; 71: 24-25.
76. Lambelle FW A further report of the case of pensioner W. Du T., late drummer, No. 5669, permanent staff, 4th battalion, West Yorkshire Regiment. Journal of the Royal Army Medical Corps. 1910 ; 14: 316-318.
77. Proctor RN The Nazi War on Cancer. Princeton, NJ: Princeton University Press ; 2000.
78. Cohnheim J. Lectures on General Pathology. London: New Sydenham Society ; 1889.
79. Borst M. Die Lehre von den Geschwülsten. Wiesbaden, Germany: Verlag von J. F. Bergmann ; 1902.
80. Simmer HH Der Berliner Pathologe Ludwig Pick (1868-1944): Leben und Werk eines jüdischen Deutschen. Abhandlungen zur Geschichte der Medizin und der Naturwissenschaften. Heft 94. Husum, Germany: Matthiesen ; 2000.
81. Blumenthal F. Verhandlungen der Internationalen Konferenz für Krebsforschung vom 25-27 September 1906 zu Heidelberg und Frankfurt. J Cancer Res Clin Oncol. 1907 ; 5: 1-26.
82. Pinkuss A., Pinkus S. Die Krebskrankheit und ihre therapeutische Beeinflussung durch Fermente. Sonderabdruck au der Medizinische Klinik. 1907: 28-29: 15.
83. Leyden E. and Bergell P. Über die therapeutische Verwendung des Trypsin (Pankreatin) bei Carcinom. Zeitschrift für klin. Medizin. 1907 ; 61: 4.
84. Anonymous. Treatment of cancer: a medical dispute. The Scotsman. September 10, 1908 :7.
85. Anonymous. Cancer - can it be cured [taken from JAMA, August 4, 1906]. JAMA. 2006: 296: 712.
86. Foster M. A Text Book of Physiology. London, England: Macmillan ; 1883.
87. Witthaus RA The Medical Student's Manual of Chemistry. New York, NY: William Wood ; 1909.
88. Anonymous. Obituaries. Science. 1924 ; 26: 585.
89. Rice C. Treatment of cancer of the larynx by subcutaneous injection of pancreatic extract (trypsin). Med Rec. 1906 ; 4: 812-816.
90. Morton WJ Trypsin for the cure of cancer. With report of the microscopic examination of a breast thus treated. Med Rec. 1906 ; 4: 893.
91. Wiggins F. Case of multiple fibrosarcoma of the tongue: remarks on the use of trypsin and amylopsin in the treatment of malignant disease. JAMA. 1906 ; 47: 2003-2008.
92. Rogers WH Case history - rectal cancer. JAMA. 1906 ; 47: 2008.
93. Anonymous. The two theories of cancer origin. New York Times, Feb. 18, 1907, p. 16.
94. Luther JW The trypsin treatment of cancer. N Y Med J. 1907 (Feb. 23); 85: 341-344.
95. Clark JG On gynecology. Progressive Medicine. 1907 (June); 2: 170-172, 200-201.
96. Dupuy H. Favorable effect of trypsin in a case of laryngeal epithelioma: exhibition of case. Laryngoscope. 1907 ; 17: 373-375.
97. Teets CE Malignant tumors of the larynx: or, observations on the management and treatment of cancer of the larynx. In: Transactions of the American Homeopathic Opthalmological, Otological and Laryngological Society, 20th Annual Meeting ; June 1907 ; Jamestown, VA.
98. Gould, George. The trypsin and amylopsin treatment of human cancer [editorial]. American Medicine. 1907 (Oct.); 13: 558-560.
99. Bainbridge WS The Enzyme Treatment for Cancer. Paper presented at: the Committee on Scientific Research of the New York Skin and Cancer Hospital ; 1909 ; New York, NY.
100. Hald PT Comparative researches on the tryptic strength of different trypsin preparations and on their action on the human body. Lancet. 1907 ; 2: 1371-1375.
101. McDuffie MW Cancer: a new method of treatment. Med Times. February 1916: 48-50.
102. Lamballe FW The utility of enzymes in malaria. Med Record. November 1913: 928-931.
103. Beard J., Balfour A. The pancreatic treatment of relapse malaria. Br Med J. 1915 ; 1: 449-450.
104. Bätzner W. Trypsinbehandlung d Chir. Tuberculose. Arch Klin Chir. 1911 ; 95: 1.
105. Anonymous. The University court of Edinburgh. The Scotsman. May 18, 1921: 10.
106. Ewing J. Neoplastic Diseases. 2 nd ed. Philadelphia, PA: W. B. Saunders, 1922: 105.
107. Wolf M. Enzyme Therapy. New York: Vantage Press, 1972.