Rapid and sensitive liquid chromatography tandem mass spectrometry method for the quantification of ambroxol in human plasma

Biomedical Chromatography

Volumn 22, Issue 10, 2008, Pages 1108-1114

  Hu, Wanqun ^a   Xu, Yu ^a   Liu, Fei ^a   Liu, Aixiang ^a   Guo, Qingxiang ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Ambroxol; LC MS MS; Pharmacokinetic

Indexed keywords

ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHANOL; PLASMA (HUMAN);

AMBROXOL; CHROMATOGRAPHIC SEPARATIONS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MOBILE PHASIS; SENSITIVE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY;

PHARMACOKINETICS;

AMBROXOL; ENALAPRILAT; FORMIC ACID; METHANOL; WATER;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OPEN STUDY; PRECIPITATION; PRODUCT RECOVERY; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS; VOLUNTEER; ADOLESCENT; BLOOD; DRUG STABILITY; LIQUID CHROMATOGRAPHY; METHODOLOGY; REPRODUCIBILITY;

ADOLESCENT; ADULT; AMBROXOL; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; MALE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 58149172112     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1032     Document Type: Article

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