Lymphoepitelioma-like hepatocellular carcinoma: A case report and a review of the literature

World Journal of Gastroenterology

Volumn 14, Issue 29, 2008, Pages 4694-4696

  Nemolato, Sonia ^a   Fanni, Daniela ^a   Naccarato, Antonio Giuseppe ^b   Ravarino, Alberto ^a   Bevilacqua, Generoso ^b   Faa, Gavino ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Hepatocellular carcinoma; Liver; Liver lymphoepithelioma; Primary liver tumors; Tumor infiltrating lymphocytes

Indexed keywords

CD8 ANTIGEN;

ABDOMINAL PAIN; ADULT; ARTICLE; CASE REPORT; CD8+ T LYMPHOCYTE; CYTOTOXIC T LYMPHOCYTE; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; ECHOGRAPHY; EPSTEIN BARR VIRUS; FEMALE; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER NODULE; LIVER RESECTION; LYMPHOCYTIC INFILTRATION; LYMPHOEPITHELIOMA; MEDICAL LITERATURE; PROGNOSIS; TREATMENT OUTCOME; TUMOR LOCALIZATION; TUMOR VOLUME; UNDIFFERENTIATED CARCINOMA; CARCINOMA; LIVER TUMOR; LYMPHOCYTE; MIDDLE AGED; PATHOLOGY; REVIEW;

CARCINOMA; CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; LIVER NEOPLASMS; LYMPHOCYTES; MIDDLE AGED;

EID: 58149190112     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.4694     Document Type: Article

References (22)

1. Doerr W. [Lympnepithelial Schmincke-Regaud tumors.] Arztl Wochensch 1956; 11: 169-182
2. Kuo T, Hsueh C. Lymphoepithelioma-like salivary gland carcinoma in Taiwan: a clinicopathological study of nine cases demonstrating a strong association with Epstein-Barr virus. Histopathology 1997; 31: 75-82
3. Butler AE, Colby TV, Weiss L, Lombard C. Lymphoepithelioma-like carcinoma of the lung. Am J Surg Pathol 1989; 13: 632-639
4. Cho HJ, Kim JY, Yoo J, Lee SS. Gastric carcinoma with lymphoid stroma: incidence of EBV and Helicobacter pylori infection. Appl Immunohistochem Mol Morphol 2003; 11: 149-152
5. Samaha S, Tawfik O, Horvat R, Bhatia P. Lymphoepithelioma-like carcinoma of the colon: report of a case with histologic, immunohistochemical, and molecular studies for Epstein-Barr virus. Dis Colon Rectum 1998; 41: 925-928
6. Hartmann CA, Roth C, Minck C, Niedobitek G. Thymic carcinoma. Report of five cases and review of the literature. J Cancer Res Clin Oncol 1990; 116: 69-82
7. Bais AG, Kooi S, Teune TM, Ewing PC, Ansink AC. Lymphoepithelioma-like carcinoma of the uterine cervix: absence of Epstein-Barr virus, but presence of a multiple human papillomavirus infection. Gynecol Oncol 2005; 97: 716-718
8. Chen KC, Chiang HS, Fang CL. EBER expression of pure urinary bladder lymphoepithelioma-like carcinoma in two unique Asian patients. Urol Int 2005; 74: 280-282
9. Holmang S, Borghede G, Johansson SL. Bladder carcinoma with lymphoepithelioma-like differentiation: a report of 9 cases. J Urol 1998; 159: 779-782
10. Tamas EF, Nielsen ME, Schoenberg MP, Epstein JI. Lymphoepithelioma-like carcinoma of the urinary tract: a clinicopathological study of 30 pure and mixed cases. Mod Pathol 2007; 20: 828-834
11. Gulley ML, Amin MB, Nicholls JM, Banks PM, Ayala AG, Srigley JR, Eagan PA, Ro JY. Epstein-Barr virus is detected in undifferentiated nasopharyngeal carcinoma but not in lymphoepithelioma-like carcinoma of the urinary bladder. Hum Pathol 1995; 26: 1207-1214
12. Takeuchi H, Fujita H, Iwasaki F, Takeuchi T, Imadome K, Okumiya T, Matsui T, Takahashi M. A case of Epstein-Barr Virus (EBV)-associated thymic carcinoid and investigation of existence of EBV-infected cells in thymus and thymic tumors. J Clin Microbiol 2004; 42: 2850-2854
13. Wu MS, Shun CT, Wu CC, Hsu TY, Lin MT, Chang MC, Wang HP, Lin JT. Epstein-Barr virus-associated gastric carcinomas: relation to H. pylori infection and genetic alterations. Gastroenterology 2000; 118: 1031-1038
14. Gulley ML, Burton MP, Allred DC, Nicholls JM, Amin MB, Ro JY, Schneider BG. Epstein-Barr virus infection is associated with p53 accumulation in nasopharyngeal carcinoma. Hum Pathol 1998; 29: 252-259
15. Niemhom S, Kitazawa S, Murao S, Kunachak S, Maeda S. Co-expression of p53 and bcl-2 may correlate to the presence of epstein-barr virus genome and the expression of proliferating cell nuclear antigen in nasopharyngeal carcinoma. Cancer Lett 2000; 160: 199-208
16. Kim YB, Park YN, Han JY, Hong KC, Hwang TS. Biliary lymphoepithelioma-like carcinoma not associated with Epstein-Barr virus. Arch Pathol Lab Med 1999; 123: 441-443
17. Emile JF, Adam R, Sebagh M, Marchadier E, Falissard B, Dussaix E, Bismuth H, Reynes M. Hepatocellular carcinoma with lymphoid stroma: a tumour with good prognosis after liver transplantation. Histopathology 2000; 37: 523-529
18. Quaglia A, Bhattacharjya S, Dhillon AP. Limitations of the histopathological diagnosis and prognostic assessment of hepatocellular carcinoma. Histopathology 2001; 38: 167-174
19. Szekely E. Hepatocellular carcinoma with lymphoid stroma: 'lymphoepithelioma-like carcinoma'? Histopathology 2001; 39: 540
20. Si MW, Thorson JA, Lauwers GY, DalCin P, Furman J. Hepatocellular lymphoepithelioma-like carcinoma associated with epstein barr virus: a hitherto unrecognized entity. Diagn Mol Pathol 2004; 13: 183-189
21. Chen CJ, Jeng LB, Huang SF. Lymphoepithelioma-like hepatocellular carcinoma. Chang Gung Med J 2007; 30: 172-177
22. Fu J, Xu D, Liu Z, Shi M, Zhao P, Fu B, Zhang Z, Yang H, Zhang H, Zhou C, Yao J, Jin L, Wang H, Yang Y, Fu YX, Wang FS. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology 2007; 132: 2328-2339