Caveolin-1 expression in human breast lobular cancer progression

Modern Pathology

Volumn 22, Issue 1, 2009, Pages 71-78

  Perrone, Giuseppe ^a   Altomare, Vittorio ^a   Zagami, Mariagiovanna ^a   Morini, Sergio ^a   Petitti, Tommaso ^a   Battista, Cleonice ^a   Muda, Andrea Onetti ^a   Rabitti, Carla ^a  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

Breast; Caveolin 1; Immunohistochemistry; Invasive lobular cancer; Lobular intraepithelial neoplasia

Indexed keywords

CAVEOLIN 1;

ARTICLE; BREAST CANCER; BREAST EPITHELIUM; BREAST LESION; CANCER GRADING; CANCER GROWTH; CONTROLLED STUDY; EPITHELIUM CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 58149168960     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2008.154     Document Type: Article

References (33)

1. Okamoto T, Schlegel A, Scherer PE, et al. Caveolins, a family of scaffolding proteins for organizing 'preassembled signaling complexes' at the plasma membrane. J Biol Chem 1998;273:5419-5422.
2. Lisanti MP, Scherer PE, Tang Z, et al. Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis. Trends Cell Biol 1994;4:231-235.
3. Lee SW, Reimer CL, Oh P, et al. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells. Oncogene 1998;16:1391-1397.
4. Sager R, Sheng S, Anisowicz A, et al. RNA genetics of breast cancer: maspin as paradigm. Cold Spring Harb Symp Quant Biol 1994;59:537-546.
5. Engelman JA, Lee RJ, Karnezis A, et al. Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer. J Biol Chem 1998;273:20448-20455.
6. Engelman JA, Zhang XL, Lisanti MP. Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5′ promoter region of the caveolin-1 gene in human breast cancer cell lines. FEBS Lett 1999;448:221-230.
7. Cohen AW, Hnasko R, Schubert W, et al. Role of caveolae and caveolins in health and disease. Physiol Rev 2004;84:1341-1379.
8. Engelman JA, Zhang XL, Galbiati F, et al. Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3). Cav-1 and and Cav-2 genes map to a known tumor suppressor locus (6-A2/7q31). FEBS Lett 1998;429:330-336.
9. Engelman JA, Zhang X, Galbiati F, et al. Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy. Am J Hum Genet 1998;63:1578-1587.
10. Engelman JA, Zhang XL, Lisanti MP. Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers. FEBS Lett 1998;436:403-410.
11. Zenklusen JC, Bièche I, Lidereau R, et al. (C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer. Proc Natl Acad Sci USA 1994;91:12155-12158.
12. Zenklusen JC, Thompson JC, Troncoso P, et al. Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1. Cancer Res 1994;54:6370-6373.
13. Zenklusen JC, Thompson JC, Klein-Szanto AJ, et al. Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: evidence for a broad range tumor suppressor gene. Cancer Res 1995;55:1347-1350.
14. Kerr J, Leary JA, Hurst T, et al. Allelic loss on chromosome 7q in ovarian adenocarcinomas: two critical regions and a rearrangement of the PLANH1 locus. Oncogene 1996;13:1815-1818.
15. Shridhar V, Sun QC, Miller OJ, et al. Loss of heterozygosity on the long arm of human chromosome 7 in sporadic renal cell carcinomas. Oncogene 1997;15:2727-2733.
16. Jenkins RB, Qian J, Lee HK, et al. A molecular cytogenetic analysis of 7q31 in prostate cancer. Cancer Res 1998;58:759-766.
17. Lee H, Park DS, Razani B, et al Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia. Am J Pathol 2002;161:1357-1369.
18. Park DS, Lee H, Riedel C, et al. Prolactin negatively regulates caveolin-1 gene expression in the mammary gland during lactation, via a Ras-dependent mechanism. J Biol Chem 2001;276:48389-48397.
19. Park DS, Lee H, Frank PG, et al. Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. Mol Biol Cell 2002;13:3416-3430.
20. Park SS, Kim JE, Kim YA, et al. Caveolin-1 is downregulated and inversely correlated with HER2 and EGFR expression status in invasive ductal carcinoma of the breast. Histopathology 2005;47:625-630.
21. Perrone G, Zagami M, Altomare V, et al. COX-2 localization within plasma membrane caveolae-like structures in human lobular intraepithelial neoplasia of the breast. Virchows Arch 2007;451:1039-1045.
22. Bratthauer GL, Tavassoli FA. Lobular intraepithelial neoplasia: previously unexplored aspects assessed in 775 cases and their clinical implications. Virchows Arch 2002;440:134-138.
23. Sotgia F, Williams TM, Schubert W, et al. Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness. Am J Pathol 2006;168:292-309.
24. Salatino M, Beguelin W, Peters MG, et al. Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation. Oncogene 2006;25:7723-7739.
25. Hanby AM, Hughes TA. In situ and invasive lobular neoplasia of the breast. Histopathology 2008;52:58-66.
26. Page DL, Dupont WD, Rogers LW, et al. Atypical hyperplastic lesions of the female breast. A long-term follow-up study. Cancer 1985;55:2698-2708.
27. Vos CB, Cleton-Jansen AM, Berx G, et al. E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis. Br J Cancer 1997;76:1131-1133.
28. Matsuura K, Shiga K, Yokoyama J, et al. Loss of heterozygosity of chromosome 9p21 and 7q31 is correlated with high incidence of recurrent tumor in head and neck squamous cell carcinoma. Anticancer Res 1998;18:453-458.
29. Zenklusen JC, Weitzel JN, Ball HG, et al. Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene. Oncogene 1995;11:359-363.
30. Scherer PE, Tang Z, Chun M, et al. Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe. J Biol Chem 1995;270:16395-16401.
31. Razani B, Schlegel A, Liu J, et al. Caveolin-1, a putative tumour suppressor gene. Biochem Soc Trans 2001;29:494-499.
32. Sagara Y, Mimori K, Yoshinaga K, et al. Clinical significance of Caveolin-1, Caveolin-2 and HER2/neu mRNA expression in human breast cancer. Br J Cancer 2004;91:959-965.
33. Perrone G, Zagami M, Santini D, et al. COX-2 expression in lobular in situ neoplasia of the breast: correlation with histopathological grading system according to the Tavassoli classification. Histopathology 2007;51:33-39.