Effect of topical autologous platelet-rich fibrin versus no intervention on epithelialization of donor sites and meshed split-thickness skin autografts: A randomized clinical trial

Plastic and Reconstructive Surgery

Volumn 122, Issue 5, 2008, Pages 1431-1440

  Danielsen, Patricia ^a   Jørgensen, Bo ^a   Karlsmark, Tonny ^a   Jorgensen, Lars N ^a   Ågren, Magnus S ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

KERATIN; FIBRIN GLUE; WATER;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DERMATOME; DONOR SITE; EPITHELIZATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEG ULCER; MALE; MICROBIOLOGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN WATER LOSS; SPLIT THICKNESS SKIN GRAFT; STATISTICAL SIGNIFICANCE; THROMBOCYTE RICH PLASMA; TISSUE SECTION; AUTOTRANSPLANTATION; BIOPSY; CHRONIC DISEASE; DRUG EFFECT; EPITHELIUM CELL; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOLOGY; SKIN; SKIN TRANSPLANTATION; THROMBOCYTE; TREATMENT FAILURE; WOUND HEALING;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; BLOOD PLATELETS; CHRONIC DISEASE; EPITHELIAL CELLS; FEMALE; FIBRIN TISSUE ADHESIVE; HUMANS; LEG ULCER; MALE; MIDDLE AGED; SKIN; SKIN TRANSPLANTATION; TRANSPLANTATION, AUTOLOGOUS; TREATMENT FAILURE; WATER; WOUND HEALING;

EID: 58149170394     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/PRS.0b013e318188202c     Document Type: Article

References (41)

1. Bitsch, M., Saunte, D. M., Lohmann, M., Holstein, P. E., Jørgensen, B., and Gottrup, F. Standardised method of surgical treatment of chronic leg ulcers. Scand. J. Plast. Reconstr. Surg. Hand Surg. 39: 162, 2005.
2. Jones, J. E., and Nelson, E. A. Skin grafting for venous leg ulcers. Cochrane Database Syst. Rev. 2: CD001737, 2007.
3. Rakel, B. A., Bermel, M. A., Abbott, L. I., et al. Split-thickness skin graft donor site care: A quantitative synthesis of the research. Appl. Nurs. Res. 11: 174, 1998.
4. Disa, J. J., Alizadeh, K. A., Smith, J. W., Hu, Q., and Cordeiro, P. G. Evaluation of a combined calcium sodium alginate and bio-occlusive membrane dressing in the management of split-thickness skin graft donor sites. Ann. Plast. Surg. 46: 405, 2001.
5. Wiechula, R.The useofmoist wound-healing dressingsinthe management of split-thickness skin graft donor sites: A systematic review. Int. J. Nurs. Pract. 9: S9, 2003.
6. Chaby, G., Senet, P., Vaneau, M., et al. Dressings for acute and chronic wounds: A systematic review. Arch. Dermatol. 143: 1297, 2007.
7. Eming, S. A., Krieg, T., and Davidson, J. M. Gene therapy and wound healing. Clin. Dermatol. 25: 79, 2007.
8. Cross, K. J., and Mustoe, T. A. Growth factors in wound healing. Surg. Clin. North Am. 83: 531, 2003.
9. Fu, X., Li, X., Cheng, B., Chen, W., and Sheng,Z. Engineered growth factors and cutaneous wound healing: Success and possible questions in the past 10 years. Wound Repair Regen. 13: 122, 2005.
10. Breuing, K., Andree, C., Helo, G., Slama, J., Liu, P. Y., and Eriksson, E. Growth factors in the repair of partial thickness porcine skin wounds. Plast. Reconstr. Surg. 100: 657, 1997.
11. Hong, J. P., Kim, Y. W., Jung, H. D., and Jung, K. I. The effect of various concentrations of human recombinant epidermal growth factor on split-thickness skin wounds. Int. Wound J. 3: 123, 2006.
12. Nanney, L. B., Paulsen, S., Davidson, M. K., Cardwell, N. L., Whitsitt, J. S., and Davidson, J. M. Boosting epidermal growth factor receptor expression by gene gun transfection stimulates epidermal growth in vivo. Wound Repair Regen. 8: 117, 2000.
13. Brown, G. L., Nanney, L. B., Griffen, J., et al. Enhancement of wound healing by topical treatment with epidermal growth factor. N. Engl. J. Med. 321: 76, 1989.
14. Cohen, I. K., Crossland, M. C., Garrett, A., and Diegelmann, R. F. Topical application of epidermal growth factor onto partial-thickness wounds in human volunteers does not enhance reepithelialization. Plast. Reconstr. Surg. 96: 251, 1995.
15. Cooper, M. L., Hansbrough, J. F., Foreman, T. J., Sakabu, S. A., and Laxer, J. A. The effects of epidermal growth factor and basic fibroblast growth factor on epithelialization of meshed skin graft interstices. Prog. Clin. Biol. Res. 365: 429, 1991.
16. Smith, P. D., Polo, M., Soler, P. M., et al. Efficacy of growth factors in the accelerated closure of interstices in explanted meshed human skin grafts. J. Burn Care Rehabil. 21: 5, 2000.
17. Lynch, S. E., Colvin, R. B., and Antoniades, H. N. Growth factors in wound healing: Single and synergistic effects on partial thickness porcine skin wounds. J. Clin. Invest. 84: 640, 1989.
18. Eppley, B. L., Woodell, J. E., and Higgins, J. Platelet quantification and growth factor analysis from platelet-rich plasma: Implications for wound healing. Plast. Reconstr. Surg. 114: 1502, 2004.
19. Eppley, B. L., Pietrzak, W. S., and Blanton, M. Platelet-rich plasma: A review of biology and applications in plastic surgery. Plast. Reconstr. Surg. 118: 147e, 2006.
20. Everts, P. A. M., Knape, J. T. A., Weibrich, G., et al. Plateletrich plasma and platelet gel: A review. J. Extra Corpor. Technol. 38: 174, 2006.
21. Roukis, T. S., Zgonis, T., and Tiernan, B. Autologous plateletrich plasma for wound and osseous healing: A review of the literature and commercially available products. Adv. Ther. 23; 218, 2006.
22. Lundquist, R., Dziegiel, M. H., and Ågren, M. S. Bioactivity and stability of endogenous fibrogenic factors in platelet-rich fibrin. Wound Repair Regen. 16: 356, 2008.
23. Drake, D. B., and Wong, L. G. Hemostatic effect of Vivostat patient-derived fibrin sealant on split-thickness skin graft donor sites. Ann. Plast. Surg. 50: 367, 2003.
24. Holt, D. R., Kirk, S. J., ReganM. C., Hurson, M., Lindblad, W. J., and Barbul, A. Effect of age on wound healing in healthy human beings. Surgery 112: 293, 1992.
25. Innes, M. E., Umraw, N., Fish, J. S., Gomez, M., and Cartotto, R. C. The useof silver coated dressings ondonor site wounds: A prospective, controlled matched pair study. Burns 27: 621, 2001.
26. Malpass, K. G., Snelling, M. D., and Tron, V. Comparison of donor-site healing under Xeroform and Jelonet dressings: Unexpected findings. Plast. Reconstr. Surg. 112: 430, 2003.
27. Steenfos, H. H., and Agren, M. S. A fibre-free alginate dressing in the treatment of split thickness skin graft donor sites. J. Eur. Acad. Dermatol. Venereol. 11: 252, 1998.
28. Atiyeh, B. S., El-Musa, K. A., and Dham, R. Scar quality and physiologic barrier function restoration after moist and moist-exposed dressings of partial-thickness wounds. Dermatol. Surg. 29: 14, 2003.
29. The World Medical Association (web site). World Medical Association Declaration of Helsinki. Available at: http://www.wma.net/e/policy/b3.htm. Accessed March 1, 2008.
30. European Medicines Agency (web site). ICH topic E 6 (R1): Guidelines for good clinical practice. Available at http://www.emea.europa.eu/pdfs/human/ich/ 013595en.pdf. Accessed March 1, 2008.
31. Gottrup, F., Holstein, P., Jørgensen, B., Lohmann, M., and Karlsmark, T. A new concept of a multidisciplinary wound healing center and a national expert function of wound healing. Arch. Surg. 136: 765, 2001.
32. Ågren, M. S., Ostenfeld, U., Kallehave, F., et al. A randomized, double-blind, placebo-controlled multicenter trial evaluating topical zinc oxide for acute open wounds following pilonidal disease excision. Wound Repair Regen. 14: 526, 2006.
33. Ansai, S. I., Katagata, Y., Yoshikawa, K. I., Hozumi, Y., and Aso, K. Keratin specificity analyses of eight anti-keratin monoclonal antibodies, and their immunostaining patterns in normal skin using formalin-fixed and paraffin-embedded tissue specimens. Arch. Dermatol. Res. 285: 6, 1993.
34. Ksander, G. A., Sawamura, S. J., Ogawa, Y., Sundsmo, J., and McPherson, J. M. The effect of platelet releasate on wound healing in animal models. J. Am. Acad. Dermatol. 22: 781, 1990.
35. Otberg, N., Richter, H., Schaefer, H., Blume-Peytavi, U., Sterry, W., and Lademann, J. Variations of hair follicle size and distribution in different body sites. J. Invest. Dermatol. 122: 14, 2004.
36. Jorgensen, L. N., Ågren, M. S., Madsen, S. M., et al. Dose-dependent impairment of collagen deposition by topical granulocyte- macrophage colony-stimulating factor in human experimental wounds. Ann. Surg. 236: 684, 2002.
37. Vogt, P. M., Lehnhardt, M., Wager, D., Jansen, V., Krieg, M., and Steinau, H. U. Determination of endogenous growth factors in human wound fluid: Temporal presence and profiles of secretion. Plast. Reconstr. Surg. 102: 117, 1998.
38. Okuda, K., Kawase, T., Momose, M., Murata, M., and Yoshie, H. Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-beta and modulates the proliferation of periodontally related cells in vitro. J. Periodontol. 74: 849, 2003.
39. Lasa, C. I., Kidd, R. R., Nunez, H. A., and Drohan, W. N. Effect of fibrin glue on open wounds in DB/DB mice. J. Surg. Res. 54: 202, 1993.
40. Pal, S. K., Cortiella, J., and Herndon, D. Adjunctive methods for pain control in burns. Burns 23: 404, 1997.
41. Zavadil, D. P., Satterlee, C. C., Costigan, J. M., Holt, D. W., and Shostrom, V. K. Autologous platelet gel and platelet-poor plasma reduce pain with total shoulder arthroplasty. J. Extra Corpor. Technol. 39: 177, 2007.