Comparison of stereotactic radiosurgery (SRS) alone and whole brain radiotherapy (WBRT) plus a stereotactic boost (WBRT + SRS) for one to three brain metastases

Strahlentherapie und Onkologie

Volumn 184, Issue 12, 2008, Pages 655-662

  Rades, Dirk ^a,b,e   Kueter, Jan Dirk ^a   Hornung, Dagmar ^b   Veninga, Theo ^c   Hanssens, Patrick ^c   Schild, Steven E ^d   Dunst, Juergen ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c DR BERNARD VERBEETEN INSTITUTE   (Netherlands)

^d MAYO CLINIC   (United States)

^e UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Brain metastases; Stereotactic radiosurgery; Treatment outcome; Whole brain radiation therapy

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN METASTASIS; CANCER CONTROL; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; INTERMETHOD COMPARISON; IRRADIATION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROGNOSIS; SCORING SYSTEM; STEREOTACTIC PROCEDURE; STEREOTACTIC RADIOSURGERY; TREATMENT OUTCOME; TUMOR DIAGNOSIS; WHOLE BODY RADIATION;

AGE FACTORS; BRAIN NEOPLASMS; COHORT STUDIES; COMBINED MODALITY THERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RADIOSURGERY; RADIOTHERAPY DOSAGE; RETROSPECTIVE STUDIES; SEX FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 58149163316     PISSN: 01797158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00066-008-1946-8     Document Type: Article

References (22)

1. H. Aoyama H. Shirato M. Tago 2006 Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases. A randomized controlled trial JAMA 295 2483 2491
2. P.D. Brown A.L. Asher E. Farace 2008 Adjuvant whole brain radiotherapy: strong emotions decide but rationale studies are needed Int J Radiat Oncol Biol Phys 70 1305 1309
3. D.W. Bruner T. Wasserman 1995 The impact on quality of life by radiation late effects Int J Radiat Oncol Biol Phys 31 1353 1355
4. A. Fahrig O. Ganslandt U. Lambrecht 2007 Hypofractionated stereotactic radiotherapy for brain metastases-results from three different dose concepts Strahlenther Onkol 183 625 630
5. L. E. Gaspar C. Scott M. Rotman 1997 Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials Int J Radiat Oncol Biol Phys 37 745 751
6. Joiner MC, Van der Kogel AJ. The linear-quadratic approach to fractionation and calculation of isoeffect relationships. In: Steel GG. Basic clinical radiobiology. New York: Oxford University Press; 1997:106-112.
7. E.L. Kaplan P. Meier 1958 Non parametric estimation from incomplete observations J Am Stat Assoc 53 457 481
8. D. Khuntia P. Brown J. Li 2006 Whole-brain radiotherapy in the management of brain metastasis J Clin Oncol 24 1295 1304
9. C.A. Meyers J.A. Smith A. Bezjak 2004 Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: results of a randomized phase III trial J Clin Oncol 22 157 165
10. C. Nieder S.T. Astner A.L. Grosu 2007 The role of postoperative radiotherapy after resection of a single brain metastasis. Combined analysis of 643 patients Strahlenther Onkol 183 576 580
11. M.D. Piroth B. Gagel M. Pinkawa 2007 Postoperative radiotherapy of glioblastoma multiforme: analysis and critical assessment of different treatment strategies and predictive factors Strahlenther Onkol 183 695 702
12. A. Pirzkall J. Debus F. Lohr 1998 Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases J Clin Oncol 16 3563 3569
13. B.P. O'Neill N.J. Iturria M.J. Link 2003 A comparison of surgical resection and stereotactic radiosurgery in the treatment of solitary brain metastases Int J Radiat Oncol Biol Phys 55 1169 1176
14. D. Rades G. Bohlen R. Lohynska 2007 Whole-brain radiotherapy with 20 Gy in 5 fractions for brain metastases in patients with cancer of unknown primary (CUP) Strahlenther Onkol 183 631 636
15. W.F. Regine J.L. Huhn R.A. Patchell 2002 Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implications Int J Radiat Oncol Biol Phys 52 333 338
16. W.F. Regine C. Scott K. Murray 2001 Neurocognitive outcome in brain metastases patients treated with accelerated-fractionation vs. accelerated-hyperfractionated radiotherapy: an analysis from Radiation Therapy Oncology Group Study 91-04 Int J Radiat Oncol Biol Phys 51 711 717
17. A. Schoggl K. Kitz M. Reddy 2000 Defining the role of stereotactic radiosurgery versus microsurgery in the treatment of single brain metastases Acta Neurochir (Wien) 142 621 626
18. P.K. Sneed K.R. Lamborn J.M. Forstner 1999 Radiosurgery for brain metastases: is whole brain radiotherapy necessary? Int J Radiat Oncol Biol Phys 43 549 558
19. P.K. Sneed J.H. Suh S.J. Goetsch 2002 A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases Int J Radiat Oncol Biol Phys 53 519 526
20. A. Trotti R. Byhardt J. Stetz 2000 Common toxicity criteria: version 2.0. An improved reference for grading the acute effects of cancer treatment: impact on radiotherapy Int J Radiat Oncol Biol Phys 47 13 47
21. M.A. Vogelbaum J.H. Suh 2006 Resectable brain metastases J Clin Oncol 24 1289 1294
22. J. Yuan J.Z. Wang S. Lo 2008 Hypofractionation Regimens for Stereotactic Radiotherapy for Large Brain Tumors Int J Radiat Oncol Biol Phys 72 390 397