Convection-enhanced delivery of polyethylene glycol-coated liposomal doxorubicin: Characterization and efficacy in rat intracranial glioma models: Laboratory investigation

Journal of Neurosurgery

Volumn 109, Issue 5, 2008, Pages 867-873

  Kikuchi, Toshio ^a   Saito, Ryuta ^a   Sugiyama, Shin Ichirou ^a   Yamashita, Yoji ^a   Kumabe, Toshihiro ^a   Krauze, Michal ^b   Bankiewicz, Krystof ^b   Tominaga, Teiji ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chemotherapy; Convection enhanced delivery; Glioma; Liposomal doxorubicin; Rat

Indexed keywords

DOXORUBICIN; ANTINEOPLASTIC ANTIBIOTIC; MACROGOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN; CONTROLLED STUDY; CONVECTION ENHANCED DELIVERY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG RELEASE; DRUG RETENTION; FLUORESCENCE; GLIOMA; HUMAN; HUMAN CELL; LIPOSOMAL DELIVERY; MALE; NEUROTOXICITY; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; RAT; SURVIVAL; SUSTAINED DRUG RELEASE; TOXICITY TESTING; TUMOR CELL LINE; TUMOR XENOGRAFT; ANIMAL; BRAIN TUMOR; DISEASE MODEL; DRUG SCREENING; FISCHER 344 RAT; METHODOLOGY; PATHOLOGY; SPRAGUE DAWLEY RAT; THERMODYNAMICS; TREATMENT OUTCOME;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BRAIN NEOPLASMS; CELL LINE, TUMOR; CONVECTION; DISEASE MODELS, ANIMAL; DOXORUBICIN; DRUG DELIVERY SYSTEMS; GLIOMA; HUMANS; MALE; POLYETHYLENE GLYCOLS; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 58149163011     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/JNS/2008/109/11/0867     Document Type: Article

References (18)

1. Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH: Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci U S A 91:2076-2080, 1994 (Pubitemid 24092045)
2. Brem H, Piantadosi S, Burger PC, Walker M, Selker R, Vick NA, et al: Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. Lancet 345:1008-1012, 1995
3. Fleming AB, Saltzman WM: Pharmacokinetics of the carmustine implant. Clin Pharmacokinet 41:403-419, 2002
4. Groothuis DR: The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery. Neuro Oncol 2:45-59, 2000
5. Hau P, Fabel K, Baumgart U, Rummele P, Grauer O, Bock A, et al: Pegylated liposomal doxorubicin-efficacy in patients with recurrent high-grade glioma. Cancer 100:1199-1207, 2004 (Pubitemid 38325948)
6. Krauze MT, Saito R, Noble C, Tamas M, Bringas J, Park JW, et al: Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents. J Neurosurg 103:923-929, 2005 (Pubitemid 43194589)
7. Mamot C, Nguyen JB, Pourdehnad M, Hadaczek P, Saito R, Bringas JR, et al: Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neurooncol 68:1-9, 2004 (Pubitemid 39137344)
8. O'Shaughnessy JA: Pegylated liposomal doxorubicin in the treatment of breast cancer. Clin Breast Cancer 4:318-328, 2003
9. Ozawa T, Wang J, Hu LJ, Bollen AW, Lamborn KR, Deen DF: Growth of human glioblastomas as xenografts in the brains of athymic rats. In Vivo 16:55-60, 2002 (Pubitemid 34436176)
10. Perez-Lopez ME, Curiel T, Gomez JG, Jorge M: Role of pegylated liposomal doxorubicin (Caelyx) in the treatment of relapsing ovarian cancer. Anticancer Drugs 18:611-617, 2007 (Pubitemid 46597416)
11. Saito R, Bringas JR, McKnight TR, Wendland MF, Mamot C, Drummond DC, et al: Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res 64:2572-2579, 2004 (Pubitemid 38523915)
12. Saito R, Krauze MT, Bringas JR, Noble C, McKnight TR, Jackson P, et al: Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain. Exp Neurol 196:381-389, 2005 (Pubitemid 41607827)
13. Saito R, Krauze MT, Noble CO, Drummond DC, Kirpotin DB, Berger MS, et al: Convection-enhanced delivery of Ls-TPT enables an effective, continuous, low-dose chemotherapy against malignant glioma xenograft model. Neuro Oncol 8:205-214, 2006 (Pubitemid 46542645)
14. Saito R, Krauze MT, Noble CO, Tamas M, Drummond DC, Kirpotin DB, et al: Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: implications for local drug delivery. J Neurosci Methods 154:225-232, 2006 (Pubitemid 43949058)
15. Siegal T, Horowitz A, Gabizon A: Doxorubicin encapsulated in sterically stabilized liposomes for the treatment of a brain tumor model: biodistribution and therapeutic efficacy. J Neurosurg 83:1029-1037, 1995 (Pubitemid 26048143)
16. Voulgaris S, Partheni M, Karamouzis M, Dimopoulos P, Papadakis N, Kalofonos HP: Intratumoral doxorubicin in patients with malignant brain gliomas. Am J Clin Oncol 25:60-64, 2002 (Pubitemid 34131031)
17. Westphal M, Hilt DC, Bortey E, Delavault P, Olivares R, Warnke PC, et al: A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma. Neuro Oncol 5:79-88, 2003 (Pubitemid 36422560)
18. Yamashita Y, Saito R, Krauze MT, Kawaguchi T, Noble CO, Drummond DC, et al: Convection-enhanced delivery of liposomal doxorubicin in intracranial brain tumor xenografts. Targeted Oncol 1:79-85, 2006