Clinicopathological features, background liver disease, and survival analysis of HCV-positive patients with hepatocellular carcinoma: Differences between young and elderly patients

Journal of Gastroenterology

Volumn 43, Issue 12, 2008, Pages 975-981

  Saneto, Hiromi ^a   Kobayashi, Masahiro ^a   Kawamura, Yusuke ^a   Yatsuji, Hiromi ^a   Sezaki, Hitomi ^a   Hosaka, Tetsuya ^a   Akuta, Norio ^a   Suzuki, Fumitaka ^a   Suzuki, Yoshiyuki ^a   Arase, Yasuji ^a   Ikeda, Kenji ^a   Kumada, Hiromitsu ^a  

^a TORANOMON HOSPITAL   (Japan)

Author keywords

Chronic hepatitis; Elderly patients; HCC; HCV

Indexed keywords

ALCOHOL; ANTINEOPLASTIC AGENT; BILIRUBIN; HYALURONIC ACID; IMMUNOGLOBULIN; PROTHROMBIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; BILIRUBIN BLOOD LEVEL; CANCER INCIDENCE; CANCER SIZE; CANCER SURVIVAL; CHEMOEMBOLIZATION; CHRONIC HEPATITIS; CONTROLLED STUDY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; JAPAN; LAPAROSCOPY; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FUNCTION TEST; LIVER SURGERY; MAJOR CLINICAL STUDY; MALE; MICROWAVE THERAPY; ONSET AGE; PATIENT INFORMATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; RADIOFREQUENCY ABLATION; RETROSPECTIVE STUDY; THROMBOCYTE COUNT;

AGE FACTORS; AGED; BILIRUBIN; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATITIS C, CHRONIC; HUMANS; INCIDENCE; LIVER CIRRHOSIS; LIVER DISEASES; LIVER FUNCTION TESTS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROTHROMBIN; RETROSPECTIVE STUDIES; SEX FACTORS; SURVIVAL RATE; TOKYO; TUMOR MARKERS, BIOLOGICAL;

EID: 58149177255     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-008-2268-4     Document Type: Article

References (17)

1. Liver Cancer Study Group of Japan. Report of the 17th nationwide follow-up survey of primary liver cancer in Japan. Hepatol Res 2007;37:676-691.
2. Taura N, Hamasaki K, Nakao K, Ichikawa T, Nishimura D, Goto T, et al. Aging of patients with hepatitis C virus-associated hepatocellular carcinoma: Long-term trends in Japan. Oncol Rep 2006;16:837-843.
3. Kiyosawa K, Sodeyama T, Tanaka E, Gibo Y, Yoshizawa K, Nakano Y, et al. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma. Hepatology 1990;12:671-675.
4. Ikeda K, Saitoh S, Koida I, Arase Y, Tsubota A, Chayama K, et al. A multivariate analysis of risk factors for hepatocellular carcinogenesis. Hepatology 1993;18:47-53.
5. Ikeda K, Saitoh S, Kobayashi M, Suzuki Y, Tsubota A, Suzuki F, et al. Distinction between chronic hepatitis and liver cirrhosis in patients with hepatitis C virus infection. Hepatol Res 2000;18:252-266.
6. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: Diagnosis, grading and staging, Hepatology 1994;19:1513-1520.
7. Kaneko S, Unoura M, Takeuchi M, Terasaki S, Ogino H, Matsushita E, et al. The role of hepatitis C virus in hepatocellular carcinoma in Japan. Intervirology 1994;37:108-113.
8. Ikeda K, Saitoh S, Suzuki Y, Kobayashi M, Tsubota A, Koida I, et al. Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis. J Hepatol 1998;28:930-938.
9. Hamada H, Yatsuhashi H, Yano K, Daikoku M, Arisawa K, Inoue O, et al. Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C. Cancer 2002;95:331-339.
10. Aizawa Y, Shibamoto Y, Takagi I, Zeniya M, Toda G. Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C. Cancer 2000;89:53-59.
11. Matsumura H, Moriyama M, Goto I, Tanaka N, Okubo H, Arakawa Y. Natural course of progression of liver fibrosis in Japanese patients with chronic liver disease type C - a study of 527 patients at one establishment. J Viral Hepat 2000;7:268-275.
12. Shimauchi Y, Tanaka M, Koga K, Itano S, Ishii K, Kumashiro R, et al. Clinical characteristics of patients in their 40s with HCV antibody-positive hepatocellular carcinoma. Alcohol Clin Exp Res 2000;24Suppl 4:64S-67S.
13. Fujishima T, Ishikawa T, Shiratori Y, Kanda M, Tateishi R, Akamatsu M, et al. Age-related comparison of the profiles of patients with hepatocellular carcinoma. Hepatogastroenterology 2006;53:913-918.
14. Yano M, Yatsuhashi H, Inoue O, Inokuchi K, Koga M. Epidemiology and long term prognosis of hepatitis C virus infection in Japan. Gut 1993;34Suppl 2:S13-S16.
15. Anisimov VN. Biology of aging and cancer. Cancer Control 2007;14:23-31.
16. Kitagawa M, Utsuyama M, Kurata M, Yamamoto K, Yuasa Y, Ishikawa Y, et al. Cancer and aging: Symposium of the 27 th annual meeting of the Japanese society for biomedical gerontology, Tokyo. Cancer Immunol Immunother 2005;54:623-634.
17. Giannini E, Romagnoli P, Fasoli A, Botta F, Risso D, Testa R. Influence of age on clinical presentation, therapeutic options, and prognosis in anti-HCV positive cirrhotic patients with hepatocellular carcinoma. Age Aging 2002;31:457-462.