Endometrial eosinophilic syncytial change related to breakdown: Immunohistochemical evidence suggests a regressive process

International Journal of Gynecological Pathology

Volumn 27, Issue 4, 2008, Pages 534-538

  Shah, Sejal S ^a,b   Mazur, Michael T ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Abnormal uterine bleeding; Breakdown; Endometrium; Eosinophilic syncytial change; Ki 67; pHH3

Indexed keywords

HISTONE H3; KI 67 ANTIGEN; PHOSPHOHISTONE H3; PHOSPHOPROTEIN; SERINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; DIFFERENTIAL DIAGNOSIS; ENDOMETRIUM; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; EOSINOPHILIC SYNCYTIAL CHANGE; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MITOSIS INDEX; PRIORITY JOURNAL; SYNCYTIUM; UTERUS BLEEDING; BIOPSY; CELL GROWTH; CYTOLOGY; ENDOMETRIUM TUMOR; EOSINOPHIL; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; RETROSPECTIVE STUDY;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; CELL GROWTH PROCESSES; ENDOMETRIAL HYPERPLASIA; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; EOSINOPHILS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 58149180608     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/PGP.0b013e31817323b3     Document Type: Article

References (17)

1. Zaman SS, Mazur MT. Endometrial papillary syncytial change. A nonspecific alteration associated with active breakdown. Am J Clin Pathol 1993;99:741-5.
2. Abell MR. Endometrial biopsy: normal and abnormal diagnostic characteristics. In: Gold JJ, ed. Gynecologic Endocrinology. New York: Harper and Row; 1975:156-90.
3. Hendrickson MR, Kempson RL. Endometrial epithelial metaplasias: proliferations frequently misdiagnosed as adenocarcinoma. Report of 89 cases and proposed classification. Am J Surg Pathol 1980;4:525-42.
4. Gersell DJ. Endometrial papillary syncytial change. Another perspective. Am J Clin Pathol 1993;99:656-7.
5. Gerdes J, Lemke H, Baisch H, et al. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984;133:1710-5.
6. Goto H, Tomono Y, Ajiro K, et al. Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. J Biol Chem 1999;274:25543-9.
7. Winkler B, Alvarez S, Richart RM, et al. Pitfalls in the diagnosis of endometrial neoplasia. Obstet Gynecol 1984;64:185-94.
8. Prasad CJ, Crum CP, Weinberg DS. Endometrial papillary syncytial proliferations: diagnostic role of histology, AgNORS and DNA ploidy analysis [abstract]. Mod Pathol 1992;5:68A.
9. Mai KT, Yazdi HM, Boone SA. 'Minimal deviation' endometrioid carcinoma with oncocytic change of the endometrium. Arch Pathol Lab Med 1995;119:751-4.
10. Johnson TL, Kini SR. Endometrial metaplasia as a source of atypical glandular cells in cervicovaginal smears. Diagn Cytopathol 1996;14:25-31.
11. Kaku T, Silverberg SG, Tsukamoto N, et al. Association of endometrial epithelial metaplasias with endometrial carcinoma and hyperplasia in Japanese and American women. Int J Gynecol Pathol 1993;12:297-300.
12. Jacques SM, Qureshi F, Lawrence WD. Surface epithelial changes in endometrial adenocarcinoma: diagnostic pitfalls in curettage specimens. Int J Gynecol Pathol 1995;14:191-7.
13. Lehman MB, Hart WR. Simple and complex hyperplastic papillary proliferations of the endometrium: a clinicopathologic study of nine cases of apparently localized papillary lesions with fibrovascular stromal cores and epithelial metaplasia. Am J Surg Pathol 2001;25:1347-54.
14. Clement PB, Young RH. Endometrioid carcinoma of the uterine corpus: a review of its pathology with emphasis on recent advances and problematic aspects. Adv Anat Pathol 2002;9:145-84.
15. Maia H Jr, Maltez A, Studart E, et al. Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle. BJOG 2004;111:1242-7.
16. Morsi HM, Leers MP, Jager W, et al. The patterns of expression of an apoptosis-related CK18 neoepitope, the bcl-2 proto-oncogene, and the Ki67 proliferation marker in normal, hyperplastic, and malignant endometrium. Int J Gynecol Pathol 2000;19:118-26.
17. Brenner RM, Slayden OD, Rodgers WH, et al. Immunocytochemical assessment of mitotic activity with an antibody to phosphorylated histone H3 in the macaque and human endometrium. Hum Reprod 2003;18:1185-93.