The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease

Sleep and Breathing

Volumn 13, Issue 1, 2009, Pages 79-84

  Kryger, Meir ^a   Roth, Thomas ^b   Wang Weigand, Sherry ^c   Zhang, Jeffrey ^c  

^a Gaylord Hospital Wallingford   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c Takeda Global Research   (United States)

Author keywords

COPD; Insomnia; Ramelteon; Sleep disorder; Sleep disordered breathing; Sleep onset latency

Indexed keywords

PLACEBO; RAMELTEON;

ADULT; ARTICLE; BEDTIME DOSAGE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INSOMNIA; MALE; OXYGEN SATURATION; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; RESPIRATORY AIRFLOW; SLEEP STAGE; SLEEP TIME; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ADULT; COMORBIDITY; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INDENES; MALE; OXIMETRY; POLYSOMNOGRAPHY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, MELATONIN; SEVERITY OF ILLNESS INDEX; SLEEP APNEA SYNDROMES; SLEEP APNEA, OBSTRUCTIVE; SLEEP INITIATION AND MAINTENANCE DISORDERS; SLEEP STAGES; YOUNG ADULT;

EID: 58149184029     PISSN: 15209512     EISSN: 15221709     Source Type: Journal    
DOI: 10.1007/s11325-008-0196-4     Document Type: Article

References (21)

1. Bhullar S, Phillips B (2005) Sleep in COPD patients. COPD 2:355-361
2. Center for Disease Control. Facts about chronic obstructive pulmonary disease. http://www.cdc.gov/nceh/airpollution/copd/pdfs/copdfaq.pdf. Last updated 2003. Accessed July 25, 2007
3. Pauwells RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS (2001) Global strategy for the diagnosis, management, and prevention of chronic obstructive disease. Am J Respir Crit Care Med 163:1256-1276
4. Douglas NJ (2005) Asthma and chronic obstructive pulmonary disease. In: Kryger MH, Roth T, Dement WC (eds) Principles and practice of sleep medicine. Elsevier, Philadelphia, pp 1122-1135
5. Fleetham J, West P, Mezon B, Conway W, Roth T, Kryger M (1982) Sleep, arousals, and oxygen desaturation in chronic obstructive pulmonary disease. The effect of oxygen therapy. Am Rev Respir Dis 126:429-433
6. Catterall JR, Douglas NJ, Calverley PM et al (1983) Transient hypoxemia during sleep in chronic obstructive pulmonary disease is not a sleep apnea syndrome. Am Rev Respir Dis 128:24-29
7. White JE, Drinnan MJ, Smithson AJ, Griffiths CJ, Gibson GJ (1995) Respiratory muscle activity during rapid eye movement (REM) sleep in patients with chronic obstructive pulmonary disease. Thorax 50:376-382
8. George CF, West P, Kryger MH (1987) Oxygenation and breathing pattern during phasic and tonic REM in patients with chronic obstructive pulmonary disease. Sleep 10:234-243
9. George CF, Bayliff CD (2003) Management of insomnia in patients with chronic obstructive pulmonary disease. Drugs 63:379-387
10. Zammit G, Erman M, Wang-Weigand S, Sainati S, Zhang J, Roth T (2007) Evaluation of the efficacy and safety of ramelteon in subjects with chronic insomnia. J Clin Sleep Med 3:495-504
11. Roth T, Seiden D, Wang-Weigand S, Zhang J (2007) A 2-night, 3-period, crossover study of ramelteon's efficacy and safety in older adults with chronic insomnia. Curr Med Res Opin 23:1005-1014
12. Roth T, Seiden D, Sainati S, Wang-Weigand S, Zhang J, Zee P (2006) Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia. Sleep Med 7:312-318
13. Erman M, Seiden D, Zammit G, Sainati S, Zhang J (2006) An efficacy, safety, and dose-response study of ramelteon in patients with chronic primary insomnia. Sleep Med 7:17-24
14. Kryger M, Wang-Weigand S, Roth T (2007) Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea. Sleep Breath 11:159-164
15. Kryger M, Wang-Weigand S, Zhang J, Roth T (2007) Effect of ramelteon, a selective MT1/MT2-receptor agonist, on respiration during sleep in mild to moderate COPD. Sleep Breath (published online ahead of print December 3, 2007) DOI 10.1007/s11325-007-0156-4
16. Saaresranta T, Irjala K, Aittokallio T, Polo O (2005) Sleep quality, daytime sleepiness and fasting insulin levels in women with chronic obstructive pulmonary disease. Respir Med 99:856-863
17. Orr WC, Shamma-Othman Z, Levin D, Othman J, Rundell OH (1990) Persistent hypoxemia and excessive daytime sleepiness in chronic obstructive pulmonary disease (COPD). Chest 97:583-585
18. Steens RD, Pouliot Z, Millar TW, Kryger MH, George CF (1993) Effects of zolpidem and triazolam on sleep and respiration in mild to moderate chronic obstructive pulmonary disease. Sleep 16:318-326
19. Girault C, Muir JF, Mihaltan F et al (1996) Effects of repeated administration of zolpidem on sleep, diurnal and nocturnal respiratory function, vigilance, and physical performance in patients with COPD. Chest 110:1203-1211
20. George CFP, Series F, Kryger MH, Moscovitch A (1999) Safety and efficacy of zaleplon versus zolpidem in outpatients with chronic obstructive pulmonary disease (COPD) and insomnia. Sleep 22(Suppl):S320
21. George CF (2000) Perspectives on the management of insomnia in patients with chronic respiratory disorders. Sleep 23(Suppl 1):S31-S35